Review
Cell Biology
Pengfei Lu, Yunzhe Lu
Summary: Epithelium is traditionally considered an immotile tissue, but recent research has shown that it is actually more motile than previously thought. Epithelial-mesenchymal transition (EMT) is a crucial process for embryonic development, organ formation, and cancer metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Xu Xu, Yunan Hou, Niya Long, Lishi Jiang, Zhangwei Yan, Yuan Xu, Ying Lv, Xin Xiang, Hua Yang, Jian Liu, Xiaolan Qi, Liangzhao Chu
Summary: This study found that the expression of TPPP3 is higher in glioma compared to normal brain tissue, and increases with the grade of glioma. Up-regulation of TPPP3 enhances migration, invasion, and proliferation abilities, while reducing apoptosis in glioblastoma cells. TPPP3 also affects the process of EMT by regulating the expression of Snail1 protein. Low TPPP3 expression is associated with better survival expectations in glioblastoma patients. This study provides new insights and directions for further research on the role of TPPP3 in glioblastoma.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Xinyu Shao, Jue Wu, Shunying Yu, Yuqing Zhou, Chunli Zhou
Summary: AKR1B10 functions as a tumor suppressor in gastric cancer, with its expression level significantly impacting patient prognosis. Reduced AKR1B10 expression enhances proliferation and migration of GC cells.
Article
Cell Biology
Huanhuan Deng, Leihong Deng, Haichao Chao, Zhaojun Yu, Jianbiao Huang, Zhen Song, Lifen Peng, Tao Zeng
Summary: Bladder cancer (BLCA) is a common cancer with high mortality ranking 9th. The relationship between autophagy and epithelial to mesenchymal transition (EMT) in BLCA is poorly understood. This study identified the autophagy-related gene RAB14 and demonstrated its promotion of EMT, migration, and invasion in bladder cancer cells through the Akt-associated autophagic pathway. Knocking down RAB14 inhibited EMT and autophagy in T24 cells, and RAB14 levels were positively correlated with key autophagy genes LC3B and Beclin1. These findings suggest the potential role of RAB14 in BLCA progression.
CELL DEATH DISCOVERY
(2023)
Article
Biotechnology & Applied Microbiology
Yuanzhe Zhu, Huala Wu, Xi Yang, Zhijuan Xiong, Tiantian Zhao, Xin Gan
Summary: This study revealed that LINC00514 is upregulated in NSCLC and plays a role in the proliferation, migration, and invasion of NSCLC cells through activation of the Wnt/β-catenin pathway and EMT. Silencing LINC00514 restored the biological phenotypes of NSCLC cells by inhibiting the Wnt/β-catenin pathway. Additionally, silencing LINC00514 attenuated the growth of xenograft tumors in vivo.
Article
Biochemistry & Molecular Biology
Iveta Yotova, Quanah J. Hudson, Florian M. Pauler, Katharina Proestling, Isabella Haslinger, Lorenz Kuessel, Alexandra Perricos, Heinrich Husslein, Rene Wenzl
Summary: LINC01133 is upregulated in endometriosis and may affect pathogenesis through cellular proliferation and migration pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Ziwen Lu, Sirui Yuan, Lingling Ruan, Zhigang Tu, Hanqing Liu
Summary: Partitioning-defective protein 6 (Par6) family proteins play a critical role in the occurrence and development of ovarian cancer. This study revealed that PARD6A is highly expressed in advanced stages of ovarian cancer and is associated with poor differentiation and lymphatic metastases. Knockdown of PARD6A suppressed EMT and metastasis in ovarian cancer cells, while overexpression of PARD6A promoted EMT. PARD6A affected EMT through the SNAIL1 signaling pathway and modulated the expression of VIMENTIN and E-cadherin. ILK was identified as a regulator of SNAIL1 expression. This study highlights the importance of PARD6A in ovarian cancer metastasis and provides a potential therapeutic target for drug development.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Anna Ruiz-Mitjana, Raul Navaridas, Maria Vidal-Sabanes, Aida Perramon-Gueell, Andree Yeramian, Isidre Felip, Nuria Eritja, Joaquim Egea, Mario Encinas, Xavier Matias-Guiu, Xavier Dolcet
Summary: The extracellular matrix and cell polarity are crucial for maintaining cellular homeostasis and preventing carcinogenesis. This study investigates the role of extracellular matrix in the cellular response to TGF-beta. It shows that the absence of extracellular matrix inhibits apoptosis and promotes epithelial-to-mesenchymal transition in response to TGF-beta. The molecular mechanisms underlying these cellular responses involve AKT, ERK, and SMAD pathways.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Galym Ismagulov, Sofiane Hamidi, Guojun Sheng
Summary: During mammalian embryo development, cellular morphogenesis resembling EMT and MET transitions play a crucial role in shaping the three-dimensional structure. The integration of pluripotency regulation, morphogenetic signaling, and biomechanical force anisotropy drives the organization of the embryonic 3-D structure. Investigating the molecular regulation of epithelial cell polarity and partial EMT/MET is important for understanding mammalian early development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Hangyu Zhang, Changgang Liu, Xinbo Wang, Yongfang Wang, Jie Zheng
Summary: SCARA5 expression is downregulated in gastric cancer, associated with promoter methylation, aggressive clinicopathological characteristics, and poor prognosis. Overexpression of SCARA5 inhibits the growth and migration of GC cells, potentially serving as a biomarker for diagnosis and therapeutic target.
Article
Dentistry, Oral Surgery & Medicine
Hong Zhang, Zhenhua Wang, Zhongti Zhang
Summary: This study investigated the role and mechanism of a abnormally expressed circular RNA (hsa_circ_0009128) in oral squamous cell carcinoma (OSCC) progression. The results showed that hsa_circ_0009128 was upregulated in OSCC tissues and cell lines, and correlated with advanced TNM stage and lymph node metastasis. Knockdown of hsa_circ_0009128 inhibited cell proliferation and migration, and decreased EMT in OSCC cells. These findings suggest that hsa_circ_0009128 may play an important role in the malignant progression of OSCC by targeting MMP9 to activate EMT.
Article
Pharmacology & Pharmacy
Huanyu Gu, Yi Li, Xiuping Cui, Huiru Cao, Zhijuan Hou, Yunhe Ti, Dahua Liu, Jing Gao, Yu Wang, Pushuai Wen
Summary: This study found that MICAL1 is down-regulated in colorectal cancer (CRC) and is associated with the metastatic status of the tumor. Overexpression of MICAL1 inhibits cell migration and growth, increases the expression of E-cadherin and Occludin, and suppresses the expression of Vimentin and N-cadherin. On the other hand, silencing MICAL1 promotes cell migration and enhances epithelial-mesenchymal transition (EMT).
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Oncology
Chongqing Gao, Jing Li, Fuling Zeng, Lijuan Wang, Kaiyun Chen, Dong Chen, Jian Hong, Chen Qu
Summary: MCM6, a novel diagnostic biomarker, is upregulated in intrahepatic cholangiocarcinoma (ICC) and associated with poor prognosis. It promotes ICC progression by activating the E2F1-mediated epithelial-mesenchymal transition (EMT) and enhances the proliferation and migration of ICC cells.
Article
Dermatology
Bo Dong, Laura Simonson, Samantha Vold, Ethan Oldham, Lillian Barten, Nihal Ahmad, Hao Chang
Summary: This study reveals that FZD6 gene is overexpressed in multiple melanoma cell lines and human samples. Knockdown or knockout of FZD6 does not affect cell proliferation but significantly reduces the invasive ability of melanoma cells. Knockout of Fzd6 also dramatically reduces lung metastasis in the Pten/BRaf mouse model of melanoma, indicating a promoter role of FZD6 in melanoma progression.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Geert de Vreede, Stephan U. Gerlach, David Bilder
Summary: Animals have evolved mechanisms to remove dangerous or nonfunctional cells from tissues. This study reveals that polarity defects associated with malignant transformation can activate tumor necrosis factor signaling, which eliminates clonal malignancies. This process is different from cell competition and can promote tissue homeostasis by monitoring epithelial integrity.
