Article
Chemistry, Applied
Christiane Faerestrand Ellefsen, Christian Winther Wold, Alistair L. Wilkins, Frode Rise, Anne Berit C. Samuelsen
Summary: This study isolated and characterized Pleurotus eryngii polysaccharide fractions containing various polysaccharides, and found that different components had different effects on TLR2 and dectin-1 activation. The activation of the human β-1,3-glucan receptor dectin-1 was correlated with the amount of beta-glucan in each fraction.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Xue Zhang, Zhenyu Cai, Haoyu Mao, Pei Hu, Xiaojun Li
Summary: Coriolus versicolor, an edible medicinal mushroom in China, contains two polysaccharides CVPn and CVPa, which have been shown to possess immunomodulatory abilities on RAW 264.7 macrophages. CVPa, with higher molecular weight and fewer branches, induces significant production of NO, iNOS, and TNF-alpha mRNA expression levels in cells, suggesting enhanced immunomodulatory potential compared to CVPn.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Medicine, Research & Experimental
Rocky Lowenthal, Megan Taylor, Jennifer A. Gidden, Billie Heflin, Jackson O. Lay, Nathan Avaritt, Alan J. Tackett, Alicja Urbaniak
Summary: Melanoma is a highly aggressive form of skin cancer with a high metastatic potential, and the mortality rate among metastatic melanoma patients remains a significant clinical challenge. Trametes versicolor, a mushroom used in Chinese traditional medicine, has been found to exhibit potent cytotoxic activity against melanoma cells and can induce apoptotic cell death and inhibit cell migration, highlighting its potential as a therapeutic agent for melanoma treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Xinghan Liu, Yujun Xu, Yi Li, Yuchen Pan, Shuli Zhao, Yayi Hou
Summary: The nanocomposite FMT-beta-glucan can suppress melanoma growth by inducing the activation of M1 macrophages in the tumor microenvironment.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Chemistry, Applied
Xuan Feng, Fan Li, Mingming Ding, Ran Zhang, Tongfei Shi, Yuyuan Lu, Wei Jiang
Summary: Through MD simulation and docking techniques, we investigated the recognition mechanism between bglc and Dectin-1, revealing the important roles of Trp221, His223, and Tyr228 in stabilizing the recognition complex and the clear preference of the recognition mode on the relative direction of triple-helix bglc.
CARBOHYDRATE POLYMERS
(2022)
Article
Food Science & Technology
Michele O'Sullivan, Elaine Dempsey, Sarah Case, Emer E. Hackett, Anna E. Ledwith, Hannah Prendeville, Tara O'Brien, Faye Lewis, Dearbhla M. Murphy, Supriya Yadav, Jude Wilson, Sinead C. Corr, Frederick J. Sheedy
Summary: Mushrooms have been valued as an edible and medical resource for thousands of years. Research on powdered A. bisporus mushrooms shows that they can attenuate immune signaling triggered by microbial ligands and inhibit the development of colitis in vivo. This study highlights the importance of mushrooms in developing complementary approaches to modulate chronic inflammation and disease.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Virology
Shaohua Shi, Lei Yin, Xuehuai Shen, Yin Dai, Jieru Wang, Dongdong Yin, Danjun Zhang, Xiaocheng Pan
Summary: This study found that beta-glucans from Coriolus versicolor can effectively enhance the immune response against influenza virus. The beta-glucans induced the expression of various immune factors in mice and chickens, resulting in reduced weight loss, mortality, and lung viral titers. The results suggest that beta-glucans have a significant antiviral effect and could potentially be used as immunomodulators against influenza.
Article
Chemistry, Multidisciplinary
Zehua Liu, Wenhua Lian, Qiang Long, Ruoyu Cheng, Giulia Torrieri, Baoding Zhang, Artturi Koivuniemi, Mohammad Mahmoudzadeh, Alex Bunker, Han Gao, Hongbin He, Yun Chen, Jouni Hirvonen, Rongbin Zhou, Qiang Zhao, Xiaofeng Ye, Xianming Deng, Helder A. Santos
Summary: This study presents a method for preparing ligand-free targeted nanoparticles (NPs) for the heart, and demonstrates their potential for improving cardiac ischemic/reperfusion (I/R) injury.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Polymer Science
Kazuki Sumiya, Hiroto Izumi, Takuya Matsunaga, Motoko Tanaka, Kazuo Sakurai
Summary: This paper introduces a new quantized complex that has the ability to accurately control the quantity of AS-ODNs, and is more easily taken up by cells compared to conventional complexes, thus providing higher efficiency in antisense therapy.
Article
Immunology
Bart G. J. Moerings, Priscilla de Graaff, Matthew Furber, Renger F. Witkamp, Reno Debets, Jurriaan J. Mes, Jeroen van Bergenhenegouwen, Coen Govers
Summary: This study investigates the effects of beta-glucans from different sources on immune cell trained immunity and resilience, showing correlation with activation of the Dectin-1 receptor. However, Dectin-1 receptor activation is not the sole predictor for beta-glucan-mediated trained immunity. The modified in vitro model focuses on macrophage responses and can be applied to assess the potential of dietary polysaccharides to induce trained immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Applied
Zhaomin Zheng, Qilin Huang, Yu Kang, Yonggang Liu, Wei Luo
Summary: The study investigated the influence of molecular size and chain conformation of water-soluble yeast beta-glucan on its interaction with Dectin-1, revealing that higher molecular weight beta-glucan exhibited a spherical conformation while smaller molecular weight beta-glucan showed a stiff chain conformation. The interaction between beta-glucan and Dectin-1 was found to be easier for spherical beta-glucan with longer side chains.
CARBOHYDRATE POLYMERS
(2021)
Review
Biochemistry & Molecular Biology
Yazhuo Zhang, Xinning Liu, Jun Zhao, Jie Wang, Qiaoling Song, Chenyang Zhao
Summary: In this review, we summarize the physicochemical properties and specific processes involved in 13-glucan induced phagocytosis, as well as the cascade events triggered by 13-glucan at the cellular and molecular levels.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Food Science & Technology
Yongshuai Jing, Shilin Zhang, Mingsong Li, Yunfeng Ma, Yuguang Zheng, Danshen Zhang, Lanfang Wu
Summary: This paper summarizes the research status of Coriolus versicolor polysaccharide (CVP) in terms of extraction technology, separation and purification, structural characterization, and pharmacological activity in recent years, and points out the existing problems and research gaps.
Article
Cell Biology
Chunwei Yu, Hui Chen, Donghua Du, Wenting Lv, Songjian Li, Dongfang Li, Zixuan Xu, Min Gao, Honglian Hu, Dacheng Liu
Summary: Beta-glucan from Saccharomyces cerevisiae has been shown to alleviate oxidative stress in LPS-stimulated RAW264.7 cells by activating the Dectin-1/Nrf2/HO-1 signaling pathway, leading to decreased ROS production.
CELL STRESS & CHAPERONES
(2021)
Article
Chemistry, Multidisciplinary
Fangyi Xu, Jingyao Mu, Yun Teng, Xiangcheng Zhang, Kumaran Sundaram, Mukesh K. Sriwastva, Anil Kumar, Chao Lei, Lifeng Zhang, Qiaohong M. Liu, Jun Yan, Craig J. McClain, Michael L. Merchant, Huang-Ge Zhang
Summary: Understanding and controlling the activities of microglia can improve brain health, and oral administration of oat nanoparticles can effectively prevent alcohol-induced brain inflammation.
Article
Biochemistry & Molecular Biology
Ill-Min Chung, Chang Kwon, Yeonju An, Mohd Ali, Hannah Lee, Jung-Dae Lim, Soyeon Kim, Yujin Yang, Seung-Hyun Kim, Ateeque Ahmad
Article
Engineering, Chemical
Md Obyedul Kalam Azad, Byeong Ryeol Ryu, Md Soyel Rana, Md Hafizur Rahman, Jung-Dae Lim, Young-Seok Lim
Summary: Research showed that using hot-melt extrusion processing can enhance the decarboxylation of CBDA in hemp leaves, leading to increased CBD content. Results indicated that the CBD content was four times higher in the extrudate leaves formulated with AP compared to the raw leaves.
Article
Biochemistry & Molecular Biology
Byeong Ryeol Ryu, Md Jahirul Islam, Md Obyedul Kalam Azad, Eun-Ji Go, Md Hafizur Rahman, Md Soyel Rana, Young-Seok Lim, Jung-Dae Lim
Summary: This study developed a high-performance liquid chromatography method for fast analysis of main cannabinoids in hemp inflorescence and successfully performed decarboxylation of the raw material. Using a solvent gradient system with water and methanol containing trifluoroacetic acid at a wavelength of 220 nm in UV spectrum yielded optimal results.
Article
Plant Sciences
Md. Jahirul Islam, Byeong Ryeol Ryu, Md. Obyedul Kalam Azad, Md. Hafizur Rahman, Md. Soyel Rana, Jung-Dae Lim, Young-Seok Lim
Summary: The study demonstrated that exogenously applied putrescine can enhance salt tolerance in Panax ginseng by promoting the accumulation of certain substances and increasing antioxidant enzyme activity. Additionally, the effects of putrescine on ginsenoside levels in ginseng vary depending on the type of ginsenosides and plant parts. These findings provide valuable insights for utilizing putrescine to modulate salt tolerance and ginsenoside content in ginseng sprouts.
Article
Biology
Md Jahirul Islam, Byeong Ryeol Ryu, Md Obyedul Kalam Azad, Md Hafizur Rahman, Eun Ju Cheong, Jung-Dae Lim, Young-Seok Lim
Summary: The accumulation of cannabinoids in hemp plants is greatly influenced by the quality of light in a controlled growing system. Different light combinations affect the synthesis of CBD and THCA, with THCA playing a significant role as a stress marker. This study suggests that THC and CBD do not show significant stress responses to light conditions compared to THCA.
Article
Biochemistry & Molecular Biology
Eun-Ji Go, Byeong-Ryeol Ryu, Su-Ji Ryu, Hyun-Bok Kim, Hyun-Tai Lee, Jin-Woo Kwon, Jong-Suep Baek, Jung-Dae Lim
Summary: Hot-melt extrusion processing of mulberry samples led to the production of colloidal dispersions, improving water solubility and stability of anthocyanins with prolonged release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agronomy
Byeong-Ryeol Ryu, Chang-Hyeug Kim, Tae-Hyung Kwon, Joon-Hee Han, Gyeong-Ju Gim, Md Jahirul Islam, Md Obyedul Kalam Azad, Md Hafizur Rahman, Md Soyel Rana, Jung-Dae Lim, Young-Seok Lim
Summary: This study analyzed the characteristics and selection of medicinal cannabis lines grown under smart farm conditions and found that the CW21-5 line had the highest CBD production per cubic meter. Principal Component Analysis and Self-Organizing Map analysis revealed that CW21-5 is a unique arbitrary line with a narrow plant diameter and high CBD content, resulting in its excellent CBD yield.
Article
Biochemistry & Molecular Biology
Eun Ji Go, Byeong Ryeol Ryu, Gyeong Ju Gim, Ha Yeon Lee, Han Sol You, Hyun Bok Kim, Hyun Tai Lee, Ji Young Lee, Man Sop Shim, Jong-Suep Baek, Jung Dae Lim
Summary: In this study, a colloidal dispersion was prepared using hot melt extrusion to improve the stability and bioavailability of mulberry anthocyanins in high pH, heat, and aqueous environments. The extrudate showed sustained release and exhibited probiotic properties and antimicrobial activities against pathogenic intestinal microflora.
Article
Nutrition & Dietetics
Tae Sik Sung, Seung-Bum Ryoo, Chang-Hyun Lee, Seon-Min Choi, Joo-Won Nam, Hyun-Bok Kim, Ji Young Lee, Jung-Dae Lim, Kyu Joo Park, Hyun-Tai Lee
Summary: The fruit of Morus alba L. (MAF) has been used as a food worldwide and in traditional medicine in East Asia for thousands of years. This study found that MAF has prokinetic activity and can enhance gastrointestinal motor function in mice and human intestines. It increased both myogenic and neurogenic contractions, resulting in accelerated intestinal transit rate (ITR). These findings suggest that MAF has potential as a new prokinetic agent.
Article
Plant Sciences
Ji Won Seo, Jae Geun Lee, Ji Hye Yoo, Jung Dae Lim, Ik Young Choi, Myong Jo Kim, Chang Yeon Yu, Eun Soo Seong
Summary: In this study, the transcriptomes of Astragalus membranaceus sprouts grown under different LED light sources were compared to establish a functional substance control model. The results showed that LED light sources can influence the gene expression pattern of A. membranaceus sprouts, providing a basis for the cultivation of high-functional Astragalus sprouts.
Article
Biochemistry & Molecular Biology
Jong-Hui Kim, Min Hong, Joon-Hee Han, Byeong Ryeol Ryu, Young Seok Lim, Jung Dae Lim, Chang Hyeug Kim, Soo-Ung Lee, Tae-Hyung Kwon
Summary: CBD isolated from Pink pepper exhibits potent anti-inflammatory effects by inhibiting inflammatory markers and mediators through the involvement of NF-kappa B and MAPK pathways.
Article
Food Science & Technology
Min Woo Kim, Yu-Jin Ham, Hyun-Bok Kim, Ji young Lee, Jung-Dae Lim, Hyun-Tai Lee
Summary: The present study investigated the anti-obesity effects of mature silkworm powder in adult mice. The results showed that mature silkworm powder significantly suppressed body weight gain, intra-abdominal adipose tissue, and food efficiency in both normal diet-fed and high-fat diet-fed mice. It also decreased food intake and liver weight in high-fat diet-fed mice, indicating appetite suppression and reduced conversion of feed into body weight. Furthermore, mature silkworm powder lowered the levels of glucose, triglyceride, cholesterol, liver enzymes, and alkaline phosphatase in the serum. These findings suggest that mature silkworm powder has potent anti-obesity effects and is safe for long-term use as a potential therapeutic and/or nutraceutical.
Article
Horticulture
Md Jahirul Islam, Byeong Ryeol Ryu, Md Obyedul Kalam Azad, Md Hafizur Rahman, Md Soyel Rana, Chang-Won Kang, Jung-Dae Lim, Young-Seok Lim
Summary: The study evaluated the performance of hemp seedlings under different light treatments and found significant impacts on leaf and root growth. Certain light treatments promoted bushy growth and osmolyte accumulation, which could enhance branching and inflorescence, ultimately leading to higher cannabinoids accumulation.
Article
Agronomy
Md Obyedul Kalam Azad, Katrine Heinsvig Kjaer, Md Adnan, Most Tahera Naznin, Jung Dae Lim, In Je Sung, Cheol Ho Park, Young Seok Lim
Article
Chemistry, Medicinal
Md Obyedul Kalam Azad, Wie Soo Kang, Jung Dae Lim, Cheol Ho Park
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
