Article
Obstetrics & Gynecology
Pleun Beelen, Marian J. van den Brink, Malou C. Herman, Peggy M. A. J. Geomini, Janny H. Dekker, Ruben G. Duijnhoven, Nienke Mak, Hannah S. van Meurs, Sjors F. Coppus, Jan Willem van der Steeg, Heleen P. Eising, Diana S. Massop-Helmink, Ellen R. Klinkert, Theodoor E. Nieboer, Anne Timmermans, Lucet F. van der Voet, Sebastiaan Veersema, Nicol A. C. Smeets, Joke M. Schutte, Marchien van Baal, Patrick M. Bossuyt, Ben Willem J. Mol, Marjolein Y. Berger, Marlies Y. Bongers
Summary: This study compared the effectiveness of the levonorgestrel-releasing intrauterine system with endometrial ablation in women with heavy menstrual bleeding. Both treatments led to a significant decrease in menstrual blood loss and similar quality of life scores post-treatment, but endometrial ablation showed a significant advantage in reducing menstrual blood loss.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Lucy H. R. Whitaker, Lee J. Middleton, Jane P. Daniels, Alistair R. W. Williams, Lee Priest, Smita Odedra, Versha Cheed, Clive E. Stubbs, T. Justin Clark, Mary-Ann Lumsden, Dharani K. Hapangama, Siladitya Bhattacharya, Paul P. Smith, Elaine P. Nicholls, Neil Roberts, Scott I. Semple, Lucky Saraswat, Jane Walker, Rohan R. Chodankar, Hilary O. D. Critchley
Summary: This study compared the effectiveness of ulipristal acetate and the levonorgestrel-releasing intrauterine system in reducing heavy menstrual bleeding, regardless of the presence of fibroids. The results showed that ulipristal acetate was more effective at inducing amenorrhoea, but both treatments improved quality of life.
Review
Obstetrics & Gynecology
Tamara J. Oderkerk, Majorie M. A. van de Kar, Carlijn H. M. van Der Zanden, Peggy M. A. J. Geomini, Malou C. Herman, Marlies Y. Bongers
Summary: Immediately inserting a levonorgestrel-intrauterine system (LNG-IUS) after endometrial ablation/resection seems to reduce the need for re-intervention and hysterectomy rates, and improve patient satisfaction. However, limited observational studies with low methodological quality are currently available, highlighting the need for higher quality research to confirm these findings.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Obstetrics & Gynecology
M. J. van den Brink, P. Beelen, M. C. Herman, P. M. Geomini, J. H. Dekker, K. M. Vermeulen, M. Y. Bongers, M. Y. Berger
Summary: This study compared the costs and non-inferiority of starting treatment for heavy menstrual bleeding with LNG-IUS versus EA. The findings suggest that starting with LNG-IUS is cheaper but slightly less effective than starting with EA.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
Chihiro Ishizawa, Yasushi Hirota, Rei Iida, Tetsuaki Kaku, Tomoyuki Hirata, Yamato Fukui, Erika Omura, Shun Akaeda, Takehiro Hiraoka, Mitsunori Matsuo, Yutaka Osuga
Summary: This study aimed to investigate the efficacy of levonorgestrel-releasing intrauterine system (LNG-IUS) in improving menorrhagia-specific health-related quality of life (HR-QOL) in patients with symptomatic adenomyosis. The study found that LNG-IUS treatment effectively improved menorrhagia-specific HR-QOL in patients with incipient type adenomyosis, but its efficacy was decreased in patients with advanced type adenomyosis. LNG-IUS treatment also improved blood hemoglobin levels in incipient type adenomyosis but not in advanced type. Dysmenorrhea and heavy menstrual bleeding (HMB)-related anemia were associated with HR-QOL impairment, and LNG-IUS treatment may relieve these symptoms and improve HR-QOL. The use of magnetic resonance imaging should be reinforced to predict LNG-IUS efficacy in improving HR-QOL in patients with adenomyosis.
REPRODUCTIVE SCIENCES
(2023)
Review
Medicine, General & Internal
Paola Bianchi, Sun-Wei Guo, Marwan Habiba, Giuseppe Benagiano
Summary: This literature review examines the use of levonorgestrel-releasing intrauterine devices for heavy menstrual bleeding and/or dysmenorrhea. The review highlights that the insertion of a levonorgestrel-releasing intrauterine system is a useful option for long-term treatment, improving the quality of life and reducing menstrual blood loss and dysmenorrhea symptoms. Its ability to induce amenorrhea is considered to be the most important mechanism of action.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Hye Yun Kim, Soo Youn Song, Soo Hwa Jung, Hyun Jeong Song, Mina Lee, Ki Hwan Lee, Ye Won Jung, Heon Jong Yoo
Summary: This study suggests that using levonorgestrel releasing intrauterine system (LNG-IUS) for >5 years as postoperative maintenance therapy for endometriosis patients can significantly reduce pain with less systemic side effects compared to other treatments.
Article
Obstetrics & Gynecology
Feng Sun, Ye Zhang, Min You, YePing Yang, YingYing Yu, Hong Xu
Summary: Laparoscopic adenomyomectomy combined with intraoperative replacement of LNG-IUS is a novel and effective surgical procedure for treating symptomatic adenomyosis, showing significant reduction in dysmenorrhea and menorrhagia symptoms with a clinical effective rate of over 96%.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Review
Obstetrics & Gynecology
Aline Zurcher, Laura Knabben, Heidrun Janka, Petra Stute
Summary: This systematic review analyzed the literature on breast cancer and the use of the levonorgestrel-releasing intrauterine system (LNG-IUS). The results suggest an increased risk of breast cancer in LNG-IUS users, especially in postmenopausal women and with longer duration of use. However, the heterogeneity of the studies and various confounding factors call for further investigations.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Medicine, General & Internal
Guo-Rui Zhang, Xin Yu
Summary: Perforation of LNG-IUS one month after placement is rare and requires laparoscopic surgery for removal. Ultrasound monitoring is recommended when the operation is difficult to reduce the risk of IUD perforation. Postoperative imaging is recommended for patients with inadequate surgery to detect potential risks as soon as possible.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Medicine, Research & Experimental
Mikio Momoeda, Shigeo Akira, Tasuku Harada, Jo Kitawaki, Nagamasa Maeda, Ikuko Ota, Keisuke Yoshihara, Noriko Takahashi
Summary: This study aimed to evaluate the quality of life of Japanese women using LNG-IUS and found that LNG-IUS improves the quality of life for women with dysmenorrhea and heavy menstrual bleeding, regardless of patient background characteristics.
ADVANCES IN THERAPY
(2022)
Article
Endocrinology & Metabolism
Limei Ji, Lanying Jin, Ming Jun Shao, Min Hu, JIan Xu
Summary: This study aimed to compare the reproductive hormone levels and metabolic variables in patients with PCOS treated with LNG-IUS. The results showed that LNG-IUS did not significantly impact the clinical and metabolic variables in PCOS patients and healthy controls.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Kristen A. Matteson, Josie Valcin, Christina A. Raker, Melissa A. Clark
Summary: This study compared the effectiveness of the levonorgestrel intrauterine system and combined oral contraceptives in improving quality of life for individuals with heavy menstrual bleeding, and found no significant differences between the two treatments.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
Linling Zhu, Xinyun Yang, Benben Cao, Shanshan Tang, Jinyi Tong
Summary: The study demonstrated the feasibility and value of using the hysteroscopic cold-knife surgery system (HCSS) to fix a levonorgestrel-releasing intrauterine device (LNG-IUD) for treatment of adenomyosis. Proficient endoscopic suturing is key to the success of the technique, which can provide effective treatment for patients and prevent the risk of IUD expulsion.
FERTILITY AND STERILITY
(2021)
Article
Public, Environmental & Occupational Health
Pleun Beelen, Marian J. van den Brink, Malou C. Herman, Peggy M. Geomini, Ruben G. Duijnhoven, Marlies Y. Bongers
Summary: This study identified factors associated with failure of treatment using LNG-IUS in women with heavy menstrual bleeding, with younger age and severe dysmenorrhea found to be risk factors for discontinuation of treatment. High discontinuation rates were observed in this group of women.
