Review
Biochemistry & Molecular Biology
Supattra Chaithongyot, Phatcharida Jantaree, Olga Sokolova, Michael Naumann
Summary: Gastric cancer is a major cause of cancer-related deaths globally, with environmental factors and dysregulation of the transcription factor nuclear factor kappa B (NF-kappa B) playing crucial roles in its development. NF-kappa B actively participates in tumor microenvironment cell crosstalk, with diverse effects on tumor cell and immune cell populations.
Article
Medicine, General & Internal
Hong Lin, Ruoxuan Ni, Dongdong Li, Mei Zhao, Yan Li, Kexin Li, Qiao Zhang, Changzhi Huang, Shengkai Huang
Summary: Long non-coding RNA MIR155HG plays a crucial role in promoting proliferation, migration, and chemoresistance of gastric cancer cells. It modulates the malignant phenotype of gastric cancer cells through regulation of the NF-κB and STAT3 signaling pathways. Moreover, overexpression of MIR155HG reduces the cytotoxicity and apoptosis induced by cisplatin and 5-FU in gastric cancer cells.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Cell Biology
Lu Chen, Wujiang Gao, Chunli Sha, Meiling Yang, Li Lin, Taoqiong Li, Hong Wei, Qi Chen, Jie Xing, Mengxue Zhang, Shijie Zhao, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: The E3 ligase SIAH1 is decreased in epithelial ovarian cancer (EOC) and negatively correlated with RPS3 levels. Overexpression of SIAH1 can suppress tumor cell growth, invasion, and cisplatin resistance by promoting RPS3 degradation and subsequent NF-kappa B inactivation.
Article
Oncology
Huaizhu Chu, Nahui Han, Jianguo Xu
Summary: High expression of CMPK1 in gastric cancer samples correlates with prolonged survival and response to 5-FU treatment, miR-130b functions as a key epigenetic regulator of CMPK1, and the newly identified miR-130b-CMPK1 axis could serve as a potentially new chemotherapeutic strategy to improve response to 5-FU therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Taoqiong Li, Li Lin, Qin Liu, Wujiang Gao, Lu Chen, Chunli Sha, Qi Chen, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: The study revealed that exosomal transfer of miR-429 enhances chemoresistance and proliferation of epithelial ovarian cancer cells. NF-κB promotes miR-429 expression, affecting the calcium-sensing receptor pathway and leading to drug resistance in cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Olena Zaitseva, Annett Hoffmann, Christoph Otto, Harald Wajant
Summary: The article describes the biology and signaling of fibroblast growth factor-inducible 14 (Fn14), a member of the tumor necrosis factor receptor superfamily. It discusses the features and preclinical data of Fn14-targeting biologicals, as well as the problems and limitations encountered in these studies. The potential of targeting Fn14 in tumor therapy is highlighted, including directing cytotoxic activities to the tumor, blocking protumoral activities of the TWEAK/Fn14 system, and stimulating Fn14 for cell death.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Sepideh Mirzaei, Sam Saghari, Farzaneh Bassiri, Rasoul Raesi, Ali Zarrabi, Kiavash Hushmandi, Gautam Sethi, Vinay Tergaonkar
Summary: Metastasis of tumor cells is a significant challenge in cancer patients, and the activation of nuclear factor-kappaB (NF-kappa B) plays a crucial role in regulating the epithelial-to-mesenchymal transition (EMT). The activation of NF-kappa B enhances the invasive properties of tumor cells through inducing EMT mechanism, and this has been confirmed in various cancers.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nikee Awasthee, Anusmita Shekher, Vipin Rai, Sumit S. Verma, Shruti Mishra, Anupam Dhasmana, Subash C. Gupta
Summary: Piperlongumine (PL, piplartine), an alkaloid derived from the Piper longum L. (long pepper) roots, has shown inhibitory effects on breast cancer cells and synergizes with doxorubicin. PL reduces migration and colony formation of cancer cells, induces apoptosis and DNA damage, and modulates the expression of certain genes. Additionally, PL alters tumor microenvironment pH and glucose metabolism. In vivo studies demonstrate that PL combined with doxorubicin can reduce tumor size, volume, and weight.
Article
Plant Sciences
Mengsha Wei, Liping Huang, Qin Li, Xinyi Qiao, Ziming Zhao, Jie Yin, Aimin Fu, Jieru Guo, Xincai Hao, Lianghu Gu, Jianping Wang, Chunmei Chen, Hucheng Zhu, Yonghui Zhang
Summary: Five aromatic ergosterols with unique ring systems, named spectasterols A-E (1-5), were isolated from Aspergillus spectabilis. Compound 3 demonstrated cytotoxic activity and anti-inflammatory effects, inducing cell cycle arrest and apoptosis in HL60 cells, and inhibiting COX-2 levels and NF-kappa B p65 nuclear translocation.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biotechnology & Applied Microbiology
Dan Chen, Li Shi, Dingfu Zhong, Ying Nie, Yi Yang, Dong Liu
Summary: The role of circ_0002019 in gastric cancer (GC) was investigated in this study. It was found that circ_0002019 was highly expressed in GC tissues and cells. Silencing circ_0002019 suppressed the proliferation, migration, and invasion of GC cells. Mechanistically, circ_0002019 activated the NF-κB pathway by increasing the stability of TNFAIP6 mRNA through PTBP1. These findings indicate that circ_0002019 plays a critical regulatory role in the progression of GC.
Article
Plant Sciences
Dong Xie, Chao Wu, Dan Wang, Bahaji Azami Nisma Lena, Ningning Liu, Guan Ye, Mingyu Sun
Summary: The study demonstrated that WFC inhibits gastric intestinal metaplasia and gastric dysplasia associated with inflammation by regulating the NF-kappa B pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Olga Sokolova, Michael Naumann
Summary: Gastric cancer is a major cause of cancer-related deaths globally, and its development is influenced by genetic predisposition, environmental factors, and Helicobacter pylori infection. Matrix metalloproteinases (MMPs) play an active role in the progression of gastric cancer, with bacterial dependence being less significant in later stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Dongyang Liu, Ke Shi, Mingshi Fu, Feng Chen
Summary: This study highlights the important role of melatonin in gastric cancer treatment by inhibiting cell proliferation and metastasis, as well as reducing cancer-associated fibroblasts-induced progression of gastric cancer cells. Insights into the mechanism of action of melatonin in the tumor microenvironment are provided, suggesting its potential value in gastric cancer treatment.
Article
Oncology
Hui Shi, Yaoxiang Sun, Hongru Ruan, Cheng Ji, Jiahui Zhang, Peipei Wu, Linli Li, Chihan Huang, Yuanwang Jia, Xu Zhang, Wenrong Xu, Jiajia Jiang, Hui Qian
Summary: The study found that the anti-cancer drug DIM at therapeutic concentrations upregulated the expression of tumor-related factors in GC-MSCs and promoted the proliferation, invasion, and migration of gastric cancer cells, leading to tumor growth. This mechanism provides a new insight into anti-cancer drug resistance and suggests the need to adjust the chemotherapy regimen to minimize the side effects of drugs on targeted TME cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hang Sun, Yufeng Zhou, Rui Ma, Jia Zhang, Jinhua Shan, Yue Chen, Xianwen Li, Enfang Shan
Summary: This study revealed the protective effect of Metformin (Met) on chemotherapy-induced oral mucositis (CIOM) and found that this protective effect may be achieved by inhibiting endoplasmic reticulum stress (ERS) and reducing the activity of NF-kappa B.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Engineering, Civil
Taek-Jin Song, Jongoh Jeong, Jong-Hwan Kim
Summary: Semantic segmentation and depth estimation are crucial for scene understanding and autonomous driving. The proposed RODSNet is able to recognize unexpected small obstacles on the road by simultaneously refining semantic segmentation and disparity maps from a stereo RGB pair.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2022)
Article
Robotics
Ue-Hwan Kim, Se-Ho Kim, Jong-Hwan Kim
Summary: This study proposes the SimVODIS++ architecture, which combines neural semantic visual odometry, object detection, and instance segmentation to improve VO performance in dynamic environments. Experimental results demonstrate the effectiveness of SimVODIS++ and the solution to the data leakage problem in the conventional experiment setting.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2022)
Article
Food Science & Technology
Jae-Han Shim, Md Musfiqur Rahman, Ahmed A. Zaky, Shin-Jee Lee, Ara Jo, Seung-Hee Yun, Jong-Bang Eun, Jong-Hwan Kim, Jong-Woo Park, Emel Oz, Charalampos Proestos, Fatih Oz, A. M. Abd El-Aty
Summary: An analytical method for the simultaneous determination of pyridate, quizalofop-ethyl, and cyhalofop-butyl in agricultural products was developed using LC-MS/MS. The method utilized optimized purification with Z-SEP sorbent and achieved good linearity, with a determination coefficient of >= 0.999. The method was validated and showed acceptable recovery and precision. Real-world market samples tested negative for the herbicide residues, demonstrating the applicability of the developed method for routine analysis.
Article
Biochemistry & Molecular Biology
Sol A. Jeon, Ye Jin Ha, Jong-Hwan Kim, Jeong-Hwan Kim, Seon-Kyu Kim, Yong Sung Kim, Seon-Young Kim, Jin Cheon Kim
Summary: This study compares the genomic and transcriptomic features of South Korean and European patients with colorectal cancer, revealing differences in driver gene mutations and pathway activities. The study also identifies specific genetic mutations and fusion genes in a subset of South Korean colorectal cancer patients.
Article
Automation & Control Systems
Yong-Ho Yoo, Ue-Hwan Kim, Jong-Hwan Kim
Summary: In this article, a convolutional recurrent reconstructive network (CRRN) is proposed for anomaly detection in surface mount technology. The CRRN decomposes anomaly patterns generated by printer defects from SPI data. It learns normal data only and detects anomaly patterns through reconstruction error. The CRRN outperforms conventional models in anomaly detection and shows the discriminative power of the decomposed anomaly map.
IEEE TRANSACTIONS ON CYBERNETICS
(2022)
Article
Food Science & Technology
Wenting Wang, Yu-Jin Cho, Jong-Wook Song, Yeong-Jin Kim, Jong-Su Seo, Jong-Hwan Kim
Summary: This study aimed to determine the residual concentrations of the pesticides methoxyfenozide and pymetrozine in Chinese cabbage and assess the associated health risks. The results showed that temperature had a significant impact on the dissipation of these pesticides, with higher temperatures leading to faster degradation. Furthermore, higher pesticide residues in Chinese cabbage during low-temperature seasons resulted in higher health risk quotients.
Article
Engineering, Marine
Kyeong-Ju Kong, Sung-Wook Kang, Jong-Hwan Kim, Hong-Lae Jang
Summary: This study predicts the performance of the crankcase explosion relief valve using numerical analysis and verifies the results by comparing them with actual test results and theoretical calculations.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Article
Environmental Sciences
Young Sang Kwon, Chang-Beom Park, Seung-Min Lee, Seonggeun Zee, Go-Eun Kim, Yeong-Jin Kim, Hee-Jung Sim, Jong-Hwan Kim, Jong-Su Seo
Summary: This study investigated the protein profiles in zebrafish embryos exposed to BB using mass spectrometry. A total of 83 differentially expressed proteins were identified, and their biological functions were categorized into different functional groups. The research provides insights into the molecular basis of the ecotoxicity of BB in aquatic ecosystems.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Da Hee Hong, Jae Hoon Yoo, Won Ji Park, So Won Kim, Jong Hwan Kim, Sae Hoon Uhm, Hee Chul Lee
Summary: This study investigated the physical and electrical properties of Hf0.5Zr0.5O2 (HZO) thin films deposited by two plasma-enhanced atomic layer deposition (PEALD) methods and the effects of plasma application on the properties of HZO thin films. The results showed that HZO thin films deposited by remote plasma atomic layer deposition (RPALD) exhibited excellent fatigue endurance at a measurement temperature of 60 degrees C or less, while HZO thin films deposited by direct plasma atomic layer deposition (DPALD) quickly deteriorated at higher temperatures. Overall, the RPALD method is promising for the development of ferroelectric memory devices.
Article
Food Science & Technology
Wenting Wang, Jong-Wook Song, Seong-Hoon Jeong, Jung-Hoon Jung, Jong-Su Seo, Jong-Hwan Kim
Summary: The dissipation patterns of four different insecticides on strawberries and the efficiency of household washing methods were investigated. The concentrations of the insecticide residues were below the maximum residue limits (MRLs). Soaking the fruit in a solution and rinsing with running water proved to be more effective in removing residues compared to only soaking. Vinegar and salt solutions were the most efficient in removing residues, while tap water alone had a lower removal efficiency. The estimated risk to human health from consuming strawberries was minimal.
Proceedings Paper
Automation & Control Systems
Dong He, Furqan Abid, Jong-Hwan Kim
Summary: This paper proposes a method to improve the performance of LiDAR-camera fusion semantic segmentation, focusing on data augmentation and fusion strategy. Experimental results show that the proposed method outperforms baseline methods on key classes.
2022 22ND INTERNATIONAL CONFERENCE ON CONTROL, AUTOMATION AND SYSTEMS (ICCAS 2022)
(2022)
Proceedings Paper
Automation & Control Systems
Furcian Abid, Dong He, Jong-Hwan Kim
Summary: This paper proposes an approach that combines data augmentation and lightweight 2D semantic segmentation network for the task of semantic segmentation of point clouds. The experiments demonstrate that this approach achieves significant performance improvement and reduces the number of trainable parameters.
2022 22ND INTERNATIONAL CONFERENCE ON CONTROL, AUTOMATION AND SYSTEMS (ICCAS 2022)
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Jin-Man Park, Ue-Hwan Kim, Seon-Hoon Lee, Jong-Hwan Kim
Summary: This study proposes SimSaC, a method that concurrently performs scene flow estimation and change detection, capable of detecting imperfect matches. To train SimSaC, a training scheme with random geometric transformations and the cut-paste method is proposed, along with an evaluation protocol that reflects real-world performance. Comprehensive experiments validate the robust performance of SimSaC even with imperfect matches, with a significant performance margin compared to contemporary approaches.
2022 IEEE/CVF CONFERENCE ON COMPUTER VISION AND PATTERN RECOGNITION (CVPR)
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Curie Kim, Ue-Hwan Kim, Jong-Hwan Kim
Summary: This paper proposes a method for detecting 3D objects and predicting absolute depth using only monocular image sequences through end-to-end learning. The method outperforms other existing methods on the KITTI 3D dataset, and even when used together with 3D LiDAR, it achieves the best performance. Additionally, the method enables absolute depth prediction.
2022 IEEE INTERNATIONAL CONFERENCE ON MULTISENSOR FUSION AND INTEGRATION FOR INTELLIGENT SYSTEMS (MFI)
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
In-Ug Yoon, Ue-Hwan Kim, Hyun Myung, Jong-Hwan Kim
Summary: The study introduces a s-DRN model for online incremental clustering, which achieves more stable and accurate clustering performance through the design of a stable activation function and an effective node grouping algorithm.
ROBOT INTELLIGENCE TECHNOLOGY AND APPLICATIONS 6
(2022)
