PI3K/AKT/PTEN pathway as a target for Crohn’s disease therapy (Review)

The Role of Tumour Necrosis Factor in the Pathogenesis of Immune-Mediated Diseases

(2017) C. Blandizzi et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Rapidly expanding knowledge on the role of the gut microbiome in health and disease

(2014) M.C. Cénit et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Protective effect of 7-O-succinyl macrolactin A against intestinal inflammation is mediated through PI3-kinase/Akt/mTOR and NF-κB signaling pathways

(2014) Sumin Park et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Redox regulation of MMP-3/TIMP-1 ratio in intestinal myofibroblasts: Effect of N-acetylcysteine and curcumin

(2014) Filippo Fontani et al.   EXPERIMENTAL CELL RESEARCH

IL-7 Activates the Phosphatidylinositol 3-Kinase/AKT Pathway in Normal Human Thymocytes but Not Normal Human B Cell Precursors

(2014) S. E. Johnson et al.   JOURNAL OF IMMUNOLOGY

The Phosphoinositide 3-Kinase-Dependent Activation of Btk Is Required for Optimal Eicosanoid Production and Generation of Reactive Oxygen Species in Antigen-Stimulated Mast Cells

(2014) H. S. Kuehn et al.   JOURNAL OF IMMUNOLOGY

Effect of dietary n-3 polyunsaturated fatty acids on transcription factor regulation in the bovine endometrium

(2014) Sinéad M. Waters et al.   MOLECULAR BIOLOGY REPORTS

Link between PI3K/AKT/PTEN Pathway and NOX Protein in Diseases

(2014) Atsuko Nakanishi   Aging and Disease

Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers

(2013) Bharat B Aggarwal et al.   BRITISH JOURNAL OF PHARMACOLOGY

New insights into Notch1 regulation of the PI3K–AKT–mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia

(2013) Eric C. Hales et al.   CELLULAR SIGNALLING

Management of Postoperative Recurrence of Crohn's Disease

(2013) Anja U. van Lent et al.   DIGESTIVE DISEASES

Somatostatin receptors: From signaling to clinical practice

(2013) Marily Theodoropoulou et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Sirolimus ameliorates inflammatory responses by switching the regulatory T/T helper type 17 profile in murine colitis

(2013) Hui Yin et al.   IMMUNOLOGY

De Novo Inflammatory Bowel Disease and Its Mimics After Organ Transplantation

(2013) Sansrita Nepal et al.   INFLAMMATORY BOWEL DISEASES

Curcumin Protects Mice From Coxsackievirus B3-Induced Myocarditis by Inhibiting the Phosphatidylinositol 3 kinase/Akt/Nuclear Factor-κB Pathway

(2013) Yunxiao Song et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Equivalent Benefit of Rapamycin and a Potent mTOR ATP-Competitive Inhibitor, MLN0128 (INK128), in a Mouse Model of Tuberous Sclerosis

(2013) Yanan Guo et al.   MOLECULAR CANCER RESEARCH

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

(2013) Christian C. Dibble et al.   NATURE CELL BIOLOGY

A high ratio of dietary n-3/n-6 polyunsaturated fatty acids improves obesity-linked inflammation and insulin resistance through suppressing activation of TLR4 in SD rats

(2013) Han-Qiang Liu et al.   NUTRITION RESEARCH

Eupatilin, a Major Flavonoid of Artemisia, Attenuates Aortic Smooth Muscle Cell Proliferation and Migration by Inhibiting PI3K, MKK3/6, and MKK4 Activities

(2013) Joe Son et al.   PLANTA MEDICA

Fish Oil Attenuates Omega-6 Polyunsaturated Fatty Acid-Induced Dysbiosis and Infectious Colitis but Impairs LPS Dephosphorylation Activity Causing Sepsis

(2013) Sanjoy Ghosh et al.   PLoS One

Difluorinated-Curcumin (CDF) Restores PTEN Expression in Colon Cancer Cells by Down-Regulating miR-21

(2013) Sanchita Roy et al.   PLoS One

Beauvericin Ameliorates Experimental Colitis by Inhibiting Activated T Cells via Downregulation of the PI3K/Akt Signaling Pathway

(2013) Xue-Feng Wu et al.   PLoS One

Incidence and management of mTOR inhibitor-associated pneumonitis in patients with metastatic renal cell carcinoma

(2012) L. Albiges et al.   ANNALS OF ONCOLOGY

Attenuation of colonic inflammation by partial replacement of dietary linoleic acid with α-linolenic acid in a rat model of inflammatory bowel disease

(2012) Anupama Tyagi et al.   BRITISH JOURNAL OF NUTRITION

A new clue to explain resistance to mTOR inhibitors

(2012) Shile Huang   CELL CYCLE

Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn's disease

(2012) Josep Bassaganya-Riera et al.   CLINICAL NUTRITION

Neopterin Concentration as an Index of Disease Activity in Crohn’s Disease and Ulcerative Colitis

(2012) Nisreen Husain et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Commensal microbiome effects on mucosal immune system development in the ruminant gastrointestinal tract

(2012) Ryan Taschuk et al.   ANIMAL HEALTH RESEARCH REVIEWS

Procyanidin dimer B1 and trimer C1 impair inflammatory response signalling in human monocytes

(2011) X. Terra et al.   FREE RADICAL RESEARCH

N-cadherin is overexpressed in Crohnʼs stricture fibroblasts and promotes intestinal fibroblast migration

(2011) John P. Burke et al.   INFLAMMATORY BOWEL DISEASES

Neuroprotective effect of guanosine against glutamate-induced cell death in rat hippocampal slices is mediated by the phosphatidylinositol-3 kinase/Akt/ glycogen synthase kinase 3β pathway activation and inducible nitric oxide synthase inhibition

(2011) Simone Molz et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Clinical activity of mammalian target of rapamycin inhibitors in solid tumors

(2011) Yesid Alvarado et al.   Targeted Oncology

Role of the endothelium in inflammatory bowel diseases

(2011) Walter E Cromer   WORLD JOURNAL OF GASTROENTEROLOGY

Roles of GSK3 in metabolic shift toward abnormal anabolism in cell senescence

(2010) You-Mie Kim et al.   Annals of the New York Academy of Sciences

Dual roles of NOD2 in TLR4-mediated signal transduction and -induced inflammatory gene expression in macrophages

(2010) Wen-Hsiang Tsai et al.   CELLULAR MICROBIOLOGY

NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin Resistance

(2010) Akhilesh K. Tamrakar et al.   ENDOCRINOLOGY

Role of the TSC1-TSC2 Complex in the Integration of Insulin and Glucose Signaling Involved in Pancreatic β-Cell Proliferation

(2010) Alberto Bartolomé et al.   ENDOCRINOLOGY

n-3 polyunsaturated fatty acids prevents atrial fibrillation by inhibiting inflammation in a canine sterile pericarditis model

(2010) Zhong Zhang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2

(2010) Xin-Hua Liao et al.   JOURNAL OF CELL SCIENCE

Cox-2 expression, PGE2 and cytokines production are inhibited by endogenously synthesized n-3 PUFAs in inflamed colon of fat-1 mice

(2010) Claudia Gravaghi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Docosahexaenoic Acid (DHA) and Docosapentaenoic Acid (DPAn-6) Algal Oils Reduce Inflammatory Mediators in Human Peripheral Mononuclear Cells In Vitro and Paw Edema In Vivo

(2010) Julie M. Nauroth et al.   LIPIDS

LAPTM4B: A novel cancer-associated gene motivates multidrug resistance through efflux and activating PI3K/AKT signaling

(2010) L Li et al.   ONCOGENE

Advances in Development of Phosphatidylinositol 3-Kinase Inhibitors

(2009) Dexin Kong et al.   CURRENT MEDICINAL CHEMISTRY

Molecular alterations inAKT1,AKT2andAKT3detected in breast and prostatic cancer by FISH

(2009) Tove Kirkegaard et al.   HISTOPATHOLOGY

Licorice and Licochalcone-A Induce Autophagy in LNCaP Prostate Cancer Cells by Suppression of Bcl-2 Expression and the mTOR Pathway

(2009) Yi-Te Yo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Wormwood (Artemisia absinthium) suppresses tumour necrosis factor alpha and accelerates healing in patients with Crohn’s disease – A controlled clinical trial

(2009) Simone Krebs et al.   PHYTOMEDICINE

Exogenous zinc protects cardiac cells from reperfusion injury by targeting mitochondrial permeability transition pore through inactivation of glycogen synthase kinase-3β

(2008) Guillaume Chanoit et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The phosphatidylinositol 3-kinase/Akt pathway negatively regulates Nod2-mediated NF-κB pathway

(2008) Ling Zhao et al.   BIOCHEMICAL PHARMACOLOGY

Anti-tumor effect of honokiol alone and in combination with other anti-cancer agents in breast cancer

(2008) Hongyu Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Use of sirolimus (rapamycin) to treat refractory Crohn's disease

(2008) D C O Massey et al.   GUT

Protein Kinase G-dependent Cardioprotective Mechanism of Phosphodiesterase-5 Inhibition Involves Phosphorylation of ERK and GSK3β

(2008) Anindita Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Effects of Xanthohumol Plus Honokiol on Apoptosis in 3T3-L1 Adipocytes

(2008) Jeong-Yeh Yang et al.   Obesity

Understanding PTEN regulation: PIP2, polarity and protein stability

(2008) N R Leslie et al.   ONCOGENE

Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NFκB pathway

(2007) Byeong Hyeok Choi et al.   CANCER LETTERS