Article
Biochemistry & Molecular Biology
Rajdeep Chakraborty, Karen Vickery, Charbel Darido, Shoba Ranganathan, Honghua Hu
Summary: Oral cancer is a global health issue with low survival rates, and bacterial antigens may interfere with the effectiveness of capsaicin in treating oral cancer cells. Capsaicin's anti-cancer effects on oral cancer cells are significantly reduced by bacterial antigens, suggesting a need for clinical consideration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rajdeep Chakraborty, Honghua Hu, Charbel Darido, Karen Vickery, Shoba Ranganathan
Summary: The study investigated the effect of the calcium channel blocker ML218 HCl on oral cancer cell proliferation, finding that it effectively reduced LPS-induced proliferation and increased apoptosis and cell death. However, the efficacy of ML218 HCl was significantly reduced in the presence of bacterial antigens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Bin Huang, Chizhou Wu, Yuzhu Hu, Lu Rao, Mingzhe Yang, Mengyao Zhao, Huangqin Chen, Yuesheng Li
Summary: This study predicted and analyzed the prognosis-related hub genes of osmanthus-targeted therapy for oral squamous cell carcinoma (OSCC) using network pharmacology and molecular docking. Through experimental exploration, it was found that osmanthus extract had good binding activity and could inhibit cell migration and alter mitochondrial membrane potential.
Article
Plant Sciences
Ana Hudek Turkovic, Ksenija Durgo, Florentina Cuckovic, Ivana Ledenko, Tena Krizmanic, Arijana Martinic, Aleksandra Vojvodic Cebin, Drazenka Komes, Mirta Milic
Summary: The aim of this study was to determine the influence of rosemary and dandelion leaves aqueous extracts on oral microbiota and tongue epithelial cells, genomic damage, and H2O2-induced oxidative damage protection. The results showed that both extracts increased the adhesion of lactic acid bacteria and decreased the adhesion of bacterial pathogens to tongue epithelial cells. Rosemary extract also demonstrated a protective effect against H2O2-induced oxidative damage.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Billy Toussie Tchegnitegni, Tehmina Ahmed, Francis Tatong Ngouafong, Viviane Flore Kamlo Kamso, Remy Bertrand Teponno, Bruno Ndjakou Lenta, Leon Azefack Tapondjou, Arslan Ali, Syed Ghulam Musharraf
Summary: This paper describes the isolation and structural elucidation of eight new triterpenoid saponins from Microglossa afzelii, with only compounds 4/5 exhibiting moderate cytotoxic activity. This work represents the first chemical and biological investigation of Microglossa afzelii and the first report of saponin isolation in the genus Microglossa.
Article
Chemistry, Inorganic & Nuclear
Parameshwar Jakinala, Harikrishna Naik Lavudi, Neelima Angali, Santhosh Ganderla, Krishna K. Inampudi, Sai Balaji Andugulapati, M. Srinivas, Madhumohan Rao Katika
Summary: A novel approach using buffalo grass extract for the formation of ZnO-Ag nanocomposites is cost-effective, eco-friendly, and has high anticancer and antibacterial activities. Phenol and octadecanoic acid are the major phytochemical compounds involved in the biosynthesis of ZnO-Ag nanocomposites. The biosynthesized ZnO-Ag nanocomposites show strong antibacterial activity, with significant cell death observed in oral squamous cell carcinoma cell lines, suggesting potential applications as antimicrobial agents and for human carcinoma treatments.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Oncology
Cong Xu, Hong-Li Yang, Yi-Kun Yang, Li Pan, Hai-Ying Chen
Summary: ZNF750 has the potential to inhibit the renewal ability of CSC-like cells and decrease their invasion and migration abilities. This study provides further insights into the mechanisms of oral squamous cell carcinoma.
Article
Oncology
Yoshie Tsujiya, Motohiro Yamamori, Ai Hasegawa, Yurie Yamamoto, Masakazu Yashiro, Noboru Okamura
Summary: The study revealed that TEL has a significant inhibitory effect on SGC cells, inducing apoptosis, autophagy, and G(0)/G(1) cell cycle arrest.
ANTICANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ke Hu, Bo Li, Ruye Ma, Hongfei Yi, Zhijian Xu, Yu Peng, Dandan Yu, Huiqun Wu, Taofang Cheng, Yumeng Lu, Yong Zhang, Rong Wei, Guang Yang, Xiaosong Wu, Weiliang Zhu, Jumei Shi
Summary: DLBCL is a highly heterogeneous type of non-Hodgkin lymphoma, and patients with poor outcomes from conventional treatment may benefit from novel agents like DCZ0825, which exhibited high cytotoxicity towards DLBCL cells through inducing apoptosis and cell cycle arrest. The efficacy of DCZ0825 against DLBCL involves the PI3K-AKT-mTOR/JNK pathway.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Immunology
Ewa Jablonska, Agnieszka Iwaniuk, Wioletta Ratajczak-Wrona, Kamil Grubczak, Dorota Dziemianczyk-Pakiela, Marcin Moniuszko, Karolina Nowak, Jan Borys, Marzena Garley
Summary: The study confirmed the role of neutrophil-derived BAFF in the development of oral squamous cell carcinoma (OSCC) and found that flavonoids have beneficial effects on tumor-promoting BAFF expression in neutrophils.
Article
Oncology
Dan Ai, Yu Dou, Zhaodi Nan, Ketao Wang, Huayang Wang, Lin Zhang, Zuoqing Dong, Jintang Sun, Chao Ma, Wanye Tan, Wenjuan Gao, Jia Liu, Lei Zhao, Shaohua Liu, Bingfeng Song, Qianqian Shao, Xun Qu
Summary: This study suggests that CD68(+) macrophages may play a crucial role in the prognosis of HPV negative OSCC patients receiving radiation. The use of poly(I:C) could induce apoptosis, enhance radiosensitivity, and increase macrophage recruitment. Targeting HMGB1 could inhibit IL-6 induction and macrophage recruitment, potentially enhancing overall therapeutic effects.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Fengqin Wang, Hanzhong Zhang, Zhigang Cheng
Summary: EPHA2, a member of the ephrin receptor tyrosine kinase family, is highly expressed in human OSCC and can promote the proliferation, migration, and invasion of Cal-27 cells by enhancing the AKT/mTOR signaling pathway.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Chemistry, Medicinal
Xing Long, Peilin Yang, Lin Chen, Wen Zhong, Shaofeng Chen, Yanping Li, Shijie Lin, Wei Tian
Summary: This study designed and synthesized a novel aloe emodin derivative AE-NPC, which improved the water solubility and antitumor activity of aloe emodin in vitro. The results showed that AE-NPC induced the production of reactive oxygen species (ROS) and apoptosis in CAL-27 cells, and could be well intercalated into DNA grooves. Further molecular mechanism studies revealed that AE-NPC regulated the expression levels of key proteins in the mitochondrial apoptotic pathway and activated a key protein in the DNA damage pathway. This study provides new insights into the development of anthraquinone compounds as potential chemotherapeutic agents for oral cancer treatment.
MEDICINAL CHEMISTRY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Peng Zhao, Haiming Qiu, Qiang Wei, Yang Li, Lei Gao, Peiran Zhao
Summary: The study investigated the effect of three hexa-coordinated octahedral nickel (II) complexes on CAL-27 cells. The results showed that complex 3 exhibited significant cytotoxicity and inhibited proliferation and migration of CAL-27 cells. It induced apoptosis and increased autophagy and reactive oxygen species levels. Furthermore, complex 3 led to mitochondrial dysfunction and DNA damage mediated by intracellular ROS accumulation. The findings suggest that nickel complexes could be potential drugs for treating OSCC.
MOLECULAR & CELLULAR TOXICOLOGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Hui-Ping Ho, Yung-Chang Lin, Changjui James Fu, Ching-Ter Chang
Summary: This study proposes a new model that combines the analytic hierarchy process method, multi-choice goal programming, and multi-segment goal programming to address the issue of customized exercise plans and diet meals. By considering users' risk attitudes, the model provides personalized exercise plans and diet menus to help individuals achieve their weight loss goals. This model improves healthcare services and benefits both diabetic patients and healthy individuals.
COMPUTERS & INDUSTRIAL ENGINEERING
(2022)
Article
Environmental Sciences
Yu-Jen Chiu, Jai-Sing Yang, Fuu-Jen Tsai, Hong-Yi Chiu, Yu-Ning Juan, Yu-Hsiang Lo, Jo-Hua Chiang
Summary: This study identified the resistance of melanoma to vemurafenib and revealed that curcumin can induce apoptosis in vemurafenib-resistant melanoma cells by regulating the EGFR signaling pathway, suggesting curcumin as a potential therapeutic candidate for vemurafenib-resistant melanoma treatment.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Shih-Hua Fang, Chi-Cheng Lu, Hua-Wei Lin, Kuan-Chen Kuo, Chen-Yu Sun, Yi-Ying Chen, Wen-Dien Chang
Summary: This study examines the acute effects of nicotine gum on physiological responses and sports performance in baseball players. The results show that chewing nicotine gum can induce changes in endocrine and sympathetic nerve activity, enhance cognitive function and baseball-hitting performance, but does not increase muscle strength.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Ryosuke Senga, Yung-Chang Lin, Shigeyuki Morishita, Ryuichi Kato, Takatoshi Yamada, Masataka Hasegawa, Kazu Suenaga
Summary: This study demonstrates the unambiguous isotopic imaging of C-12 carbon atoms in C-13 graphene and the monitoring of their self-diffusion through atomic-level vibrational spectroscopy. The results confirm the high mobility of carbon atoms during growth and annealing via self-diffusion. This imaging technique provides a fundamental methodology for nanoisotope engineering and monitoring.
Article
Chemistry, Multidisciplinary
Yuji Araki, Pablo Solis-Fernandez, Yung-Chang Lin, Amane Motoyama, Kenji Kawahara, Mina Maruyama, Yanlin Gao, Rika Matsumoto, Kazu Suenaga, Susumu Okada, Hiroki Ago
Summary: This study investigates the twist angle dependence of intercalation of metal chlorides in bilayer graphene (BLG). It is found that high twist angle BLG is more favorable for intercalation due to weaker interlayer coupling. Scanning transmission electron microscope observations reveal the formation of various 2D structures through co-intercalation of AlCl3 and CuCl2 molecules. Moreover, high twist angle BLG exhibits lower sheet resistance before intercalation and intercalation further decreases the sheet resistance.
Article
Chemistry, Multidisciplinary
Mitsuhiro Okada, Jiang Pu, Yung-Chang Lin, Takahiko Endo, Naoya Okada, Wen-Hsin Chang, Anh Khoa Augustin Lu, Takeshi Nakanishi, Tetsuo Shimizu, Toshitaka Kubo, Yasumitsu Miyata, Kazu Suenaga, Taishi Takenobu, Takatoshi Yamada, Toshifumi Irisawa
Summary: The control of crystal polymorphism and exploration of metastable, two-dimensional, 1T' phase, transition-metal dichalcogenides (TMDs) have been the focus of research due to their potential applications in various fields. However, the high energy difference and phase change barrier between 1T' and 2H phases make it difficult to obtain monolayer 1T' phase TMDs. In this study, we successfully grew 1T' phase WS2 atomic layers using chemical vapor deposition (CVD) with alkali metal assistance. The resulting high-quality crystals showed superconductivity and hold promise for applications such as quantum computing and energy storage devices. The alkali metal assisted gas-source CVD growth method provides a viable approach to realizing large-scale, high-quality TMD atomic layers.
Article
Biochemistry & Molecular Biology
Peng-Hsiang Fang, Ying-Ying Lai, Chih-Ling Chen, Hsin-Yu Wang, Ya-Ning Chang, Yung-Chang Lin, Yu-Ting Yan, Cheng-Hung Lai, Bill Cheng
Summary: CoPP enhances diabetic wound healing by increasing cell migratory capacity under hyperglycemic conditions and protecting cells from oxidative and LPS-induced damage.
MOLECULAR MEDICINE
(2022)
Article
Chemistry, Physical
Jiadong Zhou, Chao Zhu, Yao Zhou, Jichen Dong, Peiling Li, Zhaowei Zhang, Zhen Wang, Yung-Chang Lin, Jia Shi, Runwu Zhang, Yanzhen Zheng, Huimei Yu, Bijun Tang, Fucai Liu, Lin Wang, Liwei Liu, Gui-Bin Liu, Weida Hu, Yanfeng Gao, Haitao Yang, Weibo Gao, Li Lu, Yeliang Wang, Kazu Suenaga, Guangtong Liu, Feng Ding, Yugui Yao, Zheng Liu
Summary: This study reveals a competitive-chemical-reaction-based growth mechanism that allows for the growth of transition metal chalcogenides and transition metal phosphorous chalcogenides with different compositions and phases. It provides an interesting platform for the exploration of 2D TMPCs and TMCs.
Article
Biotechnology & Applied Microbiology
Ken -Lin Chang, Quang Tam Huynh, Chong -Ting Zhong, Wei-Ren Chen, Hsin-Yi Wang, Paripok Phitsuwan, Yung -Chang Lin, Gordon C. C. Yang
Summary: In this study, SiO2-ATS-PTA catalyst was prepared and used to convert glucose to HMF. The effects of reaction conditions on conversion, yield, and selectivity were investigated, and the reusability of the catalyst and ionic liquid was examined. The results showed that SiO2-ATS-PTA has favorable application potential.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2022)
Article
Chemistry, Multidisciplinary
Chun-Hao Chiang, Yueh-Chiang Yang, Jia-Wei Lin, Yung-Chang Lin, Po-Tuan Chen, Chung-Li Dong, Hung-Min Lin, Kwun Man Chan, Yu-Ting Kao, Kazu Suenaga, Po-Wen Chiu, Chun-Wei Chen
Summary: This study demonstrates the fabrication of a bifunctional microreactor for efficient water splitting in a neutral medium. The microreactor consists of a two-dimensional WSe2/graphene heterojunction, and its performance is enhanced through atomic doping of metallic Cr and graphene stitching contact.
Article
Biochemistry & Molecular Biology
Da-Tian Bau, Ting-Yuan Liu, Chia-Wen Tsai, Wen-Shin Chang, Jian Gu, Jai-Sing Yang, Liang-Chun Shih, Fuu-Jen Tsai
Summary: Taiwan has the highest incidence rate of oral cancer in the world. A genome-wide association study identified several susceptibility loci for oral cancer in the Taiwanese population, highlighting the importance of both genetic and environmental factors. This study provides important insights into the etiology of oral cancer in Taiwan.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Electrical & Electronic
Satoru Fukamachi, Pablo Solis-Fernandez, Kenji Kawahara, Daichi Tanaka, Toru Otake, Yung-Chang Lin, Kazu Suenaga, Hiroki Ago
Summary: Centimetre-scale multilayer hBN can be synthesized on iron-nickel alloy foil and used as a substrate and surface-protecting layer in graphene field-effect transistors. An integrated electrochemical transfer and thermal treatment method enables the creation of high-performance graphene/hBN heterostacks. Graphene devices fabricated using conventional and scalable methods exhibit room-temperature carrier mobilities of up to around 10,000 cm(2) V-1 s(-1) when integrated with multilayers of hBN.
NATURE ELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Ryusuke Natsui, Hiroshi Shimizu, Yusuke Nakanishi, Zheng Liu, Akito Shimamura, Nguyen Tuan Hung, Yung-Chang Lin, Takahiko Endo, Jiang Pu, Iori Kikuchi, Taishi Takenobu, Susumu Okada, Kazu Suenaga, Riichiro Saito, Yasumitsu Miyata
Summary: This study presents a versatile method to fabricate nanoscale-thick bundles of indium-intercalated tungsten hexachalcogenide (W6Te6) wires. These bundles exhibit metallic behavior and mechanical flexibility, making them promising building blocks for integrated nanocircuits.
Article
Physiology
Ming-Ru Chiang, Li-Chun Shih, Chi-Cheng Lu, Shih-Hua Fang
Summary: The COVID-19 pandemic has disrupted the training and competition of athletes, leading to hesitancy in getting vaccinated. This study examined the inflammatory responses and menstrual cycles of female athletes before and after COVID-19 vaccination. The results showed that the vaccines did not significantly affect blood cell counts, inflammatory markers, or menstruation in female athletes.
PHYSIOLOGICAL REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Yung-Chang Lin, Yao-Pang Chang, Kai-Wen Chen, Tai-Ting Lee, Bo-Jiun Hsiao, Tsung-Han Tsai, Yueh-Chiang Yang, Kuang- Lin, Kazu Suenaga, Chia-Hao Chen, Po-Wen Chiu
Summary: This study presents an area-selective doping scheme for W-based dichalcogenide single layers using pre-patterned graphene as a reaction mask, allowing for local manipulation of the host 2D materials. The chemical inertness of graphene effectively differentiates the spatial doping reaction and acts as an insertion layer to reduce contact resistivity.