Article
Microbiology
Haixia Wei, Shuizhen Wu, Liying Mai, Lili Yang, Weihao Zou, Hongjuan Peng
Summary: This study reveals the important role of Cbl-b in Toxoplasma gondii infection. Knockout of Cbl-b significantly inhibits T. gondii proliferation and reduces parasitic burden. In Cbl-b KO mice, the proportion of B cells increases, while the proportion of macrophages decreases. The levels of interferon-gamma and interleukin-6 in the serum are higher, indicating that Cbl-b negatively regulates the host's immune response through the TLR/MyD88 pathway.
MICROBIOLOGY SPECTRUM
(2023)
Article
Fisheries
Alianet Rodriguez, Janet Velazquez, Luis Gonzalez, Tania Rodriguez-Ramos, Brian Dixon, Fidel Herrera Miyares, Antonio Morales, Osmany Gonzalez, Mario Pablo Estrada, Yamila Carpio
Summary: PACAP-38 from African catfish enhances antibacterial activity and modulates gene expression of immune-related molecules, suggesting its potential as an antimicrobial agent in aquaculture.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Daisuke Yamanaka, Suzuka Kurita, Yuka Hanayama, Yoshiyuki Adachi
Summary: Beta-glucan, consisting of beta-1,3-linked D-glucose units, is present in various plants and microorganisms with diverse structures and bioactivities. A split-luciferase complementation assay was developed for the structural analysis of long-chain beta-1,6-branched beta-1,3-glucan, demonstrating the potential for real-time monitoring and differentiation of beta-glucans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Mayuka Inukai, Naoya Kobayashi, Hirotoshi Endo, Koki Asakawa, Keisuke Amano, Yuki Yasuda, Ugo Cenci, Christophe Colleoni, Steven Ball, Shoko Fujiwara
Summary: Haptophytes synthesize unique beta-glucans with more beta-1,6-linkages than beta-1,3-linkages as storage polysaccharides. The study found that PhTGS, a homolog of yeast 1,6-beta-transglycosylase, is involved in beta-glucan synthesis in the haptophyte Pleurochrysis haptonemofera. Knockdown of PhTGS repressed beta-glucan accumulation and induced lipid production, suggesting its role in carbon metabolic flow. Furthermore, PhTGS was expressed more in light, indicating its specific function in beta-glucan synthesis during photosynthesis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Fan Yang, Shang Shang, Mengfei Qi, Yajinjing Xiang, Lingmin Wang, Xinyi Wang, Tao Lin, Doudou Hao, Jiajia Chen, Jia Liu, Qing Wu
Summary: This review summarizes the recent advances in the application of yeast glucan particles (YGPs) in oral targeted delivery systems, including their structure, preparation methods, drug encapsulation, and characterization. It highlights the mechanism and validation of the target recognition interaction between YGPs and macrophages, and presents inspiring cases to demonstrate the promising applications of yeast cells. The future opportunities and challenges that YGPs may face are also emphasized in this article.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Fisheries
Pengzhi Qi, Yashu Wu, Zhongqi Gu, Hongfei Li, Jiji Li, Baoying Guo, Zhi Liao, Xiaojun Yan
Summary: This study identified a novel TLR isoform called McTLRlike1 in the mollusk Mytilus coruscus. McTLR-like1 was highly expressed in immune-related tissues and its levels increased when challenged with V. alginolyticus. It was found that McTLR-like1 activated NF-kappa B and influenced the expression and phosphorylation of its subunit P65. Silencing McTLR-like1 led to downregulation of pro-inflammatory cytokines and increased resistance to V. alginolyticus challenge. McTLR-like1 also showed affinity with McMyD88a. These findings contribute to our understanding of TLR signaling in mollusks and provide insights into TLR evolution.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Immunology
Beate J. Muller, Arne Westheider, Katharina Birkner, Birte Seelig, Susanne Kirschnek, Christian Bogdan, Friederike D. von Loewenich
Summary: Research shows that TLR, rather than NLR or CLR, is crucial for the detection of A. phagocytophilum, and defective TLR signaling may be compensated for by the redundancy of the immune system in vivo.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Biochemistry & Molecular Biology
Yanmin Cui, Xuedong Han, Xiaopei Hu, Tuoping Li, Suhong Li
Summary: In this study, the structural and physicochemical properties of beta-glucans from Lentinula edodes, yeast, and oat were compared using HPLC and FT-IR analysis. Different micro surfaces and structures were observed for beta-glucans from different species. Additionally, the antioxidant activities and alpha-glucosidase inhibitory activity varied among the beta-glucans.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Developmental Biology
Laura F. Bennett, Melanie D. Mumau, Yan Li, Nancy A. Speck
Summary: The study reveals that MyD88-dependent toll like receptor (TLR) signaling regulates the numbers of lympho-myeloid biased progenitors (LMPs) and adult-repopulating hematopoietic stem cells (HSCs) in hemogenic endothelial cells and intra-arterial hematopoietic clusters.
Article
Pharmacology & Pharmacy
Xiaobing Lin, Junhan Zhang, Decai Fan, Jiqin Hou, Hao Wang, Lin Zhu, Ruina Tian, Xiaofei An, Ming Yan
Summary: Frutescone O was found to inhibit LPS-induced inflammation by suppressing the secretion of nitric oxide, inducing inducible nitric oxide synthase, and expression of pro-inflammatory cytokines. Additionally, Frutescone O exerts anti-inflammatory effects by interfering with NF-kappa B and MAPK signaling pathways, and inhibiting Myd88 and iNOS expression.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Fengmin Yang, Lu Meng, Sisi Lin, Feng Wu, Jinyao Liu
Summary: By encapsulating antigen-carrying pseudoviruses inside positively charged polyethyleneimine-modified yeast capsules, a robust oral delivery system has been developed, providing a versatile platform for the development of various oral vaccines.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Jie Huang, Tiantian Wu, Youbao Zhong, Jiaqi Huang, Zengping Kang, Bugao Zhou, Haimei Zhao, Duanyong Liu
Summary: Curcumin can regulate the differentiation and function of Breg cells to alleviate chronic colitis by inhibiting the TLR/MyD88 signaling pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Applied
Dominik Rotrekl, Petra Salamunova, Lenka Parakova, Ondrej Bado, Ivan Salon, Frantisek Stepanek, Jaroslav Hanus, Jan Hosek
Summary: The study assessed the usability of yeast glucan particles as carriers for curcumin and the beneficial effect of curcumin in the particles on colitis in rats. The composites showed promising results in reducing colitis symptoms and decreasing pro-inflammatory cytokines, with a greater anti-inflammatory effect compared to pure particles or curcumin alone.
CARBOHYDRATE POLYMERS
(2021)
Review
Biotechnology & Applied Microbiology
Zorica Ubiparip, Marc De Doncker, Koen Beerens, Jorick Franceus, Tom Desmet
Summary: Beta-glucan phosphorylases are important carbohydrate-active enzymes with great potential for the biocatalytic synthesis of beta-glucans. Their preference for sugar phosphates highlights their significance in the carbohydrate industry.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Md Ezazul Haque, Mahbuba Akther, Shofiul Azam, In-Su Kim, Yuxi Lin, Young-Ho Lee, Dong-Kug Choi
Summary: In Parkinson's disease, the aggregated alpha-synuclein in Lewy bodies and mitochondrial dysfunction play crucial roles in neurodegeneration, with interactions between aggregated alpha-synuclein and mitochondria potentially leading to neuronal loss, making it an emerging drug target for Parkinson's disease treatment.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Agronomy
Spandana Rajendra Kopalli, Kyu-Min Cha, Jae Youl Cho, Si-Kwan Kim, Sushruta Koppula
Summary: This study investigated the beneficial effects of cordycepin on aging-associated testicular inflammation and serum biochemical changes in naturally aged rats. The results showed that cordycepin treatment significantly improved the altered biochemical parameters and attenuated the increased expression of inflammatory mediators in aged rats.
Review
Biochemistry & Molecular Biology
Rengasamy Balakrishnan, Duk-Yeon Cho, In-Su Kim, Sang-Ho Seol, Dong-Kug Choi
Summary: Neurological disorders are an important global health issue, and there is a lack of effective treatment options. Alpha- and beta-asarone, secondary metabolites found in plants, show potential neuroprotective effects. They act through multiple mechanisms, including antioxidant, anti-inflammatory, and antiapoptotic effects, making them a promising therapeutic approach for neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Shofiul Azam, Ju-Young Park, In-Su Kim, Dong-Kug Choi
Summary: Piperine (PIP) has shown potential therapeutic effects in various diseases, including inflammation, cardiac and hepatic diseases, neurodegenerative diseases, and cancer. Although PIP has poor pharmacokinetic properties, its interaction with metabolic enzymes and the Monoamine oxide B (MAO-B) active site make it a xenobiotics bioenhancer and a potential MAO-B inhibitor. Advancements in pharmaceutical technology have improved PIP's limitations. However, the structure activity relationship (SAR) study suggests that some of PIP's metabolites may be toxic or have pharmacological potential.
Article
Biochemistry & Molecular Biology
Spandana Rajendra Kopalli, Sung-Kwang Yoo, Bokyung Kim, Si-Kwan Kim, Sushruta Koppula
Summary: This study demonstrated that apigenin isolated from Carduus crispus can protect the testes from oxidative damage. Apigenin can inhibit H2O2-induced cellular damage and increase ROS levels, and it can also restore the expression levels of antioxidants and spermatogenesis-associated molecules.
Article
Biochemistry & Molecular Biology
Shofiul Azam, Md. Ezazul Haque, Duk-Yeon Cho, Joon-Soo Kim, Md. Jakaria, In-Su Kim, Dong-Kug Choi
Summary: Dioscin treatment can protect neuronal cells by inducing autophagy and suppressing the mitochondrial apoptosis pathway, reducing apoptosis and autophagic flux impairment caused by MPP+.
Review
Biochemistry & Molecular Biology
Shofiul Azam, Md. Jakaria, JoonSoo Kim, Jaeyong Ahn, In-Su Kim, Dong-Kug Choi
Summary: Metabotropic glutamate receptors (mGluRs), especially mGluR5, play important roles in neurodegenerative diseases and neuropsychiatric disorders. Recent research suggests that mGluR5 radioligands could be used to assess disease progression and track drug properties.
Review
Biochemistry & Molecular Biology
Spandana Rajendra Kopalli, Venkata Prakash Annamneedi, Sushruta Koppula
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disease caused by dysregulation of cytokines and other immune mediators. The JAK/STAT pathway plays a crucial role in AD pathogenesis, and its dysregulation can lead to inflammation and pruritus. SOCS proteins negatively regulate the immune-related inflammatory responses mediated by the JAK/STAT pathway. Natural product-derived biomolecules targeting JAK/STAT/SOCS signaling have shown potential in treating AD and other inflammatory disorders.
Article
Biochemistry & Molecular Biology
Shofiul Azam, Yon-Suk Kim, Md Jakaria, Ye-Ji Yu, Jae-Yong Ahn, In-Su Kim, Dong-Kug Choi
Summary: The study shows that Dioscorea nipponica Makino ethanol extract and its active compound dioscin can protect against neurotoxicity by inhibiting NF-kappa B phosphorylation and upregulating neurotrophic factor BDNF expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Lei Jin, Daemyoung Yun, Wei Zhang, Jinsung Lee, Hongchul Shin, Donghyuk Kim, Tae-Bong Kang, Hyung-Sik Won, Hohyoun Jang, Whangi Kim
Summary: Recently, there has been a renewed interest in hair dyeing due to developments in cosmetics. However, concerns over hair damage during the dyeing process have increased hesitation. This study focuses on developing hair dyes with minimal side effects by using natural-extract polyphenols, pyrogallol, and gallic acid coordinated by CuCl2. These polyphenols form an ion-channel coating on the hair surface, protecting it from damage. The results show successful hair dyeing using the polyphenol-based dye reagent, with increased hair thickness and varying tensile strength.
Article
Infectious Diseases
Su-Jin Kim, Tae-Bong Kang, Dong-Hyuk Kim, Minho Keum, Sung-Hee Lee, Ji-Hun Kim, Sang-Hyuck Lee, Jihoon Kim, Hyuk-Jung Kweon, Jae-Won Park, Beom-Jun Kim, Hyung-Sik Won
Summary: Natural antimicrobial peptides (AMPs) have potential as therapeutic agents for infectious inflammation. Two peptides, WALK244.04 and WALK243.04, showed promising antibacterial and anti-inflammatory activities.
Article
Biochemistry & Molecular Biology
Se-Bin Lee, Ju-Hui Kang, Eun-Jung Sim, Ye-Rin Jung, Jeong-Hyeon Kim, Prima F. Hillman, Sang-Jip Nam, Tae-Bong Kang
Summary: This study investigated the inhibitory activity of ethanolic extracts from Cornus officinalis seeds on AIM2 inflammasome activation. The results showed that the extract could inhibit the release of IL-1 beta induced by dsDNA and alleviate psoriasis-like symptoms in a mouse model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ju-Hui Kang, Se-Bin Lee, Jiu Seok, Dong-Hyuk Kim, Gaeun Ma, Jooho Park, Ae Jin Jeong, Sang-Kyu Ye, Tae-Bong Kang
Summary: In this study, a chemical compound called ODZ10117 (ODZ) was found to have anti-inflammatory effects targeting the NLRP3 inflammasome. ODZ inhibited inflammasome activation by disrupting the NLRP3-NEK7 interaction required for its formation. Furthermore, ODZ administration reduced IL-1β release and mortality in mice with sepsis, suggesting its potential as a treatment for NLRP3 inflammasome-associated immune disorders and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
So-Hyeon Park, Jun-Hyuck Lee, Seong-Bin Yang, Dong-Nyeong Lee, Tae-Bong Kang, Jooho Park
Summary: A novel peptide and drug conjugate (PDC) called RR-BA was developed using a cathepsin-B-specific peptide (RR) and bile acid (BA), which could self-assemble in an aqueous solution to form stable nanoparticles. The nano-sized RR-BA conjugate exhibited significant inhibitory effects on cathepsin B and showed anticancer effects against mouse colorectal cancer cells (CT26). In vivo experiments in CT26 tumor-bearing mice also confirmed its therapeutic effect and low toxicity. Therefore, the RR-BA conjugate holds promise as an effective anticancer drug candidate for targeting cathepsin B in cancer therapy.
Review
Chemistry, Medicinal
Monu Kumar Kashyap, Shubhada V. Mangrulkar, Sapana Kushwaha, Akash Ved, Mayur B. Kale, Nitu L. Wankhede, Brijesh G. Taksande, Aman B. Upaganlawar, Milind J. Umekar, Sushruta Koppula, Spandana Rajendra Kopalli
Summary: Cardiotoxicity is a well-known adverse effect of cancer-related therapy, and it significantly affects patient outcomes and quality of life. The use of antineoplastic drugs to treat colorectal cancers (CRCs) can result in cardiac complications. The mechanisms underlying cardiotoxicity associated with CRC treatment are complex and involve the modulation of various signaling pathways, ultimately damaging cardiac tissue. Therefore, the identification and management of cardiotoxicity associated with CRC drug therapy have become increasingly important.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
