Recent insights into the biology of neuroblastoma

Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice

(2015) Lucille Lopez-Delisle et al.   Oncotarget

Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma

(2015) Alex Cazes et al.   Oncotarget

High Genomic Instability Predicts Survival in Metastatic High-Risk Neuroblastoma

(2015) Sara Stigliani et al.   NEOPLASIA

Clinical Characteristics and Outcome of Patients with Neuroblastoma Presenting Genomic Amplification of Loci Other than MYCN

(2014) Anne Guimier et al.   PLoS One

Th-MYCN Mice with Caspase-8 Deficiency Develop Advanced Neuroblastoma with Bone Marrow Metastasis

(2013) Tal Teitz et al.   CANCER RESEARCH

New Strategies in Neuroblastoma: Therapeutic Targeting of MYCN and ALK

(2013) G. Barone et al.   CLINICAL CANCER RESEARCH

Recurrent pre-existing and acquired DNA copy number alterations, including focalTERTgains, in neuroblastoma central nervous system metastases

(2013) David Cobrinik et al.   GENES CHROMOSOMES & CANCER

Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study

(2013) Yael P Mossé et al.   LANCET ONCOLOGY

The genetic landscape of high-risk neuroblastoma

(2013) Trevor J Pugh et al.   NATURE GENETICS

Emerging landscape of oncogenic signatures across human cancers

(2013) Giovanni Ciriello et al.   NATURE GENETICS

Focal DNA Copy Number Changes in Neuroblastoma Target MYCN Regulated Genes

(2013) Candy Kumps et al.   PLoS One

Breakpoint Features of Genomic Rearrangements in Neuroblastoma with Unbalanced Translocations and Chromothripsis

(2013) Valentina Boeva et al.   PLoS One

Distinct Neuroblastoma-associated Alterations of PHOX2B Impair Sympathetic Neuronal Differentiation in Zebrafish Models

(2013) Desheng Pei et al.   PLoS Genetics

A Simple, Highly Visual in Vivo Screen for Anaplastic Lymphoma Kinase Inhibitors

(2012) Frederico S. L. M. Rodrigues et al.   ACS Chemical Biology

The ALKF1174L Mutation Potentiates the Oncogenic Activity of MYCN in Neuroblastoma

(2012) Teeara Berry et al.   CANCER CELL

Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis

(2012) Shizhen Zhu et al.   CANCER CELL

Common Variation at BARD1 Results in the Expression of an Oncogenic Isoform That Influences Neuroblastoma Susceptibility and Oncogenicity

(2012) K. R. Bosse et al.   CANCER RESEARCH

A Three-Gene Expression Signature Model for Risk Stratification of Patients with Neuroblastoma

(2012) I. Garcia et al.   CLINICAL CANCER RESEARCH

Age-dependent accumulation of genomic aberrations and deregulation of cell cycle and telomerase genes in metastatic neuroblastoma

(2012) Simona Coco et al.   INTERNATIONAL JOURNAL OF CANCER

Association of Age at Diagnosis and Genetic Mutations in Patients With Neuroblastoma

(2012) Nai-Kong V. Cheung   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expression

(2012) Mayumi Nagashimada et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical Significance of Tumor-Associated Inflammatory Cells in Metastatic Neuroblastoma

(2012) Shahab Asgharzadeh et al.   JOURNAL OF CLINICAL ONCOLOGY

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

(2012) Jan J. Molenaar et al.   NATURE

Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma

(2012) Sharon J Diskin et al.   NATURE GENETICS

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression

(2012) Jan J Molenaar et al.   NATURE GENETICS

Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma

(2012) Mark Sausen et al.   NATURE GENETICS

Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells

(2012) C Schönherr et al.   ONCOGENE

Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification

(2012) L. J. Valentijn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Expression of Mutated ALK Induces Neuroblastoma in Transgenic Mice

(2012) L. C. Heukamp et al.   Science Translational Medicine

Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers

(2012) Anneleen Decock et al.   GENOME BIOLOGY

Comprehensive SNP array study of frequently used neuroblastoma cell lines; copy neutral loss of heterozygosity is common in the cell lines but uncommon in primary tumors

(2011) Hanna Kryh et al.   BMC GENOMICS

Segmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma (a SIOPEN collaborative study)

(2011) G Schleiermacher et al.   BRITISH JOURNAL OF CANCER

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

miRNA Expression Profiling Enables Risk Stratification in Archived and Fresh Neuroblastoma Tumor Samples

(2011) K. De Preter et al.   CLINICAL CANCER RESEARCH

High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma

(2011) J. H. Schulte et al.   CLINICAL CANCER RESEARCH

Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition

(2011) T. Reiff et al.   DEVELOPMENT

ALK germline mutations in patients with neuroblastoma: a rare and weakly penetrant syndrome

(2011) Franck Bourdeaut et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genome-Wide Linkage Analysis to Identify Genetic Modifiers of ALK Mutation Penetrance in Familial Neuroblastoma

(2011) Marcella Devoto et al.   HUMAN HEREDITY

Germline gain-of-function mutations of ALK disrupt central nervous system development

(2011) Loïc de Pontual et al.   HUMAN MUTATION

Differential Inhibitor Sensitivity of Anaplastic Lymphoma Kinase Variants Found in Neuroblastoma

(2011) S. C. Bresler et al.   Science Translational Medicine

Phenotype Restricted Genome-Wide Association Study Using a Gene-Centric Approach Identifies Three Low-Risk Neuroblastoma Susceptibility Loci

(2011) Lễ B. Nguyễn et al.   PLoS Genetics

Meta-analysis of Neuroblastomas Reveals a Skewed ALK Mutation Spectrum in Tumors with MYCN Amplification

(2010) S. De Brouwer et al.   CLINICAL CANCER RESEARCH

Accurate prediction of neuroblastoma outcome based on miRNA expression profiles

(2010) Johannes H. Schulte et al.   INTERNATIONAL JOURNAL OF CANCER

Prognostic Impact of Gene Expression–Based Classification for Neuroblastoma

(2010) André Oberthuer et al.   JOURNAL OF CLINICAL ONCOLOGY

Accumulation of Segmental Alterations Determines Progression in Neuroblastoma

(2010) Gudrun Schleiermacher et al.   JOURNAL OF CLINICAL ONCOLOGY

A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients

(2010) Paolo Fardin et al.   Molecular Cancer

Hypermethylation of apoptotic genes as independent prognostic factor in neuroblastoma disease

(2010) Elena Grau et al.   MOLECULAR CARCINOGENESIS

Integrative genomics identifies LMO1 as a neuroblastoma oncogene

(2010) Kai Wang et al.   NATURE

An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

(2010) P Mestdagh et al.   ONCOGENE

High-risk neuroblastoma tumors with 11q-deletion display a poor prognostic, chromosome instability phenotype with later onset

(2010) H. Caren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overall Genomic Pattern Is a Predictor of Outcome in Neuroblastoma

(2009) Isabelle Janoueix-Lerosey et al.   JOURNAL OF CLINICAL ONCOLOGY

Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1

(2009) Hilde Brems et al.   LANCET ONCOLOGY

Predicting outcomes for children with neuroblastoma using a multigene-expression signature: a retrospective SIOPEN/COG/GPOH study

(2009) Joëlle Vermeulen et al.   LANCET ONCOLOGY

Copy number variation at 1q21.1 associated with neuroblastoma

(2009) Sharon J. Diskin et al.   NATURE

Common variations in BARD1 influence susceptibility to high-risk neuroblastoma

(2009) Mario Capasso et al.   NATURE GENETICS

High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors; Four cases of homozygous deletions of the CDKN2A gene

(2008) Helena Caren et al.   BMC GENOMICS

Characterization of amplicons in neuroblastoma: High-resolution mapping using DNA microarrays, relationship with outcome, and identification of overexpressed genes

(2008) Anne Fix et al.   GENES CHROMOSOMES & CANCER

The International Neuroblastoma Risk Group (INRG) Classification System: An INRG Task Force Report

(2008) Susan L. Cohn et al.   JOURNAL OF CLINICAL ONCOLOGY

Identification of ALK as a major familial neuroblastoma predisposition gene

(2008) Yaël P. Mossé et al.   NATURE

Activating mutations in ALK provide a therapeutic target in neuroblastoma

(2008) Rani E. George et al.   NATURE

Oncogenic mutations of ALK kinase in neuroblastoma

(2008) Yuyan Chen et al.   NATURE

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

(2008) Isabelle Janoueix-Lerosey et al.   NATURE

Chromosome 6p22 Locus Associated with Clinically Aggressive Neuroblastoma

(2008) John M. Maris et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Constitutional Translocation t(1;17)(p36.2;q11.2) in a Neuroblastoma Patient Disrupts the Human NBPF1 and ACCN1 Genes

(2008) Karl Vandepoele et al.   PLoS One