Article
Pharmacology & Pharmacy
Leanne De Silva, Ju-Yen Fu, Thet Thet Htar, Wan Hamirul Bahrin Wan Kamal, Azahari Kasbollah, Saravanan Muniyandy, Lay-Hong Chuah
Summary: The study found that Technetium-99m-labeled niosomes had high radiolabeling efficiency and stability in vivo, with scintigraphic imaging showing radioactivity mainly accumulated in the liver, spleen, and kidneys, indicating higher specificity for the tumor area.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dorte Glintborg, Naja Due Kolster, Pernille Ravn, Marianne Skovsager Andersen
Summary: The prospective risk of type 2 diabetes in normal weight women with polycystic ovary syndrome (PCOS) is still debated, with conflicting results from different studies. Individual risk markers such as hyperandrogenism, age >40 years, Asian ethnicity, and weight gain should be considered in prospective screening programs for normal weight women with PCOS.
Article
Integrative & Complementary Medicine
Dan Li, Peng Bai, Jin-yang Wu, Min Xie, Rui-zhen Zhao, Zhong-peng Wang, Xiao-han Qi
Summary: Acupuncture and metformin can improve ovary morphology and function in DHEA-induced PCOS model rats, reducing weight gain, FSH, LH, and T levels while increasing E-2 and P levels significantly. IL-6 and visfatin levels were also decreased in both treatment groups.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Li-Ying Kam, Jia-Woei Wong, Kah-Hay Yuen
Summary: A floating tablet system containing thiamine hydrochloride was evaluated. The tablet showed a floating lag time of less than 30 s and sustained drug release over 12 h in vitro. The gastro-retentive time of the tablet was prolonged up to 10 h under the fed state, resulting in increased oral bioavailability of thiamine compared to the fasted state.
Article
Medicine, Research & Experimental
Nese Basak Turkmen, Hande Yuce, Muhterem Aydin, Asli Taslidere, Aysegul Dogan, Dilan Askin Ozek, Taha Bartu Hayal, Seyma Yasar, Osman Ciftci, Songul Unuvar
Summary: Based on the experimental results, it can be deduced that nerolidol has a significant ameliorating effect on lipid peroxidation, oxidative stress, inflammation, histopathological damage, and apoptosis accompanying PCOS in female rats.
Article
Pharmacology & Pharmacy
Ling Zuo, Yang Hai, Ruoyu Zhang, Biao Zuo, Jiayu Tian, Pan Li, Xiumei Ke, Meng Wang, Li Ren, Xuezhi Li, Xuekuan Huang, Jianwei Wang
Summary: This study aimed to determine the therapeutic effect and pharmacological mechanism of icariin in PCOS rats. The results showed that icariin significantly improved ovarian function and reproductive endocrine disorders by regulating sex hormones, restoring the estrous cycle, and reducing ovarian morphological damage in PCOS rats. In addition, icariin also reduced weight gain and improved glucolipid metabolism in PCOS rats.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Natalia Respekta, Agnieszka Maslanka, Ewa Mlyczynska, Maria Billert, Agata Szlaga, Patryk Sambak, Piotr Pawlicki, Bartosz Plachno, Marek Skrzypski, Malgorzata Kotula-Balak, Anna Basiak, Agnieszka Rak
Summary: This study found tissue-dependent differences in SPX/GALR2/3 levels between PCOS and control rats, indicating possible new mechanisms of PCOS neuroendocrinology.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Obstetrics & Gynecology
Daniel A. Dumesic, Ayli Tulberg, Karen L. Leung, Samantha C. Fisch, Tristan R. Grogan, David H. Abbott, Rajanigandha Naik, Gregorio D. Chazenbalk
Summary: In vitro differentiation of adipose stem cells into adipocytes in SC abdominal fat may predict insulin sensitivity in vivo in normal-weight women with PCOS, suggesting a potential role for hyperandrogenism in metabolic thrift. PCOS patients exhibited higher androgen levels, adipose-IR, and android fat percentage, while their adipocyte differentiation and gene expression in vitro were negatively correlated with adipose-IR and serum free testosterone but positively correlated with insulin sensitivity.
FERTILITY AND STERILITY
(2021)
Article
Medicine, Research & Experimental
Tingting Zhang, Huimin Gao, Yali Fan, Shuya Chen, Yingying Li, Ruixia Liu, Tianhe Li, Chenghong Yin
Summary: This study aimed to investigate the impact of gut microbiota and serum metabolites on the regulation of liver dysfunction in PCOS. PCOS rat models were established and various analyses were conducted to assess ovarian and liver functions, gut microbiome, and serum metabolites. The study found significant differences in gut microbiota and serum metabolite profiles among the groups, and identified a significant correlation between the metabolite ros-marinic acid (RA) and liver enzymes. The study suggests that restoring gut microbiota and targeting serum metabolites, particularly RA, may provide new strategies to treat liver dysfunction in PCOS patients.
Article
Medicine, Research & Experimental
Basma Abdel Fattah Helal, Ghada Mahmoud Ismail, Salma Elwy Nassar, Abeer Abed Abo Zeid
Summary: The study showed that vitamin D administration can improve the manifestation of letrozole-induced PCOS in female rats, with positive effects on biochemical metabolic and oxidative stress markers, but only partially improved coronary vasculopathy.
Article
Pharmacology & Pharmacy
Nazia Begum, Kandavalli Manipriya, B. Veeresh
Summary: This study developed a new animal model by combining a high-fat diet with letrozole to better simulate polycystic ovary syndrome (PCOS). Compared to the letrozole-only model, this new model can better demonstrate metabolic anomalies observed in PCOS.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Reproductive Biology
Yanna Ban, Haiying Ran, Ying Chen, Li Ma
Summary: The study aimed to investigate changes in lipids in the follicular fluid of PCOS patients with normal weight. Through lipidomic analysis, 32 lipids were found to be significantly different between PCOS patients and the control group, potentially serving as candidate biomarkers and therapeutic targets for PCOS.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Reproductive Biology
Fangfang He, Yumei Li
Summary: The composition of gut microbiota in PCOS patients with insulin resistance differs from those with PCOS alone and healthy women. This difference is correlated with clinical characteristics of PCOS, such as insulin resistance, abdominal obesity, and free fatty acids. PCOS-IR patients have increased abundance of Enterococcus, potentially impacting the host's intestinal environment and metabolic pathways related to insulin resistance.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Endocrinology & Metabolism
Xiao-lin Jiang, He Tai, Xuan-si Xiao, Shi-yu Zhang, Shi-chao Cui, Shu-bo Qi, Dan-dan Hu, Li-na Zhang, Jin-song Kuang, Xian-sheng Meng, Shun-min Li
Summary: This study found that CFDT can alleviate pathological damage and apoptosis in PCOS rat model. In addition, CFDT can improve ovarian function, reduce inflammatory response, inhibit apoptosis of granular cells, and inhibit the operation of ASK1/JNK pathway in PCOS rats.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xiaohong Ma, Xiaorong Li, LiLi Ma, Yan Chen, Shengyu He
Summary: Soy isoflavones treatment in PCOS rats significantly reduced body weight, ovarian volume and weight, improved estrous cycle, decreased cystic dilated follicles and atretic follicles in ovarian tissue, reduced testosterone and luteinizing hormone levels, increased estradiol and follicle stimulating hormone levels, inhibited NF-kappa B pathway activity, and enhanced anti-inflammatory and antioxidant capacity, thereby improving ovarian morphology and hormone disorders in PCOS rats.