Article
Biochemistry & Molecular Biology
Mateusz Zwierz, Adrian Chabowski, Klaudia Sztolsztener
Summary: This study investigated the potential therapeutic effects of alpha-lipoic acid on the inflammatory response during the development and progression of simple steatosis into steatohepatitis. The results showed that alpha-lipoic acid supplementation attenuated inflammation and had a potential protective effect on the liver.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Nutrition & Dietetics
Fabiola N. Velazquez, Valentina Viscardi, Julia Montemage, Leiqing Zhang, Carolena Trocchia, Megan M. Delamont, Rasheed Ahmad, Yusuf A. Hannun, Lina M. Obeid, Ashley J. Snider
Summary: Different types of high-fat diets were used to simulate breast cancer, and it was found that fatty acids from different sources may affect breast cancer metastasis.
Review
Medicine, Research & Experimental
Yao Tong, Huiru Gao, Qiuchen Qi, Xiaoyan Liu, Juan Li, Jie Gao, Peilong Li, Yunshan Wang, Lutao Du, Chuanxin Wang
Summary: Gastrointestinal cancer is a major cause of cancer-related deaths, with a high fat diet and gut microbiome imbalance potentially driving its occurrence and progression through inflammation and changes in the immune environment.
Article
Nutrition & Dietetics
Nives Bogataj Jontez, Sasa Kenig, Karin Sik Novak, Ana Petelin, Zala Jenko Praznikar, Nina Mohorko
Summary: This study compared the dietary patterns of individuals following LCHF, vegan, vegetarian, and omnivorous diets. The results showed that compared to other groups, the LCHF group had higher intakes of saturated fats, cholesterol, and animal proteins, while the intakes of sugars and dietary fibers were lower. The levels of total and LDL cholesterol were significantly higher in the LCHF group. Thus, it is recommended to select healthy fat sources, increase dietary fiber intake, and partially replace animal sources with plant sources in the LCHF diet.
FRONTIERS IN NUTRITION
(2023)
Article
Oncology
Makoto Matsushita, Kazutoshi Fujita, Koji Hatano, Takuji Hayashi, Hisako Kayama, Daisuke Motooka, Hiroaki Hase, Akinaru Yamamoto, Toshihiko Uemura, Gaku Yamamichi, Eisuke Tomiyama, Yoko Koh, Taigo Kato, Atsunari Kawashima, Motohide Uemura, Satoshi Nojima, Ryoichi Imamura, Aysha Mubeen, George J. Netto, Kazutake Tsujikawa, Shota Nakamura, Kiyoshi Takeda, Eiichi Morii, Norio Nonomura
Summary: The consumption of Western high-fat diets is considered a major risk factor for prostate cancer. A study found that these diets can lead to dysbiosis in the gut microbiota, contributing to the growth of inflammatory prostate cancer. It was also discovered that histamine signaling plays a role in this process.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Rongrong Tan, Jiayang Li, Lu Liu, Qian Wu, Lei Fan, Ningning Ma, Chuwei Yu, Henglei Lu, Xuemei Zhang, Jing Chen, Likun Gong, Jin Ren
Summary: This study discovered that cysteine sulfinic acid decarboxylase (CSAD) expression significantly decreased in non-alcoholic fatty liver disease (NAFLD) patients, which was confirmed in multiple NAFLD mouse models. The overexpression of CSAD in the liver of high-fat diet-fed mice alleviated NAFLD-associated pathologies and increased the expression of fatty acid beta-oxidation genes. CSAD was also found to improve mitochondrial injury. These findings suggest that CSAD has the potential to become a new therapeutic target for NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sourav Roy, Md Abdur Rahman Ripon, Rahima Begum, Dipty Rani Bhowmik, Mohammad Tohidul Amin, Md Aminul Islam, Firoz Ahmed, Mohammad Salim Hossain
Summary: This study investigated the effects of arachidonic acid (AA) supplementation on obesity, adipocyte morphology, inflammation, and AA cascade signaling. The results suggest that AA does not significantly affect body weight, visceral fat mass, or serum lipid profile. However, it effectively alleviates obesity-induced adipocyte inflammation in high-fat diet-induced obese mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Oncology
Bin Luo, Dandan Yan, Honglin Yan, Jingping Yuan
Summary: Treatment options for breast cancer are limited, necessitating the exploration of novel therapeutic targets. The cytochrome P450 enzyme plays a crucial role in breast cancer tissues, with associations to cancer risk, progression, and prognosis.
Editorial Material
Nutrition & Dietetics
Birgitta Strandvik
Summary: Nutrition plays a crucial role in cystic fibrosis (CF) due to its association with increased energy consumption, specific nutritional deficiencies, and malabsorption related to pancreatic insufficiency. The deterioration of lung function in CF patients has been linked to nutrition. However, despite the general recommendation of high energy intake, clinical deterioration remains difficult to control, suggesting the need for identifying and specifying special nutritional needs. Lipid abnormalities, particularly in essential or conditionally essential fatty acids, are commonly observed in CF patients. This article focuses on the qualitative aspects of fat metabolism, which has been neglected in dietary fat recommendations that only emphasize fat quantity. The deficiency of linoleic acid, an essential fatty acid important for membrane structure and function, has been recognized for over 60 years in CF patients. The ratio between arachidonic acid and docosahexaenoic acid, conditionally essential fatty acids in the n-6 and n-3 series respectively, is often increased. Recent discoveries regarding the connection between CFTR modulators and lipid metabolism have generated new interest in this field, and advancements in technology provide opportunities for more personalized therapy.
Article
Agriculture, Multidisciplinary
Jing Zhang, Congmin Yi, Jiaojiao Han, Tinghong Ming, Jun Zhou, Chenyang Lu, Ye Li, Zhonghua Wang, Xiurong Su
Summary: High DHA tuna oil can reverse high-fat-diet-induced metabolic disorders and alter the composition and function of gut microbiota, but the effects are not uniformly dose dependent. Through regulating multiple perturbed pathways, various doses of high DHA tuna oil can attenuate endogenous disorders to varying degrees.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Endocrinology & Metabolism
Lucie Marousez, Sandy Hanssens, Laura Butruille, Celine Petit, Charlene Pourpe, Capucine Besengez, Thameur Rakza, Laurent Storme, Philippe Deruelle, Jean Lesage, Delphine Eberle
Summary: Recent studies have shown that breast milk apelin levels increase with maternal obesity, while plasma apelin levels decrease. In lactating rats, maternal high-fat feeding leads to increased breast milk apelin levels without changing body weight. Additionally, breast milk leptin levels increase with maternal obesity in humans.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Biochemistry & Molecular Biology
Wenge Li, Xiaoyu Guo, Changzheng Chen, Juanjuan Li
Summary: This study revealed that high levels of AA metabolism are associated with a good prognosis in breast cancer, and identified immune-related pathways and infiltrating immune cell types in the high AA metabolism group. Additionally, a novel AA metabolism prognostic signature was constructed, providing a new therapeutic strategy for breast cancer.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Cell Biology
Haiting He, Yaxi Zhang, Yue Sun, Yanwei Zhang, Jingjing Xu, Yuzhen Yang, Jihua Chen
Summary: The study found that folic acid can reduce body fat percentage in obese mice, alleviate related metabolic disorders, and improve symptoms of osteoporosis. Folic acid modulates lipid metabolism and oxidative stress responses by activating the AMPK signaling pathway, thus alleviating HFD-induced osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Aden Geonhee Lee, Sora Kang, Suyeol Im, Youngmi Kim Pak
Summary: The active compound cinnamic acid (CA) in cinnamon can effectively ameliorate obesity and associated symptoms, such as fat gain, insulin resistance, and dyslipidemia. CA also reduces inflammation by decreasing the deposition and infiltration of inflammatory cells, thus improving obesity-related metabolic disorders.
Article
Biochemistry & Molecular Biology
Jiaheng Xia, Ping Yu, Zheling Zeng, Maomao Ma, Xianghui Yan, Junxin Zhao, Deming Gong, Guohua Zhang, Jun Wang
Summary: This study aimed to compare the effects of three different medium chain triglycerides (MCTs) on lipid metabolism in obese rats. The results showed that all the three MCTs reduced the body weight and fat coefficient in obese rats, and improved the levels of plasma and liver lipids. Furthermore, the three MCTs had different effects on the expression levels of lipid metabolism-related proteins (PPARs and SREBPs) in obese rats.
Article
Biochemistry & Molecular Biology
Meng-Ting Wu, Hui-Min Su, Yi Cui, Anthony Windust, Hong-Nong Chou, Ching-jang Huang
Article
Biochemistry & Molecular Biology
Chiao-Fang Teng, Wen-Chuan Hsieh, Ching-Wen Yang, Hui-Min Su, Ting-Fen Tsai, Wang-Chou Sung, Wenya Huang, Ih-Jen Su
MOLECULAR CARCINOGENESIS
(2016)
Editorial Material
Biotechnology & Applied Microbiology
Karsten H. Weylandt, Yong Q. Chen, Kyu Lim, Hui-Min Su, Achille Cittadini, Gabriella Calviello
BIOMED RESEARCH INTERNATIONAL
(2015)
Article
Biochemistry & Molecular Biology
Gou-Chun Chen, Hui-Min Su, Yu-Shun Lin, Po-Yen Tsou, Jong-Ho Chyuan, Pei-Min Chao
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2016)
Article
Nutrition & Dietetics
Ya-Yuan Chang, Hui-Min Su, Szu-Han Chen, Wen-Tsong Hsieh, Jong-Ho Chyuan, Pei-Min Chao
Article
Multidisciplinary Sciences
Man-Chin Hua, Hui-Min Su, Tsung-Chieh Yao, Ming-Ling Kuo, Ming-Wei Lai, Ming-Han Tsai, Jing-Long Huang
Article
Biochemistry & Molecular Biology
Hui-Feng Chen, Hui-Min Su
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Hui-Feng Chen, Hui-Min Su
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2013)
Editorial Material
Biotechnology & Applied Microbiology
Achille Cittadini, Gabriella Calviello, Hui-Min Su, Karsten Weylandt
BIOMED RESEARCH INTERNATIONAL
(2013)
Review
Biotechnology & Applied Microbiology
Gabriella Calviello, Hui-Min Su, Karsten H. Weylandt, Elena Fasano, Simona Serini, Achille Cittadini
BIOMED RESEARCH INTERNATIONAL
(2013)
Article
Allergy
Man-Chin Hua, Hui-Min Su, Ming-Ling Kuo, Chien-Chang Chen, Tsung-Chieh Yao, Ming-Han Tsai, Sui-Ling Liao, Shen-Hao Lai, Chih-Yung Chiu, Kuan-Wen Su, Li-Chen Chen, Kuo-Wei Yeh, Jing-Long Huang
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2019)
Article
Pediatrics
Man-Chin Hua, Hui-Min Su, Ming-Wei Lai, Tsung-Chieh Yao, Ming-Han Tsai, Sui-Ling Liao, Shen-Hao Lai, Jing-Long Huang
Summary: Abdominal obesity has a significant impact on plasma fatty acid composition in obese and overweight children. Higher proportions of palmitoleic acid and dihomo-gamma-linolenic acid, as well as increased stearoyl-coenzyme A desaturase-1(16) and delta-6 desaturase activities, are strongly correlated with metabolic risk factors in these children.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Po-Yuan Chang, Shwu-Fen Chang, Ting-Yu Chang, Hui-Min Su, Shao-Chun Lu
Summary: The study found that PA-BSA cooperates with LDL(-) to trigger the production of IL-1 beta in macrophages through the LOX-1 and Kv channel pathways.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Psychiatry
Ya-Hui Yu, Hui-Min Su, Sheng-Hsiang Lin, Po-Chang Hsiao, Yi-Ting Lin, Chih-Min Liu, Tzung-Jeng Hwang, Ming H. Hsieh, Chen-Chung Liu, Yi-Ling Chien, Chian-Jue Kuo, Hai-Gwo Hwu, Wei J. Chen
Summary: Schizophrenia patients exhibit a long-term attenuated flush response to niacin. This response is related to altered levels of membrane polyunsaturated fatty acids (PUFAs), particularly dihomo-gamma-linolenic acid, docosahexaenoic acid, and arachidonic acid (ARA). The persistence of this attenuated response suggests a long-term vulnerability to schizophrenia beyond acute exacerbation.
Article
Oncology
Li-Hsuan Huang, Hsin-Yun Chung, Hui-Min Su