Article
Multidisciplinary Sciences
Pippa F. Cosper, Laura C. F. Hrycyniak, Maha Paracha, Denis L. Lee, Jun Wan, Kathryn Jones, Sophie A. Bice, Kwangok Nickel, Samyukta Mallick, Alison M. Taylor, Randall J. Kimple, Paul F. Lambert, Beth A. Weaver
Summary: This study reveals that high-risk human papillomavirus (HPV) induces chromosomal instability in head and neck cancer cells by degradation of the mitotic kinesin CENP-E. Specifically, the HPV16 oncogene E6, not E7, is responsible for inducing this degradation. Understanding the mechanism by which HPV induces chromosomal instability can have significant implications for HPV-mediated tumor development and therapeutic response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Barbara Gardella, Mattia Dominoni, Marianna Francesca Pasquali, Chiara Melito, Giacomo Fiandrino, Stefania Cesari, Marco La Verde, Arsenio Spinillo
Summary: This study aimed to evaluate the effect of anti-HPV preventive vaccination on patients with low-grade cervical lesions. The results showed that the rate of persistence and progression of CIN was higher in the unvaccinated group compared to the vaccinated group. The study also found that vaccination, age, and HPV genotypes were associated with the development of CIN2+.
Article
Virology
Wei Lu, Tingting Chen, Yimin Yao, Ping Chen
Summary: This study investigated the epidemiological characteristics of high-risk HPV in Zhejiang province, China, and found a significant association between HPV16 infection and cervical lesions. The presence of HPV16/18 was also linked to increased risk of developing high-grade cervical lesions and cancer progression in this population. These findings underscore the importance of HPV testing in early screening and prevention of cervical cancer.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Immunology
Haruna Arakawa, Shohei Yokoyama, Takehiro Ohira, Dedong Kang, Kazuho Honda, Yoshihiko Ueda, Akihiro Tojo
Summary: A 16-year-old girl developed fever and renal abnormalities after receiving the HPV vaccine, and was diagnosed with secondary membranous nephropathy. Although HPV proteins were not detected in the vaccine, it is possible that the vaccine triggered a pre-existing HPV infection in the patient.
Article
Otorhinolaryngology
Martha Zakrzewski, Orla Margaret Gannon, Benedict James Panizza, Nicholas Andrew Saunders, Annika Antonsson
Summary: Our study revealed significant differences in the oral microbiota and bacterial richness of oropharyngeal cancer patients based on HPV status, confirming previous findings. This provides new microbiome evidence to support the treatment and prevention of oropharyngeal cancer.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Virology
Toshiyuki Maehama, Sumire Shimada, Jinichi Sakamoto, Takeo Shibata, Satoko Fujita, Masahiro Takakura, Hiroaki Takagi, Toshiyuki Sasagawa
Summary: This study aimed to validate the use of liquid phenol-based chemical peeling therapy for cervical and vaginal intraepithelial neoplasia (CIN and VaIN) and determine the factors associated with treatment resistance. The results showed that phenol-based therapy is safe and effective for treating CINs and VaINs. Women under 35 years with persistent CIN1 or CIN2 with a single HPV-type infection are suitable candidates for this therapy, although multiple lengthy sessions are required.
Article
Oncology
Fangbin Song, Jerome L. Belinson, Peisha Yan, Xia Huang, Chun Wang, Hui Du, Xinfeng Qu, Ruifang Wu
Summary: This study evaluated the performance of a novel p16 immunocytology approach and HPV genotyping in triaging HPV-positive self-samples. The findings suggest that p16 is more sensitive and less specific than ASC-US+, and two triage strategies combining p16 with cytology or genotypes were superior to the ASC-US+ strategy. These strategies achieved better balance between diseases detection and colposcopy referral.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Irene H. Nauta, Danielle A. M. Heideman, Arjen Brink, Berdine van der Steen, Elisabeth Bloemena, Senada Koljenovic, Robert J. Baatenburg de Jong, C. Rene Leemans, Ruud H. Brakenhoff
Summary: The prevalence of HPV in oral cavity squamous cell carcinoma is low, and neither HPV status nor p16 status affects outcome, making it seem irrelevant for clinical management to determine HPV status in OCSCC.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Medicine, General & Internal
Muhammad Awawda, Saeed Salman, Salem Billan
Summary: This study investigated the role of human papillomavirus (HPV) in patients with nasopharyngeal carcinoma (NPC) treated with radiotherapy. The results showed that 13.5% of patients had HPV infection, which was not associated with age or lymph node metastasis, but had no prognostic significance.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Kevin Parza, Arfa Mustasam, Filip Ionescu, Mahati Paravathaneni, Reagan Sandstrom, Houssein Safa, G. Daniel Grass, Peter A. Johnstone, Steven A. Eschrich, Juskaran Chadha, Niki Zacharias, Curtis A. Pettaway, Philippe E. Spiess, Jad Chahoud
Summary: This paper systematically reviewed the literature on the impact of HPV and p16 immunohistochemistry on the prognosis of PSCC. The study found that HPV-positive and p16-positive PSCC patients had better overall survival and disease-free survival. This highlights the need for a meta-analysis to determine the role of routine HPV status or p16 staining testing in the initial diagnosis and staging of PSCC patients worldwide.
Article
Oncology
Federica Inturrisi, Birgit Lissenberg-Witte, Nienke J. Veldhuijzen, Johannes A. Bogaards, Guglielmo Ronco, Chris J. L. M. Meijer, Johannes Berkhof
Summary: The study found that HPV vaccination leads to a significant decline in lifetime CIN3+ risk, with the remaining absolute CIN3+ risk being very low. Even after nonavalent vaccination, primary HPV testing with adjunct cytology at five-year intervals seems feasible.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Obstetrics & Gynecology
Renee M. F. Ebisch, L. Lucia Rijstenberg, Gilda Ghazi Soltani, Judith van der Horst, Judith E. M. Vedder, Meyke Hermsen, Remko P. Bosgraaf, Leon F. A. G. Massuger, Chris J. L. M. Meijer, Danielle A. M. Heideman, Folkert J. van Kemenade, Willem J. G. Melchers, Ruud L. M. Bekkers, Albert G. Siebers, Johan Bulten
Summary: This study shows that adjunctive use of p16 immunohistochemistry to hematoxylin and eosin (H&E) morphology reduces the number of CIN1 and CIN2 classifications with a proportional increase in no CIN and CIN3 diagnoses. The pathologists felt more confident in classifying the material with H&E and p16 immunohistochemistry than by using H&E alone, particularly during assessment of small biopsies.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Oncology
Ryo Ikesu, Ayumi Taguchi, Konan Hara, Kei Kawana, Tetsushi Tsuruga, Jun Tomio, Yutaka Osuga
Summary: Previous studies have shown that individuals with HPV-related cervical lesions have different prognoses according to the HPV genotype, but failed to account for possible diagnostic misclassification. This retrospective study aimed to clarify the natural course of cervical lesions according to HPV genotype and estimate diagnostic misclassification. The study found that lesions in HPV 16-positive patients were more likely to progress to CIN3/cancer compared to lesions in patients with other HPV genotypes.
Article
Immunology
Howard D. Strickler, Marla J. Keller, Nancy A. Hessol, Isam-Eldin Eltoum, Mark H. Einstein, Philip E. Castle, L. Stewart Massad, Lisa Flowers, Lisa Rahangdale, Jessica M. Atrio, Catalina Ramirez, Howard Minkoff, Adaora A. Adimora, Igho Ofotokun, Christine Colie, Megan J. Huchko, Margaret Fischl, Rodney Wright, Gypsyamber D'Souza, Jason Leider, Olga Diaz, Lorraine Sanchez-Keeland, Sadeep Shrestha, Xianhong Xie, Xiaonan Xue, Kathryn Anastos, Joel M. Palefsky, Robert D. Burk
Summary: The study found that in women living with HIV, primary human papillomavirus screening (PHS) combined with reflex HPV16/18 genotyping can reduce unnecessary colposcopies, potentially serving as an alternative to co-testing.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Oncology
Yuki Saito, Akihiro Homma, Naomi Kiyota, Makoto Tahara, Nobuhiro Hanai, Takahiro Asakage, Kazuto Matsuura, Ichiro Ota, Tomoya Yokota, Daisuke Sano, Takeshi Kodaira, Atsushi Motegi, Koichi Yasuda, Shunji Takahashi, Kaoru Tanaka, Takuma Onoe, Susumu Okano, Yoshinori Imamura, Yosuke Ariizumi, Ryuichi Hayashi
Summary: This article discusses the clinical trials and prevention of human papillomavirus-related oropharyngeal carcinoma in Japan. It emphasizes the increasing incidence of the disease and the importance of surgical treatment for eligible patients undergoing chemotherapy and radiation.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xavier Bargallo, Belen Ubeda, Sergi Ganau, Blanca Gonzalez, Miguel Macedo, Inma Alonso, Gabriela Oses, Maria Vidal, Gorane Santamaria
Summary: The study aimed to describe the magnetic resonance characteristics of radial scars/complex sclerosing lesions (RS/CSL) of the breast using the current BI-BADS lexicon, and investigate the value of diffusion weighted imaging for predicting malignancy. The majority of RS/CSL showed enhancement at MR, predominantly presenting as non-mass, focal, heterogeneous internal enhancement. All cases associated with cancer showed non-mass enhancement.
CURRENT MEDICAL IMAGING
(2022)
Review
Biochemistry & Molecular Biology
Inmaculada Ribera-Cortada, Jose Guerrero-Pineda, Isabel Trias, Luis Veloza, Adriana Garcia, Lorena Marimon, Sherley Diaz-Mercedes, Jose Ramon Alamo, Maria Teresa Rodrigo-Calvo, Naiara Vega, Ricardo Lopez del Campo, Rafael Parra-Medina, Tarek Ajami, Antonio Martinez, Oscar Reig, Maria J. Ribal, Juan Manuel Corral-Molina, Pedro Jares, Jaume Ordi, Natalia Rakislova
Summary: Penile squamous cell carcinoma (PSCC) is a rare and aggressive tumor with dual pathogenesis. The understanding of its molecular landscape is limited, hindering the development of targeted treatment. Current studies on genetic alterations in PSCC have shown inconsistency in methodologies and limited case numbers, leading to different findings. Identified mutations and copy number alterations involve several genes and pathways. However, their relevance, role in signaling pathways, and association with HPV status remain unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Nuria Carreras-Dieguez, Ariel Glickman, Meritxell Munmany, Georgina Casanovas, Nuria Agusti, Berta Diaz-Feijoo, Adela Saco, Beatriz Sanchez, Lydia Gaba, Martina Aida Angeles, Jaume Pahisa, Esther Fernandez-Galan, Aureli Torne, Pere Fuste
Summary: ROMA and CPH-I perform better than tumor markers alone in identifying patients with EOC or MCO. They can be helpful in assessing the risk of malignancy in adnexal masses, especially in cases where ultrasonographic diagnosis is challenging (stage I EOC, inconclusive diagnosis of malignancy by ultrasound features).
Article
Infectious Diseases
Camila G. Beiras, Michael Marks, Llorenc Quinto, Sergi Gavilan, Reman Kolmau, Maria Ubals, Marti Vall-Mayans, Oriol Mitja
Summary: Recurrent episodes of Yaws can occur in children living in remote rural areas, with a higher risk for those aged 15 or younger. The number of previous ulcers and reinfection with the same microorganism are associated with a higher risk of recurrence. Active follow-up is necessary for young children diagnosed with cutaneous ulcers, especially those with a history of recurrence.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Oncology
Blanca Gil-Ibanez, Antonio Gil-Moreno, Aureli Torne, Angel Martin Jimenez, Mikel Gorostidi, Ignacio Zapardiel, Alvaro Tejerizo Garcia, Berta Diaz-Feijoo
Summary: The study aimed to analyze the impact of tumor size >= 2 cm on oncological outcomes of fertility-sparing surgery (FSS) in early cervical cancer in a Spanish cohort. Tumor size >= 2 cm was found to be the most important negative prognostic factor in this multicenter cohort of patients with early cervical cancer and gestational desire who underwent FSS in Spain. Rigorous selection criteria for fertility preservation are crucial, especially for patients with tumors larger than 2 cm, to achieve better oncological outcomes.
Article
Immunology
Carla Henere, Aureli Torne, Anna Llupia, Marta Aldea, Cristina Marti, Ariel Glickman, Adela Saco, Lorena Marimon, Carolina Manzotti, Natalia Rakislova, Jaume Ordi, Marta del Pino
Summary: This study demonstrates that HPV vaccination before treatment reduces the prevalence of post-treatment HSIL, and suggests that vaccination might even benefit women with persistent HPV after treatment.
Article
Oncology
Carolina Manzotti, Laurina Chulo, Ricardo Lopez del Campo, Isabel Trias, Marta del Pino, Ofelia Saude, Iracema Basilio, Nelson Tchamo, Lucilia Lovane, Cesaltina Lorenzoni, Fabiola Fernandes, Adela Saco, Maria Teresa Rodrigo-Calvo, Lorena Marimon, Mamudo R. Ismail, Carla Carrilho, Inmaculada Ribera-Cortada, Jaume Ordi, Natalia Rakislova
Summary: This study compares the etiopathogenic features of penile squamous cell carcinomas (PSCC) from Mozambique and Spain. The results show significant differences in age distribution and HPV association between the two countries. These findings have important implications for primary prevention of PSCC worldwide.
Article
Biochemistry & Molecular Biology
Elena Elez, Nuria Mulet-Margalef, Miriam Sanso, Fiorella Ruiz-Pace, Francesco M. Mancuso, Raquel Comas, Javier Ros, Guillem Argiles, Giulia Martini, Enrique Sanz-Garcia, Iosune Baraibar, Francesc Salva, Alba Noguerido, Jose Luis Cuadra-Urteaga, Roberta Fasani, Ariadna Garcia, Jose Jimenez, Susana Aguilar, Stefania Landolfi, Javier Hernandez-Losa, Irene Brana, Paolo Nuciforo, Rodrigo Dienstmann, Josep Tabernero, Ramon Salazar, Ana Vivancos
Summary: In this study, the search for immunotherapy biomarkers in Microsatellite Instability High/Deficient Mismatch Repair system (MSI-H/dMMR) metastatic colorectal cancer (mCRC) was conducted. Different gene mutations were found to be more frequent in patients with resistance to PD-1/PD-L1 inhibitors compared to those with response. Analysis of the immune microenvironment showed higher immune infiltration and PD-L1 expression in patients responding to the inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Cedric Nesti, Konstantin Braeutigam, Marta Benavent, Laura Bernal, Hessa Boharoon, Johan Botling, Antonin Bouroumeau, Iva Brcic, Maximilian Brunner, Guillaume Cadiot, Maria Camara, Emanuel Christ, Thomas Clerici, Ashley K. Clift, Hamish Clouston, Lorenzo Cobianchi, Jaroslaw B. Cwikla, Kosmas Daskalakis, Andrea Frilling, Rocio Garcia-Carbonero, Simona Grozinsky-Glasberg, Jorge Hernando, Valerie Hervieu, Johannes Hofland, Pernille Holmager, Frediano Inzani, Henning Jann, Paula Jimenez-Fonseca, Enes Kacmaz, Daniel Kaemmerer, Gregory Kaltsas, Branislav Klimacek, Ulrich Knigge, Agnieszka Kolasinska-Cwikla, Walter Kolb, Beata Kos-Kudla, Catarina Alisa Kunze, Stefania Landolfi, Stefano La Rosa, Carlos Lopez Lopez, Kerstin Lorenz, Maurice Matter, Peter Mazal, Claudia Mestre-Alagarda, Patricia Morales del Burgo, Els J. M. Nieveen van Dijkum, Kira Oleinikov, Lorenzo A. Orci, Francesco Panzuto, Marianne Pavel, Marine Perrier, Henrik Mikael Reims, Guido Rindi, Anja Rinke, Maria Rinzivillo, Xavier Sagaert, Ilker Satiroglu, Andreas Selberherr, Alexander R. Siebenhuener, Margot E. T. Tesselaar, Michael J. Thalhammer, Espen Thiis-Evensen, Christos Toumpanakis, Timon Vandamme, Jose G. van den Berg, Alessandro Vanoli, Marie-Louise F. van Velthuysen, Chris Verslype, Stephan A. Vorburger, Alessandro Lugli, John Ramage, Marcel Zwahlen, Aurel Perren, Reto M. Kaderli
Summary: This study investigated whether patients with 1-2 cm appendiceal neuroendocrine tumors (NETs) need to undergo right-sided hemicolectomy, and found that right-sided hemicolectomy is not necessary after appendectomy for appendiceal NETs. Furthermore, it was found that regional lymph node metastases of appendiceal NETs are clinically irrelevant and additional postoperative exclusion of metastases and histopathological evaluation of risk factors is not supported. These findings should inform the development of treatment guidelines.
Editorial Material
Cardiac & Cardiovascular Systems
Jara Gayan Ordas, Carlos Eduardo Izurieta, Eva Maria Pueo Crespo, Stefania Landolfi, Fernando Worner Diz
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Oncology
Isaac Cebrecos, Eduard Mension, Inmaculada Alonso, Helena Castillo, Esther Sanfeliu, Sergi Vidal-Sicart, Sergi Ganau, Maria Vidal, Francesco Schettini
Summary: In early stage breast cancer patients without lymph node metastasis, the presence of positive sentinel lymph nodes after primary systemic treatment directs axillary lymph node dissection. This study aimed to identify factors associated with non-sentinel lymph node involvement and develop a predictive score. The results showed that non-sentinel lymph node involvement was infrequent (22.2%) and associated with progesterone receptor levels and macrometastatic sentinel lymph nodes. The developed predictive score accurately predicted the absence of non-sentinel lymph node involvement, suggesting that unnecessary axillary lymph node dissection could be safely avoided in most patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Iosune Baraibar, Ariadna Garcia, Francesc Salva, Javier Ros, Nadia Saoudi, Raquel Comas, Gloria Castillo, Mireia Sanchis, Alejandro Garcia-Alvarez, Jorge Hernando, Jaume Capdevila, Marta R. Castells, Marc Marti, Stefania Landolfi, Eloy Espin, Begona Navalpotro, Jorge Guevara, Cristina Dopazo, Paolo Nuciforo, Ana Vivancos, Josep Tabernero, Elena Elez
Summary: The COVID19 pandemic has impacted cancer care globally, including early onset colorectal cancer (EOCRC) patients. This study compares the clinicopathological features and outcomes of EOCRC patients in our center during the pandemic with the same period in 2019 and 2021. The frequency and stage at diagnosis remained unchanged during the given periods, and the impact on systemic therapy and clinical trials was minimal.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Eduard Mension, Inmaculada Alonso, Sonia Angles-Acedo, Cristina Ros, Jorge Otero, lvaro Villarino, Ramon Farre, Adela Saco, Naiara Vega, Natalia Castrejon, Jaume Ordi, Natalia Rakislova, Marta Tortajada, Isabel Matas, Silvia Gomez, Laura Ribera, Camil Castelo-Branco
Summary: Survivors of breast cancer with genitourinary syndrome of menopause (GSM) may experience more severe symptoms and new treatments such as vaginal laser therapy have emerged. This study aimed to assess the safety and efficacy of carbon dioxide (CO2) vs sham vaginal laser therapy in breast cancer survivors with GSM. The results showed that vaginal laser treatment was safe after 6 months of follow-up, but there were no statistically significant differences in efficacy between CO2 and sham laser therapy.
Editorial Material
Oncology
Isaac Cebrecos, Eduard Mension, Inmaculada Alonso, Helena Castillo, Esther Sanfeliu, Sergi Vidal-Sicart, Sergi Ganau, Maria Vidal, Francesco Schettini
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Infectious Diseases
Deborah N. Melo, Giovanna R. P. Lima, Carolina G. Fernandes, Andre C. Teixeira, Joel B. Filho, Fernanda M. C. Araujo, Lia C. Araujo, Andre M. Siqueira, Luis A. B. G. Farias, Renata A. A. Monteiro, Jaume Ordi, Miguel J. Martinez, Paulo H. N. Saldiva, Luciano P. G. Cavalcanti
Summary: This study reports the first case of using minimally invasive autopsy to confirm severe dengue as the cause of death in a pediatric patient. The patient, a previously healthy 10-year-old girl, presented with fever, headache, abdominal pain, diarrhea, and vomiting during the COVID-19 pandemic. Clinical, pathological, and laboratory findings confirmed complications of severe dengue as the cause of death.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)