Article
Multidisciplinary Sciences
Ping Xu, Xiaobo Xu, Hanna Fotina, Tetiana Fotina
Summary: This study found that CGA in Taraxacum officinale can reduce the expression of inflammatory genes and proteins in mammary epithelial cells of a mastitis model. It does so by inhibiting the phosphorylation of proteins in the NF-κB signaling pathway, leading to reduced expression of TNF-α, IL-6, IL-1β, and TLR2. This suggests that CGA may be a potential agent for treating mastitis in dairy cows.
Article
Biochemistry & Molecular Biology
Chong-Liang Bi, Shu-Jiu Zhang, Yi-Zhao Shen, Mirielle Pauline, Hui Li, He Tang
Summary: The results of the experiment suggest that dietary selenium can attenuate Staphylococcus aureus mastitis by inhibiting the NLRP3 inflammasome, thereby achieving immune modulation.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Biology
Mara D. Saenz-de-Juano, Giulia Silvestrelli, Andres Weber, Christian Rohrig, Mathias Schmelcher, Susanne E. Ulbrich
Summary: This study investigates the impact of Staphylococcus aureus extracellular vesicles on mammary epithelial cells, providing insights into how the bacteria evades host defense mechanisms and colonizes the mammary gland effectively.
Article
Immunology
Bo Liu, Qianru Li, Zhiguo Gong, Jiamin Zhao, Baichen Gu, Shuang Feng
Summary: This study found that lipoproteins from Staphylococcus aureus play a crucial role in inducing inflammatory responses and mediating bacterial internalization into bovine mammary epithelial cells.
MICROBIAL PATHOGENESIS
(2022)
Article
Veterinary Sciences
Xiaozhou Wang, Mingchao Liu, Na Geng, Yongzhen Du, Zhaoming Li, Xin Gao, Bo Han, Jianzhu Liu, Yongxia Liu
Summary: Cell death and inflammation are closely linked during mastitis caused by Staphylococcus aureus. Bovine mammary epithelial cells respond to S. aureus by NLRP3 inflammasome activation, leading to cell apoptosis and pyroptosis. This cell death process is associated with caspase-1 activation.
VETERINARY RESEARCH
(2022)
Article
Microbiology
Dianwen Xu, Guiqiu Hu, Jianchun Luo, Ji Cheng, Di Wu, Lisha Cheng, Xuejie Huang, Shoupeng Fu, Juxiong Liu
Summary: This study investigates the role and mechanism of mitophagy in the intracellular survival of Staphylococcus aureus (S.aureus) within bovine mammary epithelial cells (BMECs). The findings showed that S.aureus induced complete mitophagy to promote its survival within BMECs, which was mediated by the activation of the p38-PINK1-Parkin signaling pathway.
VETERINARY MICROBIOLOGY
(2023)
Article
Immunology
Qiang Ji, Meng Zhang, Yanfeng Wang, Yuhao Chen, Liping Wang, Xinyue Lu, Linfeng Bai, Manshulin Wang, Lili Bao, Huifang Hao, Zhigang Wang
Summary: This study found that chlorogenic acid (CGA) mitigates the inflammatory response caused by Staphylococcus aureus, protects milk protein synthesis, and improves amino acid uptake in bovine mammary epithelial cells (BMECs). CGA regulates the activity of mTORC1 and STAT5, upregulates IL-10 and IL-10RA, and reverses the inhibition of milk protein synthesis caused by Staphylococcus aureus.
MICROBIAL PATHOGENESIS
(2022)
Review
Food Science & Technology
Huanquan Chen, Junyan Zhang, Ying He, Zhuoyi Lv, Zhengtong Liang, Jianze Chen, Peishan Li, Jiawei Liu, Hongchen Yang, Ailin Tao, Xueting Liu
Summary: Staphylococcus aureus, a common bacterium, plays a crucial role in various diseases. This article discusses its virulence factors, inflammatory responses, host cell death, and associated diseases, highlighting the importance of understanding its pathogenic mechanisms for targeted treatment.
Article
Veterinary Sciences
Mingcheng Cai, Wenqiao Fan, Xiaoying Li, Hanchang Sun, Liuliu Dai, Defang Lei, Ying Dai, Yuhua Liao
Summary: Mastitis, an inflammatory disease mainly caused by bacteria, leads to severe economic loss in the dairy industry. Research showed that LTA can activate inflammatory responses via the TLR2/MyD88/PI3K/AKT signaling pathway, while miR-23a inhibits this response by targeting PI3K. Additionally, Mac-T cell-derived exosomes may be associated with inflammatory responses by promoting M1 polarization of bovine macrophages.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Xiao-Yan Zhu, Meng-Ling Wang, Meng Cai, Xue-Mei Nan, Yi-Guang Zhao, Ben-Hai Xiong, Liang Yang
Summary: Mastitis is a common infectious disease in dairy farms that results in decreased milk production and quality. Staphylococcus aureus is one of the main bacteria causing subclinical mastitis. Exosomes play a role in various physiological and pathological functions by containing proteins, lipids, and nucleic acids.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Immunology
Haojun Xu, Changjie Lin, Ting Li, Yifan Zhu, Jinghan Yang, Sijie Chen, Jianguo Chen, Xi Chen, Yingyu Chen, Aizhen Guo, Changmin Hu
Summary: In this study, the researchers aimed to investigate the effect of Staphylococcus aureus and Escherichia coli on m(6)A-modified circRNAs in bovine mammary epithelial cells. They found that these modified circRNAs were associated with cell injury, inflammation, apoptosis, and autophagy, and identified their regulatory roles in MAPK, WNT, and inflammation pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Veterinary Sciences
Bruno Toledo-Silva, Ana Claudia Dumont Oliveira, Fernando N. Souza, Freddy Haesebrouck, Sarne De Vliegher
Summary: This study found that cell-free supernatants from bovine non-aureus staphylococcal isolates can prevent adhesion and internalization of Staphylococcus aureus into bovine mammary epithelial cells, potentially through the S. aureus accessory gene regulator system. These findings provide new anti-virulence strategies for treating and controlling bovine S. aureus mastitis.
VETERINARY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Changjie Lin, Yifan Zhu, Zhiyu Hao, Haojun Xu, Ting Li, Jinghan Yang, Xi Chen, Yingyu Chen, Aizhen Guo, Changmin Hu
Summary: This study investigated the effects of E.coli and S.aureus on bovine mammary epithelial cell injuries and explored the lncRNA profile. The results showed differential expression of a large number of lncRNAs induced by these two pathogens, targeting signaling pathways with similar functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Shunzhi He, Xinrong Wang, Zhenteng Liu, Wei Zhang, Jianye Fang, Jingwen Xue, Hongchu Bao
Summary: The study found that HYA can significantly reduce S. aureus-induced mouse endometrial inflammation by inhibiting the expression of various inflammatory proteins, potentially through blocking the TLR2-mediated NF-kB and MAPK pathways.
Article
Veterinary Sciences
Jirao Shen, Feng Yang, Guibo Wang, Xiaoqing Mou, Jinyu Li, Xuezhi Ding, Xurong Wang, Hongsheng Li
Summary: In this study, it was found that Paeoniflorin (PF) inhibited the inflammatory response induced by S. haemolyticus in bovine mammary epithelial cells. It exerted its effects by suppressing the TLR2-NF-kappa B signaling pathway. Therefore, PF has the potential to be developed as a drug for treating CoNS-induced bovine mastitis.
RESEARCH IN VETERINARY SCIENCE
(2023)
Article
Immunology
Xue-jiao Gao, Tian-cheng Wang, Ze-cai Zhang, Yong-guo Cao, Nai-sheng Zhang, Meng-yao Guo
INTERNATIONAL IMMUNOPHARMACOLOGY
(2015)
Article
Cell Biology
Tiancheng Wang, Mengyao Guo, Xiaojing Song, Zecai Zhang, Haichao Jiang, Wei Wang, Yunhe Fu, Yongguo Cao, Lianqin Zhu, Naisheng Zhang
Article
Cell Biology
Xiaojing Song, Tiancheng Wang, Zecai Zhang, Haichao Jiang, Wei Wang, Yongguo Cao, Naisheng Zhang
Review
Cell Biology
Dengyu Yang, Tiancheng Wang, Miao Long, Peng Li
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)