Article
Oncology
Huimin Qiao, Changxin Wang, Chunhong Yang, Lei Lei, Yijing Chen, Yun Luo, Xiangfu Zeng, You Guo
Summary: This study investigated the association between increased C-reactive protein (CRP) and cardiovascular disease (CVD) in individuals with rectal cancer, as well as the impact of chemotherapy on increasing CRP and its underlying mechanisms.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Adam R. Markowski, Agnieszka U. Blachnio-Zabielska, Karolina Pogodzinska, Anna J. Markowska, Piotr Zabielski
Summary: Colorectal cancer is a heterogeneous group of tumors with varied clinical and pathological features based on anatomical location. Sphingolipids play a role in cancer formation and progression, and their changes are important in carcinogenesis. This study analyzed the sphingolipid profile in colorectal cancer and found differences in cellular sphingolipid amounts between rectal and colonic cancer. The study also revealed qualitative and quantitative disturbances in sphingolipid metabolism in colorectal cancer, indicating the complexity of changes during cancer development depending on the tumor's location.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Anne Helene Kostner, Patricia Switten Nielsen, Jeanette Baehr Georgsen, Erik Thorlund Parner, Mette Bak Nielsen, Christian Kersten, Torben Steiniche
Summary: This study demonstrates the association of systemic inflammation with the immune response in primary colon cancer patients through histological evaluation of multiple immune markers. The results show that tumors in systemically inflamed patients exhibit more myeloid features with higher densities of neutrophils and macrophages, and less lymphoid features regardless of mismatch repair status.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Xiangliang Liu, Kaiwen Zheng, Wei Ji, Wenxin Zhang, Yuguang Li, Mingyang Liu, Jiuwei Cui, Wei Li
Summary: This study found that diabetes mellitus (DM) is associated with a higher incidence of cancer and negatively affects the survival of cancer patients. Differences in body composition and inflammation status may contribute to this phenomenon.
FRONTIERS IN NUTRITION
(2022)
Article
Immunology
Anne Helene Kostner, Anniken Jorlo Fuglestad, Jeanette Baehr Georgsen, Patricia Switten Nielsen, Kristina Bang Christensen, Helle Zibrandtsen, Erik Thorlund Parner, Ibraheem M. Rajab, Lawrence A. Potempa, Torben Steiniche, Christian Kersten
Summary: This study found that the acute phase reactant C-reactive protein (CRP), which can be diagnostically measured by serum levels, is correlated with poor outcomes in different types of cancer. Specifically, high levels of CRP are associated with the pro-inflammatory monomeric isoform of CRP (mCRP) within the tumor microenvironment (TME) in colon cancer patients. These findings shed light on the potential role of CRP in tumor biology.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Li-Chun Chang, Chia-Tung Shun, Been-Ren Lin, Silvia Sanduleanu, Weng-Feng Hsu, Ming-Shiang Wu, Han-Mo Chiu
Summary: A study conducted at the National Taiwan University Hospital from 2005 to 2014 compared the disease-free survival of T1 cancer arising from the rectum versus the colon. The results showed that T1 rectal cancer had a higher risk of recurrence compared to T1 colon cancer, with rectal location being an independent risk factor for recurrence. Further research is needed to explore whether adjuvant therapy or closer surveillance can reduce the risk of recurrence in T1 rectal cancer.
Article
Oncology
Stella Koutros, Kathy L. Decker, Dalsu Baris, Larissa A. Pardo, Alison Johnson, G. M. Monawar Hosain, Nathaniel Rothman, Margaret R. Karagas, Molly R. Schwenn, Debra T. Silverman
Summary: Twin studies suggest a familial aggregation of bladder cancer, with individuals having a first-degree relative with bladder cancer having nearly double the risk of developing bladder cancer. Additionally, a family history of female genital cancer, melanoma, and tobacco-associated cancer also increased the risk of bladder cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Immunology
Junbing He, Tian Zhao, Lizhen Liu, Shuanglin Liao, Shuai Yang, Furong Lu, Yuan Hong, Ning Wei, Hongxiao Cheng, Wenying Zhang, Yiming Shao
Summary: This study investigated the association between ADAM17-172A > G polymorphism and sepsis, and found that it enhanced sepsis-induced inflammatory responses through the EGR1/ADAM17 pathway, making individuals more susceptible with lower survival rate and poor prognosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Marzieh Araghi, Melina Arnold, Mark J. Rutherford, Marianne Gronlie Guren, Citadel J. Cabasag, Aude Bardot, Jacques Ferlay, Hanna Tervonen, Lorraine Shack, Ryan R. Woods, Nathalie Saint-Jacques, Prithwish De, Carol McClure, Gerda Engholm, Anna T. Gavin, Eileen Morgan, Paul M. Walsh, Christopher Jackson, Geoff Porter, Bjorn Moller, Oliver Bucher, Michael Eden, Dianne L. O'Connell, Freddie Bray, Isabelle Soerjomataram
Summary: The study provides the most recent estimates of colon and rectal cancer survival in seven high-income countries, showing variations in survival rates based on stage at diagnosis, age, and country.
Article
Surgery
Supparerk Laohawiriyakamol, Siripong Chewatanakornkul, Worawit Wanichsuwan, Sakchai Ruangsin, Somkiat Sunpaweravong, Tanan Bejrananda
Summary: Urogenital dysfunction is a common complication after surgery for sigmoid colon or rectal cancers, and it may result from various causes. This study evaluated urogenital dysfunction and associated factors after laparoscopic surgery at different follow-up times. The results showed that voiding function improved, but sexual function deteriorated, especially in male patients. Age <= 60 years and postoperative complications were strongly associated with male sexual dysfunction.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Multidisciplinary Sciences
Shuiqing Hu, Yan Fang, Xiang Chen, Tianlei Cheng, Miaoqing Zhao, Mingjian Du, Tuo Li, Minghao Li, Zhiqun Zeng, Yonglong Wei, Zhimin Gu, Conggang Zhang, Lijun Sun, Zhijian J. Chen
Summary: cGAS plays a crucial role in controlling the development of colitis-associated colon cancer by defending the integrity of the intestinal mucosa, suppressing inflammation, and promoting the proliferation of intestinal epithelial cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cardiac & Cardiovascular Systems
David G. Harrison, Thomas M. Coffman, Christopher S. Wilcox
Summary: Dr. Irvine Page proposed the Mosaic Theory of Hypertension in the 1940s, advocating that hypertension is the result of many interacting factors. Over the years, new concepts have arisen that allow further refinements of the theory, emphasizing the interdependence of various nodes.
CIRCULATION RESEARCH
(2021)
Article
Medicine, General & Internal
Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider, Jacques Fellay
Summary: Multiple human pathogens can cause chronic, sometimes lifelong infections, leading to chronic low-grade inflammation. This study found associations between infections by Chlamydia trachomatis and Helicobacter pylori, as well as pathogen burden, with higher levels of C-reactive protein.
Article
Genetics & Heredity
Yahya H. Hobani, Amany I. Almars, Walla Alelwani, Eman A. Toraih, Nader A. Nemr, Aly A. M. Shaalan, Manal S. Fawzy, Samy M. Attallah
Summary: The DDX20 variant rs197412 is associated with an increased risk of colon cancer and a higher likelihood of recurrence in the study population.
Article
Biochemistry & Molecular Biology
Da-Been Lee, Seo-Yeon An, Sang-Shin Pyo, Jinkwan Kim, Suhng-Wook Kim, Dae-Wui Yoon
Summary: The study aimed to investigate the impact of sleep fragmentation on carcinogenesis and explore the underlying mechanisms in a chemical-induced colon cancer model. The results showed that mice subjected to sleep fragmentation had a significantly higher number and size of tumors compared to the control group. Immunohistochemical and immunofluorescent stainings revealed increased DNA damage and oxidative stress in the sleep fragmentation group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Heather Spencer Feigelson, Bette Caan, Sheila Weinmann, Anthony C. Leonard, J. David Powers, Panduranga R. Yenumula, David E. Arterburn, Corinna Koebnick, Mekibib Altaye, Daniel P. Schauer
Article
Nutrition & Dietetics
Jiali Zheng, Fred K. Tabung, Jiajia Zhang, E. Angela Murphy, Nitin Shivappa, Judith K. Ockene, Bette Caan, Candyce H. Kroenke, James R. Hebert, Susan E. Steck
EUROPEAN JOURNAL OF NUTRITION
(2020)
Article
Oncology
Sarah McNabb, Tabitha A. Harrison, Demetrius Albanes, Sonja I. Berndt, Hermann Brenner, Bette J. Caan, Peter T. Campbell, Yin Cao, Jenny Chang-Claude, Andrew Chan, Zhengyi Chen, Dallas R. English, Graham G. Giles, Edward L. Giovannucci, Phyllis J. Goodman, Richard B. Hayes, Michael Hoffmeister, Eric J. Jacobs, Amit D. Joshi, Susanna C. Larsson, Loic Le Marchand, Li Li, Yi Lin, Satu Mannisto, Roger L. Milne, Hongmei Nan, Christina C. Newton, Shuji Ogino, Patrick S. Parfrey, Paneen S. Petersen, John D. Potter, Robert E. Schoen, Martha L. Slattery, Yu-Ru Su, Catherine M. Tangen, Thomas C. Tucker, Stephanie J. Weinstein, Emily White, Alicja Wolk, Michael O. Woods, Amanda I. Phipps, Ulrike Peters
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Oncology
Barbara Pardini, Alda Corrado, Elisa Paolicchi, Giovanni Cugliari, Sonja Berndt, Stephane Bezieau, Stephanie A. Bien, Hermann Brenner, Bette J. Caan, Peter T. Campbell, Graham Casey, Andrew T. Chan, Jenny Chang-Claude, Michelle Cotterchio, Manish Gala, Steven J. Gallinger, Robert W. Haile, Tabitha A. Harrison, Richard B. Hayes, Michael Hoffmeister, John L. Hopper, Li Hsu, Jeroen Huyghe, Mark A. Jenkins, Loic Le Marchand, Yi Lin, Noralane M. Lindor, Hongmei Nan, Polly A. Newcomb, Shuji Ogino, John D. Potter, Robert E. Schoen, Martha L. Slattery, Emily White, Ludmila Vodickova, Veronika Vymetalkova, Pavel Vodicka, Federica Gemignani, Ulrike Peters, Alessio Naccarati, Stefano Landi
INTERNATIONAL JOURNAL OF CANCER
(2020)
Letter
Surgery
Heather Spencer Feigelson, Bette Caan, Sheila Weinmann, Anthony C. Leonard, John D. Powers, Panduranga R. Yenumula, David E. Arterburn, Corinna Koebnick, Mekibib Altaye, Daniel P. Schauer
Article
Oncology
Ashley S. Felix, Eric M. McLaughlin, Bette J. Caan, David E. Cohn, Garnet L. Anderson, Electra D. Paskett
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Oncology
Candyce H. Kroenke, Electra D. Paskett, Crystal W. Cene, Bette J. Caan, Juhua Luo, Aladdin H. Shadyab, Jamaica R. M. Robinson, Rami Nassir, Dorothy S. Lane, Garnet L. Anderson
Article
Oncology
Lauren R. Teras, Alpa Patel, Molin Wang, Shiaw-Shyuan Yaun, Kristin Anderson, Roderick Brathwaite, Bette J. Caan, Yu Chen, Avonne E. Connor, A. Heather Eliassen, Susan M. Gapstur, Mia M. Gaudet, Jeanine M. Genkinger, Graham G. Giles, I-Min Lee, Roger L. Milne, Kim Robien, Norie Sawada, Howard D. Sesso, Meir J. Stampfer, Rulla M. Tamimi, Cynthia A. Thomson, Shoichiro Tsugane, Kala Visvanathan, Walter C. Willett, Anne Zeleniuch-Jacquotte, Stephanie A. Smith-Warner
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2020)
Article
Endocrinology & Metabolism
Hailey R. Banack, Jennifer W. Bea, Andrew Stokes, Candyce H. Kroenke, Marcia L. Stefanick, Shirley A. Beresford, Chloe E. Bird, Lorena Garcia, Robert Wallace, Robert A. Wild, Bette Caan, Jean Wactawski-Wende
Article
Oncology
Elizabeth M. Cespedes Feliciano, Wendy Y. Chen, Valerie Lee, Kathleen B. Albers, Carla M. Prado, Stacey Alexeeff, Jingjie Xiao, Shlomit S. Shachar, Bette J. Caan
Article
Oncology
Matthew G. Varga, Julia Butt, William J. Blot, Loic Le Marchand, Christopher A. Haiman, Yu Chen, Sylvia Wassertheil-Smoller, Lesley F. Tinker, Richard M. Peek, John D. Potter, Timothy L. Cover, Terry Hyslop, Anne Zeleniuch-Jacquotte, Sonja Berndt, Allan Hildesheim, Tim Waterboer, Michael Pawlita, Meira Epplein
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Editorial Material
Public, Environmental & Occupational Health
Jeroen Douwes, Collin R. Brooks, Geoffrey H. Donovan, John D. Potter
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Review
Environmental Sciences
John D. Potter, Collin Brooks, Geoffrey Donovan, Chris Cunningham, Jeroen Douwes
Summary: Humans' encroachment into wild spaces has profound impacts on our relationship with nature, the survival of other species, pollution, and climate change. The benefits of being close to green and blue spaces are discussed, while the hazards of urban grey spaces are highlighted. The biodiversity hypothesis and the role of microbiota are emphasized, along with possible mechanisms of exposure through air, soil, and water. The importance of assessing exposure accurately and the need for implementing policies to restore environmental balance are also emphasized.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Oncology
Justin C. Brown, Bette J. Caan, Carla M. Prado, Elizabeth M. Cespedes Feliciano, Jingjie Xiao, Candyce H. Kroenke, Jeffrey A. Meyerhardt
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2020)
Review
Obstetrics & Gynecology
Susan D. Reed, Andrea Z. LaCroix, Garnet L. Anderson, Kristine E. Ensrud, Bette Caan, Janet S. Carpenter, Lee Cohen, Susan J. Diem, Ellen W. Freeman, Hadine Joffe, Joseph C. Larson, Susan M. McCurry, Caroline M. Mitchell, Katherine M. Newton, Barbara Sternfeld, Katherine A. Guthrie
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2020)