Article
Pharmacology & Pharmacy
Fei Qin, Jianling Li, Yong-Fa Dai, Xiao-ge Zhong, Ya-jin Pan
Summary: The study demonstrated that renal denervation reduces levels of RAAS components such as aldosterone and Ang II, leading to lower blood pressure and improved renal function.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Medicine, General & Internal
Alper Tuna Guven, Murat Ozdede, Yusuf Ziya Sener, Ali Osman Yildirim, Sabri Engin Altintop, Berkay Yesilyurt, Oguz Abdullah Uyaroglu, Mine Durusu Tanriover
Summary: This study aimed to evaluate the performance of machine learning algorithms in identifying and predicting renal adverse events associated with RAASi. The most important features for predicting these events were found to be index K and glucose levels, as well as uncontrolled diabetes mellitus. kNN, RF, xGB, and NN algorithms showed the highest performance metrics for prediction.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
M. Ekholm, T. Kahan
Summary: Atherosclerosis is a disease caused by chronic inflammation and endothelial dysfunction, with up-regulated mediators of inflammation in affected individuals. Oxidative stress, imbalance between antioxidants and oxidants, leads to tissue damage. The renin-angiotensin-aldosterone system plays a vital role in vascular disease pathobiology, with angiotensin II causing hypertension and reactive oxygen species production. Blocking this system could potentially reduce inflammatory and thrombotic complications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Natalia K. S. Lima, Wilka R. A. Farias, Marry A. S. Cirilo, Angelica G. Oliveira, Juliane S. Farias, Regina S. Aires, Humberto Muzi-Filho, Ana D. O. Paixao, Leucio D. Vieira
Summary: Acute renal injury induced by ischemia-reperfusion may lead to changes in proximal tubule ATPases and RAAS components, which are associated with renal Na+ retention and hypertension. NADPH oxidase plays a key role in these alterations.
Article
Physiology
Lale A. A. Ertuglu, Ashley Pitzer Mutchler, Fernando Elijovich, Cheryl L. L. Laffer, Quanhu Sheng, Celestine N. N. Wanjalla, Annet Kirabo
Summary: This study investigated the effects of high salt diet on the expression of RAAS genes in myeloid immune cells and its impact on salt-sensitive hypertension in humans. The results showed that high sodium exposure downregulated the expression of renin in immune cells, but there were no significant changes in the genes of the renin-angiotensin system in response to dietary salt loading and depletion. These findings suggest that acute changes in dietary salt intake do not regulate RAAS expression in myeloid immune cells, unlike the systemic RAAS.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Transplantation
Antoinette Pechere-Bertschi, Valerie Olivier, Michel Burnier, Khalil Udwan, Sophie de Seigneux, Belen Ponte, Marc Maillard, Pierre-Yves Martin, Eric Feraille
Summary: In healthy male subjects, neither spontaneous nor diuretic-induced potassium excretion was influenced by sodium intake, but the contributions of the distal convoluted tubule and collecting duct to renal sodium handling depended on dietary sodium intake.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Biochemistry & Molecular Biology
Alex Cleber Improta-Caria, Marcela Gordilho Aras, Luca Nascimento, Ricardo Augusto Leoni De Sousa, Roque Aras-Junior, Bruno Solano de Freitas Souza
Summary: MicroRNAs are small non-coding RNAs that regulate gene and protein expression, playing important roles in various cellular processes. In diseases such as hypertension, microRNAs are involved in regulating physiological processes, but the specific mechanisms need further study.
Review
Endocrinology & Metabolism
Huai Heng Loh, Norlela Sukor
Summary: This review aims to collate and summarize current research on the association between primary aldosteronism and obstructive sleep apnea, including their relationship, clinical characteristics, implications, treatment outcomes, potential causal links, and mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Susanne Rysz, Jonathan Al-Saadi, Anna Sjostrom, Maria Farm, Francesca Campoccia Jalde, Michael Platten, Helen Eriksson, Margareta Klein, Roberto Vargas-Paris, Sven Nyren, Goran Abdula, Russell Ouellette, Tobias Granberg, Malin Jonsson Fagerlund, Johan Lundberg
Summary: Studies suggest that RAAS imbalance worsens the prognosis in COVID-19 patients, and experiments in pigs show that over-activation of ACE2 and RAAS can lead to a disease state similar to COVID-19 in humans. Imbalanced RAAS state in animals can be ameliorated by angiotensin receptor blockers and low-molecular-weight heparin.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Seung-Hwa Lee, Jungchan Park, Rae Woong Park, Seo Jeong Shin, Jinseob Kim, Ji Dong Sung, Dae Jung Kim, Kwangmo Yang
Summary: Studies have shown conflicting results on the association between the use of RAAS inhibitors and cancer development. This study compared the incidence of cancer between patients using RAAS inhibitors and other antihypertensive drugs. The findings suggest that the use of RAAS inhibitors may be associated with a lower incidence of cancer.
Article
Cardiac & Cardiovascular Systems
Felix Mahfoud, Raymond R. Townsend, David E. Kandzari, Kazuomi Kario, Roland E. Schmieder, Konstantinos Tsiou, Stuart Pocock, Shukri David, Kiritkumar Patel, Anjani Rao, Antony Walton, Jason E. Bloom, Thomas Weber, Markus Suppan, Lucas Lauder, Sidney A. Cohen, Pamela McKenna, Martin Fahy, Michael Boehm, Michael A. Weber
Summary: The study aimed to evaluate the impact of renal denervation (RDN) on the renin-angiotensin-aldosterone system in blood pressure regulation. Results showed that plasma renin activity and aldosterone levels significantly decreased compared to baseline in RDN patients at 3 months, with higher baseline PRA levels associated with a more significant reduction in blood pressure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anastasia Poznyak, Dwaipayan Bharadwaj, Gauri Prasad, Andrey Grechko, Margarita A. Sazonova, Alexander N. Orekhov
Summary: Atherosclerosis has a complex pathogenesis involving inflammation, lipid metabolism alterations, and endothelial injury. The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in the inflammatory response regulation, making it a promising target for atherosclerosis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sam Siljee, Bridget Milne, Helen D. Brasch, Nicholas Bockett, Josie Patel, Paul F. Davis, Andrew Kennedy-Smith, Tinte Itinteang, Swee T. Tan
Summary: This study demonstrated the expression of PRR, ACE2, and AT(2)R by the CSCs within RCCC. Further studies may lead to novel therapeutic targeting of CSCs by manipulation of the RAS in the treatment of this aggressive cancer.
Article
Cardiac & Cardiovascular Systems
Yuliya Lytvyn, Kevin D. Burns, Jeffrey M. Testani, Andriy Lytvyn, Jaya Prakash N. Ambinathan, Oluwatosin Osuntokun, Lucas C. Godoy, David Z. Cherney, John D. Parker
Summary: Understanding cardiorenal pathophysiology in heart failure is clinically important. This study found that concentrations of PRA, aldosterone, and ACE were higher in the renal vein compared to the artery in patients with heart failure. In heart failure patients, a larger ACE gradient was associated with greater renal vascular resistance and arteriolar resistances, while a larger aldosterone and PRA gradient was associated with lower GFR, renal blood flow, and ERPF. Treatment with dobutamine and nitroprusside only decreased the transrenal gradient of ACE, aldosterone, and PRA in heart failure patients.
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Biotechnology & Applied Microbiology
Bao Zhong, Eun-Gyung Mun, Jin-Xi Wang, Youn-Soo Cha
Summary: The study found that Chinese traditional fermented soy sauce can prevent hypertension by reducing body weight, improving blood lipids, lowering blood pressure, and preventing hypertension-related kidney injury. Additionally, it showed beneficial effects on the renin-angiotensin-aldosterone system and adipogenesis, indicating its potential as a preventive measure for hypertension.
FERMENTATION-BASEL
(2021)
Article
Oncology
Karlijn E. P. E. Hermans, Piet A. van den Brandt, Caroline Loef, Rob L. H. Jansen, Leo J. Schouten
Summary: This study investigated the association between vegetable and fruit intake and the risk of Cancer of Unknown Primary (CUP). The results showed that overall, vegetable and fruit consumption was not associated with CUP incidence.
Article
Oncology
Karlijn E. P. E. Hermans, Sharmi Haque, Piet A. van den Brandt, Caroline Loef, Rob L. H. Jansen, Leo J. Schouten
Summary: This study examines the association between type 2 diabetes mellitus (T2DM) and cancer of unknown primary (CUP) in depth, and finds a nonsignificant positive association between T2DM and CUP risk. The association becomes stronger in women.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2022)
Article
Oncology
Kelly Offermans, Josien C. A. Jenniskens, Colinda C. J. M. Simons, Iryna Samarska, Gregorio E. Fazzi, Jaleesa R. M. van der Meer, Kim M. Smits, Leo J. Schouten, Matty P. Weijenberg, Heike Grabsch, Piet A. van den Brandt
Summary: This study investigated the prognostic value of mutational subgroups based on somatic mutations in RAS, BRAF, PIK3CA, MET, and mismatch repair (MMR) status in colorectal cancer (CRC) patients. The results showed that mutational subgroups were associated with survival differences in CRC patients, while Warburg-subtypes did not provide additional prognostic information within these mutational subgroups.
Article
Dermatology
Anh Ly Nguyen, Sanja Kezic, Maarten Vermeer, Koen Quint, Roderick Slieker, Remco van Doorn, Thomas Rustemeyer
Summary: Mycosis fungoides (MF) is a skin disease characterized by malignant CD4(+) T-cell infiltrates. Tape stripping technique can reveal the cytokine secretion pattern in MF skin lesions, showing the presence of pro-inflammatory cytokines. However, this technique cannot reliably distinguish MF skin from atopic dermatitis (AD) skin.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Oncology
Theodore M. Brasky, Erinn M. Hade, David E. Cohn, Alison M. Newton, Stacey Petruzella, Kelli O'Connell, Kimberly A. Bertrand, Linda S. Cook, Immaculata De Vivo, Mengmeng Du, Jo L. Freudenheim, Christine M. Friedenreich, Marc T. Goodman, Jessica Gorzelitz, Torukiri I. Ibiebele, Vittorio Krogh, Linda M. Liao, Loren Lipworth, Lingeng Lu, Susan McCann, Tracy A. O'Mara, Julie R. Palmer, Jeanette Ponte, Anna Prizment, Harvey Risch, Sven Sandin, Leo J. Schouten, Veronica Wendy Setiawan, Xiao-ou Shu, Britton Trabert, Piet A. van den Brandt, Penelope M. Webb, Nicolas Wentzensen, Lynne R. Wilkens, Alicja Wolk, Herbert Yu, Marian L. Neuhouser
Summary: This study analyzed data from 12 prospective cohort studies and found that higher dietary intake of long-chain omega-3 polyunsaturated fatty acids (LCn3PUFA) may increase the risk of endometrial cancer, especially among specific subgroups characterized by body weight and tumor pathology.
GYNECOLOGIC ONCOLOGY
(2023)
Review
Dermatology
Inger Z. M. Kreuger, Roderick C. Slieker, Tim van Groningen, Remco van Doorn
Summary: Loss of CDKN2A is a common occurrence in melanoma progression and targeting this loss can significantly improve treatment outcomes. Various therapeutic strategies, such as CDK4/6 inhibition, cell cycle dysregulation, metabolic rewiring, epigenetic restoration, co-deleted gene targeting, and modulation of immune responses, have been explored in the context of CDKN2A loss.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Oncology
Kelly Offermans, Josien C. A. Jenniskens, Colinda C. J. M. Simons, Iryna Samarska, Gregorio E. Fazzi, Kim M. Smits, Leo J. Schouten, Matty P. Weijenberg, Heike I. Grabsch, Piet A. van den Brandt
Summary: In this study, the authors found that metabolic Warburg-subtypes can predict the survival benefit from adjuvant therapy in colorectal cancer patients. Patients with moderate metabolic Warburg-subtype had a survival benefit from adjuvant therapy, while patients with low metabolic Warburg-subtype did not.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Dermatology
Jiahe Vermarien-Wang, Thom Doeleman, Remco van Doorn, Antien L. Mooyaart, Willeke A. M. Blokx, Anne M. R. Schrader
Summary: MELTUMP and SAMPUS are provisional terms for melanocytic tumors that are difficult to classify as benign or malignant. A study in the Netherlands showed that MELTUMP has a low malignant potential and SAMPUS has no malignant potential. The importance of consulting pathology for uncertain melanocytic lesions and limiting the use of MELTUMP/SAMPUS terminology is emphasized.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Oncology
Daan Jan Willem Rauwerdink, Remco van Doorn, Jos van der Hage, Alfonsus J. M. Van den Eertwegh, John B. A. G. Haanen, Maureen Aarts, Franchette Berkmortel, Christian U. Blank, Marye J. Boers-Sonderen, Jan Willem B. De Groot, Geke A. P. Hospers, Melissa de Meza, Djura Piersma, Rozemarijn S. Van Rijn, Marion Stevense, Astrid Van der Veldt, Gerard Vreugdenhil, Michel W. J. M. Wouters, Karijn Suijkerbuijk, Monique van der Kooij, Ellen Kapiteijn
Summary: This study aimed to compare the efficacy of immunotherapy and BRAF/MEK inhibitors in metastatic nodular melanoma and metastatic superficial spreading melanoma. The results showed no difference in efficacy between the two treatments for patients with either type of melanoma. However, patients with nodular melanoma had shorter distant metastasis-free survival and worse overall survival, suggesting that the poorer overall survival of nodular melanoma is mainly due to the propensity for metastatic spread after the primary diagnosis.
Article
Oncology
Romain Meer, Jeroen van de Pol, Piet A. van den Brandt, Leo J. J. Schouten
Summary: This study examined the association between a Healthy Lifestyle Index score and renal cell cancer risk using data from the Netherlands Cohort Study. The study found a weak, non-statistically significant association between adherence to a healthy lifestyle and a lower risk of renal cell cancer.
Article
Public, Environmental & Occupational Health
Silvano Gallus, Alessandra Lugo, Chiara Stival, Sonia Cerrai, Luke Clancy, Filippos T. Filippidis, Giuseppe Gorini, Maria Jose Lopez, Angel Lopez-Nicolas, Sabrina Molinaro, Anna Odone, Joan B. Soriano, Olena Tigova, Piet A. van den Brandt, Constantine I. Vardavas, Esteve Fernandez
Summary: According to the survey conducted by the TackSHS project, over 8.3 million adults in 12 European countries use electronic cigarettes. The majority of users are dual users, using both electronic and conventional cigarettes, using electronic cigarettes with nicotine, and using them in smoke-free indoor areas.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Pathology
Bartholomeus G. H. Latten, Bela Kubat, Piet A. van den Brandt, Axel zur Hausen, Leo J. Schouten
Summary: The autopsy rate is declining while major discrepancies exist between autopsies and clinical diagnoses. This study aims to investigate the relationship between the cause of death, a history of cancer, and the autopsy rate. The findings of this study are important in understanding the impact of cancer on autopsies and can help counteract the decline in the medical autopsy.
Article
Oncology
Selena Odeh, Iryna V. Samarska, Andres Matoso, Jeroen A. A. Van De Pol, Marcella M. L. L. Baldewijns, Christina A. A. Hulsbergen-Van De Kaa, Jaleesa Van Der Meer, Guido Roemen, Erik Geelkens, Manon Van Engeland, Axel Zur Hausen, Leo J. Schouten, Kim M. Smits
Summary: The aim of this study was to re-evaluate renal cell carcinoma cases from a large population-based cohort in the Netherlands, using new classifications, in order to identify newly recognized subtypes. The cases were initially evaluated using previous classifications and data on clinicopathological characteristics were obtained. Two urogenital pathologists reviewed digital slides according to new grading and classification systems. No new RCC subtypes were identified in the cases. Restaging and regrading showed the possibility of reporting newer features in an old sample collection.
Article
Clinical Neurology
Carlotta Micaela Jarach, Alessandra Lugo, Chiara Stival, Cristina Bosetti, Andrea Amerio, Luca Cavalieri D'Oro, Licia Iacoviello, Anna Odone, David Stuckler, Alberto Zucchi, Piet van den Brandt, Werner Garavello, Christopher R. Cederroth, Winfried Schlee, Silvano Gallus
Summary: This study conducted a survey on older adults aged 65 and above in Lombardy, Italy, and found that COVID-19 did not appear to have a significant impact on the severity or incidence of tinnitus, while the increased severity of hearing difficulties may be associated with the deterioration of the condition or a misperception caused by the use of face masks.
FRONTIERS IN NEUROLOGY
(2022)
