The Extracellular Vesicles of the Helminth Pathogen,Fasciola hepatica: Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis

Fasciola hepaticaFatty Acid Binding Protein Inhibits TLR4 Activation and Suppresses the Inflammatory Cytokines Induced by Lipopolysaccharide In Vitro and In Vivo

(2015) Ivelisse Martin et al.   JOURNAL OF IMMUNOLOGY

Carcinogenic Liver Fluke Secretes Extracellular Vesicles That Promote Cholangiocytes to Adopt a Tumorigenic Phenotype

(2015) Sujittra Chaiyadet et al.   JOURNAL OF INFECTIOUS DISEASES

Exosome-like vesicles derived by Schistosoma japonicum adult worms mediates M1 type immune- activity of macrophage

(2015) Lifu Wang et al.   PARASITOLOGY RESEARCH

Fasciola hepatica vaccine: We may not be there yet but we’re on the right road

(2015) Verónica Molina-Hernández et al.   VETERINARY PARASITOLOGY

The Fasciola hepatica genome: gene duplication and polymorphism reveals adaptation to the host environment and the capacity for rapid evolution

(2015) Krystyna Cwiklinski et al.   GENOME BIOLOGY

Moonlighting proteins as virulence factors of pathogenic fungi, parasitic protozoa and multicellular parasites

(2014) J. Karkowska-Kuleta et al.   Molecular Oral Microbiology

Fasciola hepatica Kunitz Type Molecule Decreases Dendritic Cell Activation and Their Ability to Induce Inflammatory Responses

(2014) Cristian R. Falcón et al.   PLoS One

Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity

(2014) Amy H. Buck et al.   Nature Communications

RNAi Dynamics in Juvenile Fasciola spp. Liver Flukes Reveals the Persistence of Gene Silencing In Vitro

(2014) Paul McVeigh et al.   PLoS Neglected Tropical Diseases

Parasitism in optima forma: Exploiting the host fibrinolytic system for invasion

(2013) Lourdes Figuera et al.   ACTA TROPICA

Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

(2013) Michel Record et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Crystal structure and immunological properties of the first annexin fromSchistosoma mansoni: insights into the structural integrity of the schistosomal tegument

(2013) Chiuan Yee Leow et al.   FEBS Journal

Intestinal innate immune cells in gut homeostasis and immunosurveillance

(2013) Elena Tomasello et al.   IMMUNOLOGY AND CELL BIOLOGY

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Surface associated antigens of Dirofilaria immitis adult worms activate the host fibrinolytic system

(2013) Javier González-Miguel et al.   VETERINARY PARASITOLOGY

Immunomodulatory molecules of Fasciola hepatica: Candidates for both vaccine and immunotherapeutic development

(2013) John P. Dalton et al.   VETERINARY PARASITOLOGY

MHJ_0125 is an M42 glutamyl aminopeptidase that moonlights as a multifunctional adhesin on the surface of Mycoplasma hyopneumoniae

(2013) M. W. Robinson et al.   Open Biology

Extracellular vesicles - vehicles that spread cancer genes

(2012) Janusz Rak et al.   BIOESSAYS

Exosomes

(2012) Bernard Thébaud et al.   CIRCULATION

Biochemical Characterization and Differential Expression of a 16.5-Kilodalton Tegument-Associated Antigen from the Liver Fluke Fasciola hepatica

(2012) José F. Gaudier et al.   Clinical and Vaccine Immunology

The ESCRT machinery

(2012) Oliver Schmidt et al.   CURRENT BIOLOGY

A helminth cathelicidin-like protein suppresses antigen processing and presentation in macrophages via inhibition of lysosomal vATPase

(2012) Mark W. Robinson et al.   FASEB JOURNAL

Trematode Infections

(2012) Thomas Fürst et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Extracellular Vesicles from Parasitic Helminths Contain Specific Excretory/Secretory Proteins and Are Internalized in Intestinal Host Cells

(2012) Antonio Marcilla et al.   PLoS One

Molecular Characterization of a Tetraspanin from the Human Liver Fluke, Opisthorchis viverrini

(2012) Supawadee Piratae et al.   PLoS Neglected Tropical Diseases

Exploring the Fasciola hepatica tegument proteome

(2011) R. Alan Wilson et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury

(2011) S. Gatti et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of α-Synuclein

(2011) Takafumi Hasegawa et al.   PLoS One

Molecular and functional characterization of a Schistosoma bovis annexin: Fibrinolytic and anticoagulant activity

(2011) Eduardo de la Torre-Escudero et al.   VETERINARY PARASITOLOGY

Collagenolytic Activities of the Major Secreted Cathepsin L Peptidases Involved in the Virulence of the Helminth Pathogen, Fasciola hepatica

(2011) Mark W. Robinson et al.   PLoS Neglected Tropical Diseases

A Family of Helminth Molecules that Modulate Innate Cell Responses via Molecular Mimicry of Host Antimicrobial Peptides

(2011) Mark W. Robinson et al.   PLoS Pathogens

Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion

(2010) Colin P. Johnson et al.   JOURNAL OF CELL BIOLOGY

Worm secretory molecules are causing alarm

(2010) Mark W. Robinson et al.   TRENDS IN PARASITOLOGY

Elucidating the transcriptome of Fasciola hepatica — A key to fundamental and biotechnological discoveries for a neglected parasite

(2009) Neil D. Young et al.   BIOTECHNOLOGY ADVANCES

Major Secretory Antigens of the Helminth Fasciola hepatica Activate a Suppressive Dendritic Cell Phenotype That Attenuates Th17 Cells but Fails To Activate Th2 Immune Responses

(2009) D. J. Dowling et al.   INFECTION AND IMMUNITY

Glyceraldehyde-3-Phosphate Dehydrogenase Is a Surface-Associated, Fibronectin-Binding Protein of Trichomonas vaginalis

(2009) A. Lama et al.   INFECTION AND IMMUNITY

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Helminth Cysteine Proteases Inhibit TRIF-dependent Activation of Macrophages via Degradation of TLR3

(2009) Sheila Donnelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Integrated Transcriptomics and Proteomics Analysis of the Secretome of the Helminth PathogenFasciola hepatica

(2009) Mark W. Robinson et al.   MOLECULAR & CELLULAR PROTEOMICS

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

The Importance of pH in Regulating the Function of the Fasciola hepatica Cathepsin L1 Cysteine Protease

(2009) Jonathan Lowther et al.   PLoS Neglected Tropical Diseases

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages

(2008) Sheila Donnelly et al.   FASEB JOURNAL

Proteomics and Phylogenetic Analysis of the Cathepsin L Protease Family of the Helminth PathogenFasciola hepatica

(2008) Mark W. Robinson et al.   MOLECULAR & CELLULAR PROTEOMICS

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE