Article
Nutrition & Dietetics
Marie Mathieu, Pascale Guillot, Typhaine Riaudel, Anne-Sophie Boureau, Guillaume Chapelet, Celine Brouessard, Laure de Decker, Gilles Berrut
Summary: This study aimed to explore the relationship between osteoporosis and sarcopenia in women aged 75 or older, revealing a significant association between fat mass and bone density, with osteosarcopenic patients having lower fat mass and body mass index.
Article
Medicine, General & Internal
Paivi E. Korhonen, Tuija Mikkola, Hannu Kautiainen, Johan G. Eriksson
Summary: This study found that both fat mass and lean mass index are positively associated with blood pressure levels, independently of other factors. Lean body mass is shown to be an important determinant of blood pressure levels, with a magnitude similar to fat mass. Excess muscle mass may not be beneficial to cardiovascular health.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Longti Li, Huiqin Zhong, Ya Shao, Xu Zhou, Yu Hua, Maoqian Chen
Summary: The study found a positive correlation between lean body mass and total BMD, while visceral fat mass showed a negative correlation. Additionally, the ratio of lean body mass to visceral fat mass was positively associated with BMD. Subgroup analysis demonstrated robustness across most groups except for the subgroup with diabetes.
ARCHIVES OF PUBLIC HEALTH
(2023)
Article
Endocrinology & Metabolism
Jingzheng Fan, Yuyan Jiang, Junlian Qiang, Bin Han, Qiang Zhang
Summary: This study investigated the relationship between body fat accumulation, fat distribution, and bone mineral density in non-obese postmenopausal women. The results showed a positive association between total fat mass and bone mineral density, while fat distribution had a negative correlation with bone mineral density.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Karina Akhiiarova, Rita Khusainova, Ildar Minniakhmetov, Natalia Mokrysheva, Anton Tyurin, Giuseppina Storlino
Summary: Peak bone mass refers to the amount of bone tissue formed when a stable skeletal state is achieved at a young age. It plays a crucial role in the prevention of osteoporosis. Factors such as hormonal levels, body composition, physical activity, nutrition, and heredity influence the level of peak bone mass.
Article
Geriatrics & Gerontology
Mengyi Liu, Zhuxian Zhang, Chun Zhou, Ziliang Ye, Panpan He, Yuanyuan Zhang, Huan Li, Chengzhang Liu, Xianhui Qin
Summary: This study explores the association between predicted fat mass and lean mass with mortality in the US general population, finding that both fat mass and lean mass are independent predictors of overall and cause-specific mortality. Age was found to significantly modify the associations.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Biochemistry & Molecular Biology
Christopher Papandreou, Jesus Garcia-Gavilan, Lucia Camacho-Barcia, Thea T. Hansen, Anders Sjodin, Joanne A. Harrold, Jason C. G. Halford, Monica Bullo
Summary: This study identified specific circulating metabolomic profiles associated with body fat mass and lean mass within human metabolism. The results suggest alterations in lipid metabolism, fatty acid oxidation, and protein degradation with changes in adiposity and lean body mass. These findings could provide insights into the interplay between body composition compartments and human metabolic processes.
Article
Endocrinology & Metabolism
Lijuan Yang, Huihui Deng, Wei Pan, Xiaoyan Huang, Ke Xu, Xingxing Zhang, Xiang Hu, Xuejiang Gu
Summary: The study found that higher levels of leg fat were associated with a lower risk of osteoporosis, independent of total lean mass.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Endocrinology & Metabolism
Nipith Charoenngam, Caroline M. Apovian, Chatlert Pongchaiyakul
Summary: This study aims to determine the association of lean mass and fat mass with bone mineral density in Thais. The results show that in men, lean mass index is positively correlated with lumbar spine and femoral neck bone density, while fat mass index is negatively correlated with femoral neck bone density. In women, both lean mass and fat mass index are positively correlated with lumbar spine and femoral neck bone density. These findings indicate a sex-specific influence of fat mass on bone density in Thais.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Seong Rae Kim, Gyeongsil Lee, Seulggie Choi, Yun Hwan Oh, Joung Sik Son, Minseon Park, Sang Min Park
Summary: This study found that increased predicted muscle mass or decreased predicted fat mass were associated with a reduced risk of cardiovascular disease (CVD) in young adults. Conversely, decreased predicted muscle mass or increased predicted fat mass were associated with an elevated risk of CVD.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Endocrinology & Metabolism
Ya Shao, Longti Li, Huiqin Zhong, Xiaojun Wang, Yu Hua, Xu Zhou
Summary: The study found a negative correlation between lean body mass and insulin resistance, while visceral fat mass was positively correlated. The Log LM/VFM ratio showed a nonlinear relationship with IR, with threshold and saturation effects observed. Subgroup analysis showed robustness in the relationship between Log LM/VFM and IR across different demographic and health variables.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yilan Ge, Jiamin Liu, Lihua Zhang, Yan Gao, Bin Wang, Xiuling Wang, Jing Li, Xin Zheng
Summary: Higher lean body mass, not fat mass, was associated with lower 1-year mortality among heart failure patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Aaron Misakian, Michelle McLoughlin, Louisa C. Pyle, Thomas F. Kolon, Andrea Kelly, Maria G. Vogiatzi
Summary: This study investigated bone mineral density and body composition in adolescents with CAIS, showing a bone mass deficit in this population. Further research is needed to understand the extent of BMD abnormalities, the impact of early gonadectomy, and the optimal hormone replacement therapy regimen for bone accrual. Data on lean mass were reassuring.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Sport Sciences
Annie M. Skinner, Dimitris Vlachopoulos, Alan R. Barker, Sarah A. Moore, Alex Rowlands, Sonja Soininen, Eero A. Haapala, Juuso Vaisto, Kate Westgate, Soren Brage, Timo A. Lakka
Summary: The study aimed to assess the associations of physical activity (PA) volume, PA intensity distribution, and moderate-to-vigorous PA (MVPA) with bone mineral content, lean mass, and fat mass in children. The results showed that PA volume was positively associated with bone mineral content in both females and males, and positively associated with lean mass (males) or negatively associated with fat mass (males). PA intensity was negatively associated with bone mineral content in males. MVPA was positively associated with lean mass and negatively associated with fat mass in both females and males.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Genetics & Heredity
Xuefei Li, Zhuo Li, Miao Yang, Yan Luo, Li Hu, Zhi Xiao, Aji Huang, Juan Huang
Summary: This study found an association between two SNPs of the BRIP1 gene and breast cancer, without affecting specific clinical phenotypes.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Article
Genetics & Heredity
Wenjin Xiao, Jinwei He, Wenzhen Fu, Youjia Xu, Zhenlin Zhang
Article
Chemistry, Medicinal
Christine Brotherton-Pleiss, Peibin Yue, Yinsong Zhu, Kayo Nakamura, Weiliang Chen, Wenzhen Fu, Casie Kubota, Jasmine Chen, Felix Alonso-Valenteen, Simoun Mikhael, Lali Medina-Kauwe, Marcus A. Tius, Francisco Lopez-Tapia, James Turkson
Summary: The study optimized proline-based STAT3 inhibitors into a new series of azetidine-2-carboxamide analogues with sub-micromolar potencies, demonstrating potential therapeutic effects on breast cancer cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Luyue Qi, Lianyong Liu, Li Li, Weiwei Hu, Wenzhen Fu, Ji Hu, Youjia Xu, Zhenlin Zhang
Summary: The study revealed that genetic variation in the SOST gene may contribute to variations in body composition among Chinese male offspring, however, no significant associations were found between haplotypes and body composition in the within-family analysis.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Cell Biology
Shanshan Lv, Jiao Zhao, Lei Xi, Xiaoyun Lin, Chun Wang, Hua Yue, Jiemei Gu, Weiwei Hu, Wenzhen Fu, Zhanying Wei, Hao Zhang, Yunqiu Hu, Shanshan Li, Zhenlin Zhang
Summary: In this study, targeted exome sequencing (TES) was used to diagnose 223 probands with genetic skeletal dysplasias (GSDs), resulting in molecular diagnoses for 110 individuals and confirmation of 129 pathogenic/likely pathogenic variants. The high diagnostic rate of TES in GSDs could aid clinicians in confirming molecular diagnoses, guiding treatment, and providing genetic counseling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Su-Qin Shi, Shan-Shan Li, Xiao-Ya Zhang, Zhe Wei, Wen-Zhen Fu, Jin-Wei He, Yun-Qiu Hu, Miao Li, Li-Li Zheng, Zhen-Lin Zhang
Summary: This study found that genetic variations of the LGR4 gene are associated with peak bone mineral density, BMI, and trunk fat mass.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Peibin Yue, Yinsong Zhu, Christine Brotherton-Pleiss, Wenzhen Fu, Nagendra Verma, Jasmine Chen, Kayo Nakamura, Weiliang Chen, Yue Chen, Felix Alonso-Valenteen, Simoun Mikhael, Lali Medina-Kauwe, Kathleen M. Kershaw, Maria Celeridad, Songqin Pan, Allison S. Limpert, Douglas J. Sheffler, Stephen L. Shiao, Marcus A. Tius, Francisco Lopez-Tapia, James Turkson
Summary: In this study, potent azetidine-based, selective, irreversible Stat3 inhibitors were identified that inhibit the growth of triple-negative breast cancer. These compounds amplify the Stat3-inhibitory activity and selectively bind to Stat3, leading to the inhibition of constitutive and ligand-induced Stat3 signaling. The inhibitors showed no effect on other proteins or cells without aberrantly-active Stat3.
Article
Genetics & Heredity
Yi-Ming Guo, Jian-Hao Cheng, Hao Zhang, Jin-Wei He, Hua Yue, Wei-Wei Hu, Jie-Mei Gu, Yun-Qiu Hu, Wen-Zhen Fu, Chun Wang, Zhen-Lin Zhang
Summary: This study investigated the association between genetic variation of the POSTN gene and the prevalence of vertebral fractures and bone mineral density (BMD) in Chinese postmenopausal women. The study found that the rs9603226 variant of POSTN was significantly associated with vertebral fractures, while the rs3923854 variant was associated with serum periostin levels. These findings suggest that genetic variation of the POSTN gene may be a predicting factor for the risk of vertebral fractures, and serum periostin levels could be a potential biochemical parameter for osteoporosis in Chinese postmenopausal women.
Article
Endocrinology & Metabolism
Ziyuan Wang, Xiang Li, Ya Wang, Wenzhen Fu, Yujuan Liu, Zhenlin Zhang, Chun Wang
Summary: This study retrospectively investigated the clinical characteristics and genetic mutations of 36 Chinese patients with ADO II. The results showed that minor trauma-related fractures were the most common clinical manifestation of the disease, while visual loss and bone marrow failure were rare. The condition of ADO II appeared to be stable in most patients. The mutation c.2299C>T (p.Arg767Trp) was the most common variant, while the mutation c.937G>A [p.(Glu313Lys)] was associated with a more severe phenotype.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yue Fu, Heyu Chen, Wenzhen Fu, Marc Garcia-Borras, Yang Yang, Peng Liu
Summary: New-to-nature radical biocatalysis has emerged as a powerful strategy for stereoselective transformations, with a novel metalloredox biocatalysis leveraging the heme cofactor of P450 enzymes to enable excellent activity and stereoselectivity. Computational and experimental studies shed light on the mechanism and enantioselectivity origins, revealing a bifunctional ATRCase with unexpectedly beneficial mutation I263Q enhancing radical cyclization enantioselectivity through a hydrogen bond donor residue.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Genetics & Heredity
Wen-Jie Wang, Jin-Wei He, Wen-Zhen Fu, Chun Wang, Zhen-Lin Zhang
Summary: The study found a significant association between the NF-kappa B1 and RELA genes and bone response to zoledronic treatment in postmenopausal Chinese women with osteoporosis, with certain haplotypes being related to improvements in bone density.
Article
Chemistry, Physical
Wenzhen Fu, Natalia M. M. Neris, Yue Fu, Yunlong Zhao, Benjamin Krohn-Hansen, Peng Liu, Yang Yang
Summary: This study describes a metalloredox biocatalysis strategy to repurpose natural cytochromes P450 for catalysing asymmetric radical cyclization to arenes through an unnatural electron transfer mechanism. Directed evolution yielded a series of engineered P450 aromatic radical cyclases with complementary selectivities. The excellent tunability of this metalloenzyme family provides an exciting platform for utilizing free radical intermediates in asymmetric catalysis.
Proceedings Paper
Computer Science, Interdisciplinary Applications
Wenzhen Fu, Yixin Zhong, Baitong Chen, Yi Cao, Jiazi Chen, Hanhan Cong
Summary: DNA N6 methyladenine (6mA) is an extensively studied and widespread epigenetic modification that plays a vital role in cell growth and development. The existing biological experimental methods are expensive and time-consuming, prompting the development of a targeted and efficient computing model like i6mA-word2vec for the prediction of 6mA sites. Experimental results indicate that this computational model performs better.
INTELLIGENT COMPUTING THEORIES AND APPLICATION, ICIC 2022, PT II
(2022)
Meeting Abstract
Oncology
Peibin Yue, Francisco Lopez-Tapia, Yinsong Zhu, Christine Brotherton-Pleiss, Wenzhen Fu, Felix Alonso-Valenteen, Simoun Mikhael, Lali Medina-Kauwe, Marcus Tius, James Turkson
Article
Computer Science, Information Systems
Chunyuan Liu, Dong Rui, He Zhu, Wenzhen Fu
Summary: This paper optimized a PMLSG for low-speed power generation systems, improving power density and efficiency while reducing material costs through a multi-physics optimization method. An experimental test platform was established to verify the accuracy of the analysis results.
Article
Chemistry, Physical
Yu Mu, Tao Zhang, Yaping Cheng, Wenzhen Fu, Zuting Wei, Wanjun Chen, Guodu Liu
Summary: This study presents an efficient nickel-catalyzed intramolecular reductive cyclization for the synthesis of chiral tetrahydrofurans, demonstrating high stereoselectivity and enantioselectivity with a broad substrate scope. The ligand effects and reaction mechanism were investigated in detail. In addition, the developed method enables the efficient synthesis of complex molecules and potentially opens up new research fields in organic synthesis and chemical biology.
CATALYSIS SCIENCE & TECHNOLOGY
(2021)