Histone H4 Lysine 20 (H4K20) Methylation, Expanding the Signaling Potential of the Proteome One Methyl Moiety at a Time

Interrogating the Function of Metazoan Histones using Engineered Gene Clusters

(2015) Daniel J. McKay et al.   DEVELOPMENTAL CELL

Fluctuations in histone H4 isoforms during cellular reprogramming monitored by middle-down proteomics

(2015) Marco Benevento et al.   PROTEOMICS

An unexpected journey: Lysine methylation across the proteome

(2014) Kaitlyn E. Moore et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Substrate Specificity Analysis and Novel Substrates of the Protein Lysine Methyltransferase NSD1

(2014) Srikanth Kudithipudi et al.   CHEMISTRY & BIOLOGY

Concerted Activities of Distinct H4K20 Methyltransferases at DNA Double-Strand Breaks Regulate 53BP1 Nucleation and NHEJ-Directed Repair

(2014) Creighton T. Tuzon et al.   Cell Reports

Genetic and epigenetic determinants of DNA replication origins, position and activation

(2013) Marcel Méchali et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2

(2013) Hong Wu et al.   FEBS LETTERS

Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin

(2013) M. Hahn et al.   GENES & DEVELOPMENT

H4K20 methylation regulates quiescence and chromatin compaction

(2013) Adam G. Evertts et al.   MOLECULAR BIOLOGY OF THE CELL

Dynamic Methylation of Numb by Set8 Regulates Its Binding to p53 and Apoptosis

(2013) Gurpreet Kaur Dhami et al.   MOLECULAR CELL

Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity

(2013) S. Jorgensen et al.   NUCLEIC ACIDS RESEARCH

A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases

(2013) Stacey M. Southall et al.   NUCLEIC ACIDS RESEARCH

Regulating DNA Replication in Eukarya

(2013) K. Siddiqui et al.   Cold Spring Harbor Perspectives in Biology

A quantitative atlas of histone modification signatures from human cancer cells

(2013) Gary LeRoy et al.   Epigenetics & Chromatin

Histone Lysine Methyltransferase SETD8 Promotes Carcinogenesis by Deregulating PCNA Expression

(2012) M. Takawa et al.   CANCER RESEARCH

Asymmetrically Modified Nucleosomes

(2012) Philipp Voigt et al.   CELL

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

(2012) Frédérick A Mallette et al.   EMBO JOURNAL

Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation

(2012) Glenn S. Van Aller et al.   Epigenetics

The role of PR-Set7 in replication licensing depends on Suv4-20h

(2012) D. B. Beck et al.   GENES & DEVELOPMENT

PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription

(2012) D. B. Beck et al.   GENES & DEVELOPMENT

Leucine-rich Repeat and WD Repeat-containing Protein 1 Is Recruited to Pericentric Heterochromatin by Trimethylated Lysine 9 of Histone H3 and Maintains Heterochromatin Silencing

(2012) Kui Ming Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lamin B Receptor Recognizes Specific Modifications of Histone H4 in Heterochromatin Formation

(2012) Yasuhiro Hirano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

Deciphering a global network of functionally associated post-translational modifications

(2012) Pablo Minguez et al.   Molecular Systems Biology

The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome

(2012) Alex J. Kuo et al.   NATURE

Perceiving the epigenetic landscape through histone readers

(2012) Catherine A Musselman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Signals and Combinatorial Functions of Histone Modifications

(2011) Tamaki Suganuma et al.   Annual Review of Biochemistry

Solution structure of the Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA

(2011) Yu Qiu et al.   BIOCHEMICAL JOURNAL

Mechanisms and pathways of growth failure in primordial dwarfism

(2011) A. Klingseisen et al.   GENES & DEVELOPMENT

Mechanism of CRL4Cdt2, a PCNA-dependent E3 ubiquitin ligase

(2011) C. G. Havens et al.   GENES & DEVELOPMENT

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

The Histone Modifications GoverningTFF1Transcription Mediated by Estrogen Receptor

(2011) Yanyan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation

(2011) Stine Jørgensen et al.   JOURNAL OF CELL BIOLOGY

NSD2 Links Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming

(2011) Alex J. Kuo et al.   MOLECULAR CELL

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

(2011) Huadong Pei et al.   NATURE

Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome

(2011) Duane L Guernsey et al.   NATURE GENETICS

Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome

(2011) Louise S Bicknell et al.   NATURE GENETICS

Mutations in the pre-replication complex cause Meier-Gorlin syndrome

(2011) Louise S Bicknell et al.   NATURE GENETICS

Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation

(2011) Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of Histone Methylation: Biochemical and Molecular Mechanisms of Histone Demethylases

(2010) Nima Mosammaparast et al.   Annual Review of Biochemistry

Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression

(2010) S. Wu et al.   GENES & DEVELOPMENT

PR-Set7-mediated monomethylation of histone H4 lysine 20 at specific genomic regions induces transcriptional repression

(2010) Lauren M. Congdon et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

SETting the Clock for Histone H4 Monomethylation

(2010) Jennifer Lee et al.   MOLECULAR CELL

A WD-Repeat Protein Stabilizes ORC Binding to Chromatin

(2010) Zhen Shen et al.   MOLECULAR CELL

Regulation of the Histone H4 Monomethylase PR-Set7 by CRL4Cdt2-Mediated PCNA-Dependent Degradation during DNA Damage

(2010) Hisanobu Oda et al.   MOLECULAR CELL

CRL4Cdt2-Mediated Destruction of the Histone Methyltransferase Set8 Prevents Premature Chromatin Compaction in S Phase

(2010) Richard C. Centore et al.   MOLECULAR CELL

CRL4Cdt2 Regulates Cell Proliferation and Histone Gene Expression by Targeting PR-Set7/Set8 for Degradation

(2010) Tarek Abbas et al.   MOLECULAR CELL

PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression

(2010) Wen Liu et al.   NATURE

Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development

(2010) Hank H. Qi et al.   NATURE

The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells

(2010) Mathieu Tardat et al.   NATURE CELL BIOLOGY

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation

(2010) Weijun Feng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain

(2010) Daesung Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Target of the NSD Family of Histone Lysine Methyltransferases Depends on the Nature of the Substrate

(2009) Yan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monomethylation of Histone H4-Lysine 20 Is Involved in Chromosome Structure and Stability and Is Essential for Mouse Development

(2009) H. Oda et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Set9-Mediated H4K20 Methylation by a PWWP Domain Protein

(2009) Yu Wang et al.   MOLECULAR CELL

Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2

(2009) Yahong Guo et al.   NUCLEIC ACIDS RESEARCH

PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse

(2008) Maëlle Pannetier et al.   EMBO REPORTS

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse

(2008) G. Schotta et al.   GENES & DEVELOPMENT

Preferential Dimethylation of Histone H4 Lysine 20 by Suv4-20

(2008) Hongbo Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Catalytic Function of the PR-Set7 Histone H4 Lysine 20 Monomethyltransferase Is Essential for Mitotic Entry and Genomic Stability

(2008) Sabrina I. Houston et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combinatorial Modification of Human Histone H4 Quantitated by Two-dimensional Liquid Chromatography Coupled with Top Down Mass Spectrometry

(2008) James J. Pesavento et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Di-methyl H4 Lysine 20 Targets the Checkpoint Protein Crb2 to Sites of DNA Damage

(2008) Nikole T. Greeson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monomethylation of Lysine 20 on Histone H4 Facilitates Chromatin Maturation

(2008) A. N. D. Scharf et al.   MOLECULAR AND CELLULAR BIOLOGY

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS