Review
Biochemistry & Molecular Biology
Nicole E. James, Morgan Woodman, Jennifer R. Ribeiro
Summary: EOC patients have low response rates to immunotherapies, but evidence suggests ovarian tumors are immunogenic and immune-related genomic profiles can serve as prognostic markers. Specific research areas that need to be addressed include developing immune-based prognostic signatures and driving advancements in this field.
Review
Obstetrics & Gynecology
Maria Lucia Moleiro, Alfredo Barroco Gouveia
Summary: This study reviewed the literature to understand the diagnostic challenges and prognostic features of ovarian and fallopian tube cancer presenting as extra-abdominal lymph nodes. The analysis of 65 English articles revealed that these cancers can spread through the lymphatic system or hematogenous spread, leading to distant disease without symptoms related to the primary cancer location. Histology and immunohistochemistry analysis, along with a high level of suspicion, are crucial for diagnosis in cases where extra-abdominal lymph nodes are the first manifested sign.
REPRODUCTIVE SCIENCES
(2023)
Article
Obstetrics & Gynecology
Philip M. Grimley, Zhenqiu Liu, Kathleen M. Darcy, Matthew T. Hueman, Huan Wang, Li Sheng, Donald E. Henson, Dechang Chen
Summary: This study successfully integrated machine learning to incorporate additional prognostic parameters into the conventional FIGO staging system for stratifying and predicting survival of epithelial ovarian carcinoma patients. Additional factors could be incorporated to further test the prognostic impact of emerging diagnostic or therapeutic advances.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Oncology
Leah Sommerfeld, Florian Finkernagel, Julia M. Jansen, Uwe Wagner, Andrea Nist, Thorsten Stiewe, Sabine Mueller-Bruesselbach, Anna M. Sokol, Johannes Graumann, Silke Reinartz, Rolf Mueller
Summary: Transcoelomic spread is the major route of metastasis for high-grade serous ovarian carcinoma, with the omentum being the major site of metastasis. The tumour microenvironment in the omentum plays a crucial role in metastatic growth, with host cells such as adipocytes, mesothelial cells, and fibroblasts secreting factors that impact tumour cells and are associated with metastasis and survival rates. Therapeutic interventions targeting these host cell-secreted factors may present novel options for treating ovarian HGSC.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Zhiyuan Hu, Paula Cunnea, Zhe Zhong, Haonan Lu, Oloruntoba I. Osagie, Leticia Campo, Mara Artibani, Katherine Nixon, Jennifer Ploski, Laura Santana Gonzalez, Abdulkhaliq Alsaadi, Nina Wietek, Stephen Damato, Sunanda Dhar, Sarah P. Blagden, Christopher Yau, Joanna Hester, Ashwag Albukhari, Eric O. Aboagye, Christina Fotopoulou, Ahmed Ahmed
Summary: In this study, a 52-gene NanoString panel was developed to validate the robustness of the OxC classifier for serous ovarian cancers (SOCs). The results revealed that EMT-high SOCs have a particularly poor prognosis, independent of established clinical parameters, and are associated with a high frequency of immunosuppressive macrophages, suggesting a potential therapeutic target to improve clinical outcomes.
CLINICAL CANCER RESEARCH
(2021)
Article
Medicine, General & Internal
Koji Matsuo, Shinya Matsuzaki, Michihide Maeda, Alesandra R. Rau, Kosuke Yoshihara, Ryo Tamura, Muneaki Shimada, Hiroko Machida, Mikio Mikami, Maximilian Klar, Lynda D. Roman, Jason D. Wright, Anil K. Sood, David M. Gershenson
Summary: This study investigates the use and survival outcomes of neoadjuvant chemotherapy (NACT) in less common histologic subtypes of epithelial ovarian cancer. The results show that NACT use has gradually increased, but for patients with low-grade serous carcinoma, NACT is associated with worse survival compared with primary debulking surgery.
Article
Multidisciplinary Sciences
Christine Bekos, Dietmar Pils, Sabine Dekan, Gerda Hofstetter, Peter Horak, Alexander Reinthaller, Stephan Polterauer, Richard Schwameis, Stefanie Aust
Summary: This study examined the infiltration rates of PD-1 and PD-L1 expressing tumor infiltrating leucocytes in primary ovarian tumor tissue and metastatic intraperitoneal implants, and found that high PD-1 expression among TILs in peritoneal metastases was associated with favorable overall survival, while high PD-L1 expression in TILs was linked to poor overall survival. Combining both factors in peritoneal metastases revealed an unfavorable prognosis. Primary ovarian tumor tissue and intraperitoneal metastatic tissues in EOC may have different immune evasion strategies. These findings are crucial for predicting patients' response to immunotherapy through biomarker assessment.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Douglas V. N. P. Oliveira, Kira P. Prahm, Ib J. Christensen, Anker Hansen, Claus K. Hogdall, Estrid V. Hogdall
Summary: Gene expression profiling is an effective tool in exploring new molecular markers for ovarian cancer patients, with specific markers still needing further research on their association with patient survival and clinical outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Jiong-Ze Fang, Yong Yang, Hong-Da Zhu, Jian-Nan Sun, Hong-Chao Mi, Cai-De Lu
Summary: This study retrospectively analyzed the significance of surgical treatment for intra-abdominal metastases after hepatocellular carcinoma surgery. It found that surgical resection is recommended for patients with limited or solitary metastasis in the abdominal cavity.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Stanislav Slavchev, Yavor Kornovski, Angel Yordanov, Yonka Ivanova, Stoyan Kostov, Svetoslava Slavcheva
Summary: The study found that patients with advanced ovarian cancer who also had cardiovascular diseases and diabetes had lower overall survival rates and disease-specific survival rates, potentially impacting disease progression. Therefore, effective control of cardiovascular diseases and diabetes may have a positive impact on the survival of patients with advanced ovarian cancer.
Article
Reproductive Biology
Yi Hu, Kun Fu, Huining Liu, Qiongqiong He, Xiaoqin Qiu, Wenqing Yang, Yu Zhang
Summary: This study aimed to investigate whether ovarian seromucinous carcinoma truly represented a distinct category of ovarian tumors or an analogue of ovarian endometrioid carcinoma. Through the analysis of clinicopathological features and prognosis of 12 patients, it was found that ovarian seromucinous carcinoma and ovarian endometrioid carcinoma had significant differences in clinical characteristics and prognosis, indicating that direct classification of ovarian seromucinous carcinoma as ovarian endometrioid carcinoma is not appropriate.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Oncology
Robert L. Hollis
Summary: Ovarian carcinoma is a term used to describe multiple distinct diseases with different developmental origins, clinical behaviors, and molecular profiles. The management of ovarian carcinoma is shifting towards more personalized and molecularly-driven strategies for each histotype. Recent advances in understanding the driver events in high grade serous ovarian carcinoma have led to significant improvements in treatment, but patients with rare histotypes still lack suitable targeted therapies. Further research is needed to comprehensively understand the molecular landscape of each histotype and develop targeted therapeutic strategies. This review summarizes our current knowledge of each histotype, highlighting recent advances and outlining research priorities for improving patient outcomes.
Article
Reproductive Biology
Xiao Li, Wei Ding, Yang Rao, Pengpeng Qu
Summary: In this study, low expression of protein tyrosine phosphatase receptor type M (PTPRM) was found in patients with epithelial ovarian cancer (EOC), and the positive expression rate of PTPRM significantly decreased with advancing stages of EOC and tumor recurrence, suggesting that PTPRM acts as a tumor suppressor in EOC progression. Negative PTPRM expression may predict poor clinical outcomes in patients with EOC.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Oncology
Violante Di Donato, Andrea Giannini, Ottavia D'Oria, Michele Carlo Schiavi, Anna Di Pinto, Margherita Fischetti, Francesca Lecce, Giorgia Perniola, Francesco Battaglia, Pasquale Berloco, Ludovico Muzii, Pierluigi Benedetti Panici
Summary: The study aimed to evaluate the feasibility and safety of cytoreduction in patients with advanced ovarian cancer and hepato-biliary metastasis. Results showed that 20.9% of patients had liver, biliary tract, or porta hepatis metastasis, with 71.6% achieving complete cytoreduction. Severe complications related to hepatobiliary surgery were reported in 2.9% of patients, but complete cytoreduction was associated with survival benefits.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
J. M. de Jong, J. P. Hoogendam, A. J. A. T. Braat, R. P. Zweemer, C. G. Gerestein
Summary: FGCS targeting either HER2 or FR alpha appears to be feasible in both EOC animal models and patients with EOC. It can increase the detection rate of tumor deposits, but further research is needed to validate these results, particularly studying the survival benefit.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Engineering, Multidisciplinary
Xiaoyan Wang, Shaopeng Li, Yuanfei Han, Guangfa Huang, Jianwei Mao, Weijie Lu
Summary: TiC crystals are important reinforcements in metal matrix composites, but they can accelerate fatigue crack propagation and lead to premature fracture. To improve performance, reducing TiC content and minimizing crystal size are recommended.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Oncology
Jiajian Wang, Jie Dong, Yinjian Zhou, Kaiyi Wang, Min Pan, Zaixing Deng, Pengfei Wang, Ying Du, Weiguo Lu
Summary: This study aimed to assess the clinical performance of an HPV E6/E7 mRNA assay (Aptima HPV, AHPV) and AHPV 16 18/45 genotype assay (AHPV-GT) combined with age stratification for triaging women with atypical squamous cells of undetermined significance (ASC-US) cytology. The results showed that AHPV testing with age stratification is effective for triaging women with ASC-US cytology, and AHPV-GT testing may be a proper risk stratification method for women with AHPV-positive ASC-US cytology.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Min Wang, Xin Chen, Henglu Zhang, Lanlan Li, Yang Xu, Weiping Lu, Yibing Lu
Summary: This study reveals that ENSMUST00000147869 can inhibit the proliferation and fibrosis of MMCs by regulating Hspa9 and inhibiting its interaction with HMGB1. This finding may provide a molecular marker for diagnosis and a therapeutic target for DN.
Article
Oncology
Jianying Xu, Xuan Rao, Weiguo Lu, Xing Xie, Xinyu Wang, Xiao Li
Summary: This study aimed to identify risk factors for malignant lesions in asymptomatic endometrial polyps (EPs) diagnosed by ultrasound and establish a noninvasive predictor. The study found that abnormal uterine bleeding, large polyps, and blood flow signal in EPs were independent predictive factors for malignancy. A noninvasive predictor combining these factors showed excellent sensitivity and negative predictive value in distinguishing benign and malignant EPs.
FRONTIERS IN ONCOLOGY
(2022)
Article
Microbiology
Yunfeng Fu, Xiao Li, Ying Li, Weiguo Lu, Xing Xie, Xinyu Wang
Summary: This study compares the clinical performance of DH3 HPV assay and HC2 test for cervical cancer screening and finds similar sensitivity and specificity for detecting high-grade lesions between the two tests. DH3 assay has the advantage of providing 92% sensitivity in primary screening strategy.
MICROBIOLOGY SPECTRUM
(2022)
Article
Oncology
Elizabeth Zhang-Velten, You Zhang, Sepeadeh Radpour, Xuejun Gu, D. Nathan Kim, Prasanna Alluri, Chika Nwachukwu, Tsuicheng Chiu, Weiguo Lu, David Parsons, Jun Tan, Jennifer Gillespie, Stella Stevenson, Hak Choy, Robert Timmerman, Asal Rahimi
Summary: The article describes the institutional experience of using GammaPod for breast cancer radiation therapy from 2019 to 2021, including workflow, procedure step times, and techniques for improved efficiency.
PRACTICAL RADIATION ONCOLOGY
(2022)
Article
Peripheral Vascular Disease
Gang Peng, Weiping Lu, Kai Chen, Xiaodan Yang, Jianguo Wei, Bo Wang, Bingcang Huang
Summary: Fourdimensional CT angiography-CT perfusion (4D CTA-CTP)-integrated technology was used to evaluate the cerebral collateral circulation in patients with acute ischemic stroke (AIS). It was found that the mCTA cerebral collateral circulation score can independently predict the neurological prognosis of AIS patients, while the baseline serum S100B protein concentration cannot independently predict the neurological prognosis of AIS patients.
MICROVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Wenying Yang, Dalong Zhu, Shenglian Gan, Xiaolin Dong, Junping Su, Wenhui Li, Hongwei Jiang, Wenjuan Zhao, Minxiu Yao, Weihong Song, Yibing Lu, Xiuzhen Zhang, Huifang Li, Guixia Wang, Wei Qiu, Guoyue Yuan, Jianhua Ma, Wei Li, Ziling Li, Xiaoyue Wang, Jiao'e Zeng, Zhou Yang, Jingdong Liu, Yongqian Liang, Song Lu, Huili Zhang, Hui Liu, Ping Liu, Kuanlu Fan, Xiaozhen Jiang, Yufeng Li, Qing Su, Tao Ning, Huiwen Tan, Zhenmei An, Zhaoshun Jiang, Lijun Liu, Zunhai Zhou, Qiu Zhang, Xuefeng Li, Zhongyan Shan, Yaoming Xue, Hong Mao, Lixin Shi, Shandong Ye, Xiaomei Zhang, Jiao Sun, Ping Li, Tao Yang, Feng Li, Jingna Lin, Zhinong Zhang, Ying Zhao, Ruonan Li, Xiaohui Guo, Qi Yao, Weiping Lu, Shen Qu, Hongmei Li, Liling Tan, Wenbo Wang, Yongli Yao, Daoxiong Chen, Yulan Li, Jialin Gao, Wen Hu, Xiaoqiang Fei, Tianfeng Wu, Song Dong, Wenlong Jin, Chenzhong Li, Dong Zhao, Bo Feng, Yu Zhao, Yi Zhang, Xiaoying Li, Li Chen
Summary: In patients with inadequate glycemic control using metformin alone, dorzagliatin as an add-on therapy resulted in effective glycemic control with good tolerability and safety.
Article
Optics
Hepeng Zhao, Xinchao Zhao, Xuehong Zhang, Zhuangzhuang Cui, Yu Ou-Yang, Maobin Xie, Min Zheng, Xueyu Guan, Lijun Wu, Xinglei Zhou, Lihui Li, Yushuang Zhang, Yang Li, Ying Jiang, Wei Lu, Xiaoli Zhu, Chao Peng, Xiao Wang, Shaowei Wang, Xiujuan Zhuang
Summary: This study demonstrates the realization of a silicon-based vertical cavity surface-emitting laser by controlled preparation of high-gain erbium silicate materials and novel design of high optical feedback microcavity. The laser exhibits a small footprint, high efficiency, and low lasing threshold, making it a potential sub-micrometer coherent light source for optical communication.
Article
Medicine, Research & Experimental
Yixuan Cen, Tingjia Zhu, Yanan Zhang, Lu Zhao, Jiawei Zhu, Lingfang Wang, Junfen Xu, Tian Ding, Xing Xie, Xinyu Wang, Weiguo Lu
Summary: This study identified a downregulated circular RNA (hsa_circ_0005358) derived from the host gene Gli1 in cervical cancer tissues, which suppressed the migration and invasion abilities of cervical cancer cells by interacting with polypyrimidine tract-binding protein 1 (PTBP1), ultimately reducing cancer metastasis.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Biotechnology & Applied Microbiology
Yanyi Lu, Lin Zeng, Min Li, Bowen Yan, Dandan Gao, Bangfu Zhou, Weiping Lu, Qinghua He
Summary: This study explored the possibility of identifying common wound infection bacteria in mixed culture using gas chromatograph-ion migration spectroscopy (GC-IMS). The headspace gas of single and mixed cultures of Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa was analyzed, and specific volatile organic compounds (mVOCs) were obtained. The findings suggest that GC-IMS can be used to identify compound bacteria based on specific mVOCs.
Review
Pharmacology & Pharmacy
Linwei Lu, Qianzhu Xu, Jun Wang, Sunyi Wu, Zimiao Luo, Weiyue Lu
Summary: Drug nanocrystals can enhance the solubility and bioavailability of poorly water-soluble drugs, and active tumor-targeted drug delivery systems can improve the efficacy and safety of chemotherapy.
Article
Engineering, Mechanical
Weiping Lu, Wen Cui, Xiaogang Zhang, Yali Zhang, Shu Yang, Jian Pu, Junyan Li, Zhongmin Jin
Summary: The friction and wear behaviors between cartilage replacement materials and articular cartilage are crucial for the function and performance of the replacements. This study investigated the difference between cross-shear motion and reciprocal linear motion on the frictional and wear behaviors of cartilage, as well as the effect of bearing surface roughness. The results showed that there was no significant difference between the two motion types. The water contact angle of the bearing surface affected the friction and wear behaviors for low roughness implants, while the surface roughness of the material affected the behaviors for high roughness implants. PEEK was found to be a suitable material for osteochondral implants.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART J-JOURNAL OF ENGINEERING TRIBOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qianqian Wu, Mingjing Wei, Lifang Yao, Xiaodong Cheng, Weiguo Lu, Xing Xie, Xiao Li
Summary: Hyperthermia can enhance the sensitivity of epithelial ovarian carcinoma cells with sufficient homologous recombination abilities to PARP inhibitors by impairing homologous recombination efficiency and increasing oxidative stress.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Engineering, Electrical & Electronic
Xin Li, Jian Chen, Jiale He, Jin Chen, Huijun Guo, Liao Yang, Chuan Shen, Feilong Yu, Zengyue Zhao, Guanhai Li, Xiaoshuang Chen, Wei Lu
Summary: This study proposes a collapse breakdown mechanism to explain the relatively low-voltage breakdown in traditional HgCdTe positive-intrinsic-negative structures. The competitive behavior in the breakdown phenomenon is revealed through temperature-change measurements. With optimized structure, high photoelectric gain and low dark current are achieved, and a semi-empirical formula is derived to predict the optimal doping concentrations. Results from literature further confirm the flexibility and universality of the mechanism.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2022)