Article
Chemistry, Applied
Xiaohui Xi, Jialing Huang, Shengyang Zhang, Qian Lu, Zhengfeng Fang, Cheng Li, Qing Zhang, Yuntao Liu, Hong Chen, Aiping Liu, Shuxiang Liu, Caixia Wang, Shanshan Li, Bin Hu
Summary: This study prepared the inclusion complex (IC) of nutmeg essential oil (NEO) with 2-hydroxypropyl ss-cyclodextrin (HP-ss-CD) by the coprecipitation method, overcoming the poor stability and low aqueous solubility of NEO in food. The optimal conditions were an inclusion temperature of 36 degrees C, time of 247 min, stirring speed of 520 r/min, and wall-core ratio of 12:1, resulting in a recovery of 80.63%. The formation of IC was confirmed by various techniques, and it was found that encapsulation improved the thermal stability, antioxidant, and nitrite scavenging activities of NEO. Moreover, the release of NEO from IC can be controlled by regulating the temperature and relative humidity. Overall, NEO/HP-ss-CD IC has great potential for application in the food industry.
Article
Plant Sciences
Vesna Nikolic, Ljubisa Nikolic, Ana Dinic, Ivana Gajic, Maja Urosevic, Ljiljana Stanojevic, Jelena Stanojevic, Bojana Danilovic
Summary: This study successfully isolated essential oil from nutmeg seeds, determined its chemical composition and antioxidant, antimicrobial activities. The essential oil demonstrated good antioxidant and antimicrobial properties, particularly showing significant inhibition against fungi and certain bacteria.
JOURNAL OF ESSENTIAL OIL BEARING PLANTS
(2021)
Review
Chemistry, Medicinal
Kaliyaperumal Ashokkumar, Jesus Simal-Gandara, Muthusamy Murugan, Mannananil Krishnankutty Dhanya, Arjun Pandian
Summary: This study summarizes the composition and therapeutic potential of Myristica fragrans essential oil. The essential oil showed various pharmacological activities such as antioxidant, antimicrobial, anti-inflammatory, and anticancer effects.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jiaqi Sun, Fuyin Zhao, Zhenlei Wang, Weina Zhang, Xiudong Yang, Hongli Zhou, Peng Wan
Summary: This study aims to optimize the processing of Myristica fragrans Houtt. by talcum powder simmering, and the results show that the new process can reduce the content of toxic components and enhance the antioxidant and antibacterial activity of the essential oils.
Article
Pharmacology & Pharmacy
Jurga Andreja Kazlauskaite, Inga Matulyte, Mindaugas Marksa, Raimundas Lelesius, Alvydas Pavilonis, Jurga Bernatoniene
Summary: This study aimed to investigate the biological activity of selected plant extracts and essential oil and to produce microcapsules. The main compounds in extracts and oil were determined, and antioxidant and antimicrobial activities were evaluated. Microcapsules with extracts and oil showed stability and size changes in different media.
Article
Polymer Science
Bara Yudhistira, Andi Syahrullah Sulaimana, Fuangfah Punthi, Chao-Kai Chang, Chun-Ta Lung, Shella Permatasari Santoso, Mohsen Gavahian, Chang-Wei Hsieh
Summary: This study developed a new approach using cold plasma treatment to incorporate Myristica fragrans essential oil (MFEO) into a film. The results showed that the addition of MFEO significantly improved the optical, physical, and bacterial inhibition properties of the film, reducing water vapor and oxygen permeability, and exhibiting antimicrobial activity against E. coli and S. aureus.
Article
Multidisciplinary Sciences
Daniela Lanari, Claudia Zadra, Francesca Negro, Rima Njem, Maria Carla Marcotullio
Summary: Natural deep eutectic solvents (NADES) were used as co-solvents to improve the yield and reduce the content of toxic phenylpropenoids in nutmeg essential oil. The addition of NADES improved the extraction efficiency and composition of the essential oil. The best results were achieved using ultrasound-assisted pretreatment with ChCl-CA NADES followed by traditional hydrodistillation.
Article
Biochemistry & Molecular Biology
Yasukiyo Yoshioka, Ryunoshin Kono, Masaki Kuse, Yoko Yamashita, Hitoshi Ashida
Summary: This study investigated the active compounds in Myristica fragrans and their mechanism in promoting glucose uptake. The researchers found that myristicin, licarin B, ADDP, and ADTP were the active compounds that promoted GLUT4 translocation. Oral administration of Myristica fragrans extract suppressed post-prandial hyperglycemia in mice. Therefore, Myristica fragrans shows promise as a functional food for preventing post-prandial hyperglycemia and type 2 diabetes mellitus.
Article
Plant Sciences
Adriana Trifan, Gokhan Zengin, Izabela Korona-Glowniak, Krystyna Skalicka-Wozniak, Simon Vlad Luca
Summary: The essential oil of nutmeg is widely used in the food, pharmaceutical, and cosmetic industries. This study identified bioactive compounds with potential antioxidant, anti-enzymatic, and antimicrobial activities in nutmeg post-distillation by-products. These findings provide valuable insights for the valorization of nutmeg waste in the pharmaceutical, cosmeceutical, and food industries.
Article
Biology
Wahidah H. Al-Qahtani, Yuvaraj Dinakarkumar, Selvaraj Arokiyaraj, Vigneshwar Saravanakumar, Jothi Ramalingam Rajabathar, Kowsalya Arjun, P. K. Gayathri, Jimmy Nelson Appaturi
Summary: The use of plant-derived medications is safer and more secure than synthetic ones. Elemicin isolated from Myristica fragrans has significant antioxidant and antibacterial activity. It can be crucially utilized in the development of therapeutic agents and food preservatives.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Editorial Material
Plant Sciences
Hazem S. Elshafie
Summary: This article summarizes the chemical composition and biological-pharmaceutical activities of plant essential oils (PEOs), and discusses their possible modes of action and influencing factors. It provides valuable insights into the application of PEOs.
Article
Biochemistry & Molecular Biology
Thidar Oo, Bhanubong Saiboonjan, Sukanya Srijampa, Arpasiri Srisrattakarn, Khaetthareeya Sutthanut, Ratree Tavichakorntrakool, Aroonwadee Chanawong, Aroonlug Lulitanond, Patcharaporn Tippayawat
Summary: Nutmeg is commonly used in folk medicine in Asia, with its crude extract and essential oil acting as efflux pump inhibitors to enhance antimicrobial activity. When used in combination with ciprofloxacin, nutmeg extract and oil effectively sensitize MRSA, ensuring susceptibility to antibiotic treatment.
Article
Cell Biology
Mahsa Rastegar Moghaddam Poorbagher, Ehsan Karimi, Ehsan Oskoueian
Summary: In this study, nanoniosome-loaded Myristica fragrans' phenolic compounds (NLMP) were synthesized and characterized. The NLMP showed hepatoprotective effects on mice with liver toxicity induced by L-asparaginase injection. NLMP treatment increased the weight and feed intake of mice, decreased the blood levels of triglyceride, cholesterol, liver enzymes, and total bilirubin, and increased the levels of the antioxidant defence system. NLMP also downregulated the expression of inflammatory-related genes and upregulated the expression of SOD in the liver.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Engineering, Environmental
Teema Thomas, Arun Kumar Thalla
Summary: In this study, silver nanoparticles were synthesized from silver nitrate using Myristica fragrans seed shells aqueous extract. The synthesized nanoparticles were characterized and found to have antibacterial and antioxidant properties. Furthermore, the nanoparticles showed better photocatalytic degradation of dyes.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Arezoo Rastegari, Azadeh Manayi, Mahdi Rezakazemi, Mahdieh Eftekhari, Mahnaz Khanavi, Tahmineh Akbarzadeh, Mina Saeedi
Summary: This study found that the ethyl acetate fraction of Myristica fragrans has inhibitory activity against BChE and neuroprotective effects against H2O2-induced cell death. Compound 2 from Myristica fragrans showed the best inhibitory activity against both AChE and BChE.
