From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A

A role for the membrane Golgi protein Ema in autophagy

(2012) Sungsu Kim et al.   Autophagy

C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses

(2012) Lara M Kingeter et al.   Cellular & Molecular Immunology

The Centrosome Regulates the Rab11- Dependent Recycling Endosome Pathway at Appendages of the Mother Centriole

(2012) Heidi Hehnly et al.   CURRENT BIOLOGY

Role of autophagy in immunity and autoimmunity, with a special focus on systemic lupus erythematosus

(2012) Marina Pierdominici et al.   FASEB JOURNAL

Age-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes

(2012) A Gyllenberg et al.   GENES AND IMMUNITY

CIITA gene variants are associated with rheumatoid arthritis in Scandinavian populations

(2012) M C Eike et al.   GENES AND IMMUNITY

Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus

(2012) I S Leikfoss et al.   GENES AND IMMUNITY

Association of primary biliary cirrhosis with variants in the CLEC16A, SOCS1, SPIB and SIAE immunomodulatory genes

(2012) G M Hirschfield et al.   GENES AND IMMUNITY

Linking disease associations with regulatory information in the human genome

(2012) M. A. Schaub et al.   GENOME RESEARCH

CD226 Gly307Ser association with multiple autoimmune diseases: A meta-analysis

(2012) Zhi-Xin Qiu et al.   HUMAN IMMUNOLOGY

Seven newly identified loci for autoimmune thyroid disease

(2012) Jason D. Cooper et al.   HUMAN MOLECULAR GENETICS

The genetics of multiple sclerosis: an up-to-date review

(2012) Pierre-Antoine Gourraud et al.   IMMUNOLOGICAL REVIEWS

Environmental Risk Factors for Multiple Sclerosis: A Review with a Focus on Molecular Mechanisms

(2012) Cullen O’Gorman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Follow-Up Study of the First Genome-Wide Association Scan in Alopecia Areata: IL13 and KIAA0350 as Susceptibility Loci Supported with Genome-Wide Significance

(2012) Dagny Jagielska et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Systematic review of disease-modifying therapies to assess unmet needs in multiple sclerosis: tolerability and adherence

(2012) G Giovannoni et al.   Multiple Sclerosis Journal

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

(2012) Steve Eyre et al.   NATURE GENETICS

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

The Correlation between the CLEC16A Gene and Genetic Susceptibility to Type 1 Diabetes in Chinese Children

(2012) Yanmei Sang et al.   International Journal of Endocrinology

SOCS, Inflammation, and Autoimmunity

(2012) Akihiko Yoshimura et al.   Frontiers in Immunology

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci

(2011) Nikolaos A. Patsopoulos et al.   ANNALS OF NEUROLOGY

Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population

(2011) X.-j. Zhou et al.   ANNALS OF THE RHEUMATIC DISEASES

Genome-wide association studies in multiple sclerosis: lessons and future prospects

(2011) A. Kemppinen et al.   Briefings in Functional Genomics

Genetic Analysis of Adult-Onset Autoimmune Diabetes

(2011) J. M. M. Howson et al.   DIABETES

Analysis of the HLA and non-HLA susceptibility loci in Japanese type 1 diabetes

(2011) Hisakuni Yamashita et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

The STAT3 beacon: IL-6 recurrently activates STAT 3 from endosomal structures

(2011) Christopher L. German et al.   EXPERIMENTAL CELL RESEARCH

The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus

(2011) P G Bronson et al.   GENES AND IMMUNITY

A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis

(2011) K Vandenbroeck et al.   GENES AND IMMUNITY

Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA–CLEC16A–SOCS1 gene complex

(2011) Rebecca L. Zuvich et al.   HUMAN MOLECULAR GENETICS

Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene

(2011) Lucy J. Davison et al.   HUMAN MOLECULAR GENETICS

Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis

(2011) S. Simpson et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis

(2011) George F Mells et al.   NATURE GENETICS

Involvement of CLEC16A in Activation of Astrocytes After LPS Treated

(2011) Xinmin Wu et al.   NEUROCHEMICAL RESEARCH

The CD40-Autophagy Pathway Is Needed for Host Protection Despite IFN-Γ-Dependent Immunity and CD40 Induces Autophagy via Control of P21 Levels

(2011) Jose-Andres C. Portillo et al.   PLoS One

Promise and pitfalls of the Immunochip

(2011) Adrian Cortes et al.   ARTHRITIS RESEARCH & THERAPY

More CLEC16A gene variants associated with multiple sclerosis

(2010) S. Nischwitz et al.   ACTA NEUROLOGICA SCANDINAVICA

Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene

(2010) Eveliina Jakkula et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling

(2010) Dong-Min Shin et al.   CELLULAR MICROBIOLOGY

Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus

(2010) I-L Mero et al.   GENES AND IMMUNITY

Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility

(2010) Rebecca L. Zuvich et al.   HUMAN GENETICS

Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12 566 individuals

(2010) Farren B.S. Briggs et al.   HUMAN MOLECULAR GENETICS

CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis

(2010) Paola G. Bronson et al.   HUMAN MOLECULAR GENETICS

Genetic variation in the autophagy gene ULK1 and risk of Crohnʼs disease

(2010) Liesbet Henckaerts et al.   INFLAMMATORY BOWEL DISEASES

The novel endosomal membrane protein Ema interacts with the class C Vps–HOPS complex to promote endosomal maturation

(2010) Sungsu Kim et al.   JOURNAL OF CELL BIOLOGY

Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis

(2010) Sandra Nischwitz et al.   JOURNAL OF NEUROIMMUNOLOGY

Evaluation of the established non-MHC multiple sclerosis loci in an Indian population

(2010) Lekha Pandit et al.   Multiple Sclerosis Journal

MS prevalence in New Zealand, an ethnically and latitudinally diverse country

(2010) Bruce V Taylor et al.   Multiple Sclerosis Journal

Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis

(2010) Serena Sanna et al.   NATURE GENETICS

Phospho.ELM: a database of phosphorylation sites--update 2011

(2010) H. Dinkel et al.   NUCLEIC ACIDS RESEARCH

Candidate Causal Regulatory Effects by Integration of Expression QTLs with Complex Trait Genetic Associations

(2010) Alexandra C. Nica et al.   PLoS Genetics

Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS

(2010) Dan L. Nicolae et al.   PLoS Genetics

A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-cyclic citrullinated peptide antibody negative rheumatoid arthritis

(2009) B. Skinningsrud et al.   ANNALS OF THE RHEUMATIC DISEASES

Chromosomal region 16p13: further evidence of increased predisposition to immune diseases

(2009) A Martinez et al.   ANNALS OF THE RHEUMATIC DISEASES

Specific association of a CLEC16A/KIAA0350 polymorphism with NOD2/CARD15− Crohn's disease patients

(2009) Ana Márquez et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Multiple sclerosis susceptibility alleles in African Americans

(2009) B A Johnson et al.   GENES AND IMMUNITY

Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci

(2009) et al.   HUMAN MOLECULAR GENETICS

Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis

(2009) Ilse A Hoppenbrouwers et al.   JOURNAL OF HUMAN GENETICS

Biochemical Monitoring of the Early Endocytic Traffic of the Type I Interferon Receptor

(2009) Béatrice Payelle-Brogard et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus

(2009) Devindri Perera et al.   JOURNAL OF NEUROIMMUNOLOGY

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

(2009) Melanie Bahlo et al.   NATURE GENETICS

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

(2009) Philip L De Jager et al.   NATURE GENETICS

Mapping complex disease traits with global gene expression

(2009) William Cookson et al.   NATURE REVIEWS GENETICS

Risk alleles for multiple sclerosis in multiplex families

(2009) M. J. D'Netto et al.   NEUROLOGY

The role of the CD58 locus in multiple sclerosis

(2009) P. L. De Jager et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes in multiple sclerosis: A product of their environment

(2008) A. Nair et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Intron polymorphism in theKIAA0350gene is reproducibly associated with susceptibility to type 1 diabetes (T1D) in the Han Chinese population

(2008) Xiaopan Wu et al.   CLINICAL ENDOCRINOLOGY

Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians

(2008) J P Rubio et al.   GENES AND IMMUNITY

The expanding genetic overlap between multiple sclerosis and type I diabetes

(2008)   GENES AND IMMUNITY

Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Sardinia

(2008) M Zoledziewska et al.   GENES AND IMMUNITY

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

(2008) Sergio E. Baranzini et al.   HUMAN MOLECULAR GENETICS

Polymorphisms inCLEC16AandCIITAat 16p13 Are Associated with Primary Adrenal Insufficiency

(2008) Beate Skinningsrud et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association of Type 1 Diabetes with Two Loci on 12q13 and 16p13 and the Influence Coexisting Thyroid Autoimmunity in Japanese

(2008) Takuya Awata et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells

(2008) Noriyuki Fujikado et al.   NATURE MEDICINE

Temporal trends in the incidence of multiple sclerosis: A systematic review

(2008) A. Alonso et al.   NEUROLOGY

CDD: specific functional annotation with the Conserved Domain Database

(2008) A. Marchler-Bauer et al.   NUCLEIC ACIDS RESEARCH

Identification of a Novel Risk Locus for Multiple Sclerosis at 13q31.3 by a Pooled Genome-Wide Scan of 500,000 Single Nucleotide Polymorphisms

(2008) Manuel Comabella et al.   PLoS One