Review
Biochemistry & Molecular Biology
Magdalena Jurczyk, Janusz Kasperczyk, Dorota Wrzesniok, Artur Beberok, Katarzyna Jelonek
Summary: There is a growing interest in the use of chemosensitizers and cytostatics in combination to overcome cancer resistance to treatment. To overcome challenges such as poor bioavailability and chemical instability of drugs, attempts have been made to create nanoparticles for the delivery of docetaxel (Dtx) and resveratrol (Res). Recent reports suggest that nano-delivery systems for Dtx and Res exhibit better efficiency in cancer treatment than free drugs, and the simultaneous release of both drugs in cancer cells may help overcome limitations caused by multidrug resistance.
Article
Biophysics
Rajesh Singh Jadon, Gajanand Sharma, Neeraj K. Garg, Nikunj Tandel, Kavita R. Gajbhiye, Rajesh Salve, Virendra Gajbhiye, Ujjawal Sharma, Om Prakash Katare, Manoj Sharma, Rajeev K. Tyagi
Summary: The study developed pH-sensitive lipid polymer hybrid nanoparticles (pHS-LPHNPs) for specific cytosolic delivery of DTX, showing improved cellular uptake, cytotoxicity, and therapeutic efficacy against breast cancer cells, making it a promising platform for breast cancer therapeutic interventions.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Shruti Rawal, Shubham Khot, Vivek Bora, Bhoomika Patel, Mayur M. Patel
Summary: This study develops an orally administrable, folate-receptor-targeted Nanostructured lipid carriers (NLCs) of Docetaxel (DX) to overcome the bioavailability and toxicity issues of intravenous administration in lung cancer chemotherapy, showing promising antitumor efficacy and safety.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Vijay Sagar Madamsetty, Shima Tavakol, Saeid Moghassemi, Arezoo Dadashzadeh, John D. Schneible, Iman Fatemi, Abdolsamad Shirvani, Ali Zarrabi, Fereshteh Azedi, Ali Dehshahri, Abbas Aghaei Afshar, Kian Aghaabbasi, Abbas Pardakhty, Reza Mohammadinejad, Prashant Kesharwani
Summary: Breast cancer is a highly deadly neoplastic disease with limited efficacy in existing treatment methods, prompting a search for new remedies. Nanotechnology has shown promise in the field, particularly with chitosan as a potential carrier for anticancer drugs. Further research is ongoing to explore the therapeutic and diagnostic applications of chitosan in breast cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Manuela Curcio, Matteo Brindisi, Giuseppe Cirillo, Luca Frattaruolo, Antonella Leggio, Vittoria Rago, Fiore Pasquale Nicoletta, Anna Rita Cappello, Francesca Iemma
Summary: In this study, actively-targeted and dual stimuli-responsive lipid-polymer nanoparticles were used to deliver doxorubicin hydrochloride in triple negative breast cancer cell lines. The nanoparticles were efficiently internalized in cancer cells and modulated drug release based on the surrounding pH and redox potential. In vitro experiments demonstrated the safety and efficacy of the nanoparticles in enhancing the cytotoxic effect of the anticancer drug.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Environmental Sciences
B. H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Saad Ali Alshehri, Shadma Wahab, Lalitkumar K. Vora, Raghu Raj Singh Thakur, Prashant Kesharwani
Summary: Lyotropic liquid crystals, specifically cubosomes, are highly promising drug carriers due to their self-assembled, non-lamellar, and mesophase nanostructured properties. Cubosomes exhibit bicontinuous structures formed through the self-organization of amphiphilic lipids and stabilization using steric polymers. They have shown superior entrapment efficiency and stability for hydrophobic drugs compared to liposomes. Additionally, cubosomes have been extensively explored for their safe and effective delivery of therapeutic and contrast agents in cancer treatment and imaging.
ENVIRONMENTAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Zhengxing Su, Jinlong Zhao, Xi Zhao, Jia Xie, Ming Li, Dong Zhao
Summary: A novel albumin-bound docetaxel nanoparticle formulation was developed to improve the solubility and anticancer efficacy of docetaxel. The nanoparticles exhibited similar pharmacokinetic profiles, safety profiles, and superior anticancer efficacy compared to Docetaxel Injection. This study demonstrated the potential of albumin-bound docetaxel nanoparticles for reducing toxicity and enhancing efficacy in clinical applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Kyumin Mo, Ayoung Kim, Soohyun Choe, Miyoung Shin, Hyunho Yoon
Summary: Lipid nanoparticles (LNPs) composed of ionized lipids, helper lipids, and cholesterol have potential for gene therapies and vaccines by facilitating intracellular transport and avoiding endosomal compartments. Solid lipid nanoparticles (SLNs) derived from physiologically acceptable lipids provide high structural stability and biocompatibility, and have been used to enhance drug delivery for cancer treatments. SLNs have shown promising results in breast cancer treatment, improving the therapeutic efficacy of drugs.
Article
Pharmacology & Pharmacy
Faezeh Andisheh, Fatemeh Oroojalian, Neda Shakour, Mohammad Ramezani, Jamal Shamsara, Elham Khodaverdi, Hooriyeh Nassirli, Farzin Hadizadeh, Mona Alibolandi
Summary: This study successfully synthesized targeted micelles that exhibited higher cytotoxicity against breast cancer cells compared to non-targeted micelles, with in vivo experiments confirming their superior antitumor efficacy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Applied
Wenjia Wang, Xiaoqin Zhang, Zhiqian Li, Dayi Pan, Hongyan Zhu, Zhongwei Gu, Jie Chen, Hu Zhang, Qiyong Gong, Kui Luo
Summary: A novel stimuli-responsive dendronized hyaluronic acid-docetaxel conjugate was designed to achieve targeted delivery of anti-tumor drugs with enhanced biocompatibility into tumor tissues. The design not only improved therapeutic outcomes but also reduced toxicity, making it an efficacious nano-agent for treating triple negative breast cancer.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Multidisciplinary
Sherif Ashraf Fahmy, Soad Nasr, Asmaa Ramzy, Abdelhameed S. Dawood, Anwar Abdelnaser, Hassan Mohamed El-Said Azzazy
Summary: Loading ascorbic acid (AA) and geranium oil (GO) into niosomal nanovesicles can improve their physicochemical properties and enhance their cytotoxic effects on breast cancer cells. The AA-GO niosomal vesicles showed higher inhibitory effects on cancer cell growth and induced apoptosis compared to free AA or GO, suggesting their potential as a treatment strategy for breast cancer.
Article
Pharmacology & Pharmacy
Gajendra Singh Thakur, Charu Misra, Nagarani Thotakura, Ahmed Al Saqr, Saud Almawash, Simran Preet, Kaisar Raza
Summary: The study developed a novel chitosan-based nanoconjugate for intravenous drug delivery to enhance the therapeutic efficacy of docetaxel. The system showed superior efficacy on cancer cells compared to the naive drug, improved drug bioavailability, and enhanced hemocompatibility.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Tianli Luo, Qizhen Zheng, Leihou Shao, Tianyu Ma, Lanqun Mao, Ming Wang
Summary: Rationally designed GPX4 degrader can enhance ferroptosis induction efficiency, while the intracellular delivery of this degrader using biodegradable lipid nanoparticles enables cell-selective ferroptosis induction.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Pharmacology & Pharmacy
Raghu Solanki, Bhavana Jodha, Kleopatra Eligy Prabina, Niharika Aggarwal, Sunita Patel
Summary: Breast cancer is the most common cancer in women worldwide. Phytochemicals have been explored as potential chemotherapeutic options. However, their poor solubility and gastrointestinal instability have limited their bioavailability, hence, utilizing nano-drug delivery systems is seen as a strategy to enhance their efficacy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiangjun Chen, Mingyi Hou, Xinzhong Zhang, Haixin Liu, Wenting Li, Wei Hong
Summary: Nanoscale structures have been developed for various functions in cancer therapy, including diagnosis, biomedical visualization, tissue regeneration, and drug delivery. By using biocompatible chitosan oligosaccharides and gold nanorods, a drug delivery system was designed that effectively delivered drugs to tumor sites and selectively targeted cancer cells. The system also had drug release capability and magnetic resonance imaging functionality, showing promising outcomes for tumor diagnosis and treatment.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Elisa Poyatos-Racionero, Isabel Gonzalez-Alvarez, Paola Sanchez-Moreno, Leopoldo Sitia, Francesca Gatto, Pier Paolo Pompa, Elena Aznar, Marta Gonzalez-Alvarez, Ramon Martinez-Manez, Maria Dolores Marcos, Andrea Bernardos
Summary: By specifically controlling the release of essential oil components in the small intestine, the M41-payload-L microdevice may have potential as a hybrid system for protecting and administering bioactive molecules in the small intestine and colon.
Article
Biochemistry & Molecular Biology
Carlos Garcia-Padilla, Jorge N. Dominguez, Valeria Lodde, Rachel Munk, Kotb Abdelmohsen, Myriam Gorospe, Veronica Jimenez-Sabado, Antonino Ginel, Leif Hove-Madsen, Amelia E. Aranega, Diego Franco
Summary: Atrial fibrillation (AF) is the most common cardiac arrhythmia in humans. Recent research shows that the Pitx2 transcription factor plays a crucial role in regulating the expression of growth factors, microRNAs, and ion channels, which contribute to the onset of AF. Additionally, several lncRNAs have been discovered to be involved in AF development and are regulated by different signaling pathways.
Review
Pharmacology & Pharmacy
Marina Martin-Contreras, Saul A. Navarro-Marchal, Jose Manuel Peula-Garcia, Ana Belen Jodar-Reyes
Summary: Nanomedicine holds great promise for cancer diagnosis, prevention, and treatment. However, there are still hurdles that need to be overcome for its clinical application, which are discussed in this review.
Article
Cell Biology
Carlos Garcia-Padilla, Francisco Hernandez-Torres, Estefania Lozano-Velasco, Angel Duenas, Maria del Mar Munoz-Gallardo, Isabel S. Garcia-Valencia, Lledo Palencia-Vincent, Amelia Aranega, Diego Franco
Summary: Bmp and Fgf signaling are involved in embryonic development, and their modulation of microRNAs plays a crucial role in regulating cell fate during cardiomyogenesis and PE/ST development. However, the role of Bmp and Fgf signaling in mouse PE/ST development is different from that in chicken, and their impact on cardiomyogenesis and fibrogenesis is limited. Species-specific differences in regulating PE/ST cardiomyogenic lineage commitment are supported by the data.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Carlos Garcia-Padilla, Angel Duenas, Diego Franco, Virginio Garcia-Lopez, Amelia Aranega, Virginio Garcia-Martinez, Carmen Lopez-Sanchez
Summary: MicroRNAs play a role in cellular specification and differentiation during embryonic development, including the cardiovascular system. This study analyzed the expression profiles of different microRNAs during early cardiac development and identified dynamic expression patterns. The sinus venosus/inflow tract was found to be the most representative cardiac area for the convergent expression of the microRNAs. In silico analysis revealed potential target genes of the microRNAs within the Hox family. Functional experiments demonstrated the modulation of Hox genes by the microRNAs. This study provides insights into the role of microRNAs in Hox gene modulation during heart development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cristina Sanchez-Fernandez, Lara Rodriguez-Outeirino, Lidia Matias-Valiente, Felicitas Ramirez de Acuna, Francisco Hernandez-Torres, Estefania Lozano-Velasco, Jorge N. Dominguez, Diego Franco, Amelia Eva Aranega
Summary: The epicardium plays a crucial role in heart development, contributing to the formation of different cell types and supporting cardiac growth. It is also involved in cardiac remodeling after damage. However, the molecular mechanisms and heterogeneity of epicardial cells are not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Carlos Garcia-Padilla, Virginio Garcia-Lopez, Amelia Aranega, Diego Franco, Virginio Garcia-Martinez, Carmen Lopez-Sanchez
Summary: miR-133a plays a crucial role in the early development of the posterior cardiac tube by repressing RhoA and Cdc42 and regulating the expression of cardiac markers. Retinoic acid negatively regulates miR-133a and affects the expression of Raldh2, Tbx5, and AMHC1. Thus, miR-133a may serve as a potential therapeutic tool for the diagnosis, therapy, and prognosis of cardiac diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jaime Gomez-Morales, Raquel Fernandez-Penas, Francisco Javier Acebedo-Martinez, Ismael Romero-Castillo, Cristobal Verdugo-Escamilla, Duane Choquesillo-Lazarte, Lorenzo Degli Esposti, Yaiza Jimenez-Martinez, Jorge Fernando Fernandez-Sanchez, Michele Iafisco, Houria Boulaiz
Summary: This study successfully prepared luminescent and biomimetic Tb3+-doped citrate-functionalized carbonated apatite nanoparticles, showcasing excellent biocompatibility and luminescence properties for bioimaging applications. These nanoparticles were synthesized using a citrate-based thermal decomplexing precipitation method, with the ability to visualize intracellular uptake without the need for additional fluorescence dyes.
Article
Pharmacology & Pharmacy
Alima Murtazina, Gloria Ruiz Alcala, Yaiza Jimenez-Martinez, Juan Antonio Marchal, Anel Tarabayeva, Elmira Bitanova, Gordon McDougall, Nazira Bishimbayeva, Houria Boulaiz
Summary: The fractions of wheat cell culture polysaccharides showed anti-cancer capacity in colorectal cancer by inhibiting cell proliferation, inducing apoptosis, and enhancing cell differentiation. The study suggests the potential therapeutic value of these polysaccharides in treating colon cancer.
Review
Biochemistry & Molecular Biology
Carlos Garcia-Padilla, Estefania Lozano-Velasco, Maria del Mar Munoz-Gallardo, Juan Manuel Castillo-Casas, Sheila Cano-Carrillo, Francisco Jose Martinez-Amaro, Virginio Garcia-Lopez, Amelia Aranega, Diego Franco, Virginio Garcia-Martinez, Carmen Lopez-Sanchez
Summary: This review analyzes the impact of LncRNA H19 on chemotherapy and radiotherapy in breast cancer, lung adenocarcinoma, glioma, and colorectal carcinoma, as well as its oncogenic and protective roles in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Carlos Garcia-Padilla, Estefania Lozano-Velasco, Virginio Garcia-Lopez, Amelia Aranega, Diego Franco, Virginio Garcia-Martinez, Carmen Lopez-Sanchez
Summary: Heart failure is a complex clinical syndrome with increasing prevalence, and finding new molecular biomarkers is an interesting tool to improve its prevention, diagnosis, treatment, and prognosis. This review emphasizes the relevance of microRNAs, long non-coding RNAs, and circular RNAs as potential biomarkers in heart failure. Further studies in this field are crucial to support their widespread clinical use.
Article
Oncology
Maria Belen Garcia-Ortega, Ernesto Aparicio, Carmen Grinan-Lison, Gema Jimenez, Elena Lopez-Ruiz, Jose Luis Palacios, Gloria Ruiz-Alcala, Cristina Alba, Antonio Martinez, Houria Boulaiz, Macarena Peran, Michael Hackenberg, Jose Braganca, Sofia M. Calado, Juan A. Marchal, Maria Angel Garcia
Summary: Malignant melanoma is aggressive and resistant due to the presence of cancer stem cells (CSCs). This study evaluated the effect of interferon-alpha (IFN-a) treatments on melanoma CSCs and explored potential biomarkers. Low doses of IFN-a reduced CSC formation, stemness properties, and tumor formation ability in mice xenotransplants. IFN-a also modulated the expression of genes, microRNAs, and metabolomics in melanoma cells and exosomes. These findings suggest further investigations of new dose and combination approaches for IFN-a in melanoma treatment.
Review
Cardiac & Cardiovascular Systems
Cristina Sanchez-Fernandez, Lara Rodriguez-Outeirino, Lidia Matias-Valiente, Felicitas Ramirez de Acuna, Diego Franco, Amelia Eva Aranega
Summary: The epicardium is an essential cell population in the outermost layer of the heart, contributing to the formation of different cell types and providing signals for cardiac development. While quiescent during adulthood, the epicardium can reactivate and play a role in cardiac tissue remodeling after injury. However, it is still unclear whether the epicardium-derived cells come from specific subpopulations or a common progenitor. Further research is needed to understand the complexity of the epicardium.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Carlos Garcia-Padilla, Maria del Mar Munoz-Gallardo, Estefania Lozano-Velasco, Juan Manuel Castillo-Casas, Sheila Cano-Carrillo, Virginio Garcia-Lopez, Amelia Aranega, Diego Franco, Virginio Garcia-Martinez, Carmen Lopez-Sanchez
Summary: The cytoskeleton is crucial for cell architecture and signal transduction in biological processes. It consists of actin filaments, microtubules, and intermediate filaments. Dysregulation of the cytoskeleton is associated with cancer. Long non-coding RNAs (lncRNAs) have been identified as potential regulators of the cytoskeleton and play a role in cancer pathogenesis.
Review
Biochemistry & Molecular Biology
Carlos Garcia-Padilla, Estefania Lozano-Velasco, Carmen Lopez-Sanchez, Virginio Garcia-Martinez, Amelia Aranega, Diego Franco
Summary: All-trans retinoic acid (RA) plays a crucial role in various biological processes such as cell growth and differentiation, embryonic development, and organogenesis. Due to its high dose-dependent nature, a precise regulatory mechanism is necessary for RA signaling. Dysregulation of RA signaling has significant impacts on development and diseases, often related to oncogenic processes.