Article
Cardiac & Cardiovascular Systems
Seung-Jun Lee, Jung-Joon Cha, Young-Hoon Jeong, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Hyung Joon Loo, Kiyuk Chang, Yongwhi Park, Young Bin Song, Sung Gyun Ahn, Jung-Won Suh, Sang Yup Lee, Jung Rae Cho, Ae-Young Her, Hyo-Soo Kim, Moo Hyun Kim, Eun-Seok Shin, Do-Sun Lim, Byeong-Keuk Kim
Summary: The long-term prognostic implications of platelet reactivity after percutaneous coronary intervention (PCI) are important. High PRU is significantly associated with the occurrence of major adverse cardiac and cerebrovascular events (MACCE), all-cause death, and net adverse clinical events (NACE).
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Multidisciplinary Sciences
Rattanaporn Sukprasong, Sumonrat Chuwongwattana, Napatrupron Koomdee, Thawinee Jantararoungtong, Santirhat Prommas, Pimonpan Jinda, Jiratha Rachanakul, Nutthan Nuntharadthanaphong, Nutcha Jongjitsook, Apichaya Puangpetch, Chonlaphat Sukasem
Summary: This study examined the allele frequencies of cytochrome P450 polymorphisms in a Thai population and found significant differences in allele frequencies among different regions within Thailand. The results may contribute to understanding ethnic differences in drug responses and support the use of pharmacogenomics testing in clinical practice.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
N. M. El-Khodary, A. M. El-Behery, N. A. El-Askary, H. M. Donia, G. A. Omran
Summary: The study aimed to investigate the occurrence of clopidogrel resistance and associated factors in an Egyptian population. Results indicated that factors such as CYP2C19*2 genotype, high BMI, and diabetes were significantly associated with clopidogrel resistance.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Michele Mattia Viscusi, Fabio Mangiacapra, Simone Circhetta, Luca Paolucci, Roberta De Luca, Annunziata Nusca, Rosetta Melfi, Elisabetta Ricottini, Gian Paolo Ussia, Francesco Grigioni
Summary: This study found that platelet reactivity in patients receiving elective PCI and clopidogrel treatment exhibits diurnal variations, with the highest platelet reactivity observed in the morning. This has important implications for improving the durability and consistency of antiplatelet inhibition.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)
Article
Cardiac & Cardiovascular Systems
Ki-Hyun Jeon, Young-Hoon Jeong, In-Ho Chae, Byeong-Keuk Kim, Hyung Joon Joo, Kiyuk Chang, Yongwhi Park, Young Bin Song, Sung Gyun Ahn, Sang Yeub Lee, Jung Rae Cho, Ae-Young Her, Hyo-Soo Kim, Moo Hyun Kim, Do-Sun Lim, Eun-Seok Shin, Jung-Won Suh, PTRG DES Consortium Investigators
Summary: This study found that diabetic patients have significantly higher platelet reactivity and a higher prevalence of high platelet reactivity after percutaneous cutaneous intervention. High platelet reactivity is associated with an increased risk of major adverse cardiac and cerebrovascular events in diabetic patients, but not in non-diabetic patients.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Silvia Lee, Patricia P. Wadowski, Timothy Hoberstorfer, Constantin Weikert, Joseph Pultar, Christoph W. Kopp, Simon Panzer, Thomas Gremmel
Summary: The study found that hyperuricemia is associated with increased residual platelet reactivity in patients treated with clopidogrel and prasugrel, but not in those treated with ticagrelor.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Article
Clinical Neurology
Aurelio Jara-Prado, Jorge Luis Guerrero-Camacho, Quetzalli Denisse Angeles-Lopez, Adriana Ochoa-Morales, David Jose Davila-Ortiz de Montellano, Miguel Angel Ramirez-Garcia, Michelle Breda-Yepes, Reyna M. Duron, Antonio V. Delgado-Escueta, Diego A. Barrios-Gonzalez, Iris E. Martinez-Juarez
Summary: This study found an association between genetic variants of CYP2C9, CYP2C19, and ABCB1 genes and the development of juvenile myoclonic epilepsy (JME). These genes may interact with other genes to contribute to the pathogenesis of JME.
NEUROLOGICAL SCIENCES
(2023)
Article
Cell Biology
Mengyuan Zhou, Weiqi Chen, Yuesong Pan, Yi Lin, Xia Meng, Xingquan Zhao, Liping Liu, Jinxi Lin, Hao Li, Yongjun Wang, Yilong Wang
Summary: Our study found that Ticagrelor/aspirin therapy had greater platelet inhibition and more rapid onset in platelet inhibition compared to clopidogrel/aspirin therapy in patients with acute minor stroke or TIA, regardless of CYP2C19 metabolizer status.
Article
Biotechnology & Applied Microbiology
Zainab Omer Ali, Loulia Bader, Shaaban Mohammed, Salaheddin Arafa, Abdulrahman Arabi, Larisa Cavallari, Taimour Langaee, Fatima Mraiche, Nasser Rizk, Ahmed Awaisu, Mohamed H. Shahin, Hazem Elewa
Summary: The study demonstrated a significant association between the CYP2C19*17 allele and increased risk of bleeding, while CYP2C19*2 or *3 were associated with MACE outcomes.
PHARMACOGENETICS AND GENOMICS
(2022)
Article
Pharmacology & Pharmacy
Se-Eun Kim, Ho-Sung Jeon, Tae-Hwa Go, Jung-Hee Lee, Jun-Won Lee, Young Jin Youn, Byeong-Keuk Kim, Hyung Joon Joo, Do-Sun Lim, Kiyuk Chang, Yongwhi Park, Young Bin Song, Jung-Won Suh, Sang Yeob Lee, Jung Rae Cho, Ae-Young Her, Hyo-Soo Kim, Moo Hyun Kim, Eun-Seok Shin, Diana A. Gorog, Udaya S. Tantry, Paul A. Gurbel, Young-Hoon Jeong, Sung Gyun Ahn, PTRG DES Consortium Investigators
Summary: In Korean patients treated with DES, those with both high platelet reactivity and CYP2C19 gene loss-of-function alleles had the highest risk of adverse cardiac events. Combining platelet reactivity and CYP2C19 genotype can improve the prediction of patient outcomes.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Health Care Sciences & Services
Mariana Angulo-Aguado, Karen Panche, Caroll Andrea Tamayo-Agudelo, Daniel-Armando Ruiz-Torres, Santiago Sambracos-Parrado, Maria Jose Nino-Orrego, Nathaly Paez, Laura B. Pineros-Hernandez, Luisa-Fernanda Castillo-Leon, Juan Mauricio Pardo-Oviedo, Katherine Parra Abaunza, Paul Laissue, Nora Contreras, Carlos Alberto Calderon-Ospina, Dora Janeth Fonseca-Mendoza
Summary: The study analyzed genetic variants in CYP2C19 gene in 166 patients with acute coronary syndrome treated with clopidogrel. New potentially pathogenic mutations, intronic variants with potential splicing effects, and a new haplotype in strong linkage disequilibrium were identified. Clinical outcomes showed adverse drug reactions in some patients, with a predominance of bleeding, particularly in carriers of polymorphic alleles.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jiawen Li, Deshan Yuan, Lin Jiang, Xiaofang Tang, Jingjing Xu, Ying Song, Jue Chen, Shubin Qiao, Yuejin Yang, Runlin Gao, Bo Xu, Jinqing Yuan, Xueyan Zhao
Summary: In PCI patients treated with clopidogrel, leukocyte count and hs-CRP were found to be independent predictors of platelet reactivity, with high leukocyte count associated with more LTPR and high hs-CRP associated with more HTPR. This study provides new insights for individualized antiplatelet therapy strategies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Suli Zhang, Jinhang Zhu, Hua Li, Fengzhen Li, Bin Zhu, Tao Li, Shuxin Fang, Shengying Qin
Summary: Genetic polymorphisms in CYP2C19 and F2R genes were found to be significantly associated with platelet reactivity in Chinese ischemic stroke patients. The newly identified rs168753 variant in the F2R gene may influence the efficacy of clopidogrel-aspirin therapy. Ischemic stroke patients with low level of platelet aggregation inhibition had a higher risk of recurrent ischemic events.
PHARMACOGENETICS AND GENOMICS
(2022)
Article
Cardiac & Cardiovascular Systems
Min Zhang, Jiangrong Wang, Yong Zhang, Pei Zhang, Yangyang Chao, Mei Gao, Yinglong Hou
Summary: Individualized antiplatelet therapy based on CYP2C19 genotyping can reduce the incidence of high on-treatment platelet reactivity in ACS patients after PCI, providing guidance for antiplatelet therapy management.
Article
Medicine, General & Internal
Julia Gruttemeier, Yves Cottin, Hermann Yao, Emmanuel De Maistre, Maud Maza, Laurent Bonello, Marc Laine, Noemie Resseguier, Marianne Zeller, Laurence Camoin-Jau, Franck Paganelli
Summary: This study aimed to evaluate platelet reactivity inhibition in ACS patients undergoing PCI with oral triple antithrombotic therapy. The results showed that VASP index failed to predict bleeding and major adverse cardiovascular events, suggesting the need for prioritizing direct acting OAC over VKA in TAT regimen.
JOURNAL OF CLINICAL MEDICINE
(2021)