Review
Medicine, Research & Experimental
Xinyue Zhang, Xiaohua Pu, Caixia Pi, Jing Xie
Summary: FGF7, also known as KGF, plays a crucial role in tissue development, wound repair, tumorigenesis, and immune reconstruction. It directs cellular synaptic extension and facilitates functional gap junction communication in the skeletal system. Additionally, it promotes osteogenic differentiation and regulates key molecules in cartilage. However, the molecular mechanism of FGF7 in chondrocyte behaviors and cartilage diseases remains unknown.
Article
Engineering, Biomedical
Shibo Xu, Linna Chang, Xingjun Zhao, Yanan Hu, Yiyi Lin, Zhenhua Chen, Xiuli Ren, Xifan Mei
Summary: In this study, a multifunctional heterostructure nanoplatform with near-infrared sensitivity was developed for the treatment of osteoarthritis. The results showed that this nanoplatform could reduce cartilage damage and promote cartilage regeneration, providing a promising strategy for osteoarthritis treatment.
ACTA BIOMATERIALIA
(2022)
Review
Endocrinology & Metabolism
Zihuan Yang, Weishi Li, Chunli Song, Huijie Leng
Summary: CTGF is a multifunctional protein that plays different roles in different cells and conditions. CTGF antibodies have the potential to be a new drug for osteoarthritis. Abnormal CTGF expression is associated with inflammation and cartilage degeneration, making CTGF a potential therapeutic target for osteoarthritis treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Murad Aladal, Wei You, Rongxiang Huang, Jianghong Huang, Zhiqin Deng, Li Duan, Daping Wang, Wencui Li, Wei Sun
Summary: This article explores the potential of fibronectin 1 (FN1) in cartilage tissue engineering, highlighting its role in promoting chondrocyte differentiation and inhibiting apoptosis. It suggests that further research on FN1 could provide new insights and advanced applications in treating osteoarthritis and cartilage degeneration.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Cell Biology
Kai Sun, Jiachao Guo, Xudong Yao, Zhou Guo, Fengjing Guo
Summary: Growth differentiation factor 5 (GDF-5) plays a critical role in cartilage development and maintenance, and its dysregulation is linked to the pathogenesis of osteoarthritis (OA). Studies have shown the protective effects of GDF-5 against cartilage degeneration, making it a potential therapeutic candidate for OA treatment, despite current limitations in its clinical application.
CELL PROLIFERATION
(2021)
Review
Chemistry, Medicinal
Jhi Biau Foo, Qi Hao Looi, Chee Wun How, Sau Har Lee, Maimonah Eissa Al-Masawa, Pei Pei Chong, Jia Xian Law
Summary: Exosomes are small extracellular vesicles secreted by cells for intercellular communication, with miRNAs being a promising therapeutic factor for cartilage regeneration. They can promote chondrocyte proliferation and matrix secretion, reduce scar tissue formation, and decrease inflammation, but the optimization of exosome therapy for cartilage injuries is still lacking.
Review
Biotechnology & Applied Microbiology
Ilona Uzieliene, Ursule Kalvaityte, Eiva Bernotiene, Ali Mobasheri
Summary: Gene therapy has been explored as a potential treatment for osteoarthritis, with a focus on non-viral gene delivery technologies. While viral gene delivery has been more popular due to higher efficiency, efforts to enhance transfection efficiency of non-viral methods have shown promise for OA research and clinical applications. More research is needed to optimize transfection efficiency and duration of gene expression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhengyu Piao, Hyun Jung Lee, Byeongmoon Jeong
Summary: This study successfully induced osteoarthritis in a mouse model using a thermogel-based sustained drug release system. The results suggest that thermogels can be a precise tool for developing animal disease models by controlling drug release.
Review
Pharmacology & Pharmacy
Yanhong Song, Ziyi Wu, Ping Zhao
Summary: This article discusses the potential of using metformin in the treatment of osteoarthritis, highlighting its benefits in inhibiting inflammation, modulating autophagy, antagonizing oxidative stress, and reducing pain levels for patients. Metformin, with its anti-inflammatory and anti-aging properties, has the potential to be an effective drug for treating osteoarthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sofia Pettenuzzo, Alessandro Arduino, Elisa Belluzzi, Assunta Pozzuoli, Chiara Giulia Fontanella, Pietro Ruggieri, Valentina Salomoni, Carmelo Majorana, Alice Berardo
Summary: Biomechanical studies are expanding into various fields, playing crucial roles in the development, growth, and disease processes of organs and tissues. However, challenges exist in analyzing the passive response of cells due to cell variability, complex procedures, and different models. This review aims to provide important information on experimental techniques, results, models, and factors influencing the structural and mechanical changes in chondrocytes and chondrons.
Review
Biotechnology & Applied Microbiology
Yanxi Liu, Karan M. Shah, Jian Luo
Summary: Articular cartilage is avascular and has limited ability to repair itself, leading to degenerative joint diseases. Current clinical treatments often result in mechanically inferior cartilage. Understanding factors affecting cartilage homeostasis and exploring emerging regenerative approaches are crucial for future treatment options.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shun Yuan, Lang Zhang, Lianru Ji, Sufang Zhong, Liyun Jiang, Yang Wan, Yonggui Song, Changhua Zhang, Rikang Wang
Summary: The cooperation between FoxO3a and RUNX1 promotes chondrocyte differentiation, suggesting their interaction may serve as a therapeutic target for the treatment of osteoarthritis and other bone diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biology
Yuchen He, Katelyn E. Lipa, Peter G. Alexander, Karen L. Clark, Hang Lin
Summary: Osteoarthritis (OA) is a common degenerative joint disease with no effective treatment currently available. This review examines the similarities between OA chondrocytes and aging cells, and proposes potential methods to reverse the osteoarthritic phenotype. The challenges and future perspectives in OA research are also discussed.
Article
Biotechnology & Applied Microbiology
Xue Hao, Jing Zhao, Liyuan Jia, Ting He, Huanbo Wang, Jing Fan, Yating Yang, Fei Su, Qingda Lu, Chao Zheng, Liu Yang, Qiang Jie
Summary: This study found that XMU-MP-1 has a therapeutic effect on osteoarthritis (OA) by inhibiting inflammation, reducing chondrocyte apoptosis, and promoting cell proliferation. These findings provide a new potential option for the treatment of OA.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Orthopedics
Xiao-jian Wang, Lei Wei, Yan Xue, Rong-shan Li
Summary: The OARSI scores were lower in the 8-month-old and 10-month-old groups compared to the 12-month-old group. Aggrecan levels were higher in the articular chondrocytes of the 8-month-old and 10-month-old groups than the 12-month-old group. Collagen X levels increased with guinea pigs' age, while MMP-13 and caspase-3 levels were higher in the 10-month-old and 12-month-old groups compared to the 8-month-old group. Additionally, there was a significant increase in serum CTX-II concentration in the 12-month-old group.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Clinical Neurology
Wataru Narita, Ryota Takatori, Yuji Arai, Masateru Nagae, Hitoshi Tonomura, Tatsuro Hayashida, Taku Ogura, Hiroyoshi Fujiwara, Toshikazu Kubo
JOURNAL OF NEUROSURGERY-SPINE
(2016)
Article
Medicine, General & Internal
Kunihiko Hosoi, Hitoshi Tonomura, Ryota Takatori, Masateru Nagae, Yasuo Mikami, Toru Osawa, Yuji Arai, Hiroyoshi Fujiwara, Toshikazu Kubo
Article
Clinical Neurology
Kentaro Mizuno, Yasuo Mikami, Hitoshi Hase, Takumi Ikeda, Masateru Nagae, Hitoshi Tonomura, Toshiharu Shirai, Hiroyoshi Fujiwara, Toshikazu Kubo
CLINICAL SPINE SURGERY
(2017)
Article
Clinical Neurology
Hitoshi Tonomura, Yoichiro Hatta, Yasuo Mikami, Takumi Ikeda, Tomohisa Harada, Masateru Nagae, Hironori Koike, Hitoshi Hase, Toshikazu Kubo
CLINICAL SPINE SURGERY
(2017)
Article
Clinical Neurology
Shingo Nagashima, Masateru Nagae, Yuji Arai, Hitoshi Tonomura, Ryota Takatori, Tsuyoshi Sukenari, Hiroyoshi Fujiwara, Koshiro Sawada, Yasuo Mikami, Toshikazu Kubo
CLINICAL SPINE SURGERY
(2017)
Article
Cell & Tissue Engineering
Munehiro Sakata, Hitoshi Tonomura, Tomonori Itsuji, Hidenobu Ishibashi, Ryota Takatori, Yasuo Mikami, Masateru Nagae, Ken Ichi Matsuda, Yasuhiko Tabata, Masaki Tanaka, Toshikazu Kubo
TISSUE ENGINEERING PART A
(2018)
Article
Orthopedics
Munehiro Sakata, Hitoshi Tonomura, Tomonori Itsuji, Hidenobu Ishibashi, Ryota Takatori, Yasuo Mikami, Masateru Nagae, Ken Ichi Matsuda, Masaki Tanaka, Toshikazu Kubo
JOURNAL OF ORTHOPAEDIC SURGERY
(2018)
Article
Clinical Neurology
Shigeyuki Kitanaka, Ryota Takatori, Yuji Arai, Masateru Nagae, Hitoshi Tonornura, Yasuo Mikarni, Nozornu Inoue, Taku Ogura, Hiroyoshi Fujiwara, Toshikazu Kubo
CLINICAL SPINE SURGERY
(2018)
Article
Clinical Neurology
Ryota Takatori, Taku Ogura, Wataru Narita, Tatsuro Hayashida, Hitoshi Tonomura, Yasuo Mikami, Masateru Nagae, Kazuya Ikoma, Toshikazu Kubo
CLINICAL SPINE SURGERY
(2019)
Article
Orthopedics
Tomonori Itsuji, Hitoshi Tonomura, Hidenobu Ishibashi, Yasuo Mikami, Masateru Nagae, Ryota Takatori, Takashi Tanida, Ken-Ichi Matsuda, Masaki Tanaka, Toshikazu Kubo
Summary: This study demonstrates that HGF promotes NP cell proliferation under hypoxic conditions through HIF-1α, MAPK, PI3K/Akt, and STAT3-mediated signaling pathways. Inhibiting these pathways may be a potential therapeutic strategy for disc degeneration in hypoxic conditions.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Medicine, General & Internal
Hironori Koike, Yoichiro Hatta, Hitoshi Tonomura, Masaru Nonomura, Ryota Takatori, Masateru Nagae, Kazuya Ikoma, Yasuo Mikami
Review
Biochemistry & Molecular Biology
Hitoshi Tonomura, Masateru Nagae, Ryota Takatori, Hidenobu Ishibashi, Tomonori Itsuji, Kenji Takahashi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, General & Internal
Motoya Kobayashi, Noriaki Yokogawa, Satoshi Kato, Takeshi Sasagawa, Hiroyuki Tsuchiya, Hiroaki Nakashima, Naoki Segi, Sadayuki Ito, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Junichi Yamane, Satoshi Nori, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Akiyoshi Kuroda, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Kota Watanabe
Summary: For older patients with decreased reserve function, traumatic cervical spine injuries often result in early mortality. This study aimed to identify prognostic factors for early mortality in this patient population. The analysis included 1512 patients aged >= 65 years who were hospitalized for treatment of traumatic cervical spine injuries. The results showed that older age, male sex, cervical spine fracture, complete motor paralysis, and chronic kidney disease were risk factors for early mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Yoichiro Hatta, Hitoshi Tonomura, Masateru Nagae, Ryota Takatori, Yasuo Mikami, Toshikazu Kubo
SPINE SURGERY AND RELATED RESEARCH
(2019)
Article
Surgery
Ryota Takatori, Taku Ogura, Wataru Narita, Tatsuro Hayashida, Kazuya Tanaka, Hitoshi Tonomura, Masateru Nagae, Yasuo Mikami, Toshikazu Kubo
SPINE SURGERY AND RELATED RESEARCH
(2018)