Aptamers and Their Potential to Selectively Target Aspects of EGF, Wnt/β-Catenin and TGFβ–Smad Family Signaling

Four Amino Acids within a Tandem QxVx Repeat in a Predicted Extended α-Helix of the Smad-Binding Domain of Sip1 Are Necessary for Binding to Activated Smad Proteins

(2013) Andrea Conidi et al.   PLoS One

TGF-β signalling and its role in cancer progression and metastasis

(2012) Yvette Drabsch et al.   CANCER AND METASTASIS REVIEWS

SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer

(2012) N. I. Fleming et al.   CANCER RESEARCH

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Therapeutic RNA aptamers in clinical trials

(2012) Padma Sundaram et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

BMP signaling in vascular diseases

(2012) Jie Cai et al.   FEBS LETTERS

Zfp423/OAZ Mutation Reveals the Importance of Olf/EBF Transcription Activity in Olfactory Neuronal Maturation

(2012) Y. A. Roby et al.   JOURNAL OF NEUROSCIENCE

Recent developments in the diagnosis of Marfan syndrome and related disorders

(2012) Kim M Summers et al.   MEDICAL JOURNAL OF AUSTRALIA

The paradoxical TGF-β vasculopathies

(2012) Rosemary J. Akhurst   NATURE GENETICS

Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm

(2012) Alexander J Doyle et al.   NATURE GENETICS

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dual-Mode Modulation of Smad Signaling by Smad-Interacting Protein Sip1 Is Required for Myelination in the Central Nervous System

(2012) Qinjie Weng et al.   NEURON

An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state

(2012) C. Polytarchou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression, purification, and functional characterization of recombinant PTD-SARA

(2011) C. Huang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Role of TGF-β in chronic kidney disease: an integration of tubular, glomerular and vascular effects

(2011) Francisco J. López-Hernández et al.   CELL AND TISSUE RESEARCH

Non-Smad signaling pathways

(2011) Yabing Mu et al.   CELL AND TISSUE RESEARCH

TGF-β in progression of liver disease

(2011) Steven Dooley et al.   CELL AND TISSUE RESEARCH

Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo

(2011) Andrea Conidi et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Hereditary hemorrhagic telangiectasia: An overview of diagnosis, management, and pathogenesis

(2011) Jamie McDonald et al.   GENETICS IN MEDICINE

Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth

(2011) Roselyne Castonguay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis

(2011) Ingrid M B H van de Laar et al.   NATURE GENETICS

Feedback regulation of EGFR signalling: decision making by early and delayed loops

(2011) Roi Avraham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Neutralizing RNA Aptamer against EGFR Causes Selective Apoptotic Cell Death

(2011) Carla Lucia Esposito et al.   PLoS One

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

(2010) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

Discovery and Development of Therapeutic Aptamers

(2010) P.R. Bouchard et al.   Annual Review of Pharmacology and Toxicology

Development of aptamer therapeutics

(2010) David HJ Bunka et al.   CURRENT OPINION IN PHARMACOLOGY

Peptide ligands that use a novel binding site to target both TGF-β receptors

(2010) Lingyin Li et al.   Molecular BioSystems

TMEPAI, a Transmembrane TGF-β-Inducible Protein, Sequesters Smad Proteins from Active Participation in TGF-β Signaling

(2010) Yukihide Watanabe et al.   MOLECULAR CELL

Development of DNA aptamers using Cell-SELEX

(2010) Kwame Sefah et al.   Nature Protocols

The Cooperation between hMena Overexpression and HER2 Signalling in Breast Cancer

(2010) Francesca Di Modugno et al.   PLoS One

Targeting cancer cells with nucleic acid aptamers

(2010) Laura Cerchia et al.   TRENDS IN BIOTECHNOLOGY

Mowat-Wilson syndrome: Facial phenotype changing with age: Study of 19 Italian patients and review of the literature

(2009) L. Garavelli et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Transforming Growth Factor type β and Smad family signaling in stem cell function

(2009) Eve Seuntjens et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Intricacies of BMP receptor assembly

(2009) Joachim Nickel et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Applications of small molecule BMP inhibitors in physiology and disease

(2009) Charles C. Hong et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Proximal events in Wnt signal transduction

(2009) Stephane Angers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

New regulatory mechanisms of TGF-β receptor function

(2009) Jong Seok Kang et al.   TRENDS IN CELL BIOLOGY

Surface-Immobilized Peptide Aptamers as Probe Molecules for Protein Detection

(2008) Steven Johnson et al.   ANALYTICAL CHEMISTRY

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

(2008) C. P. Bracken et al.   CANCER RESEARCH

Peptide Aptamers Targeting Mutant p53 Induce Apoptosis in Tumor Cells

(2008) E. Guida et al.   CANCER RESEARCH

SELEX with modified nucleotides

(2008) Anthony D Keefe et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

(2008) S.-M. Park et al.   GENES & DEVELOPMENT

Atypical Mowat-Wilson patient confirms the importance of the novel association between ZFHX1B/SIP1 and NuRD corepressor complex

(2008) G. Verstappen et al.   HUMAN MOLECULAR GENETICS

Transforming Growth Factor-β Signaling in Thoracic Aortic Aneurysm Development: A Paradox in Pathogenesis

(2008) Jeffrey A. Jones et al.   JOURNAL OF VASCULAR RESEARCH

Cooperative Assembly of TGF-β Superfamily Signaling Complexes Is Mediated by Two Disparate Mechanisms and Distinct Modes of Receptor Binding

(2008) Jay Groppe et al.   MOLECULAR CELL

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY