Article
Chemistry, Medicinal
Yueting Deng, Yang Liu, Juan Li, Xiao Wang, Shan He, Xiaojun Yan, Yutong Shi, Weiyan Zhang, Lijian Ding
Summary: Biofilm is a complex microbial consortium with resistance mechanisms to known antibiotics, posing a threat to human health. Marine organisms provide abundant resources for the development of anti-biofilm agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Wanqing Cheng, Ting Xu, Liping Cui, Zihan Xue, Jifeng Liu, Ruige Yang, Shangshang Qin, Yong Guo
Summary: Infections caused by multidrug-resistant (MDR) bacteria are increasing worldwide, and novel antimicrobials are urgently needed. In this study, a class of amphiphilic xanthohumol derivatives were synthesized and molecule IV15 showed remarkable antibacterial effects, rapid bactericidal properties, low toxicity, good plasma stability, and reduced bacterial resistance. Mechanistic studies revealed that IV15 disrupted bacterial cell membranes, leading to bacterial death by increasing reactive oxygen species and causing leakage of proteins and DNA. Importantly, IV15 exhibited superior in vivo anti-MRSA efficacy compared to vancomycin.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Biotechnology & Applied Microbiology
Atanas G. Atanasov, Sergey B. Zotchev, Verena M. Dirsch, Claudiu T. Supuran
Summary: Natural products and their analogues have historically played a significant role in pharmacotherapy, however, they also present challenges. Recent technological and scientific developments are addressing these challenges and revitalizing interest in natural products as drug leads, particularly for combating antimicrobial resistance.
NATURE REVIEWS DRUG DISCOVERY
(2021)
Review
Biochemistry & Molecular Biology
K. L. T. Dilrukshi Jayawardene, Enzo A. Palombo, Peter R. Boag
Summary: Parasitic nematodes infect a wide range of organisms and have significant impact on human health and agriculture. The main method of controlling these parasites is through anthelmintic drugs, but there is limited selection in the market and resistance is a major issue. Therefore, the development of new anthelmintics is crucial for sustainable parasitic control.
Review
Food Science & Technology
Na Guo, Xue Bai, Yong Shen, Tiehua Zhang
Summary: This review discusses the biofilm formation of Staphylococcus aureus in the food industry, highlighting the potential and mechanisms of natural products as eco-friendly antibiofilm agents. The aim is to provide valuable information for the screening of potent natural anti-biofilm agents in the food industry.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Li-Juan Deng, Wei-Qing Deng, Shu-Ran Fan, Min-Feng Chen, Ming Qi, Wen-Yu Lyu, Qi Qi, Amit K. Tiwari, Jia-Xu Chen, Dong-Mei Zhang, Zhe-Sheng Chen
Summary: Abnormal N6-methyladenosine (m6A) modification is closely related to cancer development, and finding targeted anticancer drugs is important. Traditional herbs and computer-synthesized compounds are reasonable sources for these drugs. Artificial intelligence has advantages in discovering m6A-targeting anticancer drugs.
Article
Infectious Diseases
Natalie K. Boyd, Grace C. Lee, Chengwen Teng, Christopher R. Frei
Summary: The study found that four non-antibiotic drugs demonstrated varying degrees of in vitro activity against clinical isolates of Staphylococcus aureus, with ebselen showing the most potent effect.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Review
Chemistry, Multidisciplinary
Gina Porras, Francois Chassagne, James T. Lyles, Lewis Marquez, Micah Dettweiler, Akram M. Salam, Tharanga Samarakoon, Sarah Shabih, Darya Raschid Farrokhi, Cassandra L. Quave
Summary: The crisis of antibiotic resistance highlights the importance of exploring plant natural products as a potential source of antibacterial compounds. This review systematically examines the antibacterial activity of 459 plant-derived compounds, with a focus on 183 compounds that show promising potential as antibiotics. The rich chemodiversity and clinical effectiveness of plant NPs make them a valuable resource for future antibiotic discovery and development efforts.
Review
Chemistry, Medicinal
Bhawna Chopra, Ashwani Kumar Dhingra
Summary: Natural products have been used in folklore for centuries for treating various ailments, with plant-derived products recognized as a source of therapeutic agents and structural diversity. After small modifications, natural molecules can offer better pharmacological potential as new molecular entities.
PHYTOTHERAPY RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Adam Foxfire, Andrew Riley Buhrow, Ravi S. Orugunty, Leif Smith
Summary: The genus Burkholderia consists of Gram-negative, non-sporulating bacteria that mainly dwell in soil, with some virulent species like Burkholderia mallei, Burkholderia pseudomallei, and the Burkholderia cepacia complex. Research on natural products isolated from Burkholderia and the drug discovery efforts have shown promise in developing novel therapeutics against infectious diseases, which is urgent due to the increasing prevalence of antibiotic-resistant pathogens.
EXPERT OPINION ON DRUG DISCOVERY
(2021)
Review
Chemistry, Medicinal
Himangini Bansal, Rajeev K. Singla, Sahar Behzad, Hitesh Chopra, Ajmer S. Grewal, Bairong Shen
Summary: The natural product specialized metabolites are crucial for current drug development, and advancements in understanding their biosynthesis and biochemistry are leading to a new era of drug exploration. Synthetic biology is providing the tools needed to unlock the therapeutic potential of natural products, circumventing traditional screening program challenges and enabling the discovery of new molecules with novel functions.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Article
Microbiology
Maureen Kleinhenz, Pavani Beesetty, Ching Yang, Zhaotao Li, Christopher P. Montgomery
Summary: Recurrent Staphylococcus aureus infections are common, but no approved vaccine is available. Antibiotic therapy resolves infection but fails to elicit protective immunity. Combined vaccination and antibiotics can treat infection and generate durable protective immunity.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Chemistry, Medicinal
Haoran Li, Mireguli Maimaitiming, Yue Zhou, Huaxuan Li, Pingyuan Wang, Yang Liu, Till F. Schaeberle, Zhiqing Liu, Chang-Yun Wang
Summary: This review summarizes marine natural products (MNPs) isolated from marine plants, animals, and microorganisms that show promising antibiotic activities against Pseudomonas aeruginosa. Nearly 80 MNPs have been discovered in the last decade, with impressive in vitro and in vivo efficacy against the pathogen.
Review
Pharmacology & Pharmacy
Yihui Song, Xiaoke Yang, Bin Yu
Summary: Drug repurposing is an attractive strategy for finding new indications for existing drugs. Three approved antidepressants have shown potential in clinical trials for cancer treatment. By conducting further medicinal chemistry research, several TCP-based inhibitors of the histone lysine specific demethylase 1 enzyme have been discovered, showing promise for cancer treatment. Repurposing antidepressants could be a promising strategy for cancer treatment.
DRUG DISCOVERY TODAY
(2022)
Article
Public, Environmental & Occupational Health
Khaloud M. Alarjani, Milan Skalicky
Summary: This study investigated the biofilm forming ability of drug resistant S. aureus strains isolated from hospital wastewater. The isolated strains showed resistance against various antibiotics. The essential oil extracted from T. polium demonstrated antibacterial and anti-biofilm activity.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
