Article
Cell & Tissue Engineering
Ilona Uzieliene, Edvardas Bagdonas, Kazuto Hoshi, Tomoaki Sakamoto, Atsuhiko Hikita, Zivile Tachtamisevaite, Greta Rakauskiene, Giedrius Kvederas, Ali Mobasheri, Eiva Bernotiene
Summary: This study evaluated the chondrogenic differentiation potential of MenSCs and BMMSCs, finding that activin A had a promoting effect on chondrogenic differentiation in MenSCs.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Jia Q. Ng, Toghrul H. Jafarov, Christopher B. Little, Tongtong Wang, Abdullah M. Ali, Yan Ma, Georgette A. Radford, Laura Vrbanac, Mari Ichinose, Samuel Whittle, David J. Hunter, Tamsin R. M. Lannagan, Nobumi Suzuki, Jarrad M. Goyne, Hiroki Kobayashi, Timothy C. Wang, David R. Haynes, Danijela Menicanin, Stan Gronthos, Daniel L. Worthley, Susan L. Woods, Siddhartha Mukherjee
Summary: Osteoarthritis is characterized by irreversible degeneration of articular cartilage. Gremlin 1 marks a bipotent cell population on the articular surface, which plays a crucial role in chondrogenic and osteogenic progenitor cells. These cells are affected by injury and aging, leading to the development of osteoarthritis.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Qingyu Zhang, Jun Dong, Peng Zhang, Dongsheng Zhou, Fanxiao Liu
Summary: Key gene regulatory events were identified in early stages of lineage commitment in BMSCs, with two transcription factors (Tsc22d3 and Epas1) showing elevated expression throughout different stages of three-directional differentiation in rats.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Thomas H. Ambrosi, Owen Marecic, Adrian McArdle, Rahul Sinha, Gunsagar S. Gulati, Xinming Tong, Yuting Wang, Holly M. Steininger, Malachia Y. Hoover, Lauren S. Koepke, Matthew P. Murphy, Jan Sokol, Eun Young Seo, Ruth Tevlin, Michael Lopez, Rachel E. Brewer, Shamik Mascharak, Laura Lu, Oyinkansola Ajanaku, Stephanie D. Conley, Jun Seita, Maurizio Morri, Norma F. Neff, Debashis Sahoo, Fan Yang, Irving L. Weissman, Michael T. Longaker, Charles K. F. Chan
Summary: Aging of skeletal stem cells in mice alters bone marrow signaling and differentiation of bone and blood lineages, resulting in fragile bones with poor regeneration. Aged SSCs have decreased bone-forming potential but produce more stromal lineages expressing pro-inflammatory cytokines, contributing to bone marrow niche transformation.
Article
Polymer Science
Ilona Uzieliene, Anton Popov, Viktorija Lisyte, Gabija Kugaudaite, Paulina Bialaglovyte, Raminta Vaiciuleviciute, Giedrius Kvederas, Eiva Bernotiene, Almira Ramanaviciene
Summary: This study aimed to evaluate the chondrogenic potential of polypyrrole nanoparticles (Ppy NPs) on human bone marrow mesenchymal stem cells (BMMSCs) and compare it with cartilage-derived chondrocytes. The results showed that Ppy and Ppy/Au NPs can stimulate chondrogenesis in BMMSCs, with chondrocytes showing a stronger chondrogenic response to Ppy/Au NPs.
Article
Biochemistry & Molecular Biology
Fanxiao Liu, Jun Dong, Peng Zhang, Dongsheng Zhou, Qingyu Zhang
Summary: This study investigates the gene expressions during the early phase of differentiation of bone mesenchymal stem cells (BMSCs) and identifies differentially expressed genes (DEGs) in osteogenesis, adipogenesis, and chondrogenesis. The findings provide insights into the molecular mechanisms underlying BMSC differentiation and support the clinical treatment of bone diseases.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Young-Bum Son, Yeon Ik Jeong, Yeon Woo Jeong, Mohammad Shamim Hossein, Per Olof Olsson, Alex Tinson, Kuhad Kuldip Singh, Sang-Yun Lee, Woo Suk Hwang
Summary: This study demonstrates the differentiation potential into chondrocytes of mesenchymal stem cells (MSCs) from bone marrow (BM) and synovial fluid (SF) of the same donor Camelus dromedarius. SF-MSCs showed higher chondrogenic capacity and may serve as a potential source for treating camel chondrocyte-related issues. This is the first study to establish and compare BM-MSCs and SF-MSCs from the same camel donor, providing insight into their differentiation potential in camel regenerative medicine.
Article
Cell Biology
Wang Tang, Hongyi Zhang, Donghua Liu, Feng Jiao
Summary: The study demonstrated that ICA or BMSCs alone could repair rabbit knee cartilage damage, while the combined treatment of ICA and BMSCs showed better ability in repairing rabbit knee cartilage damage.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hao Xu, Changrong Ding, Cuicui Guo, Shuai Xiang, Yingzhen Wang, Bing Luo, Hongfei Xiang
Summary: The study revealed the significant role of CRLF1 in OA, affecting proliferation, apoptosis, and chondrogenic differentiation of BMSCs through regulation of miR-320. Inhibition of CRLF1 promotes chondrogenic differentiation of BMSCs and protects cartilage tissue from damage in osteoarthritis.
MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Jianzhang Zheng, Yunshuo Lin, Faqiang Tang, Huiling Guo, Laipeng Yan, Shiping Hu, Hong Wu
Summary: This study demonstrated that circATRNL1 enhances the differentiation of bone marrow mesenchymal stem cells (BMSCs) into chondrocytes by regulating miR-338-3p.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Junkun Zhu, Fengfeng Wu, Deting Xue, Xingzhen Wu, Fenfen Xu, Yali Lin, Zhijun Pan
Summary: This study investigated the effects of piperlongumine (PL) on the chondrogenic differentiation of human bone marrow mesenchymal stem cells (BMSCs) and explored the underlying mechanisms. The results showed that PL promoted the chondrogenic differentiation of BMSCs and increased reactive oxygen species (ROS) production. At the molecular level, PL upregulated chondrogenic differentiation-related genes and activated the ERK1/2 pathway. These effects were partially prevented by ROS production inhibitor and ERK1/2 inhibitor.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Ilona Uzieliene, Daiva Bironaite, Edvardas Bagdonas, Jolita Pachaleva, Arkadij Sobolev, Wei-Bor Tsai, Giedrius Kvederas, Eiva Bernotiene
Summary: This study investigated the chondrogenic responses of human bone marrow mesenchymal stem cells (BMMSCs) and osteoarthritis (OA) cartilage-derived chondrocytes in 3D hydrogels under mechanical load conditions. The results showed that chondrocytes had slower proliferation rate, smaller size, and higher intracellular calcium level compared to BMMSCs. Chondrocytes secreted more cartilage oligomeric matrix protein (COMP) and expressed collagen type II (COL2A1) and aggrecan (ACAN) genes but were more susceptible to mechanical load compared to BMMSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Lei Qi, Weiwen Ge, Cancan Pan, Weidong Jiang, Dan Lin, Lei Zhang
Summary: Stem cell senescence causes functional declines and disrupts bone environment homeostasis. Stem cell-derived exosomes are a promising therapy for aging-related osseous diseases. This study demonstrates the potential of osteoinductive exosomes in bone repair for aging individuals and highlights the importance of considering endocytic mechanisms and avoiding negative effects in future therapeutic design for aging populations.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemical Research Methods
Lu Luo, Nicola C. Foster, Kenny L. Man, Mathieu Brunet, David A. Hoey, Sophie C. Cox, Susan J. Kimber, Alicia J. El Haj
Summary: This study examined the effects of low magnitude hydrostatic pressure on stem cell differentiation and extracellular vesicle release. The results showed that pressure enhanced chondrogenic differentiation and increased the release of microvesicles.
BIOTECHNOLOGY JOURNAL
(2022)
Article
Chemistry, Medicinal
Duaa Abuarqoub, Sofia Adwan, Rand Zaza, Suha Wehaibi, Nazneen Aslam, Hanan Jafar, Nidal Qinnah, Abdalla Awidi
Summary: Diabetes Mellitus Type 1 is an autoimmune disease that destroys insulin-producing cells, leading to hyperglycemia. This study examined the differentiation potential of dental stem cells (SCAP) and bone-marrow-derived stem cells (BM-MSCs) into functional islet cell aggregates (ICAs). The results showed that both types of stem cells successfully differentiated into beta-cell-like cells.
Article
Surgery
Shaghayegh Arasteh, Sayeh Khanjani, Hannaneh Golshahi, Sahba Mobini, Masoud Taghizadeh Jahed, Hamed Heidari-Vala, Haleh Edalatkhah, Somaieh Kazemnejad
JOURNAL OF SURGICAL RESEARCH
(2020)
Review
Immunology
Ebrahim Mirzadegan, Hannaneh Golshahi, Somaieh Kazemnejad
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Review
Cell Biology
Mahmood Bozorgmehr, Shanti Gurung, Saeedeh Darzi, Shohreh Nikoo, Somaieh Kazemnejad, Amir-Hassan Zarnani, Caroline E. Gargett
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Medicine, Research & Experimental
Reyhane Rahnama, Ahmad-Reza Mahmoudi, Somayeh Kazemnejad, Mansour Salehi, Ataollah Ghahiri, Haleh Soltanghoraee, Sedigheh Vafaei, Abbas Rezaei, Amir Hassan Zarnani
Summary: This study found for the first time that TPO is expressed at gene and protein levels in human reproductive organs, potentially explaining the higher frequency of abortion and infertility in patients with thyroid autoimmunity.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Orthopedics
Arash Sharafat-Vaziri, Somayeh Khorasani, Maryam Darzi, Zahra Saffarian, Zahra Alizadeh, Mohammad Naghi Tahmasebi, Somaieh Kazemnejad
Article
Biology
Ali Lesani, Somaieh Kazemnejad, Mahdi Moghimi Zand, Mojtaba Azadi, Hassan Jafari, Mohammad R. K. Mofrad, Reza Nosrati
COMPUTERS IN BIOLOGY AND MEDICINE
(2020)
Article
Immunology
Ebrahim Mirzadegan, Hannaneh Golshahi, Zahra Saffarian, Maryam Darzi, Somayeh Khorasani, Haleh Edalatkhah, Kioomars Saliminejad, Somaieh Kazemnejad
Summary: By combining MenSCs with a bilayer scaffold, wound healing in diabetic mice can be promoted. Immunofluorescence evaluation showed higher levels of CD31 and VWF, higher ratio of M2/M1 macrophages, greater expression of IVL, and higher levels of PGP9.5 in the bSC + MenSCs group.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Mozhan Haji Ghaffari, Miganoosh Simonian, Ali Salimi, Ebrahim Mirzadegan, Niloufar Sadeghi, Mohammad-Reza Nejadmoghaddam, Nasim Ebrahimnezhad, Ghazaleh Fazli, Ramina Fatemi, Ali-Ahmad Bayat, Mohammadali Mazloomi, Hodjattallah Rabbani
Summary: The study demonstrates the surface expression of FMOD in TNBC cell lines and the potential of FMOD-ADC for targeted therapy in both in vitro and in vivo models, showing the induction of apoptosis and inhibition of tumor growth.
Article
Medicine, Research & Experimental
Simin Zafardoust, Somaieh Kazemnejad, Maryam Darzi, Mina Fathi-Kazerooni, Zahra Saffarian, Niloofar Khalili, Haleh Edalatkhah, Ebrahim Mirzadegan, Somayeh Khorasani
Summary: This study evaluated the therapeutic potential of autologous mesenchymal stromal cells obtained from menstrual blood (Men-MSCs) for patients with premature ovarian failure (POF). The results showed that the injection of Men-MSCs improved ovarian function and menstrual restoration in some POF patients.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Meeting Abstract
Cell & Tissue Engineering
Ebrahim Mirzadegan, Zahra Saffarian, Hannaneh Golshahi, Maryam Darzi, Somayeh Khorasani, Somaieh Kazemnejad
TISSUE ENGINEERING PART A
(2022)
Article
Biochemical Research Methods
Shaghayegh Arasteh, Sara Katebifar, Reza Shirazi, Somaieh Kazemnejad
STEM CELL NANOTECHNOLOGY, 2 EDITION: Methods and Protocols
(2020)
Article
Obstetrics & Gynecology
Niloofar Motaref, Sheyda Jouhari, Afsaneh Mohammadzadeh, Somaieh Kazemnejad, Narges Madadi, Abolfazl Ghoodjani
INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE
(2020)
Article
Cell & Tissue Engineering
Simin Zafardoust, Somaieh Kazemnejad, Maryam Darzi, Mina Fathi-Kazerooni, Hilda Rastegari, Afsaneh Mohammadzadeh
STEM CELL REVIEWS AND REPORTS
(2020)
