Article
Pharmacology & Pharmacy
Xiyue Zhang, Li Du, Jinrong Zhang, Chunyan Li, Jie Zhang, Xuejiao Lv
Summary: The study found that hordenine (Hor) can inhibit lipopolysaccharide-induced acute lung injury (ALI) by alleviating the disease through anti-inflammatory mechanisms. Hor can suppress the increase in inflammatory cytokine levels and exert its effects by regulating multiple signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jin-Kyu Kang, Hyun-Kyu Kang, Chang-Gu Hyun
Summary: Spiramycin has anti-inflammatory effects by inhibiting the production of pro-inflammatory mediators and cytokines in macrophages, suggesting its potential as a candidate for topical anti-inflammatory agents.
Review
Pharmacology & Pharmacy
Xin-Fang Leong, Ker Woon Choy, Aspalilah Alias
Summary: Atherosclerosis poses serious health problems and requires long-term medication for prevention. Thymoquinone, a bioactive compound from Nigella sativa L., shows potential anti-inflammatory effects in atherosclerosis, but further studies are needed to determine its effectiveness and safety.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Wei Bi, Jiawei Zhang, Zhaohao Zeng, Ruiyi Zhou, Jiayi Zhao, Wei Yan, Lu Wang, Xiaoting Li, Lihong Zhu
Summary: The study found that USP8 has a protective effect against LPS-induced spleen injury, reducing inflammation. The anti-inflammatory mechanism of USP8 may be mediated by inhibiting the MAPK and NF-κB signaling pathways.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Xingchi Kan, Yingsheng Chen, Bingxu Huang, Shoupeng Fu, Wenjin Guo, Xin Ran, Yu Cao, Dianwen Xu, Ji Cheng, Zhanqing Yang, Yanling Xu
Summary: The study found that Palmatine significantly inhibits the expression and secretion of inflammatory cytokines, reducing the levels of proinflammatory enzyme iNOS. By inhibiting the activation of the Akt/NF-kappa B signaling pathway, Palmatine alleviates LPS-induced ALI.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Article
Immunology
Bristy Sabikunnahar, Sydney Caldwell, Stella Varnum, Tyler Hogan, Alexei Cooper, Karolyn G. Lahue, Joseph J. Bivona, Phoebe M. Cousens, Menelaos Symeonides, Bryan A. Ballif, Matthew E. Poynter, Dimitry N. Krementsov
Summary: This study characterized a mouse long noncoding RNA named U90926. The expression of U90926 was induced in macrophages and dendritic cells by TLR activation. U90926 deficiency resulted in increased sickness responses and mortality in an endotoxic shock model, potentially mediated by the secreted U9-ORF protein.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Chemistry, Applied
Jinyang Cai, Xin Li, Xing Wang, Chengfei Jiang, Dan Shen, Xianwei Cui, Kaipeng Xie, Chenbo Ji, Yan Cao
Summary: In this study, a novel peptide named BCCY-1 corresponding to human beta-casein sequence was identified in human milk, showing immunomodulatory activity by enhancing monocyte migration. BCCY-1 exerts its effects by activating NF-κB and MAPK signaling pathways.
Article
Biotechnology & Applied Microbiology
Jingya Yang, Jing Li, Lanzhu Yang, Ruohui Guo
Summary: This research found that Alkannin attenuated LPS-induced inflammation by inhibiting NF-kappa B and MAPK signaling. This finding may provide a new theoretical basis for exploring new strategies against rheumatoid arthritis.
Article
Food Science & Technology
Joon Park, Eun Yeong Lim, Yun Tai Kim
Summary: This study found that AYE inhibits microglial activation-mediated inflammatory pain by suppressing the NF-kappa B and MAPK signaling pathways. Oral administration of AYE alleviated pain hypersensitivity and microglial activation in the spinal cord. The major active components in AYE, chlorogenic acid and t-Ferulic acid, showed inhibitory effects on LPS-induced microglial activation.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Mei-Lan Tsai, Ming-Kai Tsai, Yi-Giien Tsai, Yu-Chih Lin, Ya-Ling Hsu, Yi-Ting Chen, Yi-Ching Lin, Chih-Hsing Hung
Summary: This study investigated the effects of LTRAs on the expression of epithelium-derived cytokines in human airway epithelial cells and explored the underlying intracellular processes, including epigenetic regulation. It was found that LTRAs might induce the production of IL-25, IL-33, and TSLP by activating the MAPK and NF-kappa B pathways and regulating histone H3 acetylation and H3K36 and H3K79 trimethylation, exacerbating inflammation and asthma symptoms. Therefore, LTRA monotherapy may not be an appropriate therapeutic option for asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Congcong Guo, Yue Zhang, Tao Ling, Chongjie Zhao, Yanru Li, Meng Geng, Sailun Gai, Wei Qi, Xuegang Luo, Liehuan Chen, Tongcun Zhang, Nan Wang
Summary: Chitosan oligosaccharides (COS) can improve colitis by regulating intestinal microbiota and the PPAR gamma/SIRT1-mediated NF-kappa B pathway.
Article
Veterinary Sciences
Jingjing Cao, Yanhui Ni, Huaxing Zhang, Xiaoran Ning, Xiaoyong Qi
Summary: RA is an autoimmune disease that can cause joint inflammation and destruction. KLF7 expression was found to be upregulated in synovial tissues of rats with arthritis, and its loss suppressed cell proliferation, pro-inflammatory factors, and MMP expression in FLSs through inhibition of NF-kappa B and JNK pathways. miR-9a-5p negatively regulated KLF7 expression, suggesting a potential role for KLF7 as a therapeutic target for RA.
EXPERIMENTAL ANIMALS
(2021)
Article
Immunology
SangJoon Mo, Eun Young Kim, Yi-Suk Kwon, Min Young Lee, Jin Chul Ahn
Summary: Inflammation is the body's response to harmful agents. Macrophages play a key role in this process and can modulate the immune response. Organic light-emitting diodes (OLEDs) show potential for treating inflammatory conditions by reducing morphological changes and inflammatory cytokine expression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ming Kuang, Haitao Yu, Shiyan Qiao, Tao Huang, Jiaqi Zhang, Mingchao Sun, Xiumei Shi, Han Chen
Summary: The study evaluated the function of chitosan nanoparticle-peptide complexes (CNMs) in protecting against foodborne pathogen E. coli O157 infection. The CNMs exhibited excellent bactericidal activity against E. coli O157 without causing cytotoxicity or genotoxicity. Additionally, CNMs alleviated inflammation, improved antioxidant activity, and protected against E. coli O157-induced intestinal barrier damage, showing great potential as novel antimicrobial polymers in the food industry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Tong Zhang, Jiejie Sun, Liyan Wang, Hongsheng Yao, Zhicheng Guo, Wei Wu, Yinan Li, Lingling Wang, Linsheng Song
Summary: CgBCL10, a homologue identified in Pacific oysters, plays a crucial role in regulating the expression of inflammatory cytokines by activating MAPK kinase, and nuclear translocation of NF-KB/Rel and AP-1 to defend against pathogens.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Chemistry, Applied
Santosh Kumar Bose, Prianka Howlader, Wenxia Wang, Heng Yin
Summary: The lack of proper postharvest management of fruits leads to economic losses, poverty, hunger, and malnutrition. To address postharvest losses, various technologies and chemical treatments are used globally, but some may pose risks to human health and the environment. Recently, oligosaccharides have gained attention for their health benefits and potential applications in agriculture, showing promising results in improving postharvest preservation of fruits by maintaining antioxidant activity and delaying cell wall degradation through hormone regulation. This review provides insights into the preservation effects of different oligosaccharides on fruits and offers future research directions for enhancing postharvest preservation.
Article
Biotechnology & Applied Microbiology
Kuikui Li, Chaofeng Jiang, Haidong Tan, Junyan Li, Yali Xu, Dejian Tang, Xiaoming Zhao, Qishun Liu, Jianguo Li, Heng Yin
Summary: The glucomannanase PpGluB shows high specificity for degrading konjac glucomannan, producing oligosaccharides with degrees of polymerisation of 2-12. It exhibits optimal activity at 45-55 degrees C and pH 5.0-6.0, as well as high pH stability over a broad pH range.
Article
Biotechnology & Applied Microbiology
Tang Li, Ningning Zhang, Shenggang Yan, Shan Jiang, Heng Yin
Summary: Tyrosinase is an important enzyme for the oxidation of phenolic compounds, with its ability to convert monophenols to diphenols being of interest for both research and industrial purposes. A novel tyrosinase from Armillaria ostoyae strain C18/9 showed comparable monophenolase and diphenolase activities, with substrate inhibition observed in both activities. In silico analysis and mutagenesis experiments highlighted the significance of residues 262 and 266 in modulating the enzyme's activity, and the D262N variant exhibited enhanced catalytic efficiency for monophenolase/diphenolase activities.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Plant Sciences
Ruixin Li, Maolong Li, Jinxia He, Hongguo Xie, Wenxia Wang, Meng Zhang, Gustavo Cabrera-Barjas, Pierfrancesco Morganti, Heng Yin
Summary: The study found that pectin nanospheres have a promoting effect on wheat germination and seedling growth, increasing seed germination rate and net photosynthetic rate, and facilitating nutrient uptake in plants.
JOURNAL OF PLANT GROWTH REGULATION
(2022)
Article
Chemistry, Physical
Yijie Dong, Tang Li, Shiqing Zhang, Joaquin Sanchis, Heng Yin, Jie Ren, Xiang Sheng, Guangyue Li, Manfred T. Reetz
Summary: In this study, the unexpected mechanistic intricacies of Baeyer-Villiger monooxygenases (BVMOs) were discovered, providing insights for expanding their applications in synthetic organic chemistry and biotechnology. The investigation utilized complete mutational deconvolution and experimental construction of a fitness-pathway landscape to elucidate the structural changes of Criegee intermediates and their effects on the evolutionary process.
Editorial Material
Plant Sciences
Kuikui Li, Chunlai Zhang, Wenxia Wang, Changzheng Chen, Qishun Liu, Heng Yin
Article
Multidisciplinary Sciences
Yong Liu, Mingjian Zhang, Zhuan Wang, Jiandong He, Jie Zhang, Sheng Ye, Xiuli Wang, Dongfeng Li, Heng Yin, Qianhong Zhu, Huanwang Jing, Yuxiang Weng, Feng Pan, Ruotian Chen, Can Li, Fengtao Fan
Summary: This paper proposes a method to fabricate interfacial charge-collecting nanostructures on the positive and negative domains of a ferroelectric material, facilitating water splitting in ferroelectric photocatalysts. The study observes efficient accumulation of photogenerated electrons and holes around Au nanoparticles, located in the positive and negative domains of a BaTiO3 single crystal. Photocatalytic overall water splitting is achieved on a ferroelectric BaTiO3 single crystal after assembling oxidation and reduction cocatalysts on charged Au nanoparticles.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Lingfeng Long, Yun Hu, Fubao Sun, Wa Gao, Zhikui Hao, Heng Yin
Summary: This review critically discusses the advances in the study of AA9 LPMOs and their applications in lignocellulosic biomass processing. AA9 LPMOs are capable of efficiently depolymerizing crystalline cellulose, but their catalysis requires a reductant for electron supply, and the oxidation of lignin and its derivatives can activate the reaction. Protein engineering has been used to modify the structure of AA9 LPMOs and enhance their activity for extensive applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Wanchao Kang, Ruifang Wei, Heng Yin, Dongfeng Li, Zheng Chen, Qinge Huang, Pengfei Zhang, Huanwang Jing, Xiuli Wang, Can Li
Summary: Using transient absorption spectroscopy and a photo-sensitization strategy, we have successfully resolved the sequential oxidation kinetics of water oxidation in the OER catalytic cycle, providing insights into the kinetic understanding of heterogeneous catalysis with multi-sites.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Analytical
Lilin Song, Mengru Sun, Jinhui Shi, Zhenhao Tian, Yuqing Song, Huixin Liu, Shanshan Zhao, Heng Yin, Guangbo Ge
Summary: By using computer-aided molecular design and experimental verification, octanoyl luciferin (OL) was selected as a reliable bioluminescent substrate for detecting Notum activity in complex biological systems. OL showed excellent specificity, high detection sensitivity, and high signal-to-noise ratio for human Notum. This study provides a reliable and easy-to-use tool for sensing Notum activities in biological systems, which will strongly facilitate fundamental studies, disease diagnosis, and drug discovery related to Notum.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Zhongbin Xiao, Kuikui Li, Tang Li, Fanxing Zhang, Jiayi Xue, Miao Zhao, Heng Yin
Summary: Alginate lyase VwAlg7A, a novel PL7 family exolytic alginate lyase, was successfully heterologously expressed in E. coli BL21 (DE3). VwAlg7A showed specificity towards poly-guluronate and exhibited optimal temperature and pH at 30 degrees C and 7.0, respectively. The activity of VwAlg7A could be inhibited by Ni2+, Zn2+, and NaCl, and its kinetic parameters were determined as K-m of 36.9 mg/ml and V-max of 395.6 mu M/min. ESI and HPAEC-PAD results confirmed the exolytic mode of sugar bond cleavage by VwAlg7A, and important catalytic residues were identified through molecular docking and mutagenesis experiments.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Plant Sciences
Xiaochen Jia, Hongyan Zhang, Hongqiang Qin, Kuikui Li, Xiaoyan Liu, Wenxia Wang, Mingliang Ye, Heng Yin
Summary: In this study, a functional plant AGM (AtAGM) was identified from Arabidopsis thaliana, with a significant role in UDP-GlcNAc biosynthesis pathway. AtAGM catalyzes the isomerization of GlcNAc-1-P and GlcNAc-6-P, and has broad catalytic activity on different phosphohexoses. The decrease in UDP-GlcNAc content in AtAGM mutants resulted in impaired protein O-GlcNAcylation and temperature-dependent growth defects in seedlings.
Article
Plant Sciences
Yu Wang, Peiyu Xu, Wenxia Wang, Xiaochen Jia, Liping Zhu, Heng Yin
Summary: Chitosan oligosaccharides (COS) and alginate oligosaccharides (AOS) promote the growth and biosynthesis of steviol glycosides (SGs) in stevia. They increase plant biomass by improving photosynthetic efficiency and leaf number, reducing abscisic acid content, and enhancing the expression of SGs biosynthesis-related genes. Moreover, COS and AOS increase the contents of sweet compounds such as stevioside and rebaudioside A in stevia. In addition, they induce geometric changes in stevia stems, thereby increasing its lodging resistance.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Chemistry, Physical
Ruifang Wei, Dongfeng Li, Heng Yin, Xiuli Wang, Can Li
Summary: Operando electrochemical UV-Vis absorption spectroscopy with μs time resolution was achieved by introducing bias pulses and synchronizing the bias pulse and spectral signals. This novel method demonstrated good time consistency and reliability for studying water oxidation and hole sacrifice reagent oxidation reactions. It can provide insights into electrocatalytic reaction mechanisms and guide the design of high-efficiency electrocatalysts.
ACTA PHYSICO-CHIMICA SINICA
(2023)
Article
Food Science & Technology
Guojun Yang, Shuguang Li, Haidong Tan, Kuikui Li, Wei Chen, Heng Yin
Summary: Efforts are underway to efficiently biodegrade pectic polysaccharides into sustainable oligogalacturonide (OG) products for bioactivity studies and applications, with promising results reported on the successful degradation of pectin into high-purity OGs. Studies on physicochemical properties of commercial pectins and pilot experiments on OG production show the potential for commercialization of the biocatalytic transformation process with AnPG28A as a catalyst for high-value-added OGs.
ACS FOOD SCIENCE & TECHNOLOGY
(2021)