Review
Biochemistry & Molecular Biology
Selvaraj Vimalraj
Summary: Angiogenesis is the formation of new blood vessels from existing ones. Abnormal angiogenesis, seen in tumor microenvironments, is characterized by distorted and leaky blood vessels with various shapes and high perfusion efficiency. Tumor angiogenesis plays a crucial role in cancer growth, invasion, and metastasis, and is tightly regulated by signaling networks. Targeting multiple signaling pathways involved in angiogenesis is important for effective antiangiogenic therapy. New therapeutic approaches, such as blocking specific proteins or genes, are being explored to dissect alternative angiogenesis mechanisms in tumor microenvironments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Oncology
Jing Liu, Fang Zhang, Jie He, Shuyun Wang, Leirong Wang, Juan Li, Wenjing Shi, Yali Han, Aiqin Gao, Yuping Sun
Summary: Current anti-angiogenic therapies have changed the paradigm of treating colorectal cancer (CRC) patients with advanced diseases. However, the clinical response rate is still low at less than 10% due largely to complex angiogenic factors released by tumor cells. Exploring novel mechanisms of tumor angiogenesis and identifying alternative targets for combination therapies are therefore essential to effective inhibition of tumor vascularization and CRC development.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Review
Medicine, General & Internal
Kaja Michalczyk, Natalia Niklas, Malgorzata Rychlicka, Aneta Cymbaluk-Ploska
Summary: Endometrial cancer is a common gynecological neoplasm in developed countries with high early diagnosis rates and good prognosis, but a high recurrence rate in later stages. Factors secreted by adipose tissue play a significant role in regulating glucose and lipid metabolism and influence the diagnosis and prognosis of endometrial cancer.
Article
Materials Science, Multidisciplinary
W. H. Tse, S. Yang, J. Zhang
Summary: Biocompatible nanostructures provide new pathways for overcoming obstacles in conventional anti-angiogenic therapy. However, current technology is limited by therapeutics' bioavailability and imaging obstruction. In this paper, a theranostic system based on cubic lanthanide-based upconversion nanoparticles (UCNPs) has been developed. The UCNPs exhibit strong anti-angiogenic effects and cell imaging capabilities.
MATERIALS TODAY ADVANCES
(2022)
Article
Cell Biology
Ekta Manocha, Antonella Bugatti, Mirella Belleri, Alberto Zani, Stefania Marsico, Francesca Caccuri, Marco Presta, Arnaldo Caruso
Summary: ARV p17 is a non-structural protein that activates autophagy, inhibits angiogenesis in human endothelial cells, and renders cells insensitive to proangiogenic inducers. It upregulates the release of the tumor suppressor molecule DPP4, highlighting its potential antitumor activities and suggesting new therapeutic approaches for treating tumors and cancer metastasis.
Review
Biochemistry & Molecular Biology
Peace Mabeta, Vanessa Steenkamp
Summary: The VEGF/VEGFR axis plays a crucial role in angiogenesis and tumor vascularization. Current therapies targeting VEGF and its receptors have shown limited effectiveness and undesirable off-target effects. Recent studies have identified VEGF splice variants that modulate angiogenesis, and their expression is regulated by cues within the tumor microenvironment. These variants challenge the established norm of VEGF signaling and their aberrant expression has been observed in several cancers, highlighting the need for further research on their role in cancer and their impact on antiangiogenic therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Donghwa Kim, Sang Won Choi, Jihee Cho, Jae-Hui Been, Kyoungsun Choi, Wenzhe Jiang, Jaeho Han, Jedo Oh, Changmin Park, Soongyu Choi, Songyi Seo, Koung Li Kim, Wonhee Suh, Sang Kook Lee, Sanghee Kim
Summary: Diabetic retinopathy is a leading cause of blindness associated with excessive angiogenesis. Researchers have developed a novel antiangiogenesis agent by modifying the structure of wondonin marine natural products, resulting in improved bioactivity and selectivity. This compound, 31, shows potential as a lead for developing small-molecule drugs to treat diabetic retinopathy and to uncover new mechanisms of angiogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Lorenzo Fornaro, Gianna Musettini, Paola Orlandi, Irene Pecora, Caterina Vivaldi, Marta Banchi, Francesca Salani, Elisabetta Fini, Valentina Massa, Silvia Catanese, Federico Cucchiara, Monica Lencioni, Gianluca Masi, Enrico Vasile, Guido Bocci
Summary: Ramucirumab plus paclitaxel is considered standard treatment for second-line gastric carcinoma (GC) patients. This study evaluated plasma VEGF-A, VEGF-D, and sVEGFR-2 as potential markers of resistance or response to this treatment. Results showed significant increases in VEGF-A and VEGF-D levels during treatment, and early increase in sVEGFR-2 levels was associated with longer progression-free survival and overall survival.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Oncology
Domenico Ribatti, Antonio Giovanni Solimando, Francesco Pezzella
Summary: Several anti-angiogenic drugs are approved for cancer treatment, but resistance and adverse effects may occur. Combining multiple anti-angiogenic molecules or using them in combination with other treatment regimens is indicated as alternative therapeutic strategies to overcome resistance. Comprehensive omics profiling is crucial for increasing clinical benefits and overcoming resistance to anti-angiogenic therapies.
Review
Chemistry, Medicinal
Anurag Mathur, Abha Meena, Suaib Luqman
Summary: Monoterpenoids, a subclass of terpenoids, have been extensively studied for their antitumor properties, including antiproliferative, apoptotic, antiangiogenic, and antimetastatic effects. This review focuses on the effects of specific monoterpenoids on metastasis and relevant signaling pathways. Monoterpenoids exhibit complexity as natural products that regulate metastatic proteins through various signaling pathways. However, limited clinical trials hinder the drug usage of monoterpenoids in preventing cancer metastasis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Psychology, Developmental
Gokce Guldiken, Ali Karayagmurlu, Canan Kucukgergin, Murat Coskun
Summary: This study aimed to investigate the serum levels of VEGF, IGF-1, and FGF-2 in children and adolescents with ASD with and without BD, and their relationships with clinical characteristics. The study found that the ASD + BD group had higher levels of ASD severity, self-harming behavior, sleep disturbance, as well as serum VEGF and FGF-2 levels compared to the control group. There was no significant difference in serum IGF-1 levels between the two groups, and no correlation between growth factor levels and ASD severity in the study group. However, a negative correlation was found between VEGF levels and age at first diagnosis of BD, and a positive correlation between IGF-1 levels and the number of bipolar episodes in the study group.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Materials Science, Biomaterials
Lu Fu, Rupeng Li, John M. Whitelock, Megan S. Lord
Summary: This study reveals that functionalized cerium oxide nanoparticles with heparin corona can promote angiogenesis, with the surface grafting density positively correlated with angiogenesis. Heparin-nanoceria supports FGF2 signaling in vitro and promotes FGF2-mediated angiogenesis in vivo.
REGENERATIVE BIOMATERIALS
(2022)
Article
Oncology
Yunlong Yang, Yihai Cao
Summary: Metastasis, the leading cause of cancer-associated mortality, is still poorly understood. Both blood and lymphatic vasculatures play crucial roles in distal metastasis, with VEGF being a key angiogenic factor. Anti-VEGF drugs have been widely used in clinical treatment of various cancers, but their impact on cancer metastasis and systemic disease is largely unknown.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Cell Biology
Anita Novais, Eirini Chatzopoulou, Catherine Chaussain, Caroline Gorin
Summary: Bone is a hard tissue that constantly renews itself to adapt to the body's demands. The craniofacial area is prone to trauma and pathologies, often leading to large bone damage. Autologous bone grafting is the gold standard for treating these defects, but has drawbacks such as the need for a second surgical site and limitations in bone quantity.
Article
Chemistry, Multidisciplinary
Lukasz Oldak, Anna Lesniewska, Beata Zelazowska-Rutkowska, Eryk Latoch, Zenon Lukaszewski, Maryna Krawczuk-Rybak, Ewa Gorodkiewicz
Summary: A new method utilizing biosensors for the simultaneous determination of VEGF-A and FGF-2 in blood serum has been developed. The method offers fast, reliable, and accurate quantification, without the need for large samples or excess reagents.
APPLIED SCIENCES-BASEL
(2022)
Article
Veterinary Sciences
Tomasz Niemiec, Krzysztof Skowron, Wieslaw Swiderek, Joanna Kwiecinska-Pirog, Grzegorz Gryn, Katarzyna Fiszdon, Andrzej Lozicki, Klara Zglinska, Iwona Kosieradzka, Piotr Koczon
Summary: The study evaluated the efficacy of a modern technique, radiant catalytic ionization, on the microbiological status of an animal care facility and the health of the mice housed there. Results showed that using an RCI system could reduce bacterial levels in the air and on walls, without any adverse effects on the mice's prooxidative parameters.
LABORATORY ANIMALS
(2022)
Article
Chemistry, Physical
Agata Lange, Ewa Sawosz, Mateusz Wierzbicki, Marta Kutwin, Karolina Daniluk, Barbara Strojny, Agnieszka Ostrowska, Barbara Wojcik, Maciej Lojkowski, Marcin Golebiewski, Andre Chwalibog, Slawomir Jaworski
Summary: The study aims to develop a nanocomposite with precise antibacterial properties for textiles. By characterizing the nanomaterials and conducting biological studies, the advantages of the nanocomposite in antibacterial and bacterial toxicity aspects were demonstrated. The antibacterial studies on coated textiles showed promising performance without significant overall toxicity.
Review
Polymer Science
Piotr Koczon, Heidi Josefsson, Sylwia Michorowska, Katarzyna Tarnowska, Dorota Kowalska, Bartlomiej J. Bartyzel, Tomasz Niemiec, Edyta Lipinska, Eliza Gruczynska-Sekowska
Summary: The applications of substances are influenced by their macroscopic properties, which are closely related to the substances' microscopic structures. This review focuses on food-related biopolymers and provides information on their structures, properties, and applications, with emphasis on the impact of treatment methods on polysaccharides. It is valuable for both material engineers and food researchers.
Article
Pharmacology & Pharmacy
Marlena Zielinska-Gorska, Ewa Sawosz, Malwina Sosnowska, Anna Hotowy, Marta Grodzik, Konrad Gorski, Barbara Strojny-Cieslak, Mateusz Wierzbicki, Andre Chwalibog
Summary: This study aimed to assess the biocompatibility of AgNP-GO complex with a skin model in vitro. The complex did not affect tissue genotoxicity and metabolism, reduced the pro-inflammatory properties of AgNP, and had a positive effect on the microstructure of the skin model. The synergistic effect of AgNP and GO makes it suitable for use as a material for skin contact.
Article
Chemistry, Physical
Jaroslaw Szczepaniak, Malwina Sosnowska, Mateusz Wierzbicki, Olga Witkowska-Pilaszewicz, Barbara Strojny-Cieslak, Joanna Jagiello, Wiktoria Fraczek, Marcin Kusmierz, Marta Grodzik
Summary: This study evaluated and compared the effects of graphene and reduced graphene oxides on highly invasive and neoplastic cell line U87. The results showed that reduced graphene oxide flakes could reduce the migration and invasiveness of U87 cells, suggesting their potential as antitumor agents.
Article
Biochemistry & Molecular Biology
Aleksandra Kalinska, Slawomir Jaworski, Mateusz Wierzbicki, Magdalena Kot, Daniel Radzikowski, Sebastian Smulski, Marcin Golebiewski
Summary: This paper aims to evaluate the influence of common cosmetic substrates and mixtures of nanoparticles on the viability of mastitis pathogens. The results show that only collagen + elastin and glycerine increased bacterial viability, while the rest of the cosmetic substrates decreased it. Pre-dipping and dipping mixtures significantly decreased the viability of the mentioned pathogens. These promising results suggest that further testing in different herd conditions is needed to assess their efficacy in mastitis prevention or reduction. Additionally, analysis on the influence of these mixtures on other bacteria species, algae, and fungi is necessary.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Kot, Aleksandra Kalinska, Slawomir Jaworski, Mateusz Wierzbicki, Sebastian Smulski, Marcin Golebiewski
Summary: Digital dermatitis (DD) is a common disease in dairy cattle, causing losses and negative impacts on welfare and milk yield. The etiology of DD is not fully understood and there is limited data available. Antibiotic therapy for disease management has led to antibiotic resistance, reducing effectiveness. This study investigates the biocidal properties of metal nanoparticles (NPs) as an alternative to antibiotics for pathogens causing hoof diseases in cows, particularly DD. AgNPs and CuNPs showed the highest biocidal effect on the isolated pathogens, suggesting their potential use in the treatment and prevention of lameness in cows.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Mateusz Wierzbicki, Katarzyna Zawadzka, Barbara Wojcik, Slawomir Jaworski, Barbara Strojny, Agnieszka Ostrowska, Artur Malolepszy, Marta Mazurkiewicz-Pawlicka, Ewa Sawosz
Summary: Diamond nanoparticles show varying toxicity to different cell types, and our study focuses on the specific sensitivity of endothelial cells. We characterized the diamond nanoparticles and evaluated their toxicity on endothelial cells, as well as their effects on various cellular processes and protein synthesis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Kinga Zelechowska-Matysiak, Kamil Wawrowicz, Mateusz Wierzbicki, Tadeusz Budlewski, Aleksander Bilewicz, Agnieszka Majkowska-Pilip
Summary: In this study, a novel bioconjugate (DOX-AuNPs-Tmab) consisting of gold nanoparticles (AuNPs) attached to chemotherapeutic agent doxorubicin (DOX) and a monoclonal antibody, trastuzumab (Tmab), was synthesized. The bioconjugate exhibited specific binding to HER2 receptors and demonstrated high specificity of binding and internalization capabilities to HER2-positive cancer cells. Cytotoxicity experiments showed that DOX-AuNPs-Tmab significantly reduced cancer cell metabolic activity and surface area of spheroids, inducing cell cycle arrest and late apoptosis. These findings suggest that DOX-AuNPs-Tmab has great potential for targeted therapy of HER2-positive tumors.
Article
Nanoscience & Nanotechnology
Barbara Wojcik, Katarzyna Zawadzka, Slawomir Jaworski, Marta Kutwin, Malwina Sosnowska, Agnieszka Ostrowska, Marta Grodzik, Artur Malolepszy, Marta Mazurkiewicz-Pawlicka, Mateusz Wierzbicki
Summary: This study evaluated the cytotoxicity of 13 types of diamond nanoparticles with different production methods, sizes, and surface functional groups on tumor cell lines and a non-tumor cell line. The results showed that diamond nanoparticles had no toxicity on non-tumor cells but moderate toxicity on glioblastoma cell lines. The production method did not affect the toxicity, but modifications of the nanoparticles had varying effects on cell response.
Article
Nanoscience & Nanotechnology
Marta Kutwin, Malwina Sosnowska, Agnieszka Ostrowska, Maciej Trzaskowski, Agata Lange, Mateusz Wierzbicki, Slawomir Jaworski
Summary: This study investigated the effect of graphene oxide (GO) complexed with antisense miRNA-21 on cytokine expression levels in U87, U118, U251, and T98 glioma cell lines. The results showed that GO-antisense miRNA-21 complexes significantly regulated the expression levels of TIMP-2, IL-6, IL-8, ICAM-1, and MCP-1 compared to electroporation of antisense miRNA-21. Furthermore, GO-mediated antisense miRNA-21 transfection resulted in upregulation of TIMP-2 and downregulation of ICAM-1, as well as significant decrease in IL-8 expression level compared to electroporation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Physical
Wiktoria Fraczek, Kacper Kregielewski, Mateusz Wierzbicki, Patryk Krzeminski, Katarzyna Zawadzka, Jaroslaw Szczepaniak, Marta Grodzik
Summary: This study evaluated the compatibility of diamond nanoparticles with human skin according to OECD criteria. The results showed that diamond nanoparticles at a concentration of 25 μg/mL did not cause toxic effects or adverse effects on tissue structure and cytokine expression. These findings confirm the safety and biocompatibility of diamond nanoparticles for use in skincare products.
Article
Biochemistry & Molecular Biology
Daniel Radzikowski, Aleksandra Kalinska, Magdalena Kot, Slawomir Jaworski, Mateusz Wierzbicki, Marcin Golebiewski
Summary: Prevention and treatment of mastitis in dry cows is a complex issue, and current intramammary antibiotic treatment varies in effectiveness. This study evaluates the practical use of metal nanoparticles in treating cows during their dry period, as these nanoparticles have strong biocidal properties against bacteria, fungi, and algae. The results show that certain nanoparticles and their complexes have biocidal properties against mastitis pathogens, indicating their potential as alternatives to antibiotics.
Article
Chemistry, Multidisciplinary
Kamil Wawrowicz, Kinga Zelechowska-Matysiak, Agnieszka Majkowska-Pilip, Mateusz Wierzbicki, Aleksander Bilewicz
Summary: Convenient therapeutic protocols against hepatocellular carcinoma (HCC) exhibit low treatment effectiveness, especially in the context of long-term effects, which is primarily related to late diagnosis and high tumor heterogeneity. Current trends in medicine concern combined therapy to achieve new powerful tools against the most aggressive diseases. When designing modern, multimodal therapeutics, it is necessary to look for alternative routes of specific drug delivery to the cell, its selective (with respect to the tumor) activity and multidirectional action, enhancing the therapeutic effect.
NANOSCALE ADVANCES
(2023)
