Article
Endocrinology & Metabolism
Alice L. Tang, Richard T. Kloos, Benjamin Aunins, Tammy M. Holm, Mara Y. Roth, Michael W. Yeh, Gregory W. Randolph, Meredith E. Tabangin, Mekibib Altaye, David L. Steward
Summary: The study found that pathological features such as metastasis, gross extra-thyroidal extension, and multifocality were more prevalent in BRAF-like tumors compared to RAS-like and NBNR. A trend towards increased frequency of angioinvasion was observed in RAS-like and NBNR cancers. Further research is needed to evaluate the impact of preoperative knowledge of molecular mutations on decision-making regarding the extent of surgery.
ENDOCRINE PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Miguel A. Zaballos, Adrian Acuna-Ruiz, Marta Morante, Garcilaso Riesco-Eizaguirre, Piero Crespo, Pilar Santisteban
Summary: The study demonstrates that BRAF- and RAS-mutant thyroid cells respond differently to DEL-22379, which cannot be explained by the previously described mechanism of action of the inhibitor. Nonetheless, DEL-22379 exhibits significant anti-tumor effects against BRAF-mutant cells in vivo, while the anti-tumor effects are mild for RAS-mutant cells.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Matthew D. Ringel
Summary: Treatment of progressive metastatic follicular cell-derived and medullary thyroid cancers is challenging, with limited complete remissions, short response durations, and common toxicities. Further research into resistance mechanisms, biomarker development, and new therapeutic strategies is needed.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Oncology
Cristina Montero-Conde, Luis Javier Leandro-Garcia, Angel M. Martinez-Montes, Paula Martinez, Francisco J. Moya, Rocio Leton, Eduardo Gil, Natalia Martinez-Puente, Sonsoles Guadalix, Maria Curras-Freixes, Laura Garcia-Tobar, Carles Zafon, Mireia Jorda, Garcilaso Riesco-Eizaguirre, Patricia Gonzalez-Garcia, Maria Monteagudo, Rafael Torres-Perez, Veronika Mancikova, Sergio Ruiz-Llorente, Manuel Perez-Martinez, Guillermo Pita, Juan Carlos Galofre, Anna Gonzalez-Neira, Alberto Cascon, Cristina Rodriguez-Antona, Diego Megias, Maria A. Blasco, Eduardo Caleiras, Sandra Rodriguez-Perales, Mercedes Robledo
Summary: Comprehensive molecular studies were conducted on thyroid tumors to identify prognostic biomarkers. Telomere-related alterations, especially TERT and TERC, were found in aggressive tumors. Short telomeres led to reorganization in the 5p subtelomeric region, resulting in increased gene upregulation and a more relaxed chromatin configuration in the tumors.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Health Care Sciences & Services
Antonio Ieni, Roberto Vita, Cristina Pizzimenti, Salvatore Benvenga, Giovanni Tuccari
Summary: Differentiated thyroid tumors (DTTs) exhibit significant molecular variability that could impact therapeutic management, with intra-tumoral heterogeneity (ITH) playing a crucial role in tumor growth, aggressive behavior, and drug resistance. Molecular testing in DTTs indicates a high risk of cancer recurrence associated with specific gene fusions, while intermediate risk may be related to other genetic factors.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Dauren Adilbay, Avery Yuan, Paul B. Romesser, Richard J. Wong, Jatin P. Shah, Ashok R. Shaha, Michael R. Tuttle, Snehal Patel, Nancy Y. Lee, Ian Ganly
Summary: This study aimed to report the experience of patients with well-differentiated thyroid cancer (WDTC) who received postoperative radiation therapy (PORT). The results showed that patients who received PORT had improved locoregional recurrence-free probability, but it did not translate into improved disease-specific survival and overall survival.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Hongxi Wang, Hongyuan Dai, Qianrui Li, Guohua Shen, Lei Shi, Rong Tian
Summary: This study aimed to determine whether F-18-FDG PET/CT parameters could serve as prognostic markers for patients with DTC. The analysis of 25 studies revealed that these parameters can be useful in identifying DTC patients with poor outcomes, especially in cases with elevated Tg and negative WBS. Further research is needed to confirm these findings and explore the prognostic value of PET/CT parameters for DTC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Alan L. Ho, Marek Dedecjus, Lori J. Wirth, R. Michael Tuttle, William B. Inabnet, Jan Tennvall, Fernanda Vaisman, Lars Bastholt, Andrew G. Gianoukakis, Patrice Rodien, Ralf Paschke, Rossella Elisei, David Viola, Karen So, Danielle Carroll, Tina Hovey, Bhavana Thakre, James A. Fagin
Summary: This study investigated whether adding Selumetinib to adjuvant RAI improves complete remission rates in patients with DTC at high risk of primary treatment failure. The results showed that Selumetinib did not significantly increase the CR rate 18 months after RAI, and treatment-related adverse events were minimal.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Oncology
Fumihiko Matsumoto, Katsuhisa Ikeda
Summary: Tracheal invasion in well-differentiated thyroid cancer is a negative prognostic factor, with different resection methods having varying impacts on prognosis. Patients with well-differentiated thyroid cancer generally have a good prognosis, but factors such as quality of life and surgical risks need to be considered.
Article
Multidisciplinary Sciences
Han Luo, Xuyang Xia, Gyeong Dae Kim, Yang Liu, Zhinan Xue, Lingyun Zhang, Yang Shu, Tian Yang, Yan Chen, Shouyue Zhang, Haining Chen, Weihan Zhang, Ruicen Li, Huairong Tang, Birong Dong, Xianghui Fu, Wei Cheng, Wei Zhang, Li Yang, Yong Peng, Lunzhi Dai, Hongbo Hu, Yong Jiang, Changyang Gong, Yiguo Hu, Jingqiang Zhu, Zhihui Li, Carlos Caulin, Tao Wei, Jihwan Park, Heng Xu
Summary: By utilizing single-cell RNA sequencing, this study delved into the landscape of thyroid cancer at a single-cell level, elucidating the dedifferentiation process and suppressive immune microenvironment. It was found that ATC cells originated from a small subset of PTC cells, with CREB3L1 potentially playing a functional role in ATC development.
Article
Biochemistry & Molecular Biology
Irena Ivkovic, Zgjim Limani, Antonia Jakovcevic, Srecko Gajovic, Sven Seiwerth, Ana Danic Hadzibegovic, Drago Prgomet
Summary: By analyzing tissue samples from 146 patients with papillary thyroid cancer, we found that the BRAF V600E mutation and CPSF2 protein expression are associated with recurrence and disease-free survival. Patients with low CPSF2 protein expression and the BRAF V600E mutation were at higher risk for recurrence, while patients with high CPSF2 protein expression had longer disease-free survival. These findings provide important prognostic factors for papillary thyroid cancer.
Article
Endocrinology & Metabolism
Davide Giordano, Cecilia Botti, Simonetta Piana, Michele Zini, Andrea Frasoldati, Francesca Lusetti, Silvio Cavuto, Luisa Savoldi, Carmine Pernice, Angelo Ghidini
Summary: This retrospective study found that patients undergoing completion thyroidectomy had a lower risk of transient postoperative HPT, with female sex and PGRIS score identified as independent risk factors for postoperative HPT. These findings could help in surgical planning to reduce endocrine complications, especially with the increasing use of conservative surgery for thyroid neoplasms.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Min Wu, Deng-jie Ou-yang, Bo Wei, Pei Chen, Qi-man Shi, Hai-long Tan, Bo-qiang Huang, Mian Liu, Zi-en Qin, Ning Li, Hui-yu Hu, Peng Huang, Shi Chang
Summary: This study developed a reliable predictive model for the prognosis of differentiated thyroid cancer (DTC) patients based on glycolysis-related genes. The model outperformed conventional clinicopathological features in predicting recurrence-free survival. Functional enrichment analysis revealed that these signature genes are involved in remodeling the tumor microenvironment. An integrated decision tree and nomogram based on the model and clinical parameters were generated to optimize risk stratification.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yuxiao Xia, Xue Jiang, Yuan Huang, Qian Liu, Yin Huang, Bo Zhang, Zhanjun Mei, Dongkun Xu, Yuhong Shi, Wenling Tu
Summary: This study aimed to provide a comprehensive prognostic model related to the tumor immune microenvironment (TIME) to improve the predictive accuracy of progression-free survival (PFS) in patients with BRAF-mutated papillary thyroid carcinoma (PTC). By analyzing gene expression data and clinical data, two key TIME-related genes, HTR3A and NIPAL4, were identified and a risk scoring system based on these genes was developed. A nomogram combining risk score with clinical parameter was constructed and showed high accuracy and clinical utility in predicting PFS in BRAF-mutated PTC patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Szabina Szujo, Laszlo Bajnok, Beata Bodis, Zsuzsanna Nagy, Orsolya Nemes, Karoly Rucz, Emese Mezosi
Summary: Thyroglobulin (Tg) is a crucial tumor marker in differentiated thyroid cancer (DTC), with non-stimulated Tg values showing excellent accuracy in predicting structural disease. A patient's risk classification can be revised based on a single Tg measurement.
Article
Oncology
James E. Barrett, Allison Jones, Iona Evans, Chiara Herzog, Daniel Reisel, Adeola Olaitan, Tim Mould, Nicola MacDonald, Konstantinos Doufekas, Claire Newton, Emma J. Crosbie, Line Bjorge, Nicoletta Colombo, Lukas Dostalek, Laura Costas, Paula Peremiquel-Trillas, Jordi Ponce, Xavier Matias-Guiu, Michal Zikan, David Cibula, Jiangrong Wang, Karin Sundstroem, Joakim Dillner, Martin Widschwendter
Summary: To reduce the morbidity caused by aggressive treatment for advanced endometrial cancer, it is necessary to identify women at risk and detect the cancer earlier. A new test called WID-EC based on DNA methylation was developed and validated in different sets of samples, showing promising results in identifying women with or at risk of endometrial cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Cell Biology
Yaiza Jung-Garcia, Oscar Maiques, Joanne Monger, Irene Rodriguez-Hernandez, Bruce Fanshawe, Marie-Charlotte Domart, Matthew J. Renshaw, Rosa M. Marti, Xavier Matias-Guiu, Lucy M. Collinson, Victoria Sanz-Moreno, Jeremy G. Carlton
Summary: Metastasis involves cancer cells spreading from the primary tumor to other sites. Researchers discovered increased expression of the protein LAP1 in metastatic melanoma cells, primary melanoma tumors, and metastases. They found that a shorter isoform of LAP1, LAP1C, supports constrained cell migration and invasion by allowing a weaker coupling between the nuclear envelope and the nuclear lamina. This suggests that LAP1 contributes to melanoma aggressiveness.
NATURE CELL BIOLOGY
(2023)
Article
Nutrition & Dietetics
Enric Sanchez, Marta Sanchez, Carolina Lopez-Cano, Marcelino Bermudez-Lopez, Jose Manuel Valdivielso, Cristina Farras-Salles, Reinald Pamplona, Gerard Torres, Didac Mauricio, Eva Castro, Elvira Fernandez, Albert Lecube
Summary: This study assessed the impact of obesity on the accumulation of advanced glycation end-products (AGEs) and found that AGE levels were associated with abdominal adiposity but not total body fat. Furthermore, elevated AGE levels were related to cardiovascular risk factors.
Article
Endocrinology & Metabolism
I Mazarico-Altisent, I Capel, N. Baena, M. R. Bella-Cueto, S. Barcons, X. Guirao, L. Albert, A. Cano, R. Pareja, A. Caixas, M. Rigla
Summary: New germline mutations in CDKIs have been identified in patients with primary hyperparathyroidism (PHPT), highlighting the importance of including CDKIs in genetic testing for PHPT.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Laura Perez-Fernandez, Julia Sastre, Carles Zafon, Amelia Oleaga, Esmeralda Castelblanco, Ismael Capel, Juan C. Galofre, Sonsoles Guadalix-Iglesias, Antonio De la Vieja, Garcilaso Riesco-Eizaguirre
Summary: Dynamic risk stratification (DRS) is a new system in thyroid cancer that considers treatment response to improve the initial risk of recurrence. In this multicenter study, we validated the DRS system and found that integrating BRAFV600E into DRS does not provide additional benefit.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Nuria Alcubierre, Minerva Granado-Casas, Patricia Bogdanov, Cristina Hernandez, Hugo Ramos, Esmeralda Castelblanco, Jordi Real, Esther Rubinat-Arnaldo, Alicia Traveset, Marta Hernandez, Carmen Jurjo, Jesus Vioque, Eva Maria Navarrete-Munoz, Rafael Simo, Didac Mauricio
Summary: The study evaluated the potential benefits of caffeine intake in preventing the development of diabetic retinopathy (DR) in patients with type 2 diabetes (T2D). The cross-sectional study showed a protective effect of moderate and high caffeine intake on DR. However, the experimental model did not demonstrate any improvement in reactive gliosis or retinal vascular permeability with caffeine administration.
Editorial Material
Medicine, General & Internal
Joana Rossell, Marina Idalia Rojo-Lopez, Josep Julve, Didac Mauricio
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Lucia Sanjurjo, Esmeralda Castelblanco, Josep Julve, Nuria Villalmanzo, Erica Tellez, Anna Ramirez-Morros, Nuria Alonso, Didac Mauricio, Maria-Rosa Sarrias
Summary: The study aimed to investigate the contribution of oxLDL to the inflammatory response of macrophages under diabetic conditions. The results showed that oxLDL promoted intracellular lipid accumulation in macrophages under high glucose (HG) conditions and enhanced the production of pro-inflammatory cytokines. Moreover, HG and oxLDL upregulated the expression of the cell surface receptor TLR4 and increased the release of sCD14, which further exacerbated the inflammation.
Article
Biochemistry & Molecular Biology
Ricardo Rodriguez-Calvo, Minerva Granado-Casas, Alejandra Perez-Montes de Oca, Maria Teresa Julian, Mar Domingo, Pau Codina, Evelyn Santiago-Vacas, German Cediel, Josep Julve, Joana Rossell, Lluis Masana, Didac Mauricio, Josep Lupon, Antoni Bayes-Genis, Nuria Alonso
Summary: This study aimed to explore the prognostic value of cardiac-specific fatty acid binding proteins (FABP3) and adipose-tissue-specific fatty acid binding proteins (FABP4) in chronic heart failure (CHF) patients, with and without type 2 diabetes mellitus (T2D). It was found that the concentrations of FABP3 and FABP4 were associated with all-cause and cardiovascular mortality, particularly in patients with T2D. The study suggests that serum FABP3 and FABP4 concentrations can serve as independent predictors for the occurrence of all-cause and cardiovascular mortality in ambulatory CHF subjects with T2D.
Article
Multidisciplinary Sciences
Miquel de Homdedeu, Lidia Sanchez-Moral, Concepcio Violan, Neus Rafols, Dan Ouchi, Berta Martin, Miguel A. Peinado, Alheli Rodriguez-Cortes, Marta Arch-Sisquella, Daniel Perez-Zsolt, Jordana Munoz-Basagoiti, Nuria Izquierdo-Useros, Betlem Salvador, Joan Matllo, Sergi Lopez-Serrano, Joaquim Segales, Cristina Vilaplana, Pere Toran-Monserrat, Rosa Morros, Ramon Monfa, Maria-Rosa Sarrias, Pere-Joan Cardona
Summary: The study aims to analyze whether heat-killed environmental mycobacteria can induce trained immunity against SARS-CoV-2 infection. The results show that heat-killed mycobacteria induce cellular immune changes in vitro, but no similar effects were observed when orally administered in vivo.
Article
Nutrition & Dietetics
Jeimy Katherine Torres-Mendez, Julia Nino-Narvion, Patricia Martinez-Santos, Elena Maria Goretti Diarte-Anazco, Karen Alejandra Mendez-Lara, Tania Vazquez del Olmo, Noemi Rotllan, Maria Teresa Julian, Nuria Alonso, Didac Mauricio, Mercedes Camacho, Juan Pablo Munoz, Joana Rossell, Josep Julve
Summary: This study investigated the effects of nicotinamide (NAM) supplementation on brain inflammation and microglial activation in a mouse model of type 1 diabetes. The results showed that NAM supplementation prevented brain inflammation in diabetic mice through NAD+-dependent deacetylation mechanisms.
Article
Chemistry, Multidisciplinary
Raul Navaridas, Maria Vidal-Sabanes, Anna Ruiz-Mitjana, Gisela Altes, Aida Perramon-Guell, Andree Yeramian, Joaquim Egea, Mario Encinas, Sonia Gatius, Xavier Matias-Guiu, Xavier Dolcet
Summary: Simultaneous deletion of Pten and p53 in endometrial epithelial cells is sufficient to trigger epithelial-to-mesenchymal transition, leading to the development of metastatic uterine carcinosarcomas.
Article
Endocrinology & Metabolism
Isabel Mazarico-Altisent, Ismael Capel, Neus Baena, Maria Rosa Bella-Cueto, Santi Barcons, Xavier Guirao, Rocio Pareja, Andreea Muntean, Valeria Arsentales, Assumpta Caixas, Mercedes Rigla
Summary: Genetic screening in a Mediterranean cohort of suspected familial hyperparathyroidism revealed a high prevalence of germline variants, leading to early diagnosis and treatment for patients and early intervention in their relatives. It is recommended to conduct genetic testing for patients with primary hyperparathyroidism who present high-risk features.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Oncology
Jonathan S. Berek, Xavier Matias-Guiu, Carien Creutzberg, Christina Fotopoulou, David Gaffney, Sean Kehoe, Kristina Lindemann, David Mutch, Endometrial Canc Staging Subcomm, FIGO Womens Canc Comm
Summary: Since the 2009 update of the FIGO staging system, there have been significant advances in understanding the pathologic and molecular features of endometrial cancer. The new staging system aims to better define prognostic groups and create substages to guide more appropriate treatment.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)