Amelioration of hypoxia and LPS-induced intestinal epithelial barrier dysfunction by emodin through the suppression of the NF-κB and HIF-1α signaling pathways

Ischemia–Reperfusion Injury Induces Occludin Phosphorylation/Ubiquitination and Retinal Vascular Permeability in a VEGFR-2-Dependent Manner

(2014) Arivalagan Muthusamy et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Protective Role of Oligomycin Against Intestinal Epithelial Barrier Dysfunction Caused by IFN-? and TNF-a

(2013) Hang Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Effects of Nitric Oxide and Reactive Oxygen Species on HIF-1a Stabilization FollowingClostridium DifficileToxin Exposure of the Caco-2 Epithelial Cell Line

(2013) Joshua Y. Lee et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Overexpression of Hypoxia-Inducible Factor-1a Exacerbates Endothelial Barrier Dysfunction Induced by Hypoxia

(2013) Pei Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

On the Physiological Role of Cytosolic 5’-nucleotidase II (cN-II): Pathological and Therapeutical Implications.

(2013) M. Tozzi et al.   CURRENT MEDICINAL CHEMISTRY

Effect of Emodin on Endoplasmic Reticulum Stress in Rats with Severe Acute Pancreatitis

(2013) Li Wu et al.   INFLAMMATION

Interferon-γ-Induced Intestinal Epithelial Barrier Dysfunction by NF-κB/HIF-1α Pathway

(2013) Songwei Yang et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

IL-4 reduces the proangiogenic capacity of macrophages by down-regulating HIF-1  translation

(2013) N. Dehne et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Low doses of Celecoxib attenuate gut barrier failure during experimental peritonitis

(2013) Scott S Short et al.   LABORATORY INVESTIGATION

Hydroxylases as therapeutic targets in inflammatory bowel disease

(2013) Eoin P Cummins et al.   LABORATORY INVESTIGATION

Phospholipase D1 Has a Pivotal Role in Interleukin-1 -Driven Chronic Autoimmune Arthritis through Regulation of NF- B, Hypoxia-Inducible Factor 1 , and FoxO3a

(2013) D. W. Kang et al.   MOLECULAR AND CELLULAR BIOLOGY

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

In Vitro and in Vivo Studies of the Inhibitory Effects of Emodin Isolated from Polygonum cuspidatum on Coxsakievirus B4

(2013) Zhao Liu et al.   MOLECULES

Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis

(2013) S Keely et al.   Mucosal Immunology

Fundamental role for HIF-1α in constitutive expression of human β defensin-1

(2013) C J Kelly et al.   Mucosal Immunology

Amelioration of IFN-γ and TNF-α-Induced Intestinal Epithelial Barrier Dysfunction by Berberine via Suppression of MLCK-MLC Phosphorylation Signaling Pathway

(2013) Min Cao et al.   PLoS One

Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis

(2013) L. E. Glover et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emodin suppresses inflammatory responses and joint destruction in collagen-induced arthritic mice

(2013) Jin-Ki Hwang et al.   RHEUMATOLOGY

Characteristics of emodin on modulating the contractility of jejunal smooth muscle

(2012) Dapeng Chen et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Regulation of intestinal epithelial permeability by tight junctions

(2012) Takuya Suzuki   CELLULAR AND MOLECULAR LIFE SCIENCES

Hypoxia increases CX3CR1 expression via HIF-1 and NF-κB in androgen-independent prostate cancer cells

(2012) LI-JIE XIAO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Effect of COX-2 inhibitor lumiracoxib and the TNF-α antagonist etanercept on TNBS-induced colitis in Wistar rats

(2012) Ana Paula Ribeiro Paiotti et al.   JOURNAL OF MOLECULAR HISTOLOGY

Involvement of Hypoxia-Inducible Factor-1 in the Inflammatory Responses of Human LAD2 Mast Cells and Basophils

(2012) Vadim V. Sumbayev et al.   PLoS One

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

(2012) E. T. Clambey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels

(2012) Hiroshi Harada et al.   Nature Communications

Tight Junction Pore and Leak Pathways: A Dynamic Duo

(2011) Le Shen et al.   Annual Review of Physiology

Involvement of HIF-1α in MLCK-dependent Endothelial Barrier Dysfunction in Hypoxia

(2011) Huabing Qi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Blockade of hypoxia-inducible factor-1α by YC-1 attenuates interferon-γ and tumor necrosis factor-α-induced intestinal epithelial barrier dysfunction

(2011) Hang Liu et al.   CYTOKINE

Paneth cell-derived interleukin-17A causes multiorgan dysfunction after hepatic ischemia and reperfusion injury

(2011) Sang Won Park et al.   HEPATOLOGY

IFN-  Attenuates Hypoxia-Inducible Factor (HIF) Activity in Intestinal Epithelial Cells through Transcriptional Repression of HIF-1 

(2011) L. E. Glover et al.   JOURNAL OF IMMUNOLOGY

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components

(2011) Dulantha Ulluwishewa et al.   JOURNAL OF NUTRITION

Isoflurane Protects Human Kidney Proximal Tubule Cells against Necrosis via Sphingosine Kinase and Sphingosine-1-Phosphate Generation

(2010) Mihwa Kim et al.   AMERICAN JOURNAL OF NEPHROLOGY

HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury

(2010) Rena Feinman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury

(2010) Kolenkode B. Kannan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Expression and regulation of HIF-1alpha in macrophages under inflammatory conditions; significant reduction of VEGF by CaMKII inhibitor

(2010) Johanna Westra et al.   BMC MUSCULOSKELETAL DISORDERS

Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function

(2010) Murtaza M. Tambuwala et al.   GASTROENTEROLOGY

An Intact Canonical NF- B Pathway Is Required for Inflammatory Gene Expression in Response to Hypoxia

(2010) S. F. Fitzpatrick et al.   JOURNAL OF IMMUNOLOGY

The protective effect of enteric glial cells on intestinal epithelial barrier function is enhanced by inhibiting inducible nitric oxide synthase activity under lipopolysaccharide stimulation

(2010) Wei-Dong Xiao et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Cutting Edge: A2B Adenosine Receptor Signaling Provides Potent Protection during Intestinal Ischemia/Reperfusion Injury

(2009) M. L. Hart et al.   JOURNAL OF IMMUNOLOGY

Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia

(2009) Peter Rosenberger et al.   NATURE IMMUNOLOGY

Protective effect of polygoni cuspidati radix and emodin on Vibrio vulnificus cytotoxicity and infection

(2008) Jong Ro Kim et al.   JOURNAL OF MICROBIOLOGY