The Dual Role of Inflammation in Colon Carcinogenesis

Transcription Factor NFATc2 Controls the Emergence of Colon Cancer Associated with IL-6-Dependent Colitis

(2012) K. Gerlach et al.   CANCER RESEARCH

Role of IL-17A in the development of colitis-associated cancer

(2012) Y. S. Hyun et al.   CARCINOGENESIS

The Prognostic Value of FoxP3+ Tumor-Infiltrating Lymphocytes in Cancer: A Critical Review of the Literature

(2012) R. J. deLeeuw et al.   CLINICAL CANCER RESEARCH

IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential

(2012) Shu Zhu et al.   CLINICAL SCIENCE

The Dual Role of Tumor Necrosis Factor (TNF) in Cancer Biology

(2012) L. Bertazza et al.   CURRENT MEDICINAL CHEMISTRY

Th17-Related Cytokines in Inflammatory Bowel Diseases: Friends or Foes?

(2012) I. Monteleone et al.   CURRENT MOLECULAR MEDICINE

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

Signal Transducer and Activator of Transcription 3 (STAT3) Protein Suppresses Adenoma-to-carcinoma Transition inApcmin/+Mice via Regulation of Snail-1 (SNAI) Protein Stability

(2012) Jongdae Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer

(2011) Sylvain Ladoire et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Smad7 Expression in T cells Prevents Colitis-Associated Cancer

(2011) A. Rizzo et al.   CANCER RESEARCH

Dysregulation of CD1d-Restricted Type II Natural Killer T Cells Leads to Spontaneous Development of Colitis in Mice

(2011) Chia–Min Liao et al.   GASTROENTEROLOGY

Interleukin 21 controls tumour growth and tumour immunosurveillance in colitis-associated tumorigenesis in mice

(2011) D. Jauch et al.   GUT

Involvement of interleukin-21 in the regulation of colitis-associated colon cancer

(2011) Carmine Stolfi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Runx3 Is Required for Full Activation of Regulatory T Cells To Prevent Colitis-Associated Tumor Formation

(2011) M. Sugai et al.   JOURNAL OF IMMUNOLOGY

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18

(2010) Rosalba Salcedo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis

(2010) W.-J. Chae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

Endogenous IL-17 contributes to reduced tumor growth and metastasis

(2009) I. Kryczek et al.   BLOOD

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

The Contrasting Roles of NKT Cells in Tumor Immunity

(2009) Jay Berzofsky et al.   CURRENT MOLECULAR MEDICINE

Stat3 Is a Negative Regulator of Intestinal Tumor Progression in ApcMin Mice

(2009) Monica Musteanu et al.   GASTROENTEROLOGY

Apoptosis Signal-Regulating Kinase 1 Regulates Colitis and Colitis-Associated Tumorigenesis by the Innate Immune Responses

(2009) Yoku Hayakawa et al.   GASTROENTEROLOGY

Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis

(2009) Y. Li et al.   GUT

Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors

(2009) Masayuki Fukata et al.   INFLAMMATORY BOWEL DISEASES

Perforin deficiency attenuates inflammation and tumor growth in colitis-associated cancer

(2009) Maximilian J. Waldner et al.   INFLAMMATORY BOWEL DISEASES

Essential Roles of IL-6 Trans-Signaling in Colonic Epithelial Cells, Induced by the IL-6/Soluble-IL-6 Receptor Derived from Lamina Propria Macrophages, on the Development of Colitis-Associated Premalignant Cancer in a Murine Model

(2009) S. Matsumoto et al.   JOURNAL OF IMMUNOLOGY

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

(2009) Shaoguang Wu et al.   NATURE MEDICINE

Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility

(2009) Joshua M. Uronis et al.   PLoS One

IL-21: roles in immunopathology and cancer therapy

(2009) H. Søndergaard et al.   TISSUE ANTIGENS

Interleukin-21 as a new therapeutic target for immune-mediated diseases

(2009) Giovanni Monteleone et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Tumor-specific Th17-polarized cells eradicate large established melanoma

(2008) P. Muranski et al.   BLOOD

Activation-Induced Cytidine Deaminase Links Between Inflammation and the Development of Colitis-Associated Colorectal Cancers

(2008) Yoko Endo et al.   GASTROENTEROLOGY

Regulation of Gut Inflammation and Th17 Cell Response by Interleukin-21

(2008) Daniele Fina et al.   GASTROENTEROLOGY

RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F

(2008) Moritz Leppkes et al.   GASTROENTEROLOGY

The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance

(2008) Paola Allavena et al.   IMMUNOLOGICAL REVIEWS

Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens

(2008) Meredith M. Curtis et al.   IMMUNOLOGY

What are toll-like receptors and what role may they have in IBD?

(2008) Masayuki Fukata et al.   INFLAMMATORY BOWEL DISEASES

Inflammation: Gearing the journey to cancer

(2008) J KUNDU et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Role of Toll-like receptors in gastrointestinal malignancies

(2008) M Fukata et al.   ONCOGENE