Review
Biochemistry & Molecular Biology
Li-Jen Liao, Wan-Lun Hsu, Chi-Ju Chen, Yen-Ling Chiu
Summary: Nasopharyngeal carcinoma is endemic in southern Asia and this article describes the molecular abnormalities in NPC and potential molecular mechanisms for future therapy. It provides an up-to-date review on the molecular pathways of NPC, improving our understanding of the disease and highlighting areas for further research.
Review
Oncology
Ramon Yarza, Mateo Bover, Maria Teresa Agullo-Ortuno, Lara Carmen Iglesias-Docampo
Summary: Nasopharyngeal carcinoma (NPC) is a molecularly paradigmatic tumor with complex environmental and host dependent factors, where Epstein Barr Virus (EBV) plays a key role in malignant transformation. The dysregulation of proteasome signaling is central in NPC pathogenesis and could be a potential therapeutic target. Studies have shown the efficacy of immunotherapy in NPC, with novel strategies aiming to reverse immune resistance and favor tumor recognition.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Kelly J. Yu, Wan-Lun Hsu, Chun-Ju Chiang, Tseng-Cheng Chen, Zhiwei Liu, Pei-Jen Lou, Scott Diehl, Alisa M. Goldstein, Chien-Jen Chen, Cheng-Ping Wang, Allan Hildesheim
Summary: This study reassessed familial aggregation of cancer in high-risk Taiwanese multiplex families with NPC cases and found evidence of NPC coaggregation within families, but not a broader familial syndrome involving NPC and other tumors. The study also observed elevated rates of secondary cancers among NPC cases, mostly head and neck and hematopoietic cancers, suggesting radiation treatment effects on subsequent cancer risk.
Review
Oncology
Rina Jiromaru, Takashi Nakagawa, Ryuji Yasumatsu
Summary: Nasopharyngeal carcinoma (NPC) has shown improved treatment outcomes in recent years, but advanced stages still carry a poor prognosis. Chemoradiotherapy is the main treatment option, along with platinum-based chemotherapy. Immunotherapy, especially immune checkpoint inhibitors, is being explored as a potential treatment for recurrent or metastatic NPC. Future trends in NPC treatment include risk classification based on plasma EBV-DNA levels and personalized therapy selection.
CANCER MANAGEMENT AND RESEARCH
(2022)
Review
Cell Biology
Chin-King Looi, Lian-Chee Foong, Felicia Fei-Lei Chung, Alan Soo-Beng Khoo, Ee-Mun Loo, Chee-Onn Leong, Chun-Wai Mai
Summary: This review provides updated understanding of the roles of epigenetic factors in regulating EBV latent gene expression and promoting NPC progression. The crosstalk between epigenetic mechanisms and immune evasion in NPC is explored, along with the potential roles of DNMT and HDAC inhibitors in reversing immune suppression and augmenting antitumour immunity. Furthermore, the advantages of combining epigenetic therapy and immune checkpoint inhibitor to reverse immune resistance and improve clinical outcomes are highlighted.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Cell Biology
Xiandong Lin, Steven Wang, Keyu Lin, Jingfeng Zong, Qianlan Zheng, Ying Su, Tao Huang
Summary: This study investigated the roles of microRNAs and circular RNAs in Nasopharyngeal Carcinoma (NPC) by constructing a circRNA-miRNA-mRNA co-expression network and performing differential expression analysis. The Epstein-Barr virus (EBV) infection was found to be an important risk factor for NPC, with potential pathological differences between EBV+ and EBV- subtypes. The study identified differentially expressed coding and non-coding RNAs across different comparison groups, helping to elucidate genetic and epigenetic changes central to NPC progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Microbiology
Zhi Yi Su, Pui Yan Siak, Chee-Onn Leong, Shiau-Chuen Cheah
Summary: Nasopharyngeal carcinoma (NPC) is a metastasis-prone malignancy associated with Epstein-Barr virus (EBV). Despite global EBV infection, NPC incidences are higher in certain ethnic groups and endemic regions. Research has revealed the molecular mechanisms of NPC pathogenesis due to EBV infection and environmental/genetic factors. EBV-associated biomarkers can be used for mass population screening and EBV products may act as therapeutic targets. This review discusses the role of EBV in NPC and efforts to utilize EBV-associated molecules as biomarkers and therapeutic targets.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Oncology
Zhi Yi Su, Pui Yan Siak, Chee-Onn Leong, Shiau-Chuen Cheah
Summary: Nasopharyngeal carcinoma microenvironment is a complex niche with important clinical value, which can serve as a rich field for the discovery of potential predictive or diagnostic biomarkers and the development of therapeutic strategies. Studying this environment can provide a better understanding of tumor biology mechanisms and guide clinical practice.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xiao-Hui Zheng, Chang-Mi Deng, Ting Zhou, Xi-Zhao Li, Cao-Li Tang, Cheng-Tao Jiang, Ying Liao, Tong-Min Wang, Yong-Qiao He, Wei-Hua Jia
Summary: Saliva sampling is a non-invasive method that can be done by individuals themselves. This study used saliva samples to explore the use of EBV methylation as a biomarker in the diagnosis of NPC. The results showed that EBV methylation was significantly increased in NPC patients compared to controls, and detection of specific CpG sites showed good diagnostic performance. The study suggests that non-invasive detection of NPC through saliva sampling could be a promising alternative for future large-scale screening.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Pathology
Sudipta Samanta, Muthukaruppan Swaminathan, Jianing Hu, Khai Tuck Lee, Ajitha Sundaresan, Chuan Keng Goh, Chor Hiang Siow, Kwok Seng Loh, Soh Ha Chan, Joshua K. Tay, Ian Cheong
Summary: The use of immunofluorescence assay for detecting serum Epstein-Barr virus antibodies is the gold standard screening test for nasopharyngeal cancer in high-risk populations. This study demonstrates that integrating deep learning with automated fuzzy inference can improve the scalability and accuracy of NPC detection.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Medicine, General & Internal
Yudi Xiong, Mengting Yuan, Zhigang Liu, Jing Huang, Jianping Bi, Guoliang Pi, Ying Li, Yanping Li, Hanping He, Vivek Verma, Suqing Tian, Guang Han
Summary: This multicenter study examined the clinical characteristics of EBV-negative patients in the Chinese population and compared their long-term outcomes with EBV-positive patients. The study found that most EBV-negative patients were diagnosed in advanced stages and were more associated with the keratinizing subtype. Compared to EBV-negative patients, EBV-positive patients were more likely to experience local recurrence, but there was no significant difference in mortality during the follow-up period. Additionally, EBV-positive NPC patients seemed to have better survival compared to EBV-negative NPC patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Virology
Tengteng Ding, Yuanbin Zhang, Zhixuan Ren, Ying Cong, Jingyi Long, Manli Peng, Oluwasijibomi Damola Faleti, Yinggui Yang, Xin Li, Xiaoming Lyu
Summary: This study developed a model using Epstein-Barr virus (EBV)-associated hub genes to predict the prognosis of nasopharyngeal carcinoma (NPC). Through differential expression analysis, regression analysis, and machine learning, 25 genes significantly associated with NPC prognosis were identified, along with six hub genes related to immune infiltration and cell cycle regulation. These genes could be used to predict NPC prognosis, with functions related to tumor proliferation and immune infiltration, making them potential therapeutic targets.
Article
Biochemistry & Molecular Biology
Yaqi Chen, Anqi Cao, Qinkai Li, JunMin Quan
Summary: In this study, DNA aptamers specifically binding to EBV positive NPC cells were developed using the Cell-SELEX procedure, and the EphA2/CD98hc complex was identified as a potential target. The results revealed a potential function of the EphA2 and CD98hc complex in NPCs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Virology
Raja Pramanik, Shalabh Arora, Preity Sharma, Ahitagni Biswas, Baibaswata Nayak, Alok Thakar, Atul Sharma, Sampa Ghose
Summary: Nasopharyngeal carcinoma is not endemic in India but shows higher incidences in its North-Eastern regions. Detecting NPC early is challenging, and assessing plasma Epstein-Barr virus DNA load can help monitor disease status, treatment response, and future relapse risk in nonendemic NPC patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Oncology
Huageng Huang, Yuyi Yao, Xinyi Deng, Zongyao Huang, Yungchang Chen, Zhao Wang, Huangming Hong, He Huang, Tongyu Lin
Summary: Nasopharyngeal carcinoma (NPC) is highly associated with Epstein-Barr virus (EBV) infection and conventional salvage treatments for advanced NPC have limited efficacy. Immunotherapy has emerged as a promising treatment modality for recurrent and metastatic NPC.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Oncology
Zhi-Qin Liu, Mei-Yin Lu, Bin Liu
PATHOLOGY & ONCOLOGY RESEARCH
(2020)
Article
Oncology
Zhi-Qin Liu, Mei-Yin Lu, Ru-Liang Sun, Zhi-nan Yin, Bin Liu, Yang-zhe Wu
JOURNAL OF ONCOLOGY
(2019)
Article
Immunology
Yirong Wang, Siqi Wu, Xun Zhu, Liyuan Zhang, Jieqiong Deng, Fang Li, Binbin Guo, Shenghua Zhang, Rui Wu, Zheng Zhang, Kexin Wang, Jiachun Lu, Yifeng Zhou
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Microbiology
Ping Zhou, Yanxia Zhou, Bin Liu, Zhenchao Jin, Xueling Zhuang, Wenkui Dai, Zhenyu Yang, Xin Feng, Qian Zhou, Yanhong Liu, Ximing Xu, Lian Zhang
Article
Oncology
Quanbin Zhang, Liya Ou, Yingying Peng, Hui Yu, Linjing Wang, Shuxu Zhang
Summary: The study evaluated the quality of radiotherapy plans for locally advanced nasopharyngeal carcinoma (NPC) generated by automatic and manual planning methods. Overall, automatic plans were comparable or superior to manual plans, especially for patients with T4 disease. Plan quality was mainly independent of T category but was affected by anatomic distance, with automatic plans performing better when the distance was greater than 5 mm. Gamma pass rates for quality assurance were similar between manual and automatic plans in some cases, but significantly higher for automatic plans in others.
STRAHLENTHERAPIE UND ONKOLOGIE
(2021)
Article
Medicine, Research & Experimental
Bin Liu
MEDICAL HYPOTHESES
(2020)
Article
Immunology
Xiao-Hong Li, Mei-Yin Lu, Yi-jia Li, Zong-hua Liu, Zhi-nan Yin, Bin Liu, Yang-zhe Wu
Summary: The study found that there is an imbalance in the gamma delta T cell population in patients with endometrial polyps, and the V delta 1/V delta 2 ratio and PD-1 expression of V delta 1(+) gamma delta T cells could potentially be valuable predictors for fertility in these patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Mei-Yin Lu, Xiao-Hong Li, Jia-Li Niu, Bin Liu
Summary: The rs369065 TT genotype of the LIN28B gene is associated with an increased risk of postoperative recurrence in patients with endometrial polyps, especially in those with fewer and smaller polyps.
Article
Oncology
Pixiao Zhou, Ruihao Wang, Hui Yu, Zhiwei Liao, Ying Zhang, Zouqin Huang, Shuxu Zhang
Summary: This study used 4DCT to generate functional lung ventilation images and evaluate the correlation between functional lung dose-volume parameters and changes in pulmonary function metrics in patients with esophageal cancer. The study also compared the effectiveness of functional lung sparing planning versus non-sparing planning. The results showed that the optimal functional lung threshold for dose-volume parameters was strongly correlated with changes in FEV1/FVC, and functional lung sparing planning reduced functional lung dose without compromising target area coverage.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Cell Biology
Xiao-Hong Li, Mei-Yin Lu, Jia-Li Niu, Dong-Yan Zhu, Bin Liu
Summary: This study investigated the relationship between cfDNA methylation profiles and T-cell differentiation in patients with endometrial polyps. The study found that differentially methylated genes were associated with T-cell differentiation in this group of patients, as well as a correlation between circulating sex hormone levels and T-cell differentiation and cfDNA methylation profiles.
Article
Reproductive Biology
Jiali Niu, Meiyin Lu, Bin Liu
Summary: This study found a dose-response relationship between insulin resistance and abnormal menstrual cycles in patients with PCOS. The relationship was more evident in younger patients with higher BMI, testosterone levels, and lower levels of progesterone.
JOURNAL OF OVARIAN RESEARCH
(2023)
Review
Obstetrics & Gynecology
Mei-Yin Lu, Jia-Li Niu, Bin Liu
Summary: The relationship between menarche age and endometriosis risk was examined in this meta-analysis. Early menarche was found to be associated with an increased risk of endometriosis, especially in low-income countries. However, the results of previous studies were inconsistent, highlighting the need for larger-scale investigations.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Genetics & Heredity
Wen-Xiong Chen, Bin Liu, Lijie Zhou, Xiaoli Xiong, Jie Fu, Zhi-Fang Huang, Ting Tan, Mingxi Tang, Jun Wang, Ya-Ping Tang
Summary: This study identified new genetic predispositions for ASD accompanied by intellectual disability and found that genes related to intelligence quotient were enriched in protein synthesis, energy metabolism, and amino acid metabolism. These findings may be helpful for etiological research and early diagnosis of intellectual disability in ASD.
Article
Neurosciences
Xiaomei Fan, Yuna Chen, Wenzhou Li, Hanbin Xia, Bin Liu, Huijuan Guo, Yanxia Yang, Chenshu Xu, Shaojie Xie, Xueqing Xu
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Zhi-Qin Liu, Mei-Yin Lu, Bin Liu
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)