Article
Multidisciplinary Sciences
Gil Lola Oreff, Barbara Maurer, Ahmed N. ELKhamary, Iris Gerner, Veronika Sexl, Florien Jenner
Summary: An immortalized cell line was established using Ink4a/Arf deficient mice tenocytes, which has similar characteristics and proliferation potential as wild-type cells. These Ink4a/Arf(-/-) tenocytes can be a valuable tool for in vitro tendon research and an alternative to animal experiments.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Zhuoqi Li, Juanli Qiao, Wanru Ma, Jing Zhou, Liankun Gu, Dajun Deng, Baozhen Zhang
Summary: This study reveals that CBX7 is essential for P14AS to upregulate the expression of P16 (INK4A), P14 (ARF), P15 (INK4B), and ANRIL genes. P14AS may upregulate these genes' expression through competitively blocking CBX7-binding to ANRIL lncRNA and target gene promoters.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pingzhao Zhang, Kun Gao, Liang Zhang, Huiru Sun, Xiaying Zhao, Yajuan Liu, Zeheng Lv, Qing Shi, Yingji Chen, Dongyue Jiao, Yao Li, Wei Gu, Chenji Wang
Summary: This study demonstrates the important role of CRL2-KLHDC3 E3 ubiquitin ligase complex in regulating the stability of p14(ARF) protein, with KLHDC3 promoting ubiquitin-proteasomal degradation of p14(ARF) to suppress ferroptosis and support tumor growth. The findings suggest that overexpression of KLHDC3 likely contributes to cancer progression by suppressing the p14(ARF)-NRF2-SLC7A11 regulatory pathway.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Biochemistry & Molecular Biology
Wenjuan Zhang, Lihui Li, Lili Cai, Yupei Liang, Junfeng Xu, Yue Liu, Lisha Zhou, Chen Ding, Yanmei Zhang, Hu Zhao, Jun Qin, Zhimin Shao, Wenyi Wei, Lijun Jia
Summary: In this study, it was discovered that Prame recognizes p14/ARF for degradation. Inhibiting Prame expression and halting p14/ARF degradation can restrain tumor growth and induce G2/M phase cell cycle arrest.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Dermatology
Inger Z. M. Kreuger, Roderick C. Slieker, Tim van Groningen, Remco van Doorn
Summary: Loss of CDKN2A is a common occurrence in melanoma progression and targeting this loss can significantly improve treatment outcomes. Various therapeutic strategies, such as CDK4/6 inhibition, cell cycle dysregulation, metabolic rewiring, epigenetic restoration, co-deleted gene targeting, and modulation of immune responses, have been explored in the context of CDKN2A loss.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Cell Biology
Umer Farooq, Dimple Notani
Summary: 9p21 locus is a highly reproducible region in genome-wide association studies (GWAS) and is associated with various diseases and cancers. The genes within this region, including CDKN2A/B genes, play critical roles in cell cycle regulation and are linked to cellular regeneration, stemness, aging, and cancers. Understanding the regulation of these genes through promoter-driven and distal mechanisms could provide insights for targeting this locus in pathologies and aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Federica Pezzuto, Francesca Lunardi, Luca Vedovelli, Francesco Fortarezza, Loredana Urso, Federica Grosso, Giovanni Luca Ceresoli, Izidor Kern, Gregor Vlacic, Eleonora Faccioli, Marco Schiavon, Dario Gregori, Federico Rea, Giulia Pasello, Fiorella Calabrese
Summary: The CDKN2A gene is important in the pathogenesis of malignant pleural mesothelioma (MPM). The study found that p14/ARF-positive epithelioid mesotheliomas may represent a more aggressive pathological phenotype, while p14/ARF-negative tumors seem less sensitive to immune checkpoint inhibitors. The association between p14/ARF-positive MPMs and PD-L1 expression suggests a possible interaction between the two pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Rui Chen, Thomas Skutella
Summary: This review proposes a novel strategy of establishing a rejuvenating microenvironment through senescent cells specific reprogramming. It discusses the potential benefits of partial reprogramming in facilitating cellular rejuvenation and improving the senescence-associated secretory phenotype. It also explores the potential of intervening in cellular senescence to improve aging and promote damage repair, while emphasizing the importance of feasible and safe clinical translational protocols.
Article
Multidisciplinary Sciences
Yuen Gao, Natalia Duque-Wilckens, Mohammad B. Aljazi, Adam J. Moeser, George I. Mias, Alfred J. Robison, Yi Zhang, Jin He
Summary: Recent clinical studies have shown that chromosomal 12q24.31 microdeletions are associated with autism spectrum disorder (ASD) and intellectual disability (ID). This study reveals that the gene Kdm2b, located in the chromosomal region 12q24.31, plays a critical role in maintaining neural stem cells in the mouse brain. Additionally, the Kdm2b mutation is found to induce ASD/ID-like behavioral and memory deficits.
Article
Pathology
Cher-Wei Liang, Ching-Yao Yang, Richard Flavin, Jonathan A. Fletcher, Tzu-Pin Lu, I-Rue Lai, Yu-I Li, Yih-Leong Chang, Jen-Chieh Lee
Summary: The key events of high-grade transformation in Gastrointestinal Stromal Tumors (GISTs) were discovered through studying biphasic GISTs, revealing downregulation of SFRP1 and loss of chromosome 9/9p as the main features of GIST high-grade transformation.
Article
Multidisciplinary Sciences
Kelsy C. Cotto, Yang-Yang Feng, Avinash Ramu, Megan Richters, Sharon L. Freshour, Zachary L. Skidmore, Huiming Xia, Joshua F. McMichael, Jason Kunisaki, Katie M. Campbell, Timothy Hung-Po Chen, Emily B. Rozycki, Douglas Adkins, Siddhartha Devarakonda, Sumithra Sankararaman, Yiing Lin, William C. Chapman, Christopher A. Maher, Vivek Arora, Gavin P. Dunn, Ravindra Uppaluri, Ramaswamy Govindan, Obi L. Griffith, Malachi Griffith
Summary: RegTools is a software package that integrates genomic data with transcriptomic data to identify somatic variants that may cause aberrant splicing. It has been applied to over 9000 tumor samples and discovered numerous splice-associated variants.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Kamini Singh, Jianan Lin, Nicolas Lecomte, Prathibha Mohan, Askan Gokce, Viraj R. Sanghvi, Man Jiang, Olivera Grbovic-Huezo, Antonija Burcul, Stefan G. Stark, Paul B. Romesser, Qing Chang, Jerry P. Melchor, Rachel K. Beyer, Mark Duggan, Yoshiyuki Fukase, Guangli Yang, Ouathek Ouerfelli, Agnes Viale, Elisa de Stanchina, Andrew W. Stamford, Peter T. Meinke, Gunnar Raetsch, Steven D. Leach, Zhengqing Ouyang, Hans-Guido Wendel
Summary: This study demonstrates the crucial role of the eIF4A RNA helicase in pancreatic adenocarcinoma (PDAC), particularly in the KRAS signaling pathway. Through ribosome footprinting in conjunction with deep RNA sequencing, eIF4A-dependent mRNAs in PDAC were accurately identified. These findings reveal the therapeutic mechanism of eIF4A inhibitors in PDAC.
Article
Oncology
Luis I. Prieto, Ines Sturmlechner, Sara I. Graves, Cheng Zhang, Nick P. Goplen, Eunhee S. Yi, Jie Sun, Hu Li, Darren J. Baker
Summary: In an oncogenic Kras-driven lung cancer mouse model, senescent cells, specifically alveolar macrophages, accumulate early in neoplasia. These macrophages have upregulated expression of p16INK4a and Cxcr1, are distinct from previously defined subsets, and suppress cytotoxic T cell responses. The removal of these cells attenuates adenoma development and progression in mice, suggesting their tumorigenesis-promoting role. Notably, alveolar macrophages with these properties increase with normal aging in mouse lung and in human lung adenocarcinoma in situ. Overall, targeting senescent macrophages may attenuate lung cancer progression during the early stages of disease.
Article
Pathology
Mariana Chantre-Justino, Ingrid Goncalves da Veiga Pires, Marcelo Cardoso Figueiredo, Aline dos Santos Moreira, Gilda Alves, Maria Helena Faria Ornellas
Summary: The text emphasizes the importance of development and the copyright statement.
Article
Multidisciplinary Sciences
Yusuke Onozato, Yu Sasaki, Yasuhiko Abe, Hidenori Sato, Makoto Yagi, Naoko Mizumoto, Takashi Kon, Takayuki Sakai, Minami Ito, Matsuki Umehara, Ayumi Koseki, Yoshiyuki Ueno
Summary: Alcohol consumption and smoking are significant risk factors for male esophageal squamous cell neoplasia, but the mechanisms behind the development of ESCN in non-drinking and non-smoking females remain unclear. The study found that CDKN2A may play an important role in ESCC development independent of known risk factors, and p14ARF overexpression in the unknown-risk group is noteworthy.
SCIENTIFIC REPORTS
(2021)
Correction
Cell Biology
Zarah M. Lof-Ohlin, Pia Nyeng, Matthew E. Bechard, Katja Hess, Eric Bankaitis, Thomas U. Greiner, Jacqueline Ameri, Christopher V. Wright, Henrik Semb
NATURE CELL BIOLOGY
(2017)
Article
Cell Biology
Zarah M. Lof-Ohlin, Pia Nyeng, Matthew E. Bechard, Katja Hess, Eric Bankaitis, Thomas U. Greiner, Jacqueline Ameri, Christopher V. Wright, Henrik Semb
NATURE CELL BIOLOGY
(2017)
Article
Developmental Biology
Gokul Kesavan, Oliver Lieven, Anant Mamidi, Zarah Lof Ohlin, Jenny Kristina Johansson, Wan-Chun Li, Silvia Lommel, Thomas Uwe Greiner, Henrik Semb
Article
Oncology
Zarah M. Lof-Ohlin, Bengt Sorbe, Sten Wingren, Torbjorn K. Nilsson
INTERNATIONAL JOURNAL OF ONCOLOGY
(2011)
Article
Oncology
Zarah M. Lef-Ohlin, Sonja Levanat, Maja Sabol, Bengt Sorbe, Torbjorn K. Nilsson
INTERNATIONAL JOURNAL OF ONCOLOGY
(2011)
Article
Oncology
Zarah M. Lof-Ohlin, Torbjorn K. Nilsson
Article
Medicine, Research & Experimental
T. K. Nilsson, Z. M. Lof-Ohlin, A. K. Bottiger
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2008)
Article
Neurosciences
Zarah M. Lof-Ohlin, Nils-Olof Hagnelius, Torbjorn K. Nilsson