Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectives

The innate immune response status correlates with a divergent clinical course in congenital Chagas disease of twins born in a non-endemic country

(2014) Ana Fernández-Villegas et al.   ACTA TROPICA

Serum biomarkers predictive of cure in Chagas disease patients after nifurtimox treatment

(2014) Cynthia Santamaria et al.   BMC INFECTIOUS DISEASES

Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review

(2014) Maria-Jesús Pinazo et al.   Expert Review of Anti-Infective Therapy

Innovations in diagnosis and post-therapeutic monitoring of Chagas disease: Simultaneous flow cytometric detection of IgG1 antibodies anti-live amastigote, anti-live trypomastigote, and anti-fixed epimastigote forms of Trypanosoma cruzi

(2014) Glaucia Diniz Alessio et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Plasma Cytokine Expression Is Associated with Cardiac Morbidity in Chagas Disease

(2014) Giovane Rodrigo Sousa et al.   PLoS One

Cytokine Profiling in Chagas Disease: Towards Understanding the Association with Infecting Trypanosoma cruzi Discrete Typing Units (A BENEFIT TRIAL Sub-Study)

(2014) Cristina Poveda et al.   PLoS One

Aptamer Based, Non-PCR, Non-Serological Detection of Chagas Disease Biomarkers in Trypanosoma cruzi Infected Mice

(2014) Rana Nagarkatti et al.   PLoS Neglected Tropical Diseases

Usefulness of a Combination of Monocyte Chemoattractant Protein-1, Galectin-3, and N-Terminal Probrain Natriuretic Peptide to Predict Cardiovascular Events in Patients With Coronary Artery Disease

(2013) José Tuñón et al.   AMERICAN JOURNAL OF CARDIOLOGY

Evaluation of Nifurtimox Treatment of Chronic Chagas Disease by Means of Several Parasitological Methods

(2013) Catalina Muñoz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High levels of soluble CD40 ligand and matrix metalloproteinase-9 in serum are associated with favorable clinical evolution in human visceral leishmaniasis

(2013) Fabrícia Alvisi de Oliveira et al.   BMC INFECTIOUS DISEASES

Evaluating Chagas disease progression and cure through blood-derived biomarkers: a systematic review

(2013) Ana Requena-Méndez et al.   Expert Review of Anti-Infective Therapy

New, Combined, and Reduced Dosing Treatment Protocols Cure Trypanosoma cruzi Infection in Mice

(2013) J. M. Bustamante et al.   JOURNAL OF INFECTIOUS DISEASES

VNI Cures Acute and Chronic Experimental Chagas Disease

(2013) Fernando Villalta et al.   JOURNAL OF INFECTIOUS DISEASES

A serological, parasitological and clinical evaluation of untreated Chagas disease patients and those treated with benznidazole before and thirteen years after intervention

(2013) Girley Francisco Machado-de-Assis et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Potential use of synthetic α-galactosyl-containing glycotopes of the parasite Trypanosoma cruzi as diagnostic antigens for Chagas disease

(2013) Roger A. Ashmus et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Comparison of conventional serology and PCR methods for the routine diagnosis of Trypanosoma cruzi infection

(2013) Soraia Reda Gilber et al.   Revista da Sociedade Brasileira de Medicina Tropical

Evaluation of the ELISA-F29 test as an early marker of therapeutic efficacy in adults with chronic Chagas disease

(2013) Diana Fabbro et al.   REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO

Posttherapeutic Cure Criteria in Chagas' Disease: Conventional Serology followed by Supplementary Serological, Parasitological, and Molecular Tests

(2012) G. F. Machado-de-Assis et al.   Clinical and Vaccine Immunology

High Interleukin 17 Expression Is Correlated With Better Cardiac Function in Human Chagas Disease

(2012) Luisa M. D. Magalhães et al.   JOURNAL OF INFECTIOUS DISEASES

Development of an Aptamer-Based Concentration Method for the Detection of Trypanosoma cruzi in Blood

(2012) Rana Nagarkatti et al.   PLoS One

Humoral Immune Response against P2β from Trypanosoma cruzi in Persons with Chronic Chagas Disease: Its Relationship with Treatment Against Parasites and Myocardial Damage

(2011) Diana L. Fabbro et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Short-term follow-up of chagasic patients after benznidazole treatment using multiple serological markers

(2011) Ana Fernández-Villegas et al.   BMC INFECTIOUS DISEASES

Trypanosoma cruziinfection results in the reduced expression of caveolin-3 in the heart

(2011) Daniel Adesse et al.   CELL CYCLE

Methodological advances in drug discovery for Chagas disease

(2011) Juan M Bustamante et al.   Expert Opinion on Drug Discovery

Combinations of Host Biomarkers Predict Mortality among Ugandan Children with Severe Malaria: A Retrospective Case-Control Study

(2011) Laura K. Erdman et al.   PLoS One

Hypercoagulability biomarkers in Trypanosoma cruzi-infected patients

(2011) Dolors Tassies et al.   THROMBOSIS AND HAEMOSTASIS

Impact of Aetiological Treatment on Conventional and Multiplex Serology in Chronic Chagas Disease

(2011) Rodolfo Viotti et al.   PLoS Neglected Tropical Diseases

Plasma  -Type Natriuretic Peptide As a Predictor of Mortality in Community-Dwelling Older Adults With Chagas Disease: 10-Year Follow-up of the Bambui Cohort Study of Aging

(2010) M. F. Lima-Costa et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Successful Treatment with Posaconazole of a Patient with Chronic Chagas Disease and Systemic Lupus Erythematosus

(2010) María-Jesús Pinazo et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Chagas disease in Latin American migrants: a Spanish challenge

(2010) A. Pérez-Ayala et al.   CLINICAL MICROBIOLOGY AND INFECTION

Usefulness of PCR for monitoring benznidazole response in patients with chronic Chagas' disease: a prospective study in a non-disease-endemic country

(2010) L. Murcia et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

IL-17 Is Necessary for Host Protection against Acute-Phase Trypanosoma cruzi Infection

(2010) Y. Miyazaki et al.   JOURNAL OF IMMUNOLOGY

Clinical and laboratory status of patients with chronic Chagas disease living in a vector-controlled area in Minas Gerais, Brazil, before and nine years after aetiological treatment

(2010) Marta de Lana et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Role of CCL3/MIP-1α and CCL5/RANTES during acute Trypanosoma cruzi infection in rats

(2010) Ester Roffê et al.   MICROBES AND INFECTION

What are biomarkers?

(2010) Kyle Strimbu et al.   Current Opinion in HIV and AIDS

Clinical Features and Serum Biomarkers in HIV Immune Reconstitution Inflammatory Syndrome after Cryptococcal Meningitis: A Prospective Cohort Study

(2010) David R. Boulware et al.   PLOS MEDICINE

Chagas Cardiomiopathy: The Potential of Diastolic Dysfunction and Brain Natriuretic Peptide in the Early Identification of Cardiac Damage

(2010) Ana Garcia-Alvarez et al.   PLoS Neglected Tropical Diseases

In Vitro and In Vivo High-Throughput Assays for the Testing of Anti-Trypanosoma cruzi Compounds

(2010) Adriana M. C. Canavaci et al.   PLoS Neglected Tropical Diseases

Changes inTrypanosoma cruzi–Specific Immune Responses after Treatment: Surrogate Markers of Treatment Efficacy

(2009) Susana A. Laucella et al.   CLINICAL INFECTIOUS DISEASES

Plasma ACE2 Activity is an Independent Prognostic Marker in Chagas' Disease and Equally Potent as BNP

(2009) Yong Wang et al.   JOURNAL OF CARDIAC FAILURE

CCL2/MCP-1 controls parasite burden, cell infiltration, and mononuclear activation during acute Trypanosoma cruzi infection

(2009) Cláudia N. Paiva et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cellular and genetic mechanisms involved in the generation of protective and pathogenic immune responses in human Chagas disease

(2009) Walderez Ornelas Dutra et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Immunological imbalance between IFN-³ and IL-10 levels in the sera of patients with the cardiac form of Chagas disease

(2009) Daniela A D'Ávila et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Diagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies?

(2009) Yara M Gomes et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Efficacy of benznidazol treatment for asymptomatic chagasic patients from state of Rio Grande do Sul evaluated during a three years follow-up

(2009) CD Fernandes et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Enhanced Nitrosative Stress during Trypanosoma cruzi Infection Causes Nitrotyrosine Modification of Host Proteins

(2008) Monisha Dhiman et al.   AMERICAN JOURNAL OF PATHOLOGY

Phenotype and function of human T lymphocyte subsets: Consensus and issues

(2008) Victor Appay et al.   CYTOMETRY PART A

Functional IL‐10 Gene Polymorphism Is Associated with Chagas Disease Cardiomyopathy

(2008) Germano C. Costa et al.   JOURNAL OF INFECTIOUS DISEASES

Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease

(2008) Juan M Bustamante et al.   NATURE MEDICINE

HLA Class I-T Cell Epitopes from trans-Sialidase Proteins Reveal Functionally Distinct Subsets of CD8+ T Cells in Chronic Chagas Disease

(2008) María G. Alvarez et al.   PLoS Neglected Tropical Diseases

High Throughput Selection of Effective Serodiagnostics for Trypanosoma cruzi infection

(2008) Gretchen Cooley et al.   PLoS Neglected Tropical Diseases