Article
Biochemistry & Molecular Biology
Jing Cao, Guogang Zhang, Zhaoya Liu, Qian Xu, Chan Li, Guangjie Cheng, Ruizheng Shi
Summary: PXDN plays a role in AGEs-induced diabetic vascular endothelial dysfunction by inhibiting eNOS phosphorylation through the NOX2/HOCl/Akt pathway.
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Review
Endocrinology & Metabolism
Bowen Wang, Deepak Vashishth
Summary: Hyperglycemia and oxidative stress in diabetes and aging lead to excessive accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone. AGEs/AGOEs disrupt bone turnover and deteriorate bone quality through alterations of organic matrix, mineral, and water content. This review explains the accumulation and impact of AGEs/AGOEs in bone, as well as their targeting in preclinical and clinical investigations for the management of diabetic, osteoporotic, and insufficiency fractures.
Article
Multidisciplinary Sciences
Hathaichanok Chuntakaruk, Prachya Kongtawelert, Peraphan Pothacharoen
Summary: Purple corn anthocyanins have shown to be beneficial in reducing inflammation associated with diabetes and may help ameliorate cartilage degradation. By inhibiting the NF kappa b and MAPK signaling pathways, purple corn anthocyanins and the metabolite PCA exhibit anti-inflammatory effects on AGEs-induced cartilage degradation.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mariyam Khalid, Georg Petroianu, Abdu Adem
Summary: Persistent hyperglycemia in type 2 diabetes mellitus triggers a glycation reaction, resulting in the formation of AGEs. Binding of AGEs with its receptor RAGE activates various signaling pathways, leading to oxidative stress, inflammation, compromised insulin signaling, metabolic disturbances, pancreatic beta cell toxicity, and epigenetic modifications. This review summarizes the sources of AGEs, their role in metabolic dysfunction, and the AGEs/RAGE signaling cascade in type 2 diabetes mellitus and its associated complications.
Article
Biochemistry & Molecular Biology
Xiao Yang, Cong-Jin Liu, Zhen-Zhen Wang, Dong Ding, Jing-Wen Shi, Xin-Tong Wu, Lian-Wen Sun, Yu-Bo Fan
Summary: AGEs negatively impact the mechanosensitivity of osteocytes, affecting the bone remodeling process. This study provides a new perspective on exploring the mechanism of osteoporosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Patricia Budihartanti Liman, Karina Shasri Anastasya, Nabila Maudy Salma, Yenny Yenny, Meutia Atika Faradilla
Summary: The aim of this study was to analyze scientific articles on advanced glycation end products (AGEs) and obesity using bibliometric methods. The results showed an increase in studies on processed foods and obesity, with the United States making the largest contribution in this field. Open access journals had higher citation numbers and younger publication years compared to closed access journals.
Article
Nanoscience & Nanotechnology
Gopal Ammanath, Carla Giorgia Delachi, Soner Karabacak, Yusuf Ali, Bernhard O. Boehm, Umit Hakan Yildiz, Palaniappan Alagappan, Bo Liedberg
Summary: A simple method for colorimetric and fluorometric profiling of AGEs was reported in this study, utilizing changes in optical properties of PTs and Apts to estimate the concentrations of AGEs in plasma, and achieving distinct profiling of different AGEs through PCA analysis. The approach allows for rapid analysis of spiked AGEs in plasma samples without the need for preanalytical processing and advanced instrumentation, facilitating on-site diagnosis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Endocrinology & Metabolism
Xingyu Zhang, Xiaoyu Chen, Shengjie Li, Mengze Gao, Peipei Han, Liou Cao, Jing Gao, Qiongying Tao, Jiayi Zhai, Dongyu Liang, Li Qin, Qi Guo
Summary: This study found that elevated levels of AGEs are associated with sarcopenia, but not with presarcopenia. Osteoporosis plays a partial mediating role in the association between AGEs and sarcopenia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Cong-Jin Liu, Xiao Yang, Shou-Hui Wang, Xin-Tong Wu, Yan Mao, Jing-Wen Shi, Yu-Bo Fan, Lian-Wen Sun
Summary: Bone loss occurs in astronauts during long-term space flight, and this study investigated the improvement effects of blocking AGEs formation on microgravity-induced bone loss using the AGES formation inhibitor, irbesartan. Results showed that irbesartan significantly inhibited AGEs and 8-OHdG expression, improving bone quality and bone formation process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Govigerel Bayarsaikhan, Delger Bayarsaikhan, Pyung Chun Oh, Woong Chol Kang, Bonghee Lee
Summary: Researchers investigated the utility of AGEs as prognostic biomarkers for AMI and found that CUPRAC-reactive AGEs exhibit various patterns of changes in serum samples of AMI patients.
Review
Nutrition & Dietetics
Kate Phuong-Nguyen, Bryony A. A. McNeill, Kathryn Aston-Mourney, Leni R. R. Rivera
Summary: Consuming a high-AGE diet can lead to changes in gastrointestinal structure, modifications in enteric neurons, and reshaping of the microbiota, resulting in poor health outcomes.
Article
Oncology
Ziling Mao, Jacqueline Roshelli Baker, Masayoshi Takeuchi, Hideyuki Hyogo, Anne Tjonneland, Anne Kirstine Eriksen, Gianluca Severi, Joseph Rothwell, Nasser Laouali, Verena Katzke, Rudolf Kaaks, Matthias B. Schulze, Domenico Palli, Sabina Sieri, Maria Santucci de Magistris, Rosario Tumino, Carlotta Sacerdote, Jeroen W. G. Derksen, Inger T. Gram, Guri Skeie, Torkjel M. Sandanger, Jose Ramon Quiros, Marta Crous-Bou, Maria-Jose Sanchez, Pilar Amiano, Sandra M. Colorado-Yohar, Marcela Guevara, Sophia Harlid, Ingegerd Johansson, Aurora Perez-Cornago, Heinz Freisling, Marc Gunter, Elisabete Weiderpass, Alicia K. Heath, Elom Aglago, Mazda Jenab, Veronika Fedirko
Summary: Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) are associated with the development and progression of colorectal cancer due to their oxidative and inflammatory properties. This study found that circulating glycer-AGEs concentrations are positively associated with both colorectal cancer-specific and all-cause mortality. The association between glycer-AGEs and colorectal cancer-specific mortality is stronger in patients with distal colon cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Cardiac & Cardiovascular Systems
Xin Tang, Lihong Pan, Shuang Zhao, Feiyue Dai, Menglin Chao, Hong Jiang, Xuesong Li, Zhe Lin, Zhengrong Huang, Guoliang Meng, Chun Wang, Chan Chen, Jin Liu, Xin Wang, Albert Ferro, Hong Wang, Hongshan Chen, Yuanqing Gao, Qiulun Lu, Liping Xie, Yi Han, Yong Ji
Article
Cell Biology
Virginia Tajadura, Marie Haugsten Hansen, Joy Smith, Hannah Charles, Matthew Rickman, Keith Farrell-Dillon, Vasco Claro, Christina Warboys, Albert Ferro
CELL DEATH & DISEASE
(2020)
Article
Cardiac & Cardiovascular Systems
Deepak L. Bhatt, Juan Carlos Kaski, Sean Delaney, Mirvat Alasnag, Felicita Andreotti, Dominick J. Angiolillo, Albert Ferro, Diana A. Gorog, Alberto J. Lorenzatti, Mamas Mamas, John McNeil, Jose C. Nicolau, Philippe Gabriel Steg, Juan Tamargo, Doreen Tan, Marco Valgimigli
Summary: This study utilized crowdsourcing to investigate variations in antiplatelet therapy practices in NSTE-ACS patients at high bleeding risk following percutaneous coronary intervention. The results indicated strong agreement on initial monotherapy with either aspirin or a P2Y12 inhibitor within the first year. However, there was significant disagreement regarding the optimal duration of DAPT and choice of monotherapy.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Gabriella Passacquale, Pankaj Sharma, Divaka Perera, Albert Ferro
Summary: Antiplatelet medications are crucial in the treatment of cardiovascular and cerebrovascular diseases, with different choices and risks depending on the specific conditions of the patients. Personalized therapy based on individual patient characteristics is essential to optimize treatment outcomes.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Albert Ferro
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Albert Ferro
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Genetics & Heredity
Andrea Boscutti, Alessandro Pigoni, Giuseppe Delvecchio, Matteo Lazzaretti, Gian Mario Mandolini, Paolo Girardi, Adele Ferro, Michela Sala, Vera Abbiati, Marco Cappucciati, Marcella Bellani, Cinzia Perlini, Maria Gloria Rossetti, Matteo Balestrieri, Giuseppe Damante, Carolina Bonivento, Roberta Rossi, Livio Finos, Alessandro Serretti, Paolo Brambilla
Summary: Impulsivity levels were compared between individuals with bipolar disorder (BD) and healthy controls, with BD patients showing higher impulsivity levels. The BDNF rs6265 Met/Met homozygosis was associated with lower impulsivity scores, while the 5-HTTLPR SS genotype was linked to higher impulsivity scores in females only. Further studies with larger samples are needed to define the genetic basis of impulsivity in BD.
Article
Oncology
Amaia Mentxaka, Javier Gomez-Ambrosi, Gabriela Neira, Beatriz Ramirez, Sara Becerril, Amaia Rodriguez, Victor Valenti, Rafael Moncada, Jorge Baixauli, Maria A. Burrell, Camilo Silva, Vasco Claro, Albert Ferro, Victoria Catalan, Gema Fruhbeck
Summary: This study found that excess visceral adipose tissue in patients with obesity and colon cancer is associated with increased expression levels of NTN-1 and its main receptors, leading to the development of an inflammatory microenvironment that favors colon cancer progression.