Article
Biochemistry & Molecular Biology
Anita Singh, Sara Busacca, Aarti Gaba, Michael Sheaff, Charlotte Poile, Apostolos Nakas, Joanna Dzialo, Aleksandra Bzura, Alan G. G. Dawson, Dean A. A. Fennell, Andrew M. M. Fry
Summary: This study identifies the tumour suppressor gene BAP1 as frequently mutated in mesothelioma and reveals novel functions for BAP1 in mitotic progression, highlighting its role in genome stability control with therapeutic implications. Depletion of BAP1 leads to proteasome-mediated degradation of BRCA1, mitotic defects similar to BRCA1 loss, and additional changes including abnormal spindle length and enhanced growth of astral microtubules. These consequences are explained by the loss of KIF18A and KIF18B expression, which can be rescued by their re-expression. Therefore, inactivation of BAP1 causes mitotic defects through both BRCA1-dependent and independent mechanisms, suggesting new pathways for genome instability and altered response to microtubule-targeted agents in BAP1-deficient mesothelioma cells.
Article
Biochemistry & Molecular Biology
Linchang Dai, Yaxin Dai, Jinhua Han, Yan Huang, Longge Wang, Jun Huang, Zheng Zhou
Summary: The study reveals the mechanism of BRCA1-BARD1 complex recruitment and retention by DSB-flanking nucleosomes, shedding light on cancer therapeutic avenues.
Article
Biology
Marion Rosello, Juliette Vougny, Francois Czarny, Marina C. Mione, Jean-Paul Concordet, Shahad Albadri, Filippo Del Bene
Summary: Researchers have successfully generated precise point mutations in zebrafish models using gene editing technology, mimicking oncogenic mutations in human genes and creating new disease models.
Article
Multidisciplinary Sciences
Scisung Chung, Mi-Sun Kang, Dauren S. Alimbetov, Gil-Im Mun, Na-Oh Yunn, Yunjin Kim, Byung-Gyu Kim, Minwoo Wie, Eun A. Lee, Jae Sun Ra, Jung-Min Oh, Donghyun Lee, Keondo Lee, Jihan Kim, Seung Hyun Han, Kyong-Tai Kim, Wan Kyun Chung, Ki Hyun Nam, Jaehyun Park, ByungHoon Lee, Sunghoon Kim, Weixing Zhao, Sung Ho Ryu, Yun-Sil Lee, Kyungjae Myung, Yunje Cho
Summary: The structure of the vertebrate IARS1 and EARS1 complex reveals that IARS1 protects BRCA1 from degradation via its UBX-fold domain. This study provides insights into the non-translational functions of aminoacyl-tRNA synthetases and the regulation of DNA repair.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Jianjie Li, Xiaodong Shu, Jun Xu, Sek Man Su, Un In Chan, Lihua Mo, Jianlin Liu, Xin Zhang, Ragini Adhav, Qiang Chen, Yuqing Wang, Tingting An, Xu Zhang, Xueying Lyu, Xiaoling Li, Josh Haipeng Lei, Kai Miao, Heng Sun, Fuqiang Xing, Aiping Zhang, Chuxia Deng, Xiaoling Xu
Summary: This study explores the mechanism behind the poor response to immune checkpoint blockade in breast cancers caused by BRCA1 deficiency. The authors identify the activation of S100A9-CXCL12 signaling and the accumulation of myeloid-derived suppressor cells as contributing factors. They also demonstrate that the combination of inhibitors targeting S100A9-CXCL12 signaling and alpha PD-1 antibody can effectively suppress the oncogenic actions and improve immunotherapy response.
NATURE COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Karim Taouis, Sophie Vacher, Josee Guirouilh-Barbat, Jacques Camonis, Etienne Formstecher, Tatiana Popova, Anne-Sophie Hamy, Ambre Petitalot, Rosette Lidereau, Sandrine M. Caputo, Sophie Zinn-Justin, Ivan Bieche, Keltouma Driouch, Francois Lallemand
Summary: The WWOX tumor suppressor gene is located in an unstable chromosomal region and its expression is decreased or absent in various types of cancer, including breast cancer. Recent studies have shown that WWOX plays a role in maintaining genome stability through its involvement in the DNA damage response. It inhibits homologous recombination in breast cancer cells and promotes DNA repair through non-homologous end joining. Additionally, WWOX has been found to interact with MERIT40, preventing excessive homologous recombination activity and its associated deleterious impact on breast cancer development.
CANCER GENE THERAPY
(2023)
Article
Cell Biology
Kailing Zhou, Yu Sun, Dan Dong, Chenghai Zhao, Wei Wang
Summary: EMP3 acts as a potential tumor suppressor in breast cancer by inhibiting cell cycle progression, DNA repair, and stem-like properties, leading to enhanced sensitivity of breast cancer cells to DNA-damaging agents.
CELL DEATH & DISEASE
(2021)
Editorial Material
Hematology
Ian J. Majewski
Summary: The study investigates how loss of the tumor suppressor gene Cux1 modulates DNA repair activity in the hematopoietic compartment and contributes to the pathogenesis of therapy-related myeloid neoplasms.
Article
Neurosciences
Feifei Luo, Yifu Liao, Endong Cao, Yong Yang, Kai Tang, Dexiang Zhou, Dong Zhou, Haiping Cai
Summary: This study found that HIC2 gene is hypermethylated and expressed at low levels in glioma. Hypermethylation and low expression of HIC2 predict poor prognosis. Further experiments showed that HIC2 inhibits glioma proliferation in vitro and in vivo by interacting with RNF44 and PTPRN2.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Oncology
Tianyuan Liu, Xuan Zhao, Yuan Lin, Qi Luo, Shaosen Zhang, Yiyi Xi, Yamei Chen, Lin Lin, Wenyi Fan, Jie Yang, Yuling Ma, Alok K. Maity, Yanyi Huang, Jianbin Wang, Jiang Chang, Dongxin Lin, Andrew E. Teschendorff, Chen Wu
Summary: This study develops a computational strategy to identify stem-like preneoplastic cells that may drive cancer progression by dissecting the heterogeneity of differentiation states within a preneoplastic cell population.
Review
Oncology
Kung-Kai Kuo, Pi-Jung Hsiao, Wen-Tsan Chang, Shih-Chang Chuang, Ya-Han Yang, Kenly Wuputra, Chia-Chen Ku, Jia-Bin Pan, Chia-Pei Li, Kohsuke Kato, Chung-Jung Liu, Deng-Chyang Wu, Kazunari K. Yokoyama
Summary: Tumor suppressor genes play critical roles in cancer development, with loss of function or mutations contributing to abnormal cell growth, differentiation, and cancer progression. Understanding the roles of tumor suppressor gene products and identifying novel therapeutic targets are crucial for combating aggressive cancers like pancreatic cancer.
Article
Oncology
Rick A. C. M. Boonen, Wouter W. Wiegant, Nandi Celosse, Bas Vroling, Stephan Heijl, Zsofia Kote-Jarai, Martina Mijuskovic, Simona Cristea, Nienke Solleveld-Westerink, Tom van Wezel, Niko Beerenwinkel, Rosalind Eeles, Peter Devilee, Maaike P. G. Vreeswijk, Giancarlo Marra, Haico van Attikum
Summary: This study describes a method using mouse embryonic stem cells to quantitatively determine the functional impact of 50 uncertain missense variants in the gene CHEK2. The results show that some missense variants impair protein function to a similar extent as truncating variants and are associated with an increased risk of breast cancer.
Article
Chemistry, Analytical
Yong Wang, Dandan Wang, Guohua Qi, Ping Hu, Erkang Wang, Yongdong Jin
Summary: In this study, a gold nanoparticles nanomembrane-modified plasmonic glass nanopipette surface-enhanced Raman scattering (SERS) sensing platform was constructed to sensitively detect the content variation of intracellular miRNA-21. The proposed method provides a simple way to study intracellular substance change and evaluate cancer treatment outcomes.
ANALYTICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Rakesh Srivastava, Niraj Lodhi
Summary: Mammalian genomic DNA methylation is an important epigenetic modification that regulates gene expression during development. Aberrant DNA methylation can lead to various inheritable diseases, including cancer. Recent research has uncovered the dynamic regulation of DNA methylation and emphasized the role of PARP1 enzyme in its maintenance.
Article
Multidisciplinary Sciences
Yan Guo, Alison. A. Chomiak, Ye Hong, Clara C. Lowe, Caroline A. Kopsidas, Wen-Ching Chan, Jorge Andrade, Hongna Pan, Xiaoming Zhou, Edwin S. Monuki, Yuanyi Feng
Summary: Aging is a complex process consisting of multiple characteristics, including stem cell exhaustion, genome instability, epigenetic alterations, impaired protein regulation, and cellular senescence. This study reveals that inhibiting the protein Brap, which is essential for neurogenesis, leads to persistent DNA damage and increased levels of histone H2Aub, resulting in cellular senescence, proteasome-mediated histone H2A degradation, and changes in cellular proteomic and epigenetic states. Deletion of Brap in the mouse brain causes neuroinflammation, impaired protein regulation, accelerated neurodegeneration, and significantly reduced lifespan. The study also finds elevated levels of H2Aub in human brain tissues with Alzheimer's disease, suggesting that H2Aub-mediated chromatin aberrations may contribute to multiple aging characteristics and tissue-wide degeneration.
Article
Biochemistry & Molecular Biology
Opeyemi Joshua Olatunji, Oladipupo Odunayo Olatunde, Titilope John Jayeoye, Sudarshan Singh, Sirinporn Nalinbenjapun, Sasikarn Sripetthong, Warangkana Chunglok, Chitchamai Ovatlarnporn
Summary: This study investigated the antioxidant, antimicrobial, anticancer, and phytochemical profiling of extracts from the leaves and stem/root of Acanthus ebracteatus. The results showed that the extracts contained various bioactive compounds and exhibited high antioxidant and anticancer activities.
Article
Biochemistry & Molecular Biology
Sobia Tabassum, Saeed Ahmad, Kashif Ur Rehman Khan, Fouzia Tabassum, Anjum Khursheed, Qamar Uz Zaman, Najat A. Bukhari, Alanoud Alfagham, Ashraf A. Hatamleh, Yinglong Chen
Summary: The study aimed to investigate the phytochemical composition of Portulacaria afra and evaluate its potential in antioxidant, anticoagulant, anti-inflammatory, and enzyme-inhibitory activities. The results demonstrated that P. afra extracts exhibited high antioxidant activity and could inhibit clotting and inflammation.
Article
Chemistry, Physical
Gabriela Gastelu, David Savary, Martin Hulla, Daniel Ortiz, Jorge G. Uranga, Paul J. Dyson
Summary: The article introduces an alternative reaction pathway for the O-formylation of alcohols and bio-alcohols, which produces industrially relevant formate esters. The reaction is catalyzed by formic acid, which can be produced from CO2 captured in the reaction. The in situ produced formic acid improves the reaction rate, and each catalyst can be recycled for reuse.
Article
Chemistry, Multidisciplinary
Jawaher Al-Qahtani, Aliza Abbasi, Hanan Y. Aati, Areej Al-Taweel, Ali Al-Abdali, Sultan Aati, Atheer N. Yanbawi, Mohsin Abbas Khan, Bilal Ahmad Ghalloo, Mariyam Anwar, Kashif-ur-Rehman Khan
Summary: Ficus palmata is a medicinally valuable plant that is commonly used in folk medicine for treating various diseases. The phytochemical composition, antioxidant potential, enzyme inhibition, antimicrobial activity, thrombolytic activity, and anticancer potential of the plant extract were evaluated. The extract exhibited high total phenolic and flavonoid contents, and showed significant activities in terms of antiviral, antifungal, antibacterial, and anticancer effects. The study also conducted molecular docking and ADMET studies to analyze the binding affinity and pharmacokinetic properties of the identified phytocompounds. The research demonstrated the potential of Ficus palmata as a source of bioactive compounds for new drug development.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Editorial Material
Chemistry, Organic
Xiao-Feng Wu, Paul J. Dyson, Bruce A. Arndtsen
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Lorenzo Pietracci, Riccardo Pettinari, Alessia Tombesi, Fabio Marchetti, Claudio Pettinari, Agustiïn Galindo, Farzaneh Fadaei-Tirani, Mouna Hadiji, Paul J. Dyson
Summary: This study investigates the coordination mechanisms of pyrazolone ligands containing a pyridine ring with the (Ru(II)) fragment through experimental and theoretical calculations. The ligands were found to coordinate in an unusual N,O-chelating fashion with Ru(II), and various complexes were synthesized. The study provides important insights into the properties of the ligands and complexes.
Article
Chemistry, Inorganic & Nuclear
Alfonso Annunziata, Maria Elena Cucciolito, Maddalena Di Ronza, Giarita Ferraro, Mouna Hadiji, Antonello Merlino, Daniel Ortiz, Rosario Scopelliti, Farzaneh Fadaei Tirani, Paul J. Dyson, Francesco Ruffo
Summary: This article reports a series of Ruthenium(II) complexes with a three-legged piano-stool structure based on an arene ring and an N-heterocyclic carbene(NHC)-carbene ligand with a peracetylated glucose moiety. The complexes undergo hydrolysis in water and show reactivity towards model nucleophiles and biological macromolecules. However, they exhibit low anti-tumor activity against human ovarian carcinoma cells and cisplatin-resistant cells.
Article
Chemistry, Multidisciplinary
Shunlin Zhang, Yuxin Xie, Rosie J. J. Somerville, Farzaneh Fadaei Tirani, Rosario Scopelliti, Zhaofu Fei, Dunru Zhu, Paul J. J. Dyson
Summary: This study reports a new family of proton conductors based on MIL-101 and protic ionic liquid polymers (PILPs) containing different anions. The PILP@MIL-101 composites maintain the nanoporous cavities and water stability of MIL-101, while providing much-improved proton transport. The PILP@MIL-101 composite with HSO4- anions shows superprotonic conductivity (6.3 x 10(-2) S cm(-1)) at 85 degrees C and 98% relative humidity.
Article
Chemistry, Multidisciplinary
Haodan Guo, Yanyan Fang, Yan Lei, Jinpeng Wu, Minghua Li, Xiangrong Li, Hong Bo Cheng, Yuan Lin, Paul J. Dyson
Summary: This study demonstrates the use of a self-assembled ionic insulating layer to improve the performance of wide-bandgap perovskite solar cells. The layer effectively suppresses halide phase separation, reducing open-circuit voltage loss and improving device stability.
Article
Multidisciplinary Sciences
Mingyang Liu, Paul J. Dyson
Summary: Efficient valorization of lignin, a sustainable and renewable source, is essential for reducing dependence on fossil-derived feedstocks. This study presents a highly efficient strategy for extracting aromatic monomers and generating functionalized diaryl ethers from lignin using oxidative cross-coupling reactions.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Gabriela Gastelu, Pritha Saha, Paul J. Dyson, Martin Hulla, Jorge G. Uranga
Summary: Autocatalytic reactions play a key role in the beginning of life and carbon capture and utilization, providing inspiration for the development of advanced systems for the synthesis of value-added chemicals.
Article
Chemistry, Multidisciplinary
Yue Hu, Xinmin Li, Mingyang Liu, Stephan Bartling, Henrik Lund, Paul J. Dyson, Matthias Beller, Rajenahally V. Jagadeesh
Summary: Catalytic hydrodeoxygenation is a crucial technology for converting biomass-based feedstocks into essential chemicals and fuels. This study reports the preparation and application of Ni nanoparticles supported on ZSM-5 as an efficient hydrodeoxygenation catalyst. The Ni-based nanoparticles exhibit selective hydrodeoxygenation of various functional substrates, showcasing their versatility.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Patrick Doerflinger, Yong Ding, Valentin Schmid, Melina Armer, Roland C. Turnell-Ritson, Bin Ding, Paul J. Dyson, Mohammad Khaja Nazeeruddin, Vladimir Dyakonov
Summary: This study investigates the effect of a stabilizing additive on the charge carrier mobility and lifetime in triple cation perovskite thin films under thermal stress. The results reveal different conductivity behaviors in two temperature regions and identify two dominant scattering mechanisms. The stabilizing additive limits temperature-activated mobile ions and retards degradation of the perovskite film, leading to improved performance and stability.
Article
Chemistry, Inorganic & Nuclear
Sarah A. P. Pereira, Jan Romano-deGea, Ana Isabel Barbosa, Sofia A. Costa A. Lima, Paul J. J. Dyson, M. Lucia M. F. S. Saraiva
Summary: The study demonstrates that ruthenium-based compounds, especially [Ru(& eta;(6)-toluene)(PPh3)(2)Cl]Cl, show high selectivity and cytotoxicity against breast cancer cells. This compound has potential as a promising candidate for breast cancer treatment.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Alberto Gobbo, Sarah A. P. Pereira, Lorenzo Biancalana, Stefano Zacchini, M. Lucia M. F. S. Saraiva, Paul J. Dyson, Fabio Marchetti
Summary: Compared with Ru-II-arene compounds, the medicinal potential of homologous Ru-II-tpm compounds [tpm = tris(pyrazolyl)methane] is not well explored. A series of [RuCl(kappa(3)-tpm)(PPh3)(L)]Cl complexes were synthesized by reacting pyridine, 4-pyridinemethanol, and four functionalized pyridines with the precursor [RuCl(kappa(3)-tpm)(PPh3)(2)]Cl. The complexes exhibited antiproliferative activity against cancerous cell lines and inhibition towards COX-2 and GSTP1 enzymes.
DALTON TRANSACTIONS
(2022)