Article
Oncology
Mireia Bachiller, Lorena Perez-Amill, Anthony Matthew Battram, Sebastian Ciro Carne, Amer Najjar, Els Verhoeyen, Manel Juan, Alvaro Urbano-Ispizua, Beatriz Martin-Antonio
Summary: This study demonstrates the important immunoregulatory role of CB-NK collaborating with CAR-T cells to enhance their antitumor activity. Combinatorial treatment based on CAR-T and CAR-NK cells or CB-NK and CAR-T cells showed that CB-NK required high doses for effectiveness, while a low number of CB-NK in the CAR-T product promoted early activation of CAR-T cells and enhanced anti-MM efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Ratna S. Wijaya, Scott A. Read, Sakthi P. Selvamani, Stephen Schibeci, Mahmoud K. Azardaryany, Adrian Ong, David van der Poorten, Rita Lin, Mark W. Douglas, Jacob George, Golo Ahlenstiel
Summary: Direct acting antiviral therapies clear chronic hepatitis C virus (HCV) infection rapidly and restore natural killer (NK) cell function. Following HCV clearance, NK-cell memory formation involving KLRG1(+) NK cells is observed, which indicates their role in HCV clearance and potential for vaccine design.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Umut Can Kucuksezer, Esin Aktas Cetin, Fehim Esen, Ilhan Tahrali, Nilgun Akdeniz, Metin Yusuf Gelmez, Gunnur Deniz
Summary: NK cells are a subset of innate lymphoid cells that play important roles in anti-tumor immune responses and immune regulation, with different subgroups showing cytotoxic functions or cytokine production. Their activation is influenced by a variety of factors, including cell surface receptors and cytokines, and their dysregulation can contribute to various immune-mediated diseases. Further research on NK cell biology and their potential therapeutic applications is necessary for better understanding and treatment of inflammatory disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Pauline Rettman, Matthew D. Blunt, Rebecca J. Fulton, Andres F. Vallejo, Leidy Y. Bastidas-Legarda, Laura Espana-Serrano, Marta E. Polak, Aymen Al-Shamkhani, Christelle Retiere, Salim Khakoo
Summary: This study demonstrates the feasibility of a peptide-based KIR-targeting vaccine strategy to activate NK cells and enhance antitumor responses. The DNA vaccine upregulated genes associated with cellular metabolism and downregulated genes related to immune cell maturation. Vaccination led to enhanced antitumor responses against melanoma cells and a tumor model expressing the KIR2DS2 ligand HLA-C*0102.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Alvaro Haroun-Izquierdo, Marianna Vincenti, Herman Netskar, Hanna van Ooijen, Bin Zhang, Laura Bendzick, Minoru Kanaya, Pouria Momayyezi, Shuo Li, Merete Thune Wiiger, Hanna Julie Hoel, Silje Zandstra Krokeide, Veronika Kremer, Geir Tjonnfjord, Stephanie Berggren, Kristina Wikstroem, Pontus Blomberg, Evren Alici, Martin Felices, Bjoern oenfelt, Petter Hoeglund, Bahram Valamehr, Hans-Gustaf Ljunggren, Andreas Bjoerklund, Quirin Hammer, Lise Kveberg, Frank Cichocki, Jeffrey S. Miller, Karl-Johan Malmberg, Ebba Sohlberg
Summary: This study demonstrates the feasibility of off-the-shelf therapy with a non-engineered, yet highly specific, NK cell population for hematological malignancies. The expanded adaptive NK cells retained high cytotoxicity and efficiently killed leukemia cells from AML patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Siqin Duan, Shuwen Liu
Summary: This review highlights the immunotherapy strategies for HIV infection that utilize the beneficial properties of natural killer (NK) cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Nurul Izza Ismail
Summary: As the placenta is semi-allogenic, it is expected that maternal immune cells would attack the invading trophoblast, but studies have shown that they cooperate with the trophoblast to disrupt the arterial wall. uNK cells, unique immune cells, play a role in pregnancy. The interaction between HLA class 1b genes and maternal uNK cells in humans is described in this review.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Daun Jung, Young Seok Baek, In Jee Lee, Ki Yeon Kim, Heejoo Jang, Sohyun Hwang, Jieun Jung, Yong-wha Moon, Kyung-Soon Park, Yong-Soo Choi, Hee Jung An
Summary: This study focused on ex vivo expansion and cryopreservation of allogeneic NK cells, which showed upregulated genes related to NK cell functions and exhibited potent cytolytic activity against cancer cell lines. The research suggests the potential use of expanded and cryopreserved NK cells as a promising immunotherapy for drug-resistant cancer patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Oncology
Ying Tang, Mei Jiang, Hai-Mei Jiang, Zeng Jie Ye, Yu-Sheng Huang, Xiu-Shen Li, Bin-Yu Qin, Rui-Sheng Zhou, Hua-Feng Pan, Da-Yong Zheng
Summary: Circular RNAs (circRNAs) have various functions in liver cancer, including involvement in proliferation, metastasis, cell apoptosis, immune evasion, and other important biological processes. Immune evasion is considered a crucial hallmark of liver cancer development, and circRNAs may participate in this process by regulating NK cell function.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Alberto Mendoza-Valderrey, Maite Alvarez, Andrea De Maria, Kim Margolin, Ignacio Melero, Maria Libera Ascierto
Summary: NK cells, with their unique capacity to attack cancer cells without antigen specificity, are being explored as a powerful tool for immunotherapy against tumors. Various strategies are being pursued to maximize the anti-tumor properties of NK cells in the clinic, with the need for further optimization to enhance the clinical outcome of NK cell-based immunotherapy targeting tumors.
Review
Oncology
Frederique St-Pierre, Shailender Bhatia, Sunandana Chandra
Summary: Cancer immunotherapy has traditionally focused on adaptive immunity, but there is increasing recognition of the important role innate immunity plays in the body's response to neoplastic cells. Targeting natural killer (NK) cells, a key component of the innate immune response, for cancer treatment shows promise in developing innovative strategies for immunotherapy.
Article
Oncology
Brwa Ali Hussein, Linnea Kristenson, Silvia Pesce, Anne Wohr, Yarong Tian, Alexander Hallner, Mats Brune, Kristoffer Hellstrand, Ka-Wei Tang, Elin Bernson, Fredrik B. Thoren
Summary: This study found that the NKG2A gene variant is associated with enhanced NK cell effector function and improved outcome of IL-2-based immunotherapy in AML.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Diana Schnoegl, Mathias Hochgerner, Dagmar Gotthardt, Leigh M. Marsh
Summary: NK cell deficiency caused by aberrant expression of the transcription factor Fra-2 is associated with pulmonary fibrosis and inflammation in systemic sclerosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Caiyun Qi, Fang Liu, Wenjun Zhang, Yali Han, Nan Zhang, Qiang Liu, Handong Li
Summary: This study identified a distinct subset of NK cells and its potential involvement in Alzheimer's disease (AD) through analyzing single-cell RNA sequencing data and flow cytometry. The unique NK cell subset was found to be associated with the progression of AD and negatively correlated with cognitive function.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Allergy
Nicholas R. Pollock, Genelle F. Harrison, Paul J. Norman
Summary: Interactions between killer cell immunoglobin-like receptors (KIR) and human leukocyte antigens (HLA) class I play crucial roles in regulating the effector functions of key cytotoxic cells in innate and adaptive immunity. The extreme diversity of this interaction is genetically determined and has evolved in response to the ever-changing environment of pathogen exposure. The independent segregation of KIR and HLA genes on separate chromosomes further contributes to the diversity. Specific combinations of inherited receptors and ligands may predispose individuals to certain immune-mediated diseases, including autoimmunity. The combinatorial diversity of KIR and HLA class I also affects the success rates of immunotherapy for these diseases. Detailed characterization of the extent and consequences of the combinatorial diversity is helping in understanding the etiopathology and predicting response to therapy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Gastroenterology & Hepatology
Stephanie Patouraux, Deborah Rousseau, Stephanie Bonnafous, Cynthia Lebeaupin, Carmelo Luci, Clemence M. Canivet, Anne-Sophie Schneck, Adeline Bertola, Marie-Christine Saint-Paul, Antonio Iannelli, Jean Gugenheim, Rodolphe Anty, Albert Tran, Beatrice Bailly-Maitre, Philippe Gual
JOURNAL OF HEPATOLOGY
(2017)
Article
Immunology
Hadi Zarif, Sarah Nicolas, Melanie Guyot, Salma Hosseiny, Anne Lazzari, Maria Magdalena Canali, Julie Cazareth, Frederic Brau, Valentine Golzne, Elisa Dourneau, Maud Maillaut, Carmelo Luci, Agnes Paquet, Kevin Lebrigand, Marie-Jeanne Arguel, Douglas Daoudlarian, Catherine Heurteaux, Nicolas Glaichenhaus, Joelle Chabry, Alice Guyon, Agnes Petit-Paitel
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Article
Gastroenterology & Hepatology
Cynthia Lebeaupin, Deborah Vallee, Deborah Rousseau, Stephanie Patouraux, Stephanie Bonnafous, Gilbert Adam, Frederic Luciano, Carmelo Luci, Rodolphe Anty, Antonio Iannelli, Sandrine Marchetti, Guido Kroemer, Sandra Lacas-Gervais, Albert Tran, Philippe Gual, Beatrice Bailly-Maitre
Article
Biochemistry & Molecular Biology
Elena Tomasello, Karima Naciri, Rabie Chelbi, Gilles Bessou, Anissa Fries, Elise Gressier, Abdenour Abbas, Emeline Pollet, Philippe Pierre, Toby Lawrence, Thien-Phong Vu Manh, Marc Dalod
Article
Multidisciplinary Sciences
Meri K. Tulic, Elisa Cavazza, Yann Cheli, Arnaud Jacquel, Carmelo Luci, Nathalie Cardot-Leccia, Hanene Hadhiri-Bzioueche, Patricia Abbe, Maeva Gesson, Laura Sormanil, Claire Regazzetti, Guillaume E. Beranger, Cedric Lereverend, Caroline Pons, Abdallah Khemis, Robert Ballotti, Corine Bertolotto, Stephane Rocchi, Thierry Passeron
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Arnaud Sans, Stephanie Bonnafous, Deborah Rousseau, Stephanie Patouraux, Clemence M. Canivet, Pierre S. Leclere, Jeanne Tran-Van-Nhieu, Carmelo Luci, Beatrice Bailly-Maitre, Xu Xu, Ann-Hwee Lee, Kaori Minehira, Rodolphe Anty, Albert Tran, Antonio Iannelli, Philippe Gual
SCIENTIFIC REPORTS
(2019)
Review
Immunology
Carmelo Luci, Elodie Vieira, Thibaut Perchet, Philippe Gual, Rachel Golub
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Clemence M. Canivet, Stephanie Bonnafous, Deborah Rousseau, Pierre S. Leclere, Sandra Lacas-Gervais, Stephanie Patouraux, Arnaud Sans, Carmelo Luci, Beatrice Bailly-Maitre, Antonio Iannelli, Albert Tran, Rodolphe Anty, Philippe Gual
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Immunology
Abdenour Abbas, Thien-Phong Vu Manh, Michael Valente, Nils Collinet, Noudjoud Attaf, Chuang Dong, Karima Naciri, Rabie Chelbi, Geoffray Brelurut, Inaki Cervera-Marzal, Benjamin Rauwel, Jean-Luc Davignon, Gilles Bessou, Morgane Thomas-Chollier, Denis Thieffry, Alexandra-Chloe Villani, Pierre Milpied, Marc Dalod, Elena Tomasello
Article
Multidisciplinary Sciences
Pierre S. Leclere, Deborah Rousseau, Stephanie Patouraux, Sophie Guerin, Stephanie Bonnafous, Aline Grechez-Cassiau, Anthony A. Ruberto, Carmelo Luci, Malayannan Subramaniam, Albert Tran, Franck Delaunay, Philippe Gual, Michele Teboul
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Sokchea Khou, Alexandra Popa, Carmelo Luci, Franck Bihl, Aida Meghraoui-Kheddar, Pierre Bourdely, Emie Salavagione, Estelle Cosson, Alain Rubod, Julie Cazareth, Pascal Barbry, Bernard Mari, Roger Rezzonico, Fabienne Anjuere, Veronique M. Braud
Review
Endocrinology & Metabolism
Carmelo Luci, Manon Bourinet, Pierre S. Leclere, Rodolphe Anty, Philippe Gual
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Dermatology
Carmelo Luci, Franck Bihl, Pierre Bourdely, Sokchea Khou, Alexandra Popa, Aida Meghraoui-Kheddar, Ophelie Vermeulen, Roxane Elaldi, Gilles Poissonnet, Anne Sudaka, Alexandre Bozec, Selma Bekri, Julie Cazareth, Gilles Ponzio, Pascal Barbry, Roger Rezzonico, Bernard Mari, Veronique M. Braud, Fabienne Anjuere
Summary: NK cells and ILC1s play important roles in early control of cSCC development, but become functionally impaired as the tumor progresses, potentially contributing to cSCC development. Understanding the dynamics and functions of these innate lymphoid cells could be crucial for future immunotherapies targeting cSCC.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Carmelo Luci, Elodie Vieira, Manon Bourinet, Deborah Rousseau, Stephanie Bonnafous, Stephanie Patouraux, Lauren Lefevre, Frederic Larbret, Virginie Prod'homme, Antonio Iannelli, Albert Tran, Rodolphe Anty, Beatrice Bailly-Maitre, Marcel Deckert, Philippe Gual
Summary: The SYK-3BP2 pathway plays an important role in the pathogenesis of chronic liver inflammatory diseases. Targeting the SYK-3BP2 pathway in myeloid cells and hepatocytes can effectively control liver inflammation and fibrosis, which may be a potential strategy for treating metabolic steatohepatitis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Meeting Abstract
Immunology
O. Vermeulen, P. Bourdely, C. Luci, F. Bihl, S. Khou, A. Rubod, J. Cazareth, F. Hacini-Rachinel, E. Vial, V. M. Braud, F. Anjuere
EUROPEAN JOURNAL OF IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)