Review
Immunology
Masahiro Miyata, Kazunobu Ichikawa, Eri Matsuki, Masafumi Watanabe, Daniel Peltier, Tomomi Toubai
Summary: Acute kidney injury is a common complication of allogeneic hematopoietic cell transplantation and can be caused by multiple factors. Recent studies suggest that graft-versus-host disease may attack the kidneys and contribute to the development of renal injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell & Tissue Engineering
Davod Pashoutan Sarvar, Hosein Effatpanah, Parvin Akbarzadehlaleh, Karim Shamsasenjan
Summary: The study highlights the important role of MSC-derived extracellular vesicles (MSC-EVs) in hematopoietic regulation and immune response after transplantation. MSC-EVs directly fuse with hematopoietic stem cell membranes, affecting their fate, and regulate the proliferation and differentiation of hematopoietic stem cells through the release of various bioactive factors.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Immunology
Benedikt Obermayer, Luisa Keilholz, Thomas Conrad, Marco Frentsch, Igor-Wolfgang Blau, Lam Vuong, Stella Lesch, Kamran Movasshagi, Carola Tietze-Stolley, Lucie Loyal, Larissa Henze, Olaf Penack, Ulrik Stervbo, Nina Babel, Simon Haas, Dieter Beule, Lars Bullinger, Friedrich Wittenbecher, Il-Kang Na
Summary: The fate of individual donor T-cells is crucial for the balance between intended and adverse effects in allogeneic hematopoietic stem cell transplantation (alloHSCT). In this study, we tracked alpha beta T-cell clonotypes during stem cell mobilization and immune reconstitution after transplant. We found over 250 alpha beta T-cell clonotypes that consisted mainly of CD8(+) effector memory T cells. These clonotypes showed a distinct transcriptional signature and enhanced effector and cytotoxic functions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Michael Spencer Chapman, Alyssa H. Cull, Marioara F. Ciuculescu, Erica B. Esrick, Emily Mitchell, Hyunchul Jung, Laura O'Neill, Kirsty Roberts, Margarete A. Fabre, Nicholas Williams, Jyoti Nangalia, Joanne Quinton, James M. Fox, Danilo Pellin, Julie Makani, Myriam Armant, David A. Williams, Peter J. Campbell, David G. Kent
Summary: The impact of gene therapy on patients with sickle cell disease is thought to be related to the activation of mutant clones. This study used whole-genome sequencing to track hematopoietic stem cells from six patients and identified certain mutant clones associated with myeloid malignancies and clonal hematopoiesis.
Article
Hematology
Linus Angenendt, Isabel Hilgefort, Jan-Henrik Mikesch, Bernhard Schlueter, Wolfgang E. Berdel, Georg Lenz, Matthias Stelljes, Christoph Schliemann
Summary: High posttransplant magnesium levels have been independently associated with a lower relapse rate, an increased risk of acute graft-versus-host disease, and higher non-relapse mortality in patients with acute myeloid leukemia.
ANNALS OF HEMATOLOGY
(2021)
Review
Cell Biology
Stefania Crippa, Ludovica Santi, Margherita Berti, Giada De Ponti, Maria Ester Bernardo
Summary: The human organism requires the production of approximately 1 trillion new blood cells per day through hematopoiesis in the bone marrow, regulated by the BM microenvironment and HSPCs. The BM niche, defined by interactions between HSPCs and non-hematopoietic cells, controls HSPC maintenance and orchestrates hematopoiesis according to the body's needs. Mesenchymal stromal cells (MSCs) play a key role in the BM niche by regulating HSPC homeostasis and impacting the outcome of hematopoietic stem cell transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell & Tissue Engineering
Teng Li, Chengxin Luo, Jiasi Zhang, Ling Wei, Wei Sun, Qin Xie, Yan Liu, Yongli Zhao, Shuangnian Xu, Lihua Wang
Summary: The co-infusion of mesenchymal stem cells (MSCs) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) has shown improvement in engraftment and reduced risk of chronic graft-versus-host disease (cGVHD). However, the effects varied among different age and disease groups, suggesting potential benefits for certain populations.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Bernard J. Smilde, Esmee Botman, Teun J. de Vries, Ralph de Vries, Dimitra Micha, Ton Schoenmaker, Jeroen J. W. M. Janssen, Elisabeth M. W. Eekhoff
Summary: Fibroblasts play a crucial role in maintaining the extracellular matrix of connective tissues. Recent studies have found donor-derived fibroblasts in bone marrow transplant recipients, though some findings were not replicated. This systematic review provides an overview of hematopoietic stem cells differentiating into fibroblasts in various tissues, revealing evidence of fibroblasts derived from hematopoietic stem cells in almost all organs.
Article
Immunology
Hongfeng Huang, Qixia Shen, Jingyi Zhou, Xiuyan Yang, Qiuqin Cai, Jia Shen, Shi Feng, Wenqing Xie, Hong Jiang, Jianghua Chen
Summary: The clinical experience demonstrates the efficacy of non-myeloablative conditioning protocol in inducing tolerance in HLA identical patients, and complete chimerism may be a risk factor for GVHD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Masayuki Yamashita, Atsushi Iwama
Summary: This review summarizes the changes in hematopoietic stem cells (HSCs) during aging and how different clones of HSCs can be expanded. Research shows that in mice and humans, the clonal behavior of HSCs is closely related to the risk of hematological malignancies and cardiovascular diseases. Therefore, understanding the impact of aging on the hematopoietic system is critical to prevent or overcome age-related changes in the blood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Sophie Servais, Frederic Baron, Chantal Lechanteur, Laurence Seidel, Etienne Baudoux, Alexandra Briquet, Dominik Selleslag, Johan Maertens, Xavier Poire, Wilfried Schroyens, Carlos Graux, Ann De Becker, Pierre Zachee, Aurelie Ory, Julie Herman, Tessa Kerre, Yves Beguin
Summary: BM-derived MSC from a third-party donor appeared to improve hematological function after alloHCT, but comparative studies are needed to confirm these results.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Karin Melanie Cabanillas Stanchi, Judith Boehringer, Manuel Stroelin, Samuel Groeschel, Katrin Lenglinger, Claudia Treuner, Christiane Kehrer, Lucia Laugwitz, Andrea Bevot, Nadja Kaiser, Michael Schumm, Peter Lang, Rupert Handgretinger, Ingeborg Kraegeloh-Mann, Ingo Mueller, Michaela Doering
Summary: The application of mesenchymal stem cells (MSCs) in pediatric metachromatic leukodystrophy (MLD) patients after allogeneic hematopoietic stem cell transplantation (HSCT) is safe and well tolerated. MSC application leads to higher levels of ARSA, leukocyte, and thrombocyte in patients within the first year of MSC application. However, there was no significant effect on graft-versus-host disease (GvHD), immune cell regeneration, MRI changes, gross motor function, and clinical outcomes. Further larger trials are needed to evaluate the impact of MSC application on engraftment and hematopoietic recovery.
STEM CELLS AND DEVELOPMENT
(2022)
Review
Hematology
Mariam T. Nawas, Johannes Schetelig, Frederik Damm, Ross L. Levine, Miguel-Angel Perales, Sergio A. Giralt, Marcel R. VanDenBrink, Maria E. Arcila, Ahmet Zehir, Elli Papaemmanuil, Anja Klussmeier, Alexander H. Schmidt, Stephanie Maiwald, Kelly L. Bolton, Roni Tamari
Summary: Clonal hematopoiesis refers to somatic mutations in hematopoietic stem and progenitor cells leading to clonal expansion, which increases with age; its role in hematopoietic cell transplantation is becoming increasingly important; post-transplant hematopoiesis is influenced by various factors, requiring more large-scale studies to establish a management approach for CH.
Article
Biochemistry & Molecular Biology
Sanshiro Kanazawa, Hiroyuki Okada, Dan Riu, Yo Mabuchi, Chihiro Akazawa, Junichi Iwata, Kazuto Hoshi, Atsuhiko Hikita
Summary: This study demonstrates the important role of c-Mpl signal in the proliferation and differentiation ability of mesenchymal stem cells (MSCs), which are maintained through co-culture with hematopoietic stem cells (HSCs). Furthermore, the study suggests the existence of a hematopoietic-mesenchymal signal and highlights the significance of HSC state in the stability of MSC properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Ting Lin, Yunfan Yang, Xinchuan Chen
Summary: Hematopoietic stem cell transplantation (HSCT) is an effective treatment for malignant hematological diseases. Mesenchymal stem cells (MSCs) play a role in promoting hematopoietic stem cell implantation and enhancing hematopoietic function reconstruction. They also show promise in preventing and treating graft-versus-host disease (GVHD), but larger randomized controlled trials are needed for validation. Factors such as dose, source, application time, and frequency need to be considered when using MSCs clinically.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
