Article
Cell Biology
David Rabbolini, Hai Po Helena Liang, Marie-Christine Morel-Kopp, David Connor, Shane Whittaker, Scott Dunkley, Dea Donikian, Mayuko Kondo, Walter Chen, William S. Stevenson, Heather Campbell, Joanne Joseph, Christopher Ward, Timothy Brighton, Vivien M. Chen
Summary: Variants of the DIAPH1 gene have been reported to cause inherited macrothrombocytopenia, early-onset progressive sensorineural hearing loss, and mild asymptomatic neutropenia, along with alterations in procoagulant platelet formation and possible dental anomalies.
Review
Biochemistry & Molecular Biology
Eleonora Sarantelli, Apostolis Mourkakis, Lefteris C. Zacharia, Andreas Stylianou, Vasiliki Gkretsi
Summary: As metastasis is a major cause of cancer-related deaths, understanding the cellular and molecular events involved in cancer cell migration and invasion is crucial for developing novel anti-metastatic therapies. Fascin-1, an actin-bundling protein, plays a fundamental role in cell migration processes. It is significantly elevated in most cancers and its high expression is associated with aggressive disease and poor prognosis. Recent studies show that Fascin-1 is critically involved in metastasis and suggest it as a promising target for anti-metastatic treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Kathryn N. Becker, Krista M. Pettee, Amanda Sugrue, Kevin A. Reinard, Jason L. Schroeder, Kathryn M. Eisenmann
Summary: Targeting mDia is an effective strategy against invasion and tumor microtube networking, while inhibiting ROCK is contraindicated for treating brain cancer.
Article
Cell Biology
Xing Li, Mingyu Liao, Jiaqing Shao, Weixin Li, Liu Shi, Dong Wang, Juan Ni, Qiuyue Shen, Fan Yang, Guiliang Peng, Ling Zhou, Yuling Zhang, Zheng Sun, Hongting Zheng, Min Long
Summary: This study found an association between plasma DIAPH1 levels and glucose metabolism, insulin resistance, and sex hormones in patients with PCOS. DIAPH1 may be a potential predictive factor for PCOS.
MEDIATORS OF INFLAMMATION
(2022)
Article
Cell Biology
Mathilde Kerherve, Sara Rosinska, Kilian Trillet, Alya Zeinaty, Magalie Feyeux, Steven Nedellec, Julie Gavard
Summary: Glioblastoma multiforme (GBM) is a rare but devastating brain tumor in adults, with current treatments being generally ineffective. This study focused on a population of self-sustaining transformed cells with stem-like properties (GSCs) within GBM, which play a crucial role in tumor initiation, growth, invasion, and recurrence. An ex vivo model was established to explore the invasive behavior of GSCs, and it was found that the glycoprotein Neuropilin-1 (NRP1) contributes to their spreading and invasion. This study proposes a reliable approach to studying invasive properties of patient glioma cells and identifies NRP1 as a mediator in this malignant process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bixi Zhang, Qing Hu, Yanchun Li, Canxia Xu, Xiaoran Xie, Peng Liu, Meihua Xu, Siming Gong, Hao Wu
Summary: This study reveals that DIAPHs are abundantly expressed in pancreatic adenocarcinoma and are significantly correlated with clinical prognosis, immune response, and other factors.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Cell Biology
Yinan Wang, Chuan He Yang, Andrew P. Schultz, Michelle M. Sims, Duane D. Miller, Lawrence M. Pfeffer
Summary: BRG1 promotes invasion and migration, and decreases chemotherapy sensitivity in GBM cells, indicating its oncogenic role in this deadly form of brain cancer.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Dylan Jones, Clarissa A. Whitehead, Marija Dinevska, Samuel S. Widodo, Liam M. Furst, Andrew P. Morokoff, Andrew H. Kaye, Katharine J. Drummond, Theo Mantamadiotis, Stanley S. Stylli
Summary: Glioblastoma is a highly invasive and destructive brain tumor, and current standard treatments often fail to effectively eliminate it. In this study, we investigate the effects of several FDA-approved drugs on the invasion and viability of GBM cells. We found that these drugs can reduce cell invasion and viability, suggesting their potential as therapeutic options for GBM.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Oncology
Prabhat Suman, Vikrant Mehta, Andrew W. B. Craig, Harish Chander
Summary: This study reports a novel axis between the tumor-suppressor p53 and FBP17 in breast cancer. The expression of FBP17 is correlated with mutant p53 and enhanced p53 accumulation leads to reduced FBP17 expression. Immunohistochemistry analysis showed a correlation between p53 accumulation and enhanced FBP17 staining in invasive ductal carcinomas. Double knockdown experiments revealed the contribution of FBP17 in cancer cell invasion where p53 lost its regulatory control.
Article
Multidisciplinary Sciences
Atsushi Sugimoto, Tomohisa Okuno, Gen Tsujio, Tomohiro Sera, Yurie Yamamoto, Koji Maruo, Shuhei Kushiyama, Sadaaki Nishimura, Kenji Kuroda, Shingo Togano, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Masakazu Yashiro
Summary: The study found high expression of Tks5 in PMCs of advanced-stage gastric cancer patients, with positive expression being associated with greater tumor depth and increased rate of peritoneal recurrence. Tks5 might serve as a useful predictor for peritoneal recurrence in GC patients.
Article
Multidisciplinary Sciences
Chiara Chiereghin, Michela Robusto, Morag A. Lewis, Susana Caetano, Valentina Massa, Pierangela Castorina, Umberto Ambrosetti, Karen P. Steel, Stefano Duga, Rosanna Asselta, Giulia Solda
Summary: Diaphanous related formins are cytoskeletal proteins involved in actin elongation and microtubule stabilization. Defects in two diaphanous genes have been associated with hearing loss, and this study investigates the role of the third member, DIAPH2, in nonsyndromic hearing loss. A mutation in DIAPH2 was found to be linked to X-linked hearing loss in an Italian family. However, further studies are needed to fully understand the contribution of DIAPH2 to deafness.
Article
Cell Biology
Xiaosong Wang, Xiaojun Yu, Haoran Xu, Kang Wei, Shanxi Wang, Yingguang Wang, Junfei Han
Summary: In this study, the researchers found that extracellular vesicles (EVs) transfer a long non-coding RNA (lncRNA) called HOTAIR, which regulates resistance to the chemotherapy drug temozolomide (TMZ) in glioblastoma (GBM). Through in vitro and in vivo experiments, it was demonstrated that HOTAIR promotes tumor growth, increases invasiveness, and enhances resistance to TMZ. In GBM cells, HOTAIR competitively binds to miR-526b-3p, weakening its ability to bind to EVA1 and consequently increasing EVA1 expression. Furthermore, HOTAIR carried by serum-EVs suppresses miR-526b-3p-mediated inhibition of EVA1, promoting tumor growth and TMZ resistance in vivo.
CELL DEATH & DISEASE
(2022)
Article
Pharmacology & Pharmacy
Haima Li, Jia Ouyang, Ruen Liu
Summary: The study demonstrated that Platycodin D (PD) suppresses glioma development by regulating the expression of S phase kinase-related protein 2 (Skp2) in GBM cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Oncology
Chuntao Li, Bo Chen, Junxia Zhang, Jingxuan Yang, Muzi Guo, Yu Ren, Zhijun Zhou, Kar-Ming Fung, Min Li, Liyang Zhang, Zhixiong Liu
Summary: SEM1 is highly expressed in gliomas and correlated with malignant features and poor prognosis. SEM1 plays a critical role in the proliferation, apoptosis, invasion, and migration of glioma cells through regulating the PI3K-Akt pathway. The SEM1 malignant regulatory network shows significant importance for the prognosis and treatment of gliomas.
Article
Pharmacology & Pharmacy
Jen-Fu Yang, Tzu-Min Chen, Hsin-Han Chang, Yu-Ling Tsai, Wen-Chiuan Tsai, Wen-Yen Huang, Cheng-Hsiang Lo, Chun-Shu Lin, Po -Chien Shen, Ying Chen
Summary: This study found that guggulsterone (GS) can inhibit the migration and invasion abilities of glioblastoma multiforme (GBM) cells, and the underlying mechanism may involve degradation by proteasomes and lysosomes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Organic
Haopeng Wu, Chukai Shao, Di Wu, Liang Jiang, Hongquan Yin, Fu-Xue Chen
Summary: A highly regioselective protocol for intermolecular thiocyanation-amination of alkynes using N-thiocyano-dibenzenesulfonimide (NTSI) as the SCN and nitrogen sources has been developed. The reaction features a broad substrate scope, atom economy, high yields (up to 94%), and excellent functional group tolerance under simple mild conditions.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Chengcheng Li, Pingliang Long, Zhenda Fu, Di Wu, Fu-Xue Chen, Hongquan Yin
Summary: A new thiocyanation/cyclization reaction has been developed for synthesizing thiocyanato-containing oxygen heterocyclic compounds with terminal and non-terminal enols, providing an efficient method for building the multi-substituted ring and spiro ring structure of furan. The approach has a wide range of substrates, good functional group tolerance, and yields the desired products in a medium to high yield.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Yong Gao, Zhenda Fu, Di Wu, Hongquan Yin, Fu-Xue Chen
Summary: An efficient bifunctional cinchona alkaloids-catalyzed asymmetric tandem intramolecular oxa-Michael addition/electrophilic thiocyanation method was developed for the synthesis of chiral alpha-thiocyanato flavanones with two vicinal stereocenters. The method produced the desired compounds in good yields with excellent diastereo- and enantioselectivities under mild conditions, demonstrating its potential for scale-up.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Yongjie Duan, Kun Liang, Hongquan Yin, Fu-Xue Chen
Summary: This study developed an efficient dithiocyanation method using N-thiocyanato-dibenzenesulfonimide (NTSI) and ammonium thiocyanate as reagents. It can build C(sp(2))-SCN bond under simple and mild conditions to provide a variety of dithiocyanato olefin compounds.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Zhihua Qiao, Chukai Shao, Yong Gao, Kun Liang, Hongquan Yin, Fu-Xue Chen
Summary: A Lewis acid-catalyzed cyclization reaction has been achieved under mild conditions, leading to the synthesis of functionalized spirocyclohexadienone precursors. This method offers moderate to excellent yields and exhibits good functional group tolerance towards a wide range of substrates.
TETRAHEDRON LETTERS
(2022)
Article
Chemistry, Organic
Chukai Shao, Ying He, Hongquan Yin, Fu-Xue Chen
Summary: A metal-free and regioselective electrophilic thiocyanation/cyclization of alkynylbenzoates has been developed to afford a series of thiocyanato-containing isocourmarins catalyzed by Me3SiCl. This method tolerates a wide range of substrates and functional groups, with moderate to excellent yields. The mild reaction conditions make this protocol practical for accessing isocourmarins with a diverse range of transformations.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Engineering, Biomedical
Guilong Wang, Zhen-Feng Hu, Xiu-Bing Liang, Fu-Xue Chen
Summary: We report the development of a versatile and strong underwater adhesive inspired by mussel foot proteins. The adhesive, called polyelectrolyte complex coacervate adhesive (P2), exhibited outstanding underwater shear strength and increased adhesion to glass after a critical curing time.
BIOINSPIRED BIOMIMETIC AND NANOBIOMATERIALS
(2022)
Article
Oncology
Jiwei Zhang, Shengli Li, Jianian Zhang, Wen Zhang, Jiawen Jiang, Hao Wu, Enjiang Wu, Yutao Feng, Li Yang, Zhe Li
Summary: This study found that LINC01085, as a tumor suppressor, has significant clinical relevance in patients with aggressive hormone-independent prostate cancer (HIPC) who have acquired docetaxel resistance. The overexpression of LINC01085 inhibits TBK1 dimerization and affects the interaction between TBK1 and GSK313, resulting in changes in the expression levels of PD-L1, NF-xB, and interferons. Overexpression of LINC01085 combined with immune checkpoint blockade is proposed as an effective strategy for treating HIPC patients.
Article
Chemistry, Organic
Kun Liang, Ruirui Hua, Hongquan Yin, Fu-Xue Chen
Summary: An efficient metal-free tandem thiocyanation/cyclization reaction has been developed for tryptamine and tryptophol derivatives, using Me3SiCl as the Lewis acid catalyst and N-thiocyanatosaccharin as the electrophilic thiocyanating source. The reaction proceeds under mild conditions and yields various C3-SCN pyrroloindolines and furoindolines diastereoselectively in high yields (up to 96%) within 30 minutes. The protocol is practical and tolerable for diverse functional groups.
TETRAHEDRON LETTERS
(2023)
Article
Chemistry, Organic
Ying He, Qing Wang, Hongquan Yin, Fu-Xue Chen
Summary: In this study, a Lewis acid-catalyzed electrophilic dearomatizative thiocyanation and cyclization of benzofurans with N-thiocyanatosuccinimide was accomplished using CuOTf as the Lewis acid catalyst under mild conditions. The electrophilic thiocyanating reagent was activated by CuOTf, leading to difunctionalization through a thiocyanation/spirocyclization pathway. As a result, a series of thiocyanato-containing spiroketals were obtained in moderate to high yields, providing an alternative approach for the synthesis of functionalized [6,5]/[5,5]-spiroketals.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Organic
Yong Gao, Ruirui Hua, Hongquan Yin, Fu-Xue Chen
Summary: A tandem electrophilic thiocyanation and cyclization of arene-alkynes has been developed to synthesize thiocyanato-substituted phenanthrenes, dihydronaphthalenes, 2H-chromenes and dihydroquinolines in moderate to excellent yields. This reaction provides an efficient method for the construction of C-SCN and C-C bonds in one step. The N-thiocyanato reagent serves as a convenient precursor to transfer SCN+ in the presence of trimethylchlorosilane, and the cyclization shows exclusive 6-endo-dig selectivity. A gram scale reaction and further derivatizations demonstrate the utility of this synthetic strategy.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Guilong Wang, Xin Cui, Ying Chen, Zhen-feng Hu, Xiubing Liang, Fuxue Chen
Summary: Marine mussels can anchor firmly to foreign surfaces in seawater using byssus and plaque, which are composed of various mussel foot proteins containing DOPA. The strong interfacial bonding is achieved through a variety of chemical interactions. By modifying polymer systems with DOPA and its analogues, new biomimetic adhesives with excellent properties have been developed.
PROGRESS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Di Wu, Yongjie Duan, Kun Liang, Hongquan Yin, Fu-Xue Chen
Summary: A new strategy involving free radical reaction pathway initiated by AIBN was used to construct the benzylic sp(3) C-SCN bond, overcoming the disadvantage of introducing leaving groups in advance. The protocol also used readily available raw materials and resulted in high product yields, making it advantageous for synthesizing benzyl thiocyanates.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Shaoqing Wang, Congcong Li, Tian Lu, Guilong Wang, Hongquan Yin, Qing Ma, Guijuan Fan, Fu-Xue Chen
Summary: Six energetic compounds with dinitromethyl groups based on the triazolotriazine fused ring skeleton have been synthesized, showing high densities, detonation velocities, and excellent friction sensitivity.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Organic
Di Wu, Chengcheng Li, Yongjie Duan, Hongquan Yin, Fu-Xue Chen
Summary: In this study, a chlorothiocyanato difunctionalization reaction was achieved, and various alpha-chlorothio/selenocyanato difunctional ketones were synthesized through a one-pot strategy from beta-keto acids. The high yield and wide scope of substrates make this approach more practical for the synthesis of alpha-substituented difunctional ketones.
ORGANIC CHEMISTRY FRONTIERS
(2021)