Current Models of Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation by Growth Factors and Amino Acids
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Current Models of Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation by Growth Factors and Amino Acids
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 15, Issue 11, Pages 20753-20769
Publisher
MDPI AG
Online
2014-11-14
DOI
10.3390/ijms151120753
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
- (2014) Suchithra Menon et al. CELL
- Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2
- (2014) Constantinos Demetriades et al. CELL
- Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly
- (2013) José-Mario Capo-Chichi et al. JOURNAL OF MEDICAL GENETICS
- Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome
- (2013) Brittany L. Jacobs et al. JOURNAL OF PHYSIOLOGY-LONDON
- mTOR kinase structure, mechanism and regulation
- (2013) Haijuan Yang et al. NATURE
- GATORs Take a Bite Out of mTOR
- (2013) R. J. Shaw SCIENCE
- A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1
- (2013) L. Bar-Peled et al. SCIENCE
- Nutrient signaling to mTOR and cell growth
- (2013) Jenna L. Jewell et al. TRENDS IN BIOCHEMICAL SCIENCES
- mTOR: The Master Regulator
- (2012) CELL
- SnapShot: mTORC1 Signaling at the Lysosomal Surface
- (2012) Liron Bar-Peled et al. CELL
- Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
- (2012) Liron Bar-Peled et al. CELL
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway
- (2012) Jung Min Han et al. CELL
- Leucyl-tRNA synthetase: double duty in amino acid sensing
- (2012) Raúl V Durán et al. CELL RESEARCH
- Control of cell growth: Rag GTPases in activation of TORC1
- (2012) Huirong Yang et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)
- (2012) A. D. Barlow et al. DIABETOLOGIA
- SH3BP4 Is a Negative Regulator of Amino Acid-Rag GTPase-mTORC1 Signaling
- (2012) Young-Mi Kim et al. MOLECULAR CELL
- TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
- (2012) Christian C. Dibble et al. MOLECULAR CELL
- dRAGging amino Acid-mTORC1 signaling by SH3BP4
- (2012) Young-Mi Kim et al. MOLECULES AND CELLS
- Proton-Assisted Amino Acid Transporter PAT1 Complexes with Rag GTPases and Activates TORC1 on Late Endosomal and Lysosomal Membranes
- (2012) Margrét H. Ögmundsdóttir et al. PLoS One
- Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin
- (2012) R. Ruivo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
- (2012) D. W. Lamming et al. SCIENCE
- TPT1/ TCTP-regulated pathways in phenotypic reprogramming
- (2012) Robert Amson et al. TRENDS IN CELL BIOLOGY
- Amino acids and mTORC1: from lysosomes to disease
- (2012) Alejo Efeyan et al. TRENDS IN MOLECULAR MEDICINE
- Multiple Site Acetylation of Rictor Stimulates Mammalian Target of Rapamycin Complex 2 (mTORC2)-dependent Phosphorylation of Akt Protein
- (2011) Emily J. Glidden et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFβTrCP E3 Ubiquitin Ligase and Regulates Survival and Autophagy
- (2011) Yongchao Zhao et al. MOLECULAR CELL
- mTOR Generates an Auto-Amplification Loop by Triggering the βTrCP- and CK1α-Dependent Degradation of DEPTOR
- (2011) Shanshan Duan et al. MOLECULAR CELL
- mTOR Drives Its Own Activation via SCFβTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR
- (2011) Daming Gao et al. MOLECULAR CELL
- p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway
- (2011) Angeles Duran et al. MOLECULAR CELL
- Unknown
- (2011) Abid Kazi et al. MOLECULAR MEDICINE
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- The Mammalian Class 3 PI3K (PIK3C3) Is Required for Early Embryogenesis and Cell Proliferation
- (2011) Xiang Zhou et al. PLoS One
- mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
- (2011) R. Zoncu et al. SCIENCE
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
- (2010) Yasemin Sancak et al. CELL
- Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes
- (2010) Mitsunori Miyazaki et al. FEBS Journal
- Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly
- (2010) Takeshi Kaizuka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Resveratrol Inhibits mTOR Signaling by Promoting the Interaction between mTOR and DEPTOR
- (2010) Meilian Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition
- (2010) Calvin K. Yip et al. MOLECULAR CELL
- Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation
- (2010) S Heublein et al. ONCOGENE
- Inactivation of the FLCN Tumor Suppressor Gene Induces TFE3 Transcriptional Activity by Increasing Its Nuclear Localization
- (2010) Seung-Beom Hong et al. PLoS One
- Rag proteins regulate amino-acid-induced mTORC1 signalling
- (2009) Yasemin Sancak et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
- (2009) Timothy R. Peterson et al. CELL
- Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein–protein interactions for substrate recognition
- (2009) Elaine A. Dunlop et al. CELLULAR SIGNALLING
- An Emerging Role of mTOR in Lipid Biosynthesis
- (2009) Mathieu Laplante et al. CURRENT BIOLOGY
- mTOR and the control of whole body metabolism
- (2009) Pazit Polak et al. CURRENT OPINION IN CELL BIOLOGY
- Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway
- (2009) Katharina Uhlenbrock et al. FEBS LETTERS
- Specific Activation of mTORC1 by Rheb G-proteinin VitroInvolves Enhanced Recruitment of Its Substrate Protein
- (2009) Tatsuhiro Sato et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- mTOR signaling at a glance
- (2009) M. Laplante et al. JOURNAL OF CELL SCIENCE
- hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells
- (2008) Ying Yan et al. BIOCHEMICAL JOURNAL
- Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34
- (2008) Pawan Gulati et al. Cell Metabolism
- Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM
- (2008) Christian Maeurer et al. CELLULAR SIGNALLING
- Biochemical characterisation of TCTP questions its function as a guanine nucleotide exchange factor for Rheb
- (2008) H. Rehmann et al. FEBS LETTERS
- RalA Functions as an Indispensable Signal Mediator for the Nutrient-sensing System
- (2008) Tomohiko Maehama et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Re-evaluating the Roles of Proposed Modulators of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling
- (2008) Xuemin Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phospholipase D1 is an effector of Rheb in the mTOR pathway
- (2008) Y. Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
- (2008) Y. Sancak et al. SCIENCE
- The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development
- (2008) Deborah K. Morrison TRENDS IN CELL BIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search