Heat shock proteins can be targets of regulatory T cells for therapeutic intervention in rheumatoid arthritis

Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis

(2013) Hong Nie et al.   NATURE MEDICINE

Recognition of self-heat shock protein 60 by T cells from patients with atopic dermatitis

(2012) Berber Kapitein et al.   CELL STRESS & CHAPERONES

Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis

(2012) M. J. C. van Herwijnen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired suppression of synovial fluid CD4+CD25− T cells from patients with juvenile idiopathic arthritis by CD4+CD25+ Treg cells

(2011) Susanne Haufe et al.   ARTHRITIS AND RHEUMATISM

An altered peptide ligand corresponding to a novel epitope from heat-shock protein 60 induces regulatory T cells and suppresses pathogenic response in an animal model of adjuvant-induced arthritis

(2011) Maria del Carmen Dominguez et al.   AUTOIMMUNITY

Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells

(2011) E. J. Wehrens et al.   BLOOD

The inflammatory milieu in the rheumatic joint reduces regulatory T-cell function

(2011) Jessica Herrath et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Requisite Role for Induced Regulatory T Cells in Tolerance Based on Expanding Antigen Receptor Diversity

(2011) Dipica Haribhai et al.   IMMUNITY

Bacterial Heat Shock Protein 60, GroEL, Can Induce the Conversion of Naïve T Cells into a CD4+ CD25+ Foxp3-Expressing Phenotype

(2011) Ryuji Ohue et al.   Journal of Innate Immunity

Recombinant Wolbachia heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis

(2011) Chandanapurath Shiny et al.   MICROBES AND INFECTION

Cord Blood CD4+ T Cells Respond to Self Heat Shock Protein 60 (HSP60)

(2011) Joost A. Aalberse et al.   PLoS One

Regulatory T Cells Get Their Chance to Shine

(2011) M. Leslie   SCIENCE

CD30 Discriminates Heat Shock Protein 60-Induced FOXP3+CD4+ T Cells with a Regulatory Phenotype

(2010) I. de Kleer et al.   JOURNAL OF IMMUNOLOGY

Epitope-specific immunotherapy of rheumatoid arthritis: Clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial

(2009) Eva C. Koffeman et al.   ARTHRITIS AND RHEUMATISM

Treg suppress CTL responses upon immunization with HSP gp96

(2009) Zhen Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD4+CD25+Treg induction by an HSP60-derived peptide SJMHE1 fromSchistosoma japonicumis TLR2 dependent

(2009) Xuefeng Wang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Binding immunoglobulin protein-treated peripheral blood monocyte-derived dendritic cells are refractory to maturation and induce regulatory T-cell development

(2009) Valerie M. Corrigall et al.   IMMUNOLOGY

Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function

(2009) Maciej Kmieciak et al.   Journal of Translational Medicine

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

(2009) Markus Feuerer et al.   NATURE IMMUNOLOGY

IL-10 Is Critically Involved in Mycobacterial HSP70 Induced Suppression of Proteoglycan-Induced Arthritis

(2009) Lotte Wieten et al.   PLoS One

Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis

(2009) Graham P. Wright et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How do Regulatory T Cells Work?

(2009) A. Corthay   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

HSP60 as a Target of Anti-Ergotypic Regulatory T Cells

(2008) Francisco J. Quintana et al.   PLoS One

Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis

(2008) F. Flores-Borja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA