Article
Medicine, Research & Experimental
Mariko Miyashita-Ishiwata, Malak El Sabeh, Lauren D. Reschke, Sadia Afrin, Mostafa A. Borahay
Summary: This study reveals an aberrant response of leiomyoma cells to hypoxia, characterized by increased cell proliferation and secretion of angiogenic factors. This abnormal response may contribute to the development and growth of leiomyoma.
Article
Biochemistry & Molecular Biology
Balaji Kyathegowdanadoddi Srinivas, Madhu Chakkere Shivamadhu, Shankar Jayarama
Summary: This study aimed to purify lectin from the sap of Musa acuminate pseudostem and investigate its apoptotic and angiogenic mechanisms in both in-vitro and in-vivo models. The findings suggest that the lectin possesses significant anticancer potential by inducing apoptosis and suppressing neoangiogenesis in cancer cells and animal models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biotechnology & Applied Microbiology
Ling Sun
Summary: Silencing FBXW7 upregulates the HIF-1α/VEGF signaling pathway, promoting angiogenesis in neonatal rats with hypoxic-ischemic brain damage (HIBD) after brain injury, reducing infarct volume and improving recovery of nerve function in HIBD rats.
Article
Oncology
Ali Abdalla, Chandraprabha Murali, Amr Amin
Summary: This study reveals for the first time the antiangiogenic potential of safranal and proposes its possible underlying mechanism in the treatment of hepatocellular carcinoma (HCC).
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Zhiguo Niu, Jianing Fan, Fengzhe Chen, Huijie Yang, Xin Li, Ting Zhuang, Chunlei Guo, Qi Cao, Jian Zhu, Hui Wang, Qingsong Huang
Summary: Breast cancer is the most common malignancy in women globally. Abnormal expression of RBCK1 protein in breast tumors makes it a valuable diagnostic marker and drug target. Hypoxic regions in breast cancer activate the HIF1 pathway, influencing tumor recurrence and metastasis. Targeting RBCK1 could be a promising treatment strategy for ER-positive breast cancer.
CELL DEATH & DISEASE
(2022)
Article
Neurosciences
Yang Li, Tingting Ma, Xiaoyu Zhu, Mingqi Zhang, Liang Zhao, Peng Wang, Jia Liang
Summary: This study found that zinc improves neurological function recovery during the cerebral ischemia repair stage by promoting astrocyte induced angiogenesis. Zinc alleviates brain atrophy and enhances neurological function recovery. Furthermore, zinc increases the protein levels of HIF-1 alpha, VEGF-A, and VEGF-R2 in astrocytes, thereby promoting angiogenesis during cerebral ischemic repair.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Nurina Febriyanti Ayuningtyas, Chanbora Chea, Toshinori Ando, Karina Erda Saninggar, Keiji Tanimoto, Toshihiro Inubushi, Nako Maishi, Kyoko Hida, Masanobu Shindoh, Mutsumi Miyauchi, Takashi Takata
Summary: This study evaluated the inhibitory effects of bovine lactoferrin (bLF) on tumor angiogenesis in vivo and in vitro. The results showed that bLF inhibited proliferation, migration, and tube formation in tumor endothelial cells (TECs) while promoting apoptosis. This effect was achieved through the inhibition of p-p65 via binding with TNF receptor-associated factor 6 (TRAF6), leading to the down-regulation of hypoxia inducible factor-alpha (HIF-1 alpha) and vascular endothelial growth factor (VEGF), specifically in TECs.
Article
Oncology
Yueyang Mou, Yaqin Hu, Guolian Xue, Wenjian Zhao, Yang Jiao, Chen Li, Haiyan Cao, Min Chao, Jianping Deng, Penggao Dai, Hongli Zhu, Liang Wang
Summary: ELK3 plays a crucial role in glioma angiogenesis by activating the HIF-1 alpha/VEGF-A signaling axis. It may serve as a prognostic marker for glioma angiogenesis and targeting ELK3 may improve the efficacy of anti-angiogenic therapies.
Article
Pharmacology & Pharmacy
Yuanchun Fan, Huimin Cheng, Yueping Liu, Shihao Liu, Scott Lowe, Yaru Li, Rachel Bentley, Bethany King, John Pocholo W. Tuason, Qin Zhou, Chenyu Sun, Hui Zhang
Summary: This study evaluated the effects of metformin and bevacizumab on ovarian cancer cell proliferation, tumor hypoxia, and tumor stem cells in vitro and in vivo. The results showed that the combination therapy significantly inhibited tumor growth, reduced the proportion of cancer stem cells, and improved tumor hypoxia in the microenvironment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Yonghua Zheng, Huaxia Ji, Wulin Yi, Zhanjun Chen, Xiaobiao Hu, Jie Zhou, Yang Wang, Xiao Zheng
Summary: PRMT5 is overexpressed in lung cancer cells and tissues, and its expression is induced by hypoxia. Inhibiting or silencing PRMT5 disrupts the phosphorylation of the VEGFR/Akt/eNOS angiogenic signaling pathway, NOS activity, and NO production. Additionally, inhibiting PRMT5 activity reduces HIF-1a expression and stability, resulting in the down-regulation of the VEGF/VEGFR signaling pathway. Our study provides compelling evidence of the close association between PRMT5 and angiogenesis/EMT and highlights the potential of targeting PRMT5 activity as a promising therapeutic approach for treating lung cancer with abnormal angiogenesis.
Review
Oncology
Marek Samec, Alena Liskova, Lenka Koklesova, Sandra Mersakova, Jan Strnadel, Karol Kajo, Martin Pec, Kevin Zhai, Karel Smejkal, Sepideh Mirzaei, Kiavash Hushmandi, Milad Ashrafizadeh, Luciano Saso, Aranka Brockmueller, Mehdi Shakibaei, Dietrich Busselberg, Peter Kubatka
Summary: This comprehensive review discusses the anticancer effects of plant phenolic compounds, known as flavonoids, through the targeting of HIF-1 and critical enzymes contributing to the Warburg effect. Flavonoids represent a promising avenue in cancer-related research by regulating glucose metabolism through HIF-1 activity. Further investigations are needed to elucidate the mechanistic and clinical connections between HIF-1 and cancer metabolism.
Review
Biochemistry & Molecular Biology
Mohammad Bagher Majnooni, Sajad Fakhri, Syed Mustafa Ghanadian, Gholamreza Bahrami, Kamran Mansouri, Amin Iranpanah, Mohammad Hosein Farzaei, Mahdi Mojarrab
Summary: Saponins are high-molecular-weight natural compounds that consist of a non-polar moiety and a polar moiety containing sugars. They are found in various plants and marine organisms and have therapeutic effects, including anti-cancer properties. This study reviews the structural characteristics and anti-cancer effects of triterpenoid/steroid saponins, with a focus on their anti-angiogenic effects and related mechanisms. Saponins inhibit angiogenesis by targeting genes related to vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1-a (HIF-1a), as well as inflammatory signaling pathways. The sugar moiety, monosaccharide units, and aglycone structure of saponins play important roles in their anti-angiogenic and anti-cancer activity. Extensive pre-clinical and clinical trial studies are recommended to further explore the potential of saponins for cancer treatment.
Article
Biochemistry & Molecular Biology
Tian-Wen Ni, Xiao-Chuan Duan, Meng Wang, Mei-Qi Jia, Ying Chen, Yang Yu, Nan Qin, Hong-Quan Duan
Summary: The study identified a new compound, ION-31a, that significantly suppresses tumor metastasis and angiogenesis in breast cancer by inhibiting HSP90. It has the potential to be developed as an anti-metastatic agent for treating patients with breast cancer.
BIOORGANIC CHEMISTRY
(2021)
Review
Oncology
Karolina Kozal, Anna Krzeslak
Summary: Hypoxia-inducible factors play an important role in breast cancer, affecting immune response, metabolism, angiogenesis, invasion, and metastasis. The study suggests that targeting hypoxia-inducible factors in breast cancer therapy should take into account multiple factors and requires a better understanding of their role in this type of cancer.
Article
Pharmacology & Pharmacy
Ravichandran Jayasuriya, Kunka Mohanram Ramkumar
Summary: This study found that mangiferin can regulate angiogenesis in human endothelial cells under a hyperglycemic environment by activating the Nrf2 signaling pathway. Mangiferin can reduce the generation of ROS induced by high glucose and promote angiogenesis-related gene expression, as well as increase cell migration and tube network formation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Food Science & Technology
Engeda Dessalegn, Geremew Bultosa, GulelatDesse Haki, F. Chen, H. P. Vasantha Rupasinghe
Summary: This study found that the aqueous methanol extract of Ethiopian cardamom seeds has higher antioxidant activity and anti-cancer effect. In vitro, the aqueous methanol extract showed stronger anti-proliferative effect on HepG2 cells.
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2022)
Article
Biochemistry & Molecular Biology
Wasitha P. D. W. Thilakarathna, H. P. Vasantha Rupasinghe
Summary: Conventional extraction methods of proanthocyanidins using toxic organic solvents raise concerns. A new method using food-grade ethanol was developed for grape seeds and grape seed powder, optimizing extraction conditions for maximum yield of PAC.
Article
Nutrition & Dietetics
Niluni M. Wijesundara, Song F. Lee, Ross Davidson, Zhenyu Cheng, H. P. Vasantha Rupasinghe
Summary: The study found that carvacrol has anti-inflammatory properties and may be used to manage the pain associated with streptococcal pharyngitis.
Article
Chemistry, Multidisciplinary
Khushwant S. Bhullar, Manal A. Nael, Khaled M. Elokely, Jeremie A. Doiron, Luc M. LeBlanc, Gregoire Lassalle-Claux, Mohamed Salla, Fahad S. Aldawsari, Mohamed Touaibia, H. P. Vasantha Rupasinghe
Summary: Due to their robust antioxidant properties, phenolic acids and their analogs have been extensively studied for their ability to activate cellular antioxidant pathways. This study investigated the effects of modifications to the chemical structure of these phenolic acids on their antioxidant and cytoprotective activities. The ketone analog of caffeic acid phenethyl ester (CAPE) was identified as a unique antioxidant molecule with the function of ERK-mediated Nrf2 activation.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Flavia A. R. dos Santos, Jadriane A. Xavier, Felipe C. da Silva, J. P. Jose Merlin, Marilia O. F. Goulart, H. P. Vasantha Rupasinghe
Summary: The study found that the ethanolic extract of seeds of Brazilian Passiflora edulis fruits (PESE) and piceatannol (PIC) have potential in anti-diabetic, anti-glycation, and antioxidant activities, warranting further investigation.
Article
Cell Biology
Madumani Amararathna, David W. Hoskin, H. P. Vasantha Rupasinghe
Summary: Anthocyanins are effective compounds for treating various human diseases, but their therapeutic efficacy can be reduced due to degradation. This study developed a direct delivery system of anthocyanins into pulmonary tissues using encapsulated nanocarriers, which increased the stability and therapeutic efficacy of the anthocyanins.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Pharmacology & Pharmacy
Niluni M. Wijesundara, Song F. Lee, Zhenyu Cheng, Ross Davidson, David N. Langelaan, H. P. Vasantha Rupasinghe
Summary: This study investigated the bactericidal mechanism of carvacrol on Streptococcus pyogenes. It was found that carvacrol primarily killed the bacteria by disrupting membrane integrity and increasing permeability. Carvacrol also showed affinity with specific membrane phospholipids. This research provides insight for the development of natural health products for managing streptococcal pharyngitis or other therapeutic applications.
Review
Food Science & Technology
Nilushni Sivapragasam, Nilanivetha Neelakandan, H. P. Vasantha Rupasinghe
Summary: Fermented food has gained popularity as a value-added category, and blueberries are considered superfoods. However, the bioavailability of bioactives in blueberries is low. This review focuses on the fermentation processes of blueberry, and how it enhances the bioavailability of nutrients and bioactive compounds, leading to potential health benefits when consumed as fermented blueberry products.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Oladapo F. Fagbohun, Caroline R. Gillies, Kieran P. J. Murphy, H. P. Vasantha Rupasinghe
Summary: Cancer is a global issue with millions of new cases and deaths each year. Diet and nutrients have a significant impact on cancer risk, and recent advancements in research have focused on the effects of dietary components on cancer prevention through nutrigenomics. This review highlights the importance and benefits of nutrigenomics in developing approaches for cancer prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tharindu L. Suraweera, J. P. Jose Merlin, Graham Dellaire, Zhaolin Xu, H. P. Vasantha Rupasinghe
Summary: Cancer is a leading cause of death globally, but current treatments like chemotherapy and radiation therapy have significant side effects. Therefore, the prevention of cancer through dietary modifications has gained interest. This study examined the potential of selected flavonoids in reducing reactive oxygen species (ROS) and DNA damage induced by carcinogens through the activation of the Nrf2/ARE pathway. The results showed that genistein and PCB2 could effectively reduce ROS and DNA damage, and further research is needed to understand the role of dietary flavonoids in regulating the Nrf2/ARE pathway in carcinogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Oladapo F. Fagbohun, Jitcy S. Joseph, Olumayowa V. Oriyomi, H. P. Vasantha Rupasinghe
Summary: Frondosides are the major saponins of the North Atlantic sea cucumber. They possess amphiphilic characteristics and have been widely studied for their potential therapeutic activities. Recent studies have shown that frondoside-containing extracts from C. frondosa exhibit various biological activities, but the exact mechanism(s) of action are not clearly understood. This review discusses the different frondosides of C. frondosa, their potential therapeutic activities, and recent advances in extraction techniques.
Review
Chemistry, Analytical
Shahida Anusha Siddiqui, Ali Ali Redha, Molla Salauddin, Iskandar Azmy Harahap, H. P. Vasantha Rupasinghe
Summary: Replacing conventional solvents with deep eutectic solvents (DES) has shown promising effects on the extraction yield of (poly)phenols. Combining DES with ultrasound-assisted extraction (UAE) can further enhance the extraction efficiency. Factors such as DES composition, solvent-to-sample ratio, and UAE parameters need to be considered for optimizing the extraction process.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Food Science & Technology
Quinn Cavanagh, Marianne Su-Ling Brooks, H. P. Vasantha Rupasinghe
Summary: Spent coffee grounds (SCG) are a by-product of instant coffee and coffee beverage brewing, and they have the potential to be transformed into new food ingredients with various nutritional and functional benefits through innovative processing technologies. SCG contain a rich composition of nutrients and bioactive compounds, and they can be used in sustainable food production.
Article
Biodiversity Conservation
Cindy H. J. Yu, Zoe Migicovsky, Jun Song, H. P. Vasantha Rupasinghe
Summary: This study screened apple cultivars from Canada's Apple Biodiversity Collection to identify high (poly)phenol-containing specialty apples with antidiabetic properties, providing new insights into the prevention and management of Type 2 diabetes.
PLANTS PEOPLE PLANET
(2023)
Review
Toxicology
Purvi Trivedi, Amna Abbas, Christian Lehmann, H. P. Vasantha Rupasinghe
Summary: COVID-19, caused by SARS-CoV-2, is a highly contagious disease that has become a global pandemic. It is characterized by respiratory symptoms and inflammatory injury due to excessive cytokine release. Precautionary measures such as vaccination, social distancing, mask usage, hygiene, and a healthy diet can help attenuate organ damage from COVID-19 infection.
JOURNAL OF XENOBIOTICS
(2022)