Article
Geriatrics & Gerontology
Marcus Achison, Simon Adamson, Asangaedem Akpan, Terry Aspray, Alison Avenell, Margaret M. Band, Tufail Bashir, Louise A. Burton, Vera Cvoro, Peter T. Donnan, Gordon W. Duncan, Jacob George, Adam L. Gordon, Celia L. Gregson, Adrian Hapca, Emily Henderson, Cheryl Hume, Thomas A. Jackson, Paul Kemp, Simon Kerr, Alixe Kilgour, Veronica Lyell, Tahir Masud, Andrew McKenzie, Emma McKenzie, Harnish Patel, Kristina Pilvinyte, Helen C. Roberts, Christos Rossios, Avan A. Sayer, Karen T. Smith, Roy L. Soiza, Claire J. Steves, Allan D. Struthers, Deepa Sumukadas, Divya Tiwari, Julie Whitney, Miles D. Witham
Summary: The trial found that neither leucine nor perindopril improved physical function or muscle mass in older people with sarcopenia. Meta-analysis also showed no evidence of efficacy for ACE inhibitors or leucine as treatments to improve physical performance.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Geriatrics & Gerontology
Robert MacLachlan, Patrick Gavin Kehoe, J. Scott Miners
Summary: The activity of angiotensin-converting enzyme-1 (ACE-1) is induced in the early stages of Alzheimer's disease (AD), independently from the normal physiological changes in ACE-1 protein during aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Khyati Pathak, Mona Kaushal, Himani Patel
Summary: This paper discusses various analytical methods available for the estimation of Perindopril Erbumine and its related substances, including UV-spectroscopic method and liquid chromatography method.
CURRENT PHARMACEUTICAL ANALYSIS
(2021)
Article
Multidisciplinary Sciences
Atila Duque Rossi, Joao Locke Ferreira de Araujo, Tailah Bernardo de Almeida, Marcelo Ribeiro-Alves, Camila de Almeida Velozo, Jessica Maciel de Almeida, Isabela de Carvalho Leitao, Samila Natiane Ferreira, Jessica da Silva Oliveira, Hugo Jose Alves, Helena Toledo Scheid, Debora Souza Faffe, Rafael Mello Galliez, Renata Eliane de Avila, Gustavo Gomes Resende, Mauro Martins Teixeira, Orlando da Costa Ferreira Junior, Terezinha Marta P. P. Castineiras, Renan Pedra Souza, Amilcar Tanuri, Renato Santana de Aguiar, Shana Priscila Coutinho Barroso, Cynthia Chester Cardoso
Summary: ACE2 and TMPRSS2 levels are positively correlated with age, which is strongly associated with respiratory distress. Increased ACE2 levels have a protective effect against this outcome, while the TMPRSS2/ACE2 ratio is associated with risk. In modeling COVID-19 severity, the TMPRSS2/ACE2 ratio outperforms ACE2.
SCIENTIFIC REPORTS
(2021)
Article
Polymer Science
Elpida Piperopoulos, Giuseppe Scionti, Mario Atria, Luigi Calabrese, Edoardo Proverbio
Summary: This paper aims to develop and optimize flame-retardant coatings for naval applications. The study investigates the effect of adding magnesium hydroxide and aluminum hydroxide fillers in an acrylic carrier on the fire resistance of the coatings. The results show that the coatings based on aluminum and magnesium hydroxides exhibit favorable fire resistance, particularly for short times of exposure to direct flames.
Article
Medicine, Research & Experimental
Jing-Yuan Xu, Wei Chang, Qin Sun, Fei Peng, Yi Yang
Summary: The study found that plasma midkine levels were significantly elevated in sepsis patients and closely related to the ACE system. In a mouse model, increased midkine levels were associated with more severe lung injury. Regional interference of midkine expression in lung tissue was shown to alleviate acute lung injury.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biology
Hristo L. Svilenov, Florent Delhommel, Till Siebenmorgen, Florian Ruehrnoessl, Grzegorz M. Popowicz, Alwin Reiter, Michael Sattler, Carsten Brockmeyer, Johannes Buchner
Summary: The solution structure, stability, and dynamics of a broadly-acting antiviral ACE2-IgG-Fc fusion protein are determined. Small chemical compounds binding to ACE2 can be used to drastically increase the thermal stability of the ACE2 domain. Our findings reveal a general concept for stabilizing the labile receptor segments of therapeutic antiviral fusion proteins by chemical compounds.
COMMUNICATIONS BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Steven D. Brooks, Rachel L. Smith, Aline S. Moreira, Hans C. Ackerman
Summary: Lisinopril increases ACE2 expression in tissues relevant to COVID-19, while adding losartan prevents the lisinopril-induced increase. A sex difference was observed with higher ACE2 levels in the kidneys of male mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Tlili Barhoumi, Bandar Alghanem, Hayat Shaibah, Fatmah A. Mansour, Hassan S. Alamri, Maaged A. Akiel, Fayhan Alroqi, Mohammad Boudjelal
Summary: The study found that the S protein of SARS-CoV-2 can induce apoptosis, oxidative stress, and inflammatory responses in macrophages and endothelial cells, which can be mitigated by the ACE inhibitor perindopril. Additionally, the S protein can affect the mitogenic responses and proteomic regulation of PBMCs. These findings suggest that the S protein may activate blood and vascular components circulating in the body, with potential involvement of the local renin-angiotensin system in this process.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Genevieve L. Y. Rocheleau, Terry Lee, Yassene Mohammed, David Goodlett, Kevin Burns, Matthew P. Cheng, Karen Tran, David Sweet, John Marshall, Arthur S. Slutsky, Srinivas Murthy, Joel Singer, David M. Patrick, Bin Du, Zhiyong Peng, Todd C. Lee, John H. Boyd, Keith R. Walley, Francois Lamontagne, Robert Fowler, Brent W. Winston, Greg Haljan, Donald C. Vinh, Alison McGeer, David Maslove, Santiago Perez Patrigeon, Puneet Mann, Kathryn Donohoe, Geraldine Hernandez, James A. Russell
Summary: This study examined the effects of angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme (ACE) inhibitors in hospitalized COVID-19 patients, focusing on gender differences. The results showed that ARBs were associated with reduced use of ventilation and vasopressors in male patients, but not in female patients. Additionally, sex-based differences in the renin-angiotensin system (RAS) components may contribute to variations in outcomes and responses to ARBs in COVID-19.
CRITICAL CARE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Thomas L. Williams, Gregory Strachan, Robyn G. C. Macrae, Rhoda E. Kuc, Duuamene Nyimanu, Anna L. Paterson, Sanjay Sinha, Janet J. Maguire, Anthony P. Davenport
Summary: ACE2 is a membrane protein that regulates the cardiovascular system and acts as a receptor for human coronaviruses, including SARS-CoV-2. A newly discovered short ACE2 isoform, deltaACE2, may affect individual susceptibility to viral infection and likelihood of developing Long COVID. Research shows that deltaACE2 is more expressed in the lung and liver compared to full-length ACE2.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
K. Tsuchiya, S. Fuchida, C. Tokoro
Summary: The study found that LDHs (layered double hydroxides) produced from magnesium oxide (MgO) and aluminum (Al) have good performance in removing hexavalent selenium (Se(VI)). By extending the hydration time of MgO and/or the reaction time of MgO-Al, Mg-Al LDHs with good Se(VI)-removal performance can be produced.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jakub Jankowski, Hye Kyung Lee, Julia Wilflingseder, Lothar Hennighausen
Summary: This study reports on the genetic programs activated in kidney cells in response to interferons during COVID-19, and the inhibitory effect of a Janus kinase inhibitor. The findings help identify kidney-specific interferon responses.
Article
Peripheral Vascular Disease
Ana R. Gaspar, Beatriz Andrade, Sara Mosca, Mariana Ferreira-Duarte, Ana Teixeira, Dina Cosme, Antonio Albino-Teixeira, Fernanda A. Ronchi, Ana P. Leite, Dulce E. Casarini, Jose C. Areias, Teresa Sousa, Alberto C. Afonso, Manuela Morato, Liane Correia-Costa
Summary: This study found that childhood obesity is associated with increased activities of angiotensin-converting enzymes (ACE) and ACE2. Overweight/obese children had significantly higher ACE and ACE2 activities compared to normal weight children. In girls, ACE and ACE2 activities were associated with increased night-time systolic and diastolic blood pressure.
JOURNAL OF HYPERTENSION
(2023)
Article
Polymer Science
Mona Ebadi, Saifullah Bullo, Kalaivani Buskaran, Mohd Zobir Hussein, Sharida Fakurazi, Giorgia Pastorin
Summary: Iron oxide nanoparticles coated with a polymeric carrier and loaded with an anti-cancer drug showed stronger activity against liver cancer cells and no cytotoxicity towards fibroblast cell lines, demonstrating the potential of a nano delivery system for cancer treatment.
Article
Chemistry, Multidisciplinary
Umme Ruman, Kalaivani Buskaran, Giorgia Pastorin, Mas Jaffri Masarudin, Sharida Fakurazi, Mohd Zobir Hussein
Summary: Two nano delivery systems, SF-CS and SF-CS-FA nanoparticles, were developed to enhance drug delivery to HepG2 and HT29 cell lines, showing high encapsulation efficiency, good release properties, and better anticancer action compared to free sorafenib, with negligible toxicity to normal cells.
Review
Nutrition & Dietetics
Maznah Ismail, Abdulsamad Alsalahi, Musheer Abdulwahid Aljaberi, Ramlah Mohamad Ibrahim, Faizah Abu Bakar, Aini Ideris
Summary: Edible bird's nest (EBN) has neuroprotective effects on animals, improving cognitive functions in induced-cognitive dysfunction animals, enhancing cognitive performance in healthy animals, and reducing neuroinflammation and neuro-oxidative stress in the hippocampus.
Article
Polymer Science
Julia Meihua Tan, Saifullah Bullo, Sharida Fakurazi, Mohd Zobir Hussein
Summary: The study aimed to formulate highly biocompatible betulinic acid-loaded biopolymer nanocomposites using different types of carbon nanotubes. The physico-chemical properties and cell viability of the modified nanocomposites were analyzed to confirm their potential as promising nanomaterials for drug delivery applications, with significantly reduced cytotoxic effects in normal cells.
Article
Biochemistry & Molecular Biology
Kalaivani Buskaran, Mohd Zobir Hussein, Mohamad Aris Mohd Moklas, Mas Jaffri Masarudin, Sharida Fakurazi
Summary: The study utilized nanotechnology to introduce a dual drug nanodelivery method for treating hepatocellular carcinoma, showing that graphene oxide loaded with protocatechuic acid and chlorogenic acid nanocomposites exhibited anticancer activities in hepatoma cells with lower toxicity compared to individual drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Samer Hasan Hussein-Al-Ali, Mohd Zobir Hussein, Saifullah Bullo, Palanisamy Arulselvan
Summary: The application of nanotechnology in cancer treatment can increase the survival probability of patients. This study prepared Chloramb-CS-IONPs nanocomposite, which showed promising therapeutic effects on cancer cells, especially leukemia.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Nanoscience & Nanotechnology
Nur Akma Abdul Halim, Mohd Zobir Hussein, Mohd Khairuddin Kandar
Summary: Hydroxyapatite and its nanocomposites have potential applications in bone tissue engineering and drug loading systems, with research focused on enhancing their mechanical properties for broader usage.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Polymer Science
Rabia Baby, Mohd Zobir Hussein, Abdul Halim Abdullah, Zulkarnain Zainal
Summary: Nanotechnology is widely applied in various fields and can help solve environmental problems such as water contamination. Non-carbon nanomaterials have advantages in heavy metal contaminated water and environmental remediation, with great potential for applications.
Article
Energy & Fuels
Araa Mebdir Holi, Zulkarnain Zainal, Asla A. Al-Zahrani, Asmaa Kadim Ayal, Asmaa Soheil Najm
Summary: This research focuses on improving the photoelectrochemical performance of Ag2S/ZnO NRs/ITO binary heterostructure by manipulating synthesis conditions. The results show that the optimized photoanode can achieve a high photocurrent.
Article
Plant Sciences
Mahesh Tiran Gunasena, Amara Rafi, Syazwan Afif Mohd Zobir, Mohd Zobir Hussein, Asgar Ali, Abdulaziz Bashir Kutawa, Mohd Aswad Abdul Wahab, Mohd Roslan Sulaiman, Fariz Adzmi, Khairulmazmi Ahmad
Summary: This study investigated the phytochemical constituents, antimicrobial activity, and mode of action of ginger essential oil (GEO) against B. glumae. The results showed that GEO contains various bioactive compounds and effectively inhibits the growth of B. glumae.
Article
Chemistry, Applied
Nur Amilah Fadlina Basri, Mohd Haniff Wahid, Zulkarnain Zainal, Shahrul Ainliah Alang Ahmad, Mohd Rashidi Abdull Manap
Summary: Cellulose acetate/graphene oxide nanofibers functionalized with p-sulphonated calix[4]arene were successfully prepared through electrospinning technique, showing enhanced adsorption capacity for methylene blue compared to pristine nanofibers.
ADSORPTION SCIENCE & TECHNOLOGY
(2022)
Article
Food Science & Technology
Ain Nabila Syahira Shamsol Azman, Jun Jie Tan, Muhammad Nazrul Hakim Abdullah, Hasnah Bahari, Vuanghao Lim, Yoke Keong Yong
Summary: This study utilized network pharmacology to assess the potential pharmacological effects of bioactive compounds in Tualang honey on atherosclerosis. The results showed that 6 compounds in Tualang honey had potential therapeutic effects on atherosclerosis, supporting its use as a promising treatment for the disease.
Article
Materials Science, Multidisciplinary
Eydar Tey, Zulkarnain Zainal, Kean Pah Lim, Ismayadi Ismail
Summary: In this study, Cr-C-Al2O3 and Cr-C-SiC nanocomposite coatings were electrodeposited on copper substrates using a modified trivalent chromium electroplating bath. The addition of Al2O3 and SiC nanoparticles into the coatings improved their hardness, while reducing their corrosion resistance. The study also presents a novel approach for effectively incorporating nanoparticles into the chromium matrix and provides valuable insights for optimizing nanoparticle concentrations in the development of nanocomposite coatings with enhanced properties.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Review
Biochemistry & Molecular Biology
Husein Alhatim, Muhammad Nazrul Hakim Abdullah, Suhaili Abu Bakar, Sayed Amin Amer
Summary: This article discusses the impact of carcinomas on the results of genetic traits examination and paternity tests, particularly when only carcinoma tissue is available as a sample source. Genetics plays an important role in the management of carcinoma patients, but if the samples come from tissues with cancerous tumors, it may affect the examination of genetic traits.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)