Article
Pharmacology & Pharmacy
Ahmad Salimi, Zhaleh Jamali, Mohammad Shabani
Summary: Oxidative stress and mitochondrial dysfunction play crucial roles in the cardiac toxicity induced by aluminum phosphide. Myricetin, a flavonoid, shows potential in protecting cardiomyocytes and mitochondria from AlP-induced toxicity by reducing oxidative stress and cellular damage, suggesting its therapeutic potential in alleviating the adverse effects of AlP on the heart.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Sung -E Choi, Yoonjung Hwang, Soo-Jin Lee, Hyunkyung Jung, Tae Hwan Shin, Youngho Son, Seokho Park, Seung Jin Han, Hae Jin Kim, Kwan Woo Lee, Gwang Lee, Jongsook Kim Kemper, Hyun Kyu Song, Yup Kang
Summary: The reduction of mitochondrial protease ClpP is associated with the development of non-alcoholic steatohepatitis (NASH). Supplementation of ClpP may improve diet-induced NASH.
JOURNAL OF HEPATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Chennan Wu, Zhen Zhang, Weidong Zhang, Xia Liu
Summary: Cardiovascular diseases, including heart failure, are leading causes of death globally. Despite advancements in therapies, life expectancy for heart failure remains poor. Targeting mitochondrial dysfunction, which is closely related to heart failure, may be an effective approach for treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Psychiatry
Johan Fernstrom, Synthia H. Mellon, Marlon A. McGill, Martin Picard, Victor Reus, Christina M. Hough, Jue Lin, Elissa S. Epel, Owen M. Wolkowitz, Daniel Lindqvist
Summary: The study found that mitochondrial markers did not differentiate between individuals with major depressive disorder and healthy controls, but could distinguish between SSRI responders and nonresponders. Mitochondrial dysfunction may be implicated in treatment response to SSRI in MDD.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Pharmacology & Pharmacy
Xiaolin Liao, Yuanshan Han, Ying He, Jianjun Liu, Yuhong Wang
Summary: Hypertension commonly leads to target organ damage in the heart, brain, kidney, and blood vessels, including atherosclerosis, plaque formation, cardiovascular and cerebrovascular events, and renal failure. Mitochondrial dysfunction has been identified as a crucial factor in hypertensive target organ damage, leading to increasing interest in mitochondria-targeted therapies. Natural compounds have shown potential in ameliorating mitochondrial dysfunction in hypertensive target organ damage. This review summarizes the contribution of mitochondrial dysfunction to the development of target organ damage in hypertension and discusses therapeutic strategies based on natural compounds that target mitochondrial dysfunction, which may be beneficial for preventing and treating hypertensive target organ damage.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Jingjing Liu, Gaosheng Zhou, Rongping Chen, Zewen Tong, Hongmin Zhang, Xiaoting Wang, Dawei Liu
Summary: The study found that the serum levels of Sirt3 are associated with disease severity in septic patients, suggesting that Sirt3 could be a potential novel marker for sepsis diagnosis and mortality prediction.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Qian Wang, Zhenzhen Sun, Shihan Cao, Xiuli Lin, Mengying Wu, Yuanyuan Li, Jie Yin, Wei Zhou, Songming Huang, Aihua Zhang, Yue Zhang, Weiwei Xia, Zhanjun Jia
Summary: The study reveals the involvement of MAVS in cardiac dysfunction, showing reduced MAVS expression in non-hypertrophic cardiac dysfunction and enhanced MAVS expression in hypertrophic heart. MAVS deficiency leads to cardiac dysfunction, mitochondrial impairment, and disturbed energy metabolism. These findings suggest a crucial role of MAVS in the pathogenesis of non-hypertrophic cardiac dysfunction.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Liangge Li, Yiming Qin, Xijian Xin, Shendong Wang, Zhaojun Liu, Xiujing Feng
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common liver disease with a high morbidity and mortality rate. The pathogenesis of NAFLD involves excess lipid accumulation and inflammation. Currently, there are no specific drugs for NAFLD, but phytochemicals such as flavonoids have shown potential in preventing and treating excess lipid accumulation. Understanding the classification, properties, and functions of flavonoids will contribute to the development of effective therapies for NAFLD.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Endocrinology & Metabolism
Qing Zhou, Yuyan Wang, Zongshi Lu, Bowen Wang, Li Li, Mei You, Lijuan Wang, Tingbing Cao, Yu Zhao, Qiang Li, Aidi Mou, Wentao Shu, Hongbo He, Zhigang Zhao, Daoyan Liu, Zhiming Zhu, Peng Gao, Zhencheng Yan
Summary: SIRT3 is involved in regulating metabolic reprogramming in proinflammatory macrophage polarization and plays an important preventive role in obesity.
Article
Cardiac & Cardiovascular Systems
Edgar E. Nollet, Inez Duursma, Anastasiya Rozenbaum, Moritz Eggelbusch, Rob C. Wuest, Stephan A. C. Schoonvelde, Michelle Michels, Mark Jansen, Nicole N. van der Wel, Kenneth C. Bedi, Kenneth B. Margulies Jr, Jeff Nirschl, Diederik W. D. Kuster, Jolanda van der Velden
Summary: This study found that mitochondrial dysfunction is related to pathological remodelling in hypertrophic cardiomyopathy (HCM). In patients without genetic mutations, there is a stronger association between mitochondrial dysfunction and septal hypertrophy. The study also suggests that targeting mitochondria with specific drugs can restore mitochondrial function in HCM patients.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Giovanna Trinchese, Fabiano Cimmino, Gina Cavaliere, Angela Catapano, Chiara Fogliano, Adriano Lama, Claudio Pirozzi, Claudia Cristiano, Roberto Russo, Lidia Petrella, Rosaria Meli, Giuseppina Mattace Raso, Marianna Crispino, Bice Avallone, Maria Pina Mollica
Summary: This study investigates the role of the liver in autism spectrum disorders (ASD) and identifies hepatic mitochondrial dysfunction as a potential target for innovative therapeutic strategies for the disease. The findings reveal a link between liver inflammation, oxidative stress, and mitochondrial dysfunction in ASD.
Article
Chemistry, Multidisciplinary
Qiming Zhai, Xin Chen, Dongdong Fei, Xiaoyan Guo, Xiaoning He, Wanmin Zhao, Songtao Shi, John Justin Gooding, Fang Jin, Yan Jin, Bei Li
Summary: Chronic inflammation leads to mitochondrial dysfunction in tissue-specific mesenchymal stem cells (MSCs), but nanotechnology can be utilized to restore their function, providing an effective treatment for periodontitis and osteoarthritis.
Article
Multidisciplinary Sciences
Jiaxiu Li, Ya Hui, Zhiqiang Xu, Jie Tan, Kai Yin, Liuyu Kuang, Yunyun Tang, Junjie Wei, Qiongsui Zhong, Tianpeng Zheng
Summary: In this study, it was found that enhanced DPP4 expression in diabetes contributes to cognitive impairment through the formation of mitochondria-associated ER membrane (MAM) and calcium overload in mitochondria, while its knockdown has the opposite effects. Mechanistically, DPP4 binds to PAR2 and activates the ERK1/2/CEBPB signaling pathway, leading to upregulation of ERp29 expression, which promotes MAM formation and cognitive impairment. Targeting DPP4-mediated PAR2/ERK1/2/CEBPB/ERp29 signaling shows promising therapeutic effects on MAM formation, mitochondria calcium overload, and cognitive impairment. This study reveals the non-canonical role of DPP4 in the pathogenesis of cognitive impairment in type 2 diabetes and identifies a potential therapeutic target for its treatment.
Article
Fisheries
Huifan Liu, Yuke Fang, Cuiyun Zou
Summary: This study found that crude polysaccharide YZW-A extracted from pomelo fruitlets has protective effects on oxidative stress, inflammation, and mitochondrial dysfunction-mediated apoptosis. YZW-A increased activities of mitochondrial respiratory complexes and antioxidative enzymes, decreased expression of proinflammatory cytokines, and alleviated cell apoptosis through mitigating oxidative stress. These results suggest the therapeutic potential of YZW-A on aquatic animals.
Article
Endocrinology & Metabolism
Yuxia Zhou, Lu Liu, Bangming Jin, Yixuan Wu, Lifen Xu, Xuebing Chang, Laying Hu, Guifang Wang, Yali Huang, Lingyu Song, Tian Zhang, Yuanyuan Wang, Ying Xiao, Fan Zhang, Mingjun Shi, Lingling Liu, Tuanlao Wang, Rui Yan, Bing Guo
Summary: Ectopic lipid accumulation in renal tubules is closely related to the pathogenesis of diabetic kidney disease, and mitochondrial dysfunction is thought to play a key role. This study shows that the Metrnl gene product mediates lipid accumulation in the kidney and has therapeutic potential for DKD.
Article
Gastroenterology & Hepatology
Arend W. Overeem, Qinghong Li, Yi-Ling Qiu, Fernando Carton-Garcia, Changsen Leng, Karin Klappe, Just Dronkers, Nai-Hua Hsiao, Jian-She Wang, Diego Arango, Sven C. D. van Ijzendoorn
Article
Nanoscience & Nanotechnology
Petra Gener, Sara Montero, Helena Xandri-Monje, Zamira V. Diaz-Riascos, Diana Rafael, Fernanda Andrade, Francesc Martinez-Trucharte, Patricia Gonzalez, Joaquin Seras-Franzoso, Albert Manzano, Diego Arango, Joan Sayos, Ibane Abasolo, Simo Schwartz
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2020)
Review
Oncology
Agueda Martinez-Barriocanal, Diego Arango, Higinio Dopeso
FRONTIERS IN ONCOLOGY
(2020)
Article
Pharmacology & Pharmacy
Sara Montero, Joaquin Seras-Franzoso, Fernanda Andrade, Francesc Martinez-Trucharte, Mireia Vilar-Hernandez, Manuel Quesada, Helena Xandri, Diego Arango, Ibane Abasolo, Diana Rafael, Simo Schwartz
Article
Chemistry, Multidisciplinary
Fernanda Andrade, Diana Rafael, Mireia Vilar-Hernandez, Sara Montero, Francesc Martinez-Trucharte, Joaquin Seras-Franzoso, Zamira Diaz-Riascos, Ana Boullosa, Natalia Garcia-Aranda, Patricia Camara-Sanchez, Diego Arango, Marika Nestor, Ibane Abasolo, Bruno Sarmento, Simo Schwartz
Summary: The use of CD44v6-targeted polymeric micelles loaded with niclosamide shows promise as a therapeutic strategy against colorectal cancer stem cells and circulating tumor cells, with potential to improve clinical outcomes.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cell Biology
Oliver H. Voss, Daniel Arango, Justin C. Tossey, Miguel A. Villalona Calero, Andrea Doseff
Summary: Apigenin sensitizes primary lung cancer cells to TRAIL-induced apoptosis through reprogramming alternative splicing of key TRAIL/DISC components and directly binding heat shock protein 70 to promote cell death. These findings emphasize the synergies between diet and cancer treatments, providing new avenues for improved cancer therapies.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Sarah Bazzocco, Higinio Dopeso, Agueda Martinez-Barriocanal, Estefania Anguita, Rocio Nieto, Jing Li, Elia Garcia-Vidal, Valentina Maggio, Paulo Rodrigues, Priscila Guimaraes de Marcondes, Simo Schwartz, Lauri A. Aaltonen, Alex Sanchez, John M. Mariadason, Diego Arango
Summary: In this study, a set of 382 genes potentially silenced by promoter methylation in colorectal cancer were identified, which could significantly contribute to the oncogenic process. The epigenetically silenced gene ZBTB18 was found to have tumor suppressor activity and serve as a novel prognostic marker for patients with locally advanced colorectal cancer.
CLINICAL EPIGENETICS
(2021)
Article
Pharmacology & Pharmacy
Thibaut Fourniols, Valentina Maggio, Diana Rafael, Ariana Colaco, Elia Garcia Vidal, Alessandra Lopes, Simo Schwartz, Agueda Martinez-Barriocanal, Veronique Preat, Diego Arango
Summary: In this study, we evaluated the therapeutic effect of two new nano-formulations of BETi JQ1 for the treatment of colorectal cancer. The results showed that although nanoencapsulation improved the delivery of JQ1 to tumors, it did not enhance its anticancer effect. Additionally, MYC inhibition did not affect the efficacy of JQ1 in the CT26 CRC mouse model.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Irina Giralt, Gabriel Gallo-Oller, Natalia Navarro, Patricia Zarzosa, Guillem Pons, Ainara Magdaleno, Miguel F. Segura, Constantino Sabado, Raquel Hladun, Diego Arango, Jose Sanchez de Toledo, Lucas Moreno, Soledad Gallego, Josep Roma
Summary: The study demonstrates the therapeutic potential of DKK-1 pharmaceutical inhibition in rhabdomyosarcoma, resulting in beta-catenin activation and modulation of focal adhesion kinase, with positive effects on myogenic marker expression and a reduction in proliferation and invasion. In addition, the chemical inhibitor WAY-262611 was able to impair tumor cell survival in vivo, suggesting DKK-1 as a potential molecular target for novel therapeutic strategies in RMS patients, especially those with high DKK-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ian Y. Luk, Laura J. Jenkins, Kael L. Schoffer, Irvin Ng, Janson W. T. Tse, Dmitri Mouradov, Stanislaw Kaczmarczyk, Rebecca Nightingale, Allan D. Burrows, Robin L. Anderson, Diego Arango, Higinio Dopeso, Larry Croft, Mark F. Richardson, Oliver M. Sieber, Yang Liao, Jennifer K. Mooi, Natalia Vukelic, Camilla M. Reehorst, Shoukat Afshar-Sterle, Vicki L. J. Whitehall, Lochlan Fennell, Helen E. Abud, Niall C. Tebbutt, Wayne A. Phillips, David S. Williams, Wei Shi, Lisa A. Mielke, Matthias Ernst, Amardeep S. Dhillon, Nicholas J. Clemons, John M. Mariadason
Summary: In this study, co-ordinate epigenetic inactivation of two epithelial-specific transcription factors, EHF and CDX1, was identified as a mechanism driving differentiation loss in CRCs. Re-expression of EHF and CDX1 induced extensive chromatin remodelling, transcriptional re-programming, and differentiation in poorly-differentiated CRC cells, leading to reduced growth and metastasis. These findings reveal a novel mechanism driving epithelial de-differentiation and tumor progression in CRC.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Biochemistry & Molecular Biology
Daniel Arango, David Sturgill, Renbin Yang, Tapan Kanai, Paulina Bauer, Jyoti Roy, Ziqiu Wang, Masaki Hosogane, Sarah Schiffers, Shalini Oberdoerffer
Summary: mRNA function is affected by modifications that can alter the behavior of nucleobases. A specific modification can have different impacts on mRNA translation depending on its position. The acetylation of cytidine (ac4C) within protein-coding sequences enhances translation, while ac4C within 5' UTRs affects protein synthesis at the initiation level. The acetylation promotes initiation at upstream sequences and competitively inhibits annotated start codons. Additionally, ac4C within AUG-flanking Kozak sequences directly impedes initiation at optimal AUG contexts.
Article
Biochemistry & Molecular Biology
Fernando Carton-Garcia, Bruno Brotons, Estefania Anguita, Higinio Dopeso, Jordi Tarragona, Rocio Nieto, Elia Garcia-Vidal, Irati Macaya, Zsuzsanna Zagyva, Mariona Dalmau, Manuel Sanchez-Martin, Sven C. D. van Ijzendoorn, Stefania Landolfi, Javier Hernandez-Losa, Simo Schwartz Jr, Xavier Matias-Guiu, Santiago Ramon y Cajal, Agueda Martinez-Barriocanal, Diego Arango
Summary: Loss of myosin Vb reduces polarization/differentiation of colon cancer cells while enhancing their metastatic potential, demonstrating a tumor suppressor function for this myosin. Reduced expression of myosin Vb in tumors identifies a subset of poor prognosis colorectal cancer patients.
Article
Oncology
Patricia Gonzalez-Callejo, Petra Gener, Zamira Diaz-Riascos, Sefora Conti, Patricia Camara-Sanchez, Roger Riera, Sandra Mancilla, Miguel Garcia-Gabilondo, Vicente Peg, Diego Arango, Anna Rosell, Anna Labernadie, Xavier Trepat, Lorenzo Albertazzi, Jr Simo Schwartz, Joaquin Seras-Franzoso, Ibane Abasolo
Summary: Tumor-secreted extracellular vesicles play a crucial role in the establishment and growth of metastatic tumors. The diversity among these vesicles, particularly in triple-negative breast cancer, has not been fully explored. This study found that vesicles secreted by cancer stem cells and differentiated cancer cells have distinct effects on the tumor microenvironment, promoting different aspects of tumor growth and metastasis.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Pharmacology & Pharmacy
Diana Rafael, Marcelo Guerrero, Adolfo Marican, Diego Arango, Bruno Sarmento, Roser Ferrer, Esteban F. Duran-Lara, Simon J. Clark, Simo Schwartz
Summary: Slow-release delivery systems are crucial for long-term sustained treatments of retinal diseases. Hydrogels, especially temperature-responsive hydrogels, have been studied as promising delivery vehicles for intravitreal injection of retinal therapies.
Article
Cell Biology
Meenakshi Sudhakaran, Tatiana Garcia Navarrete, Katherine Mejia-Guerra, Eric Mukundi, Timothy D. Eubank, Erich Grotewold, Daniel Arango, Andrea I. Doseff
Summary: Apigenin has been found to reprogram the transcriptome of triple-negative breast cancer (TNBC), inducing apoptosis and inhibiting tumor growth, offering new options for TNBC treatments.
CELL DEATH & DISEASE
(2023)