Article
Engineering, Environmental
Olga S. Arvaniti, Georgia Cheiletzari, Eleni I. Panagopoulou, Nikolaos S. Thomaidis, Dionissios Mantzavinos, Zacharias Frontistis
Summary: The sonochemical degradation of acesulfame, a widely used artificial sweetener, was studied. It was found that complete degradation of acesulfame was achieved within 120 min under conditions suitable for high production of free radicals. The coupling of sonochemical degradation with sodium persulfate enhanced the rate of acesulfame oxidation.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Electrochemistry
Rafaella Silva Aredes, Matheus Moreira, Pedro Henrique Oliveira Amorim, Rafael Machado Dornellas, Felipe Silva Semaan
Summary: A composite electrode was developed for quantifying saccharin in commercial sweeteners using cyclic voltammetry, and its accuracy was evaluated using other techniques, showing satisfactory and comparable results.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Review
Chemistry, Applied
Fatemeh Javaheri-Ghezeldizaj, Adel Mirza Alizadeh, Parvin Dehghan, Jafar Ezzati Nazhad Dolatabadi
Summary: The use of food additives in ultra-processed food has increased attention, and propyl gallate (PG) is commonly used as an antioxidant in food, cosmetics, and pharmacies. This study aims to summarize the toxicological studies of PG, including its physicochemical properties, metabolism, and pharmacokinetics effects. The European Food Safety Authority (EFSA) has evaluated the use of PG in the food industry and established an acceptable daily intake (ADI) of 0.5 mg/kg bw per day. Based on exposure assessment, it can be concluded that PG is not a safety concern at the current level of use.
Article
Food Science & Technology
Kohei Matsushita, Takeshi Toyoda, Hirotoshi Akane, Tomomi Morikawa, Kumiko Ogawa
Summary: The study found no adverse effects of heme iron on rats, indicating its safety as a food additive and supplement.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Engineering, Environmental
Chi-Hang Chow, Japhet Cheuk-Fung Law, Kelvin Sze-Yin Leung
Summary: UV/NH2Cl is an emerging advanced oxidation process for micropollutant removal, generating reactive chlorine species (RCS) and hydroxyl radicals. Transformation products of ACE treated with UV/NH2Cl were found to be more toxic, attributed to the chlorinated transformation products and specifically halo-alcohols. The study provides insight into the role of reactive species and potential risks in using UV/NH2Cl for micropollutant removal in water treatment.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Agriculture, Multidisciplinary
Xiao-Jing Zhang, Mei-ning Diao, Yin-Feng Zhang
Summary: BHA is widely used as a food additive due to its antioxidant properties, but its extensive presence in various environmental matrices and human tissues has raised concerns. Studies have shown that BHA can cause thyroid damage, metabolic disorders, neurotoxicity, and carcinogenesis. Mechanisms such as endocrine disruption, genotoxicity, energy metabolism disturbances, ROS production, signaling pathways, and calcium homeostasis imbalances are associated with the toxic effects of BHA. Finding safe and environmentally friendly alternatives to BHA should be prioritized.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Review
Toxicology
Frederick Barreau, Celine Tisseyre, Sandrine Menard, Audrey Ferrand, Marie Carriere
Summary: The intestinal barrier function is crucial for protecting the body from harmful substances and its dysfunction is associated with various human diseases. In addition to genetic factors, environmental influences such as the use of food additives may also impact the intestinal barrier function.
PARTICLE AND FIBRE TOXICOLOGY
(2021)
Article
Medicine, Legal
Robert Maronpot, Yuval Ramot, Abraham Nyska, Christopher Sproul, Rebecca Moore, Brad Bolon, Shim-mo Hayashi
Summary: This study evaluated the chronic toxicity and carcinogenicity of alpha-Glycosyl isoquercitrin (AGIQ) in rats. The results showed no clinically or histologically evident AGIQ-related toxicity within one year of oral exposure, except for yellow discoloration of bone. However, female rats exposed to 5.0% AGIQ showed a statistically significant increase in the incidence of malignant glioma of the brain or spinal cord compared to the control group. Review by neuropathologists concluded that these gliomas were a rare, spontaneous, rat-specific neoplasm and could not be definitively attributed to AGIQ exposure, thus having limited implications for predicting human cancer risk.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Review
Food Science & Technology
Cameron Faustman, Daniel Aaron, Nicole Negowetti, Emily Broad Leib
Summary: The Government Accountability Office (GAO) criticized FDA's oversight of GRAS food ingredients and provided recommendations, but FDA only addressed a few criticisms and some important recommendations remain unaddressed. FDA has chosen to remain uninformed about food substances self-determined as GRAS by manufacturers.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Veterinary Sciences
Eman G. Abdelrazik, Faten F. Mohammed, Sherein S. Abdelgayed
Summary: Chronic use of acesulfame potassium (Ace-K) in rats has been found to cause pancreatic injury and histopathological changes, including weight gain and reduced blood glucose levels. These findings are important for evaluating the long-term safety of Ace-K exposure in humans.
PAKISTAN VETERINARY JOURNAL
(2022)
Review
Geosciences, Multidisciplinary
Fugeng Zha, Mengxin Shang, Zhuozhi Ouyang, Xuetao Guo
Summary: This review summarizes recent literature on the natural and artificial aging process of microplastics (MPs), discusses their aging characteristics and mechanisms, and evaluates the release of MPs during the aging process. It also highlights the different properties and toxic effects of aged MPs compared to pristine MPs. The potential risks associated with aging MPs and their environmental release are thoroughly examined.
Article
Medicine, Legal
Hong-ju Du, Guo-hui Tong, Jun-yu Ning, Shan Gao, Qing Yang, Ying Feng, Peng Zhang, Wei Zhang, Hai-ming Jing, Guo-jun Li
Summary: This study investigated the potential toxicity of repeated oral doses of DHA-S in rats. The results showed that DHA-S at doses of 100 or 200 mg/kg BW caused reduced body weight and food consumption, affected hematological indexes and organ weight, especially in female rats. Moreover, DHA-S significantly influenced blood biochemical parameters at doses of 100 or 200 mg/kg BW. Female rats were more susceptible to the toxic effects of DHA-S. The no observed adverse effect level (NOAEL) of DHA-S in rats was determined to be 50 mg/kg BW/day.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Medicine, Legal
Tatsuya Mitsumoto, Yuji Ishii, Moeka Namiki, Kenji Nakamura, Shinji Takasu, Kumiko Ogawa
Summary: The subchronic toxicity study on Myrrh in rats indicated that it may suppress body weight gain and affect certain blood parameters, but these changes were not considered toxicologically significant. The increase in relative kidney weight in male rats treated with Myrrh was related to histopathological observations of hyaline droplets in the kidney tubules.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Su-Min Youn, Soo-Jin Choi
Summary: This review discusses the impact of factors such as the solubility of ZnO nanoparticles in food, their interactions with bio- or food-matrices on the biological responses and oral toxicity of ZnO nanoparticles. It also provides suggestions on determination methods and safe applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Tao Ma, Xinna Hu, Shuyu Lu, Xiaojun Liao, Yi Song, Xiaosong Hu
Summary: The synthesis of novel functional materials from abundant food waste resources has great potential for applications and ecological benefits. Nanocellulose, with its modifiable surface, excellent mechanical strength, and high aspect ratio, is a renewable and sustainable polymer that shows promise in various applications, including the food industry. This review focuses on the structural characteristics and extraction approaches of nanocellulose, as well as recent advancements in its use in the food industry. Environmental and human health concerns related to nanocellulose production are also evaluated. The extraction and production of nanocellulose from food waste provide a platform for the sustainable utilization of biomass, and its application in green food packaging materials, emulsion stabilizers, dietary fiber, nutrition delivery, and 3D printing hydrogels have shown excellent performance. Validated standards for characterizing the structure and evaluating toxicity are essential for the commercialization of nanocellulose in the food industry.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)