Article
Endocrinology & Metabolism
Lauren K. Vasilakos, Baiba Steinbrekera, Donna A. Santillan, Mark K. Santillan, Debra S. Brandt, Daniel Dagle, Robert D. Roghair
Summary: Diabetes during pregnancy and chorioamnionitis are associated with increased levels of maternal insulin, leptin, and IL-6. While both leptin and IL-6 play roles in inflammation, they have contrasting effects on neurodevelopment. In a study of cord blood samples from 104 term infants, it was found that maternal diabetes increased levels of leptin and insulin, while chorioamnionitis was associated with elevated IL-6 levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Amrita Balram, Spriha Thapa, Subroto Chatterjee
Summary: This review discusses three major concepts regarding sphingolipids and diabetes: the potential involvement of GM3 in insulin-insulin receptor interactions, the potential roles of Cer and LacCer in apoptosis and mitochondrial dysfunction, and the larger role of LacCer in antioxidant status and inflammation. In addition, the review discusses the efficacy of glycosphingolipid synthesis inhibitors in ameliorating diabetes in experimental animal models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lyudmila V. Nedosugova, Yuliya V. Markina, Leyla A. Bochkareva, Irina A. Kuzina, Nina A. Petunina, Irina Y. Yudina, Tatiana V. Kirichenko
Summary: The association between type 2 diabetes and cardiovascular complications is complex, primarily due to the oxidative stress and inflammation caused by hyperglycemia. Understanding the pathogenesis of type 2 diabetes and associated cardiovascular diseases can aid in the development of new diagnostic and therapeutic approaches.
Article
Cell Biology
Marcia Spoelder, Yami Bright, Martine C. Morrison, Veerle van Kempen, Lilian de Groodt, Malvina Begalli, Nikita Schuijt, Eva Kruiger, Ronald Bulthuis, Gabriele Gross, Robert Kleemann, Janna A. van Diepen, Judith R. Homberg, Giovanni Cirillo
Summary: Increased insulin levels may contribute to the development of neural circuits involved in cognition, while chronic mild inflammation may lead to cognitive impairment. This study investigated whether cognition is affected during adolescence in a genetic rat model for obesity and type 2 diabetes. The results showed that adolescent obese rats displayed enhanced cognition despite their early diabetic profile.
Article
Medicine, General & Internal
Justin Y. Lu, Jack Wilson, Wei Hou, Roman Fleysher, Betsy C. Herold, Kevan C. Herold, Tim Q. Duong
Summary: This study compared the incidences and risk factors of new-onset persistent type-2 diabetes in COVID-19 patients to those in influenza patients. It was found that the incidence of type-2 diabetes was higher in COVID-19 patients compared to influenza patients. The risk of developing persistent type-2 diabetes was also higher in hospitalized COVID-19 patients compared to non-hospitalized COVID-19 patients and hospitalized influenza patients.
Review
Biology
Suhailah S. Al-Jameel
Summary: This review summarizes research on the impact of gut microbes on diabetes over the past decade, focusing on the relationship between gut microbiota and Type-1 Diabetes (T1D), Type-2 Diabetes (T2D), as well as how gut microbiota could be an alternative therapy for the treatment of diabetes.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Immunology
Gustav van Niekerk, Michelle van Der Merwe, Anna-Mart Engelbrecht
Summary: Diabetes is strongly linked to increased susceptibility to infection, particularly in COVID-19 cases, with dysregulated insulin signaling potentially contributing to immune pathology and defective immune response. Insulin receptors on lymphocytes following immune activation and the role of insulin in regulating immune cell functions through the PI3K/Akt/mTOR pathway are key aspects of this connection. Furthermore, insulin binding and translocation of the insulin receptor to the nucleus may modulate the transcription of immune-related genes involved in viral infections.
Review
Cell Biology
Jesus Burillo, Patricia Marques, Beatriz Jimenez, Carlos Gonzalez-Blanco, Manuel Benito, Carlos Guillen
Summary: This review examines the main molecular mechanisms that may be involved in the connection between type 2 diabetes and neurodegenerative diseases, with a focus on inflammation, endoplasmic reticulum stress, autophagy, and mitochondrial dysfunction.
Review
Immunology
Manoj Kumar Bisht, Priyanka Dahiya, Sudip Ghosh, Sangita Mukhopadhyay
Summary: Tuberculosis (TB) is an ancient human disease and a major global cause of death and illness. Mycobacterium tuberculosis (Mtb), the TB-causing pathogen, is highly successful in infecting humans. Factors such as malnutrition, smoking, co-infection with HIV, and diabetes further worsen TB pathogenesis. The association between type 2 diabetes and TB is well recognized, with hyperglycemia during active TB leading to impaired glucose tolerance and insulin resistance. This review explores potential causal factors, such as inflammation and host metabolic changes triggered by TB, that contribute to the development of insulin resistance and type 2 diabetes. The therapeutic management of type 2 diabetes during TB is also discussed, which may inform future strategies for TB-DM cases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Xinmei Huang, Bingbing Zha, Manna Zhang, Yue Li, Yueyue Wu, Rui Zhang, Li Sheng, Jiong Xu, Zhiyan Yu, Cuijun Gao, Zaoping Chen, Heyuan Ding, Ling Ma, Yanquan Zhang, Shufei Zang, Tie-Ning Zhang, Jun Liu
Summary: The study found that decreased monocyte count throughout pregnancy was closely associated with the development of gestational diabetes mellitus (GDM), macrosomia, and the chronic inflammatory state of GDM. First-trimester monocyte count performed better as a risk factor and diagnostic predictor of GDM and macrosomia compared to second and third trimester counts.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Amanda L. Missel, Laura R. Saslow, Dina H. Griauzde, Donna Marvicsin, Ananda Sen, Caroline R. Richardson, Xuefeng Liu
Summary: This study found a significant association between higher fasting insulin levels and higher levels of CRP, suggesting that treatment approaches targeting both insulin and glucose levels may have additive anti-inflammatory effects and improve long-term outcomes for adults with type 2 diabetes.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Multidisciplinary Sciences
Young-Kook Kim
Summary: This study identified specific and common long non-coding RNAs (lncRNAs) involved in the progression of diabetes in skeletal muscles and kidneys. The results provide valuable insights into the role of lncRNAs during the pathogenesis of diabetes.
Article
Biochemistry & Molecular Biology
Tina Okdahl, Anne-Marie Wegeberg, Anne Birthe Helweg Jensen, Sarah Thorius Jensen, Helene Riis Pontoppidan Andersen, Joachim Storling, Birgitte Brock, Christina Brock
Summary: Gastroenteropathy, a complication of diabetes, is associated with damage to the enteric nervous system. Systemic inflammation and neuropathy have been reported, but associations with gastroenteropathy are less known. This study explored these associations in individuals with diabetes and found that certain cytokines were associated with gastric and colonic transit times. Inverse correlations between cytokines and symptoms were also observed. These findings suggest a potential interaction between inflammation and the enteric nervous system in diabetes, highlighting the possibility of using anti-inflammatory strategies in managing diabetic gastroenteropathy.
Article
Pharmacology & Pharmacy
Reem S. Alruhaimi, Gomaa Mostafa-Hedeab, Maisa Siddiq Abduh, Albandari Bin-Ammar, Emad H. M. Hassanein, Emadeldin M. Kamel, Ayman M. Mahmoud
Summary: This study found that Euphorbia peplus extract (EPE) has anti-diabetic effects in rats with type 2 diabetes, improving hyperglycemia, insulin resistance, dyslipidemia, inflammation, and oxidative stress, and increasing antioxidant capacity.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sevda Urcar Gelen, Seckin Ozkanlar, Semin Gedikli, Mustafa Atasever
Summary: The long-term consumption of Monosodium glutamate (MSG) can lead to metabolic syndrome and obesity, as well as increased risk of developing diabetes mellitus. In a rat study, MSG administration significantly increased the production of inflammatory factors, oxidative stress markers, and caused damage to the pancreatic cells. It was concluded that the use of MSG should be limited and controlled to prevent these adverse effects.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Respiratory System
L. Baltieri, E. Cazzo, D. A. Oliveira Modena, R. C. Gobato Rentel, L. C. Martins, E. A. Chaim
Summary: This study aimed to investigate the correlation between levels of adipokines and inflammatory mediators and lung function in individuals with obesity and bronchial asthma symptoms. The results showed that an increase in interleukin-6 in the sputum was associated with worse pulmonary function, even in patients with controlled asthma, especially in measures of airway permeability.
Review
Endocrinology & Metabolism
Antonis Polymeris, Peter D. Papapetrou
Summary: Recent reports have linked increased circumferences of certain regions of the human body with insulin resistance or increased risk of cardiovascular disease. This review summarizes the findings and conclusions of some of these publications.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Engineering, Biomedical
Debora Aparecida Oliveira Modena, Ciro Dantas Soares, Elaine Cristina Candido, Felipe David Mendonca Chaim, Everton Cazzo, Elinton Adami Chaim
Summary: This study demonstrates that ESWT can stimulate the inflammatory and angiogenic processes in the dermis and epidermis of obese individuals, providing important growth factors for repair and regeneration of skin tissue, making it a promising treatment for skin diseases related to weight changes.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Juliano Henrique Borges, Daniel Minutti de Oliveira, Sofia Helena Valente de Lemos-Marini, Bruno Geloneze, Gil Guerra-Junior, Ezequiel Moreira Goncalves
Summary: This study investigated the bone health of young adults with 21-hydroxylase enzyme deficiency undergoing glucocorticoid replacement therapy and found that well-controlled patients had normal bone health. The study also suggested that glucocorticoid dose may affect the mineral density of the femoral neck region.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Marina Vilar Geraldi, Cinthia Bau Betim Cazarin, Marcelo Cristianini, Ana Carolina Junqueira Vasques, Bruno Geloneze, Mario Roberto Marostica Junior
Summary: The study showed that jabuticaba juice can increase GLP-1 concentrations and antioxidant capacity in healthy subjects, but has no significant effect on postprandial glucose, insulin, C-peptide levels, and appetite sensations.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Surgery
Camila Carvalho, Aglecio Luiz de Souza, Gisele Almeida Batista, Louise Franciscato Trivelato Duran, Debora Puzzi Fernandes, Viviane Bressane Claus Molina, Raquel Goncalves, Joelma Silvia Giorgetti, Elintom Adami Chaim, Sarah Monte Alegre
Summary: In a study of 20 morbidly obese patients who underwent RYGB, it was found that after 10 years, high levels of GLP-1 remained, which may be associated with metabolic improvement, especially in patients with normal glucose tolerance.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Urology & Nephrology
Thairo A. Pereira, Carlos A. L. D'ancona, Elaine C. Candido, Arnold P. P. Achermann, Elinton A. Chaim
Summary: The prevalence of lower urinary tract symptoms and urodynamic patterns in obese women is higher compared to nonobese volunteers, particularly for stress urinary incontinence (SUI) and overactive bladder (OAB) symptoms. The degree of obesity is directly associated with an impairment of the patient's cystometric capacity, as indicated by urodynamic studies.
NEUROUROLOGY AND URODYNAMICS
(2022)
Article
Cell Biology
Joseane Morari, Roberta Haddad-Tovolli, Pedro Augusto Silva Nogueira, Caio Jordao Teixeira, Rafael Marostica, Natalia Tobar, Celso Dario Ramos, Licio Augusto Velloso, Vanessa Cristina Dias Bobbo, Gabriel Forato Anhe
Summary: This study aimed to clarify the mechanisms underlying the variability in spontaneous weight gain in age-matched male Swiss mice. The researchers found that differences in the expression of genes related to the reward system in the midbrain as well as variations in ghrelin concentrations in the serum correlated with spontaneous variability in body mass and food intake.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Immunology
Renata G. Borges de Oliveira Nascimento Freitas, Ana Carolina J. Vasques, Gabriel da Rocha Fernandes, Francieli B. Ribeiro, Isabela Solar, Marina G. Barbosa, Bianca de Almeida-Pititto, Bruno Geloneze, Sandra Roberta G. Ferreira
Summary: This study investigated the association between gut bacteria and early-life events, nutritional status, and body composition. The results showed that gut bacteria composition is influenced by early-life events, nutritional status, and exclusive breastfeeding. Specific gut bacteria profiles were associated with healthy women, confirming the importance of early-life events in defining gut microbiota composition.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
R. G. B. O. N. Freitas, A. C. J. Vasques, G. R. Fernandes, F. B. Ribeiro, I Solar, M. G. Barbosa, B. Almeida-Pititto, B. Geloneze, S. R. G. Ferreira
Summary: The intrauterine environment can influence the distribution of body adiposity in offspring, which in turn affects cardiometabolic risk. This study investigated the associations between gestational weight gain and the gut microbiota, body adiposity, and related parameters in adult offspring.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Chemistry, Applied
Laisa Gomes Dias, Adriele Hacke, Ernane dos Santos Souza, Seema Nath, Miriam Regina Canesin, Omar Vieira Vilella, Bruno Geloneze, Juliana Azevedo Lima Pallone, Cinthia Bail Betim Cazarin, Joshua John Blakeslee, Lilian Regina Barros Mariutti, Neura Bragagnolo
Summary: The objective of this study was to investigate and characterize new rice cultivars with nutritional and economic potential. The study found that Brazilian aromatic rice had higher levels of ash, protein, lipid, alpha-tocopherol, and unsaturated fatty acids compared to Brazilian non-aromatic rice. Additionally, ingestion of aromatic rice resulted in a lower insulinemic response. The planting time influenced the bioactive compound content, but the optimal planting time for maximizing these compounds was inconclusive.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Biology
T. P. Prado, J. Morari, E. P. Araujo
Summary: Diabetes increases the risk of skin infections and foot ulcers. The effects of diabetes on uninjured skin are less studied. However, it is known that diabetes can cause increased oxidative stress and lipid peroxidation. In this study, hyperglycemia in mice induced a decrease in Il-6 and an increase in Tnf-a, Il-10, F4/80, Tgf-b, and Igf-1. It also led to lower cellular density, delayed collagen fiber maturation, decreased neuron number, and decreased Bdnf expression in the skin.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Cleliani de Cassia da Silva, Mariana Porto Zambon, Ana Carolina Junqueira Vasques, Daniella Fernandes Camilo, Maria angela Reis de Goes Monteiro Antonio, Bruno Geloneze
Summary: This study aimed to validate the homeostasis model assessment (HOMA) of insulin resistance (IR) as a surrogate to the hyperglycemic clamp to measure IR in both pubertal and postpubertal adolescents, and determine the HOMA-IR cutoff values for detecting IR in both pubertal stages. The HOMA-IR was found to be negatively associated with the clamp-derived insulin sensitivity index in both pubertal and postpubertal adolescents. The HOMA-IR showed a good discriminatory power for detecting IR, and the optimal cutoff values for detecting IR were > 3.22 for pubertal and > 2.91 for postpubertal adolescents.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Keryma Chaves da Silva Mateus, Ivan Luiz Padilha Bonfante, Amanda Veiga Sardeli, Renata Garbellini Duft, Arthur Fernandes Gaspari, Joice Cristina dos Santos Trombeta, Joseane Morari, Bruno Rodrigues, Marcio Alberto Torsoni, Mara Patricia Traina Chacon-Mikahil, Licio Augusto Velloso, Claudia Regina Cavaglieri
Summary: The aim of this study was to investigate the effects of different types of exercise on the expression of CHRNA7, CHRFAM7A, and TNF-alpha genes in individuals with normal weight and overweight with type 2 diabetes. The results showed that individuals with overweight and type 2 diabetes had higher baseline expression of CHRFAM7A and TNF-alpha. However, after exercise, the expression of CHRFAM7A increased in individuals with normal weight, especially in aerobic exercise.
Article
Endocrinology & Metabolism
Juliano Henrique Borges, Daniela Albiero Camargo, Leticia Esposito Sewaybricker, Renata Isa Santoro, Daniel Minutti de Oliveira, Sofia Helena Valente de Lemos-Marini, Bruno Geloneze, Gil Guerra-Junior, Ezequiel Moreira Goncalves
Summary: This study compared ambulatory blood pressure (ABP) between young adults with congenital adrenal hyperplasia (CAH) and a control group. The results showed no differences in systolic BP, diastolic BP, and pulse pressure between the two groups. Additionally, there were no associations between glucocorticoid dose, androgen levels, and ABP parameters.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
