IL-21: roles in immunopathology and cancer therapy

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Confirmation ofSTAT4,IL2/IL21, andCTLA4polymorphisms in rheumatoid arthritis

(2009) Nina A. Daha et al.   ARTHRITIS AND RHEUMATISM

A polymorphism withinIL21Rconfers risk for systemic lupus erythematosus

(2009) Ryan Webb et al.   ARTHRITIS AND RHEUMATISM

Clinical and Biological Efficacy of Recombinant Human Interleukin-21 in Patients with Stage IV Malignant Melanoma without Prior Treatment: A Phase IIa Trial

(2009) I. D. Davis et al.   CLINICAL CANCER RESEARCH

In vivo antitumor efficacy of interleukin-21 in combination with chemotherapeutics

(2009) Kresten Skak et al.   CYTOKINE

Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice

(2009) A. P.R. Sutherland et al.   DIABETES

Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis

(2009) E A M Festen et al.   GUT

A Positive Feedback Loop of IL-21 Signaling Provoked by Homeostatic CD4+CD25- T Cell Expansion Is Essential for the Development of Arthritis in Autoimmune K/BxN Mice

(2009) E. Jang et al.   JOURNAL OF IMMUNOLOGY

IL-21: An Executor of B Cell Fate

(2009) D. Konforte et al.   JOURNAL OF IMMUNOLOGY

Interleukin-21 effectively induces apoptosis in mantle cell lymphoma through a STAT1-dependent mechanism

(2009) P Gelebart et al.   LEUKEMIA

A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice

(2009) J. A. Bubier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection

(2009) J. S. Yi et al.   SCIENCE

IL-21 Is Required to Control Chronic Viral Infection

(2009) H. Elsaesser et al.   SCIENCE

IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection

(2009) A. Frohlich et al.   SCIENCE

Angiostatic activity of the antitumor cytokine interleukin-21

(2008) K. Castermans et al.   BLOOD

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

(2008) C. S. Hinrichs et al.   BLOOD

IL-21 induces in vivo immune activation of NK cells and CD8+ T cells in patients with metastatic melanoma and renal cell carcinoma

(2008) Klaus Stensgaard Frederiksen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Interleukin 21 Enhances Antibody-Mediated Tumor Rejection

(2008) M. J. Smyth et al.   CANCER RESEARCH

Regulation of Gut Inflammation and Th17 Cell Response by Interleukin-21

(2008) Daniele Fina et al.   GASTROENTEROLOGY

With a Little Help from Their Friends: Interleukin-21, T Cells, and B Cells

(2008) Jonathan S. Silver et al.   IMMUNITY

IRF-4-Binding Protein Inhibits Interleukin-17 and Interleukin-21 Production by Controlling the Activity of IRF-4 Transcription Factor

(2008) Qinzhong Chen et al.   IMMUNITY

IL-21 promotes survival and maintains a naive phenotype in human CD4+ T lymphocytes

(2008) Sylvie Ferrari-Lacraz et al.   INTERNATIONAL IMMUNOLOGY

Phase I Study of Recombinant Interleukin-21 in Patients With Metastatic Melanoma and Renal Cell Carcinoma

(2008) John A. Thompson et al.   JOURNAL OF CLINICAL ONCOLOGY

The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells

(2008) Thomas Y. Wuest et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interleukin 21: combination strategies for cancer therapy

(2008) Kresten Skak et al.   NATURE REVIEWS DRUG DISCOVERY

IL-21 signaling is critical for the development of type I diabetes in the NOD mouse

(2008) R. Spolski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutralizing IL-21 and IL-15 Inhibits Pro-inflammatory Cytokine Production in Rheumatoid Arthritis

(2008) A. K. Andersson et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

(2007) Rosanne Spolski et al.   Annual Review of Immunology