Reactive Oxygen Species (ROS)-Activated ATM-Dependent Phosphorylation of Cytoplasmic Substrates Identified by Large-Scale Phosphoproteomics Screen

Mechanisms of ATM Activation

(2015) Tanya T. Paull   Annual Review of Biochemistry

ATM functions at the peroxisome to induce pexophagy in response to ROS

(2015) Jiangwei Zhang et al.   NATURE CELL BIOLOGY

ATM: Expanding roles as a chief guardian of genome stability

(2014) Yosef Shiloh   EXPERIMENTAL CELL RESEARCH

The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double-strand break repair

(2014) Mengxia Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

HDGF: a novel jack-of-all-trades in cancer

(2014) Cihang Bao et al.   Future Oncology

Tug of War between Survival and Death: Exploring ATM Function in Cancer

(2014) Venturina Stagni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Most hydrogen peroxide-induced histone H2AX phosphorylation is mediated by ATR and is not dependent on DNA double-strand breaks

(2014) T. Katsube et al.   JOURNAL OF BIOCHEMISTRY

ProteomeXchange provides globally coordinated proteomics data submission and dissemination

(2014) Juan A Vizcaíno et al.   NATURE BIOTECHNOLOGY

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Direct Activation of ATM by Resveratrol under Oxidizing Conditions

(2014) Ji-Hoon Lee et al.   PLoS One

S100A11 is involved in the regulation of the stability of cell cycle regulator p21CIP1/WAF1in human keratinocyte HaCaT cells

(2013) Franziska Foertsch et al.   FEBS Journal

Functional Intersection of ATM and DNA-Dependent Protein Kinase Catalytic Subunit in Coding End Joining during V(D)J Recombination

(2013) B.-S. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling

(2013) Abderrahmane Kaidi et al.   NATURE

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphoproteomic analysis of cells treated with longevity-related autophagy inducers

(2012) Martin V. Bennetzen et al.   CELL CYCLE

Quantitative Proteomics Reveal ATM Kinase-dependent Exchange in DNA Damage Response Complexes

(2012) Serah Choi et al.   JOURNAL OF PROTEOME RESEARCH

TiSH — a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC

(2012) Kasper Engholm-Keller et al.   Journal of Proteomics

Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response

(2012) Petra Beli et al.   MOLECULAR CELL

Mitochondrial dysfunction in ataxia-telangiectasia

(2011) Y. A. Valentin-Vega et al.   BLOOD

DNA damage-induced translocation of S100A11 into the nucleus regulates cell proliferation

(2011) Theresa Gorsler et al.   BMC CELL BIOLOGY

ATM protein kinase: the linchpin of cellular defenses to stress

(2011) Shahzad Bhatti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Thr-1989 Phosphorylation Is a Marker of Active Ataxia Telangiectasia-mutated and Rad3-related (ATR) Kinase

(2011) Edward A. Nam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ–PP2A

(2011) G P Shouse et al.   ONCOGENE

Differential localization of ATM is correlated with activation of distinct downstream signaling pathways

(2010) Angela Alexander et al.   CELL CYCLE

The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress

(2010) T.-S. Kim et al.   Disease Models & Mechanisms

ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair

(2010) Claudia Cosentino et al.   EMBO JOURNAL

Multiple roles of ATM in monitoring and maintaining DNA integrity

(2010) Frederick A. Derheimer et al.   FEBS LETTERS

Autophosphorylation and ATM Activation

(2010) Sergei V. Kozlov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response

(2010) Martin V. Bennetzen et al.   MOLECULAR & CELLULAR PROTEOMICS

mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α

(2010) Hakan Cam et al.   MOLECULAR CELL

ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic Stress

(2010) Zhao-Hui Wu et al.   MOLECULAR CELL

A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation

(2010) Michael Hinz et al.   MOLECULAR CELL

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

ATM-Dependent and -Independent Dynamics of the Nuclear Phosphoproteome After DNA Damage

(2010) A. Bensimon et al.   Science Signaling

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

S100A11: Diverse Function and Pathology Corresponding to Different Target Proteins

(2009) Honglin He et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Cytoplasmic ATM in Neurons Modulates Synaptic Function

(2009) Jiali Li et al.   CURRENT BIOLOGY

Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics

(2009) Paul J Boersema et al.   Nature Protocols

RAP80 Responds to DNA Damage Induced by Both Ionizing Radiation and UV Irradiation and Is Phosphorylated at Ser205

(2008) J. Yan et al.   CANCER RESEARCH

HMGA1 protein is a novel target of the ATM kinase

(2008) Francesca Pentimalli et al.   EUROPEAN JOURNAL OF CANCER

Rad54B Targeting to DNA Double-Strand Break Repair Sites Requires Complex Formation with S100A11

(2008) Ulrike Murzik et al.   MOLECULAR BIOLOGY OF THE CELL

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

(2008) Martin F. Lavin   NATURE REVIEWS MOLECULAR CELL BIOLOGY

High-Resolution Imaging of Redox Signaling in Live Cells Through an Oxidation-Sensitive Yellow Fluorescent Protein

(2008) G. Maulucci et al.   Science Signaling