Article
Cardiac & Cardiovascular Systems
Alena S. Limonova, Alexandra I. Ershova, Alexey N. Meshkov, Anna V. Kiseleva, Mikhail G. Divashuk, Vladimir A. Kutsenko, Oxana M. Drapkina
Summary: This case study describes a 40-year-old male with premature atherosclerosis, exhibiting both eruptive and tendinous xanthomas. Genetic evaluation revealed a rare genotype of apolipoprotein E, leading to the diagnosis of familial dysbetalipoproteinemia. The implementation of genetic testing in routine clinical practice could enhance disease diagnostics, management, and prevention.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Hematology
Shripad Sinari, Juraj Koska, Yueming Hu, Jeremy Furtado, Majken K. Jensen, Matthew J. Budoff, Dobrin Nedelkov, Robyn L. McClelland, Dean Billheimer, Peter Reaven
Summary: The composition of Apo CIII proteoforms is associated with cardiovascular risk and influences plasma lipids. Total apo CIII and CIII2/III1 are positively associated with cardiovascular disease risk, while CIII0b/III1 is inversely associated with cardiovascular disease risk.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Geriatrics & Gerontology
Xiao-Li Li, Qiang Wang, Guo-Dong Jia, Hui-Jun Yin, Yao-Hui Wang, Chao Hu, Xiao-Qing Wang, Yang Yang
Summary: This study found that APOE*ε2 carriers in aspirin-treated individuals with existing cardiovascular diseases had lower cardiovascular disease risk and higher platelet reactivity. Furthermore, APOE2 interacts with COX-1 and upregulates its activity. The cardiovascular protective effect of aspirin in APOE*ε2 carriers may be attributed to APOE2 upregulating the vascular COX-1-mediated cardiovascular protective pathway, along with aspirin partially inhibiting platelet COX-1-mediated platelet aggregation.
Article
Clinical Neurology
Madia Lozupone, Bruno Pietro Imbimbo, Claudia Balducci, Filomena Lo Vecchio, Paola Bisceglia, Raffaela Rita Latino, Maurizio Leone, Vittorio Dibello, Vincenzo Solfrizzi, Antonio Greco, Antonio Daniele, Mark Watling, Davide Seripa, Francesco Panza
Summary: This article discusses the role of human apolipoprotein E (apoE) in the pathophysiology of Alzheimer's disease (AD), describing its impact on brain homeostasis, neuroinflammation, blood-brain barrier permeability, glial function, synaptogenesis, oral/gut microbiota, neural networks, amyloid beta deposition, and tau-mediated neurodegeneration. It also provides updates on different therapeutic approaches targeting apoE in AD treatment.
ALZHEIMERS & DEMENTIA
(2023)
Review
Nutrition & Dietetics
Gregory S. Nacarelli, Tracy Fasolino, Stephanie Davis
Summary: Genetic predisposition and dietary factors play a role in cardiovascular disease (CVD) risk. Evaluating the levels of apolipoprotein B and apolipoprotein A1 in plasma helps assess CVD risk. Different dietary and lifestyle interventions can impact CVD risk markers, such as these apolipoproteins. Additionally, genetic variations may affect the response to dietary interventions on these markers.
Review
Pharmacology & Pharmacy
Benjamin R. Troutwine, Laylan Hamid, Colton R. Lysaker, Taylor A. Strope, Heather M. Wilkins
Summary: Genetic variation in the APOE gene is associated with the risk of Alzheimer's disease. The APOE epsilon 4 alleles are the strongest genetic risk factor for late onset sporadic AD, while the APOE epsilon 2 alleles have lower risk and the APOE epsilon 3 alleles have neutral risk.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Cell Biology
Zhihai Cao, Yuan Xue, Jiaqian Wang
Summary: Osteoporosis is caused by decreased bone formation and increased bone absorption, with ferroptosis playing a key role. Ferroptosis may inhibit bone formation and promote bone absorption through oxidative stress, leading to osteoporosis.
Article
Clinical Neurology
Jie Xu, Xiwa Hao, Rui Zhan, Xue Jiang, Aoming Jin, Jing Xue, Aichun Cheng, Jiewen Liu, Jinxi Lin, Xia Meng, Hao Li, Lemin Zheng, Yongjun Wang
Summary: This study evaluated whether Lp(a) remains associated with stroke recurrence risk when LDL cholesterol and inflammatory levels are low. The results showed that elevated Lp(a) was significantly associated with stroke recurrence risk, but this association was attenuated at low cholesterol and inflammation levels.
Article
Biochemistry & Molecular Biology
Hong Chen, Fangfang Song, Fanxin Long
Summary: Glucocorticoids are a common cause for osteoporosis and fractures, but current treatments are not effective due to side effects. This study shows that WNT7B can restore bone mass after glucocorticoid-induced bone loss by increasing osteoblast number and function. However, WNT7B overexpression does not improve abnormal fat accumulation.
Review
Pharmacology & Pharmacy
Shenglei Yang, Yuying Sun, Leonid Kapilevich, Xin'an Zhang, Yue Huang
Summary: Osteoporosis is a common skeletal disorder that primarily affects the elderly and postmenopausal women. Drug therapy is currently used as the main treatment, but long-term use can lead to drug resistance and side effects. Therefore, researchers are exploring natural plant compounds as an alternative. Curcumin, a natural phenolic compound, has shown potential as a candidate for treating osteoporosis due to its various pharmacological and biological activities. This review summarizes the mechanisms and therapeutic applications of curcumin in preventing and mitigating osteoporosis, providing valuable references for further research and development of curcumin.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kangtao Jin, Lin Zheng, Lin Ye, Ziang Xie, Jiawei Gao, Chao Lou, Wenzheng Pan, Bin Pan, Shijie Liu, Zhenzhong Chen, Dengwei He
Summary: The study demonstrates that CSB6B suppresses osteoclast differentiation and bone resorption while enhancing osteoblast mineralization by inhibiting the NF-KB pathway and promoting Runx expression. In murine models, CSB6B has shown protective effects against pathological bone destruction and bone loss induced by estrogen deficiency. MIF inhibition by CSB6B could be a potential therapeutic approach for osteolytic bone disorders and osteoporosis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Di Ran, Dehui Zhou, Gang Liu, Yonggang Ma, Waseem Ali, Rui Yu, Qinghua Wang, Hongyan Zhao, Jiaqiao Zhu, Hui Zou, Zongping Liu
Summary: Cadmium exposure in bone tissues leads to higher Cd concentration in osteoporosis (OP) patients compared to normal subjects. This exposure also decreases the expression level of SIRT1 protein, exacerbating osteoblast apoptosis and bone resorption.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Cardiac & Cardiovascular Systems
Tamara Glavinovic, George Thanassoulis, Jacqueline de Graaf, Patrick Couture, Robert A. Hegele, Allan D. Sniderman
Summary: This review explains the physiological mechanisms behind apoB as a marker of cardiovascular risk, including the nature and numbers of apoB particles, the mechanisms governing particle numbers, the mechanisms governing cholesterol mass within the particles, and major apoB dyslipoproteinemias.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Fuxue Deng, Danni Li, Lei Lei, Qiang Yang, Qing Li, Hongtao Wang, Jie Deng, Qiangsun Zheng, Wei Jiang
Summary: The study found that the Apo B/A1 ratio was higher in ACS patients than CCS patients, and also higher in patients with plaque rupture, erosion, or thrombus. A high Apo B/A1 ratio was associated with a high percentage of vulnerable plaques, and negatively related to fibrous cap thickness in lipid-rich plaques.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chunxiao Liu, Mengdi Zhao, Jingyue Chen, Liwen Xu, Kaiying Wang, Guangyu Li
Summary: The compound Nodakenin (NK) has been found to attenuate bone loss caused by osteoporosis by promoting osteogenesis and inhibiting osteoclastogenesis. This is achieved through the activation of the PI3K/AKT/mTOR signaling pathway and the inhibition of Akt and NF kappa B signaling pathways.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alvaro Macias, J. Jaime Diaz-Larrosa, Yaazan Blanco, Victor Fanjul, Cristina Gonzalez-Gomez, Pilar Gonzalo, Maria Jesus Andres-Manzano, Andre Monteiro da Rocha, Daniela Ponce-Balbuena, Andrew Allan, David Filgueiras-Rama, Jose Jalife, Vicente Andres
Summary: This study found that heart tissue from Hutchinson-Gilford progeria syndrome (HGPS) patients has structural and electrophysiological defects, including disruption of the t-tubular system, shortened sarcomeres, bradycardia, and atrio-ventricular conduction abnormalities. Chronic treatment with low-dose paclitaxel partially corrected these abnormalities.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Ana Devesa, Manuel Lobo-Gonzalez, Juan Martinez-Milla, Belen Oliva, Ines Garcia-Lunar, Annalaura Mastrangelo, Samuel Espana, Javier Sanz, Jose M. Mendiguren, Hector Bueno, Jose J. Fuster, Vicente Andres, Antonio Fernandez-Ortiz, David Sancho, Leticia Fernandez-Friera, Javier Sanchez-Gonzalez, Xavier Rossello, Borja Ibanez, Valentin Fuster
Summary: Experimental studies suggest that increased bone marrow activity is associated with cardiovascular risk factors, inflammation, and atherosclerosis. This study found that bone marrow activation is associated with metabolic syndrome and early atherosclerosis, even in the absence of systemic inflammation.
EUROPEAN HEART JOURNAL
(2022)
Editorial Material
Pharmacology & Pharmacy
Ignacio Benedicto, Xue Chen, Martin O. Bergo, Vicente Andres
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Article
Geriatrics & Gerontology
Miriam Diez-Diez, Marta Amoros-Perez, Jorge de la Barrera, Enrique Vazquez, Ana Quintas, Domingo A. Pascual-Figal, Ana Dopazo, Fatima Sanchez-Cabo, Monica E. Kleinman, Leslie B. Gordon, Valentin Fuster, Vicente Andres, Jose J. Fuster
Summary: Clonal hematopoiesis of indeterminate potential (CHIP), the presence of somatic mutations in cancer-related genes in blood cells without hematological cancer, is an important risk factor for age-related conditions, especially cardiovascular disease. It is unknown whether CHIP plays a role in premature aging syndromes. Hutchinson-Gilford progeria syndrome (HGPS) is an ultra-rare genetic condition characterized by accelerated aging. This study investigated the prevalence of CHIP in HGPS patients and found that it is not frequent in HGPS, suggesting that it is unlikely to contribute to the pathophysiology of this accelerated aging syndrome.
Article
Geriatrics & Gerontology
Alicia Garcia-Vigara, Victor Martin-Gonzalez, Juan-Antonio Carbonell, Celia Bauset-Castello, Ana Martinez-Aspas, Aitana Monllor-Tormos, Miguel-Angel Garcia-Perez, Juan J. Tarin, Antonio Cano
Summary: This study investigated the usability of telephone-based telehealth in a women's health outpatient clinic and explored whether the severity of the COVID pandemic affected its usage. The results indicated that regardless of the pandemic stage, respondents preferred in-person visits.
Article
Cardiac & Cardiovascular Systems
Fatima Sanchez-Cabo, Valentin Fuster, Juan Carlos Silla-Castro, Gema Gonzalez, Erika Lorenzo-Vivas, Rebeca Alvarez, Sergio Callejas, Alberto Benguria, Eduardo Gil, Estefania Nunez, Belen Oliva, Jose Maria Mendiguren, Marta Cortes-Canteli, Hector Bueno, Vicente Andres, Jose Maria Ordovas, Leticia Fernandez-Friera, Antonio J. Quesada, Jose Manuel Garcia, Xavier Rossello, Jesus Vazquez, Ana Dopazo, Antonio Fernandez-Ortiz, Borja Ibanez, Jose Javier Fuster, Enrique Lara-Pezzi
Summary: This study aims to assess the association between subclinical atherosclerosis and accelerated epigenetic age and investigate the underlying mechanisms. The presence, extension, and progression of subclinical atherosclerosis in healthy individuals were found to be associated with a significant acceleration of the Grim epigenetic age, regardless of traditional cardiovascular risk factors. Transcriptomics and proteomics data suggested the involvement of pro-inflammatory pathways and genes in mediating the association between subclinical atherosclerosis and epigenetic age acceleration.
EUROPEAN HEART JOURNAL
(2023)
Article
Geriatrics & Gerontology
Alicia Garcia-Vigara, Aitana Monllor-Tormos, Miguel Angel Garcia-Perez, Juan J. Tarin, Antonio Cano
Summary: This study analyzed the association between genetic variants of the vitamin D receptor gene and dynapenia in postmenopausal women. The study found that the TT genotype of the rs11568820 SNP of the vitamin D receptor gene was associated with decreased grip strength in community-dwelling postmenopausal women.
Article
Oncology
Antonio Llombart-Cussac, Antonio Anton-Torres, Beatriz Rojas, Raquel Andres, Noelia Martinez, Cesar A. Rodriguez, Sara Marin, Teresa Puertolas, Alejandro Falcon Gonzalez, Maria Leonor Fernandez-Murga, Carlos Hagen, Manuel Ruiz-Borrego
Summary: The 21-gene Oncotype DX Breast Recurrence Score assay is predictive of chemotherapy benefit for patients with estrogen receptor-positive, HER2- early breast cancer. It has the potential to guide treatment decisions in high-risk patients with early breast cancer.
Review
Cell Biology
Maria Gonzalez-Amor, Beatriz Dorado, Vicente Andres
Summary: Population aging and age-related cardiovascular disease (CVD) are widespread and burdensome worldwide. Cellular stress responses play a crucial role in the complex regulation and interaction between aging and CVD. The ubiquitin-like protein ISG15 and its pathway have been found to have implications in age-related telomere shortening, genomic instability, DNA damage accumulation, as well as in major CVD risk factors prevalent in the elderly population such as hypertension, diabetes, and obesity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Juan J. Tarin, Eva Pascual, Miguel A. Garcia-Perez, Aitana Monllor-Tormos, Antonio Cano
Summary: There is an association between male and female infertility diagnoses and duration of infertility in couples seeking assisted reproductive technology (ART) treatment for the first time. Men with oligo-, astheno-, and teratozoospermia (ACOAT) have higher odds of having a duration of infertility > 2 years. Women from ACOAT couples with > 2 years of infertility have shorter menstrual cycles, lower antral follicular count (AFC) values, and lower serum anti-Mullerian hormone (AMH) levels.
REPRODUCTIVE HEALTH
(2023)
Review
Medicine, General & Internal
Jeanette A. Maier, Vicente Andres, Sara Castiglioni, Alessandro Giudici, Emily S. Lau, Janos Nemcsik, Francesca Seta, Paola Zaninotto, Mariella Catalano, Naomi M. Hamburg
Summary: Vascular aging predicts cardiovascular events and mortality, early assessment allows identification of at-risk individuals, and more studies are needed to develop strategies for prevention and treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Alberto Del Monte-Monge, Inigo Ruiz-Polo de Lara, Pilar Gonzalo, Carla Espinos-Estevez, Maria Gonzalez-Amor, Miguel de la Fuente-Perez, Maria J. Andres-Manzano, Victor Fanjul, Juan R. Gimeno, Roberto Barriales-Villa, Beatriz Dorado, Vicente Andres
Summary: Mutations in the LMNA gene can cause various cardiac diseases, including dilated cardiomyopathies. In order to investigate the potential vascular alterations in LMNA-DCM, researchers generated mice without lamin A/C in vascular smooth muscle cells, cardiac fibroblasts, and cardiomyocytes. These mice exhibited similar clinical features to human LMNA-DCM, including cardiac dysfunction and fibrosis, as well as vascular phenotypic alterations. This study provides the first evidence of vascular defects contributing to the pathophysiology of LMNA-DCM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Alvaro Macias, Rosa M. Nevado, Cristina Gonzalez-Gomez, Pilar Gonzalo, Maria Jesus Andres-Manzano, Beatriz Dorado, Ignacio Benedicto, Vicente Andres
Summary: HGPS is a rare genetic disease caused by expression of progerin. This disease leads to pathological alterations in the coronary and cerebral arteries, and the mechanisms behind it involve loss of vascular smooth muscle cells and overexpression of K(V)7 channels. The study suggests that targeting K(V)7 channels could be a potential treatment for HGPS.
Article
Medicine, General & Internal
Jose M. Castellano, Stuart J. Pocock, Deepak L. Bhatt, Antonio J. Quesada, Ruth Owen, Antonio Fernandez-Ortiz, Pedro L. Sanchez, Francisco Marin Ortuno, Jose M. Vazquez Rodriguez, Alexandra Domingo-Fernandez, Inigo Lozano, Maria C. Roncaglioni, Marta Baviera, Andreana Foresta, Luisa Ojeda-Fernandez, Furio Colivicchi, Stefania A. Di Fusco, Wolfram Doehner, Antje Meyer, Francois Schiele, Fiona Ecarnot, Ales Linhart, Jean-Claude Lubanda, Gregory Barczi, Bela Merkely, Piotr Ponikowski, Marta Kasprzak, Juan M. Fernandez Alvira, Vicente Andres, Hector Bueno, Timothy Collier, Frans Van de Werf, Pablo Perel, Moises Rodriguez-Manero, Angeles Alonso Garcia, Marco Proietti, Mikkel M. Schoos, Tabassome Simon, Jose Fernandez Ferro, Nicolas Lopez, Ettore Beghi, Yannick Bejot, David Vivas, Alberto Cordero, Borja Ibanez, Valentin Fuster
Summary: The study showed that taking a polypill containing aspirin, ramipril, and atorvastatin within 6 months after myocardial infarction significantly reduced the risk of major adverse cardiovascular events compared to usual care.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Meeting Abstract
Cell & Tissue Engineering
Vicente Andres
TISSUE ENGINEERING PART A
(2022)