Genetic Polymorphisms and Drug Interactions Leading to Clopidogrel Resistance: Why the Asian Population Requires Special Attention

Clopidogrel and modified-release dipyridamole for the prevention of occlusive vascular events (review of Technology Appraisal No. 90): a systematic review and economic analysis

(2014) J Greenhalgh et al.   HEALTH TECHNOLOGY ASSESSMENT

Clopidogrel Resistance is Associated with Long-Term Thrombotic Events in Patients Implanted with Drug-Eluting Stents

(2013) Lin Wang et al.   Drugs in research & development

Pharmacogenomic testing: Relevance in medical practice: Why drugs work in some patients but not in others

(2011) J. P. KITZMILLER et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Modifying Clopidogrel Maintenance Doses According to Vasodilator-Stimulated Phosphoprotein Phosphorylation Index Improves Clinical Outcome in Patients With Clopidogrel Resistance

(2011) Xiao-dong Wang et al.   CLINICAL CARDIOLOGY

Paraoxonase 1 (PON1) Gene Variants Are Not Associated With Clopidogrel Response

(2011) J P Lewis et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450-2C19 (CYP2C19) Genotype and Clopidogrel Therapy

(2011) S A Scott et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

High on Treatment Platelet Reactivity

(2011) Omar Ait-Mokhtar et al.   Heart Lung and Circulation

High Residual Platelet Reactivity After Clopidogrel Loading and Long-term Cardiovascular Events Among Patients With Acute Coronary Syndromes Undergoing PCI

(2011) Guido Parodi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

CYP2C19 Genotype, Clopidogrel Metabolism, Platelet Function, and Cardiovascular Events

(2011) Michael V. Holmes et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clopidogrel–Drug Interactions

(2011) Eric R. Bates et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Platelet function monitoring in patients on clopidogrel: What should we learn from GRAVITAS?

(2011) Dániel Aradi et al.   PLATELETS

An improved method for specific and quantitative determination of the clopidogrel active metabolite isomers in human plasma

(2011) Sebastien Roy et al.   THROMBOSIS AND HAEMOSTASIS

Risk of Adverse Outcomes in Taiwan Associated With Concomitant Use of Clopidogrel and Proton Pump Inhibitors in Patients Who Received Percutaneous Coronary Intervention

(2010) Chin-Chou Huang et al.   AMERICAN JOURNAL OF CARDIOLOGY

Heart Disease and Stroke Statistics—2011 Update

(2010) Véronique L. Roger et al.   CIRCULATION

Differential Impacts of CYP2C19 Gene Polymorphisms on the Antiplatelet Effects of Clopidogrel and Ticlopidine

(2010) A Maeda et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Oral anticoagulation with coumarin derivatives and antiplatelet effects of clopidogrel

(2010) D. Sibbing et al.   EUROPEAN HEART JOURNAL

CYP2C19*2 and CYP2C9*3 alleles are associated with stent thrombosis: a case-control study

(2010) A. M. Harmsze et al.   EUROPEAN HEART JOURNAL

Determinants of Quality of Life After Stroke in China

(2010) Candice Delcourt et al.   STROKE

Clopidogrel Resistance in Japanese Patients Scheduled forPercutaneous Coronary Intervention

(2009) Kozo Hoshino et al.   CIRCULATION JOURNAL

Gastrointestinal Complications After 3 Months of Dual Antiplatelet Therapy for Drug-eluting Stents as Assessed by Wireless Capsule Endoscopy

(2009) Ali Seddighzadeh et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Calcium-channel blockers decrease clopidogrel-mediated platelet inhibition

(2009) T. Gremmel et al.   HEART

Association of Cytochrome P450 2C19 Genotype With the Antiplatelet Effect and Clinical Efficacy of Clopidogrel Therapy

(2009) Alan R. Shuldiner   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The safety and efficacy of clopidogrel versus ticlopidine in Japanese stroke patients: combined results of two Phase III, multicenter, randomized clinical trials

(2009) Shinichiro Uchiyama et al.   JOURNAL OF NEUROLOGY

Platelet Reactivity After Clopidogrel Treatment Assessed With Point-of-Care Analysis and Early Drug-Eluting Stent Thrombosis

(2009) Dirk Sibbing et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Besides CYP2C19*2, the variant allele CYP2C9*3 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation

(2009) Ankie Harmsze et al.   Pharmacogenetics and Genomics

Impact of P2Y12-ADP receptor polymorphism on the efficacy of clopidogrel dose-adjustment according to platelet reactivity monitoring in coronary artery disease patients

(2009) Laurent Bonello et al.   THROMBOSIS RESEARCH

Platelet reactivity and clopidogrel resistance are associated with the H2 haplotype of the P2Y12-ADP receptor gene

(2008) Peter Staritz et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Optimizing Clopidogrel Therapy Before Stent Implantation: Should Clinical Setting Be Taken Into Account?

(2008) Dániel Aradi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adjusting Clopidogrel Loading Doses According to Vasodilator-Stimulated Phosphoprotein Index: On Time, Too Early, or Too Late?

(2008) Thomas Cuisset et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Influence of Omeprazole on the Antiplatelet Action of Clopidogrel Associated With Aspirin

(2008) Martine Gilard et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cytochrome P450 2C19 681G>A Polymorphism and High On-Clopidogrel Platelet Reactivity Associated With Adverse 1-Year Clinical Outcome of Elective Percutaneous Coronary Intervention With Drug-Eluting or Bare-Metal Stents

(2008) Dietmar Trenk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The common gene variants of CYP2C19 affect pharmacokinetics and pharmacodynamics in an active metabolite of clopidogrel in healthy subjects

(2008) K. UMEMURA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Genetic Determinants of Response to Clopidogrel and Cardiovascular Events

(2008) Tabassome Simon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Atorvastatin on the Pharmacokinetics and Pharmacodynamics of Prasugrel and Clopidogrel in Healthy Subjects

(2008) Nagy A Farid et al.   PHARMACOTHERAPY

Platelet reactivity to adenosine diphosphate and long-term ischemic event occurrence following percutaneous coronary intervention: A potential antiplatelet therapeutic target

(2008) Paul A. Gurbel et al.   PLATELETS